Influenza Vaccination in Italian Healthcare Workers (2018-2019 Season): Strengths and Weaknesses. Results of a Cohort Study in Two Large Italian Hospitals

Background: Annual vaccination is the most effective way to combat influenza. As influenza viruses evolve, seasonal vaccines are updated annually. Within the European project Development of Robust and Innovative Vaccine Effectiveness (DRIVE), a cohort study involving Italian healthcare workers (HCWs) was carried out during the 2018-2019 season. Two aims were defined: to measure influenza vaccine effectiveness (IVE) against laboratory-confirmed influenza cases and to conduct an awareness-raising campaign to increase vaccination coverage. Methods: Each subject enrolled was followed up from enrollment to the end of the study. Each HCW who developed ILI was swabbed for laboratory confirmation of influenza. Influenza viruses were identified by molecular assays. A Cox regression analysis, crude and adjusted for confounding variables, was performed to estimate the IVE. Results: Among the 4483 HCWs enrolled, vaccination coverage was 32.5%, and 308 ILI cases were collected: 23.4% were positive for influenza (54.2% A(H1N1) pdm09; 45.8% A(H3N2)). No influenza B viruses were detected. No overall IVE was observed. Analyzing the subtypes of influenza A viruses, the IVE was estimated as 45% (95% CI: -59 to 81) for A(H1N1) pdm09. Conclusions: Vaccination coverage among HCWs increased. Study difficulties and the circulation of drifted variants of A(H3N2) could partly explain the observed IVE

Star Formation History at the Centers of Lenticular Galaxies with Bars and Purely Exponential Outer Disks from SAURON Data

We have investigated the stellar population properties in the central regions of a sample of lenticular galaxies with bars and single-exponential outer stellar disks using the data from the SAURON integral-field spectrograph retrieved from the open Isaac Newton Group Archive. We have detected chemically decoupled compact stellar nuclei with a metallicity twice that of the stellar population in the bulges in seven of the eight galaxies. A starburst is currently going on at the center of the eighth galaxy and we have failed to determine the stellar population properties from its spectrum. The mean stellar ages in the chemically decoupled nuclei found range from 1 to 11 Gyr. The scenarios for the origin of both decoupled nuclei and lenticular galaxies as a whole are discussed.Comment: 10 pages, 4 figures, a slightly edited version of the paper published by Astronomy Letters, v. 37, no.1, 201

Inner Polar Rings and Disks: Observed Properties

A list of galaxies with inner regions revealing polar (or strongly inclined to the main galactic plane) disks and rings is compiled from the literature data. The list contains 47 galaxies of all morphological types, from E to Irr. We consider the statistics of the parameters of polar structures known from observations. The radii of the majority of them do not exceed 1.5 kpc. The polar structures are equally common in barred and unbarred galaxies. At the same time, if a galaxy has a bar (or a triaxial bulge), this leads to the polar disk stabilization - its axis of rotation usually coincides with the major axis of the bar. More than two thirds of all considered galaxies reveal one or another sign of recent interaction or merging. This fact indicates a direct relation between the external environment and the presence of an inner polar structure.Comment: 12 pages, 3 figures, accepted to Astrophysical Bulletin. Minor changes and corrections are still possibl

The growth of the central region by acquisition of counterrotating gas in star-forming galaxies

Galaxies grow through both internal and external processes. In about 10% of nearby red galaxies with little star formation, gas and stars are counter-rotating, demonstrating the importance of external gas acquisition in these galaxies. However, systematic studies of such phenomena in blue, star-forming galaxies are rare, leaving uncertain the role of external gas acquisition in driving evolution of blue galaxies. Here, based on new measurements with integral field spectroscopy of a large representative galaxy sample, we find an appreciable fraction of counterrotators among blue galaxies (9 out of 489 galaxies). The central regions of blue counterrotators show younger stellar populations and more intense, ongoing star formation than their outer parts, indicating ongoing growth of the central regions. The result offers observational evidence that the acquisition of external gas in blue galaxies is possible; the interaction with pre-existing gas funnels the gas into nuclear regions (<1 kpc) to form new stars

Kinematic properties of gas and stars in 20 disc galaxies

Ionized gas and stellar kinematical parameters have been measured along the major axis of 20 nearby disc galaxies. We discuss the properties of each sample galaxy distinguishing between those characterized by regular or peculiar kinematics. In early-type disc galaxies ionized gas tends to rotate faster than stars and to have a lower velocity dispersion, whereas in late-type spirals gas and stars show almost the same rotation velocities and velocity dispersions. Incorporating the early-type disc galaxies studied by Bertola et al. (1995), Fisher (1997) and Corsini et al. (1999), we have compiled a sample of some 40 galaxies for which the major-axis radial profiles of both the stellar and gaseous components have been measured. The value of the stellar velocity dispersion measured at Re/4 turns out to be strongly correlated with the galaxy morphological type, while the gaseous velocity dispersion is not and sometimes takes values above the range expected from thermal motions or small-scale turbulence.Comment: 18 pages, 40 postscript figures. Accepted to be published in A&A. Higher resolution images available at: http://www.iac.es/folleto/research/Publi01/preprints01.html click over the "postscript file" of PP17/200

Data-driven RANS for simulations of large wind farms

In the wind energy industry there is a growing need for real-time predictions of wind turbine wake flows in order to optimize power plant control and inhibit detrimental wake interactions. To this aim, a data-driven RANS approach is proposed in order to achieve very low computational costs and adequate accuracy through the data assimilation procedure. The RANS simulations are implemented with a classical Boussinesq hypothesis and a mixing length turbulence closure model, which is calibrated through the available data. High-fidelity LES simulations of a utility-scale wind turbine operating with different tip speed ratios are used as database. It is shown that the mixing length model for the RANS simulations can be calibrated accurately through the Reynolds stress of the axial and radial velocity components, and the gradient of the axial velocity in the radial direction. It is found that the mixing length is roughly invariant in the very near wake, then it increases linearly with the downstream distance in the diffusive region. The variation rate of the mixing length in the downstream direction is proposed as a criterion to detect the transition between near wake and transition region of a wind turbine wake. Finally, RANS simulations were performed with the calibrated mixing length model, and a good agreement with the LES simulations is observed

Identifying gene-environment interactions in schizophrenia: Contemporary challenges for integrated, large-scale investigations

Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G 7 E), however, so far, thorough replication of findings is rare and G 7 E research still faces several conceptual and methodological challenges. In this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G 7 E research, drawing on the example of a large, international, multi-center study into the identification and translational application of G 7 E in schizophrenia. While such investigations are now well underway, new challenges emerge for G 7 E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotype. \ua9 2014 The Author