Optimal strategies : theoretical approaches to the parametrization of the dark energy equation of state

The absence of compelling theoretical model requires the parameterizing the dark energy to probe its properties. The parametrization of the equation of state of the dark energy is a common method. We explore the theoretical optimization of the parametrization based on the Fisher information matrix. As a suitable parametrization, it should be stable at high redshift and should produce the determinant of the Fisher matrix as large as possible. For the illustration, we propose one parametrization which can satisfy both criteria. By using the proper parametrization, we can improve the constraints on the dark energy even for the same data. We also show the weakness of the so-called principal component analysis method.Comment: 7pages, 11 figures, 2 tables, To match the version accepted by AS

Thermoelectric properties of Ca0.9Yb0.1MnO3-x prepared by spark plasma sintering in air atmosphere

In this paper we report the densification of Ca0.9Yb0.1MnO3-x ceramics by spark plasma sintering (SPS) in different atmospheres and using different tools. The thermoelectric properties of these ceramics are reported and compared to those of ceramics obtained by conventional sintering. This study clearly demonstrated the possibility for processing oxide materials by SPS under air atmosphere and overcomes the problem of reduction due to the low oxygen partial pressure (graphitic environment, dynamic vacuum or neutral atmosphere) commonly encountered

Photoluminescence properties of GaN grown on compliant silicon-on-insulator substrates

A compliant substrate approach has been employed to release lattice-mismatch caused strain in GaN epilayers through stress absorption in the substrate. GaN layers have been grown on silicon-on-insulator (SOI) substrates by low-pressure metalorganic chemical vapor deposition. Photoluminescence measurements at 4 K show the spectrum of grown GaN being dominated by UV emission around 3.47 eV related to neutral-donor bound excitons. The much weaker yellow luminescence shows a broad spectrum around 2.16 eV. Peak position of the UV emission changes both with measurement temperature and strain. At room temperature, the UV peak is red shifted by 64 meV corresponding well to the band-gap temperature dependence. Strain-induced blue shift of the peak, compared to unstrained GaN, is much less than for growth on sapphire, indicating strain relief in the GaN by growth on SOI. Further reduction of the blue shift is consistent with increased electron mobility. © 1997 American Institute of Physics.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/70808/2/APPLAB-71-26-3880-1.pd

Placement of metallic biliary endoprostheses in complex hilar tumours

AbstractPurposeTo assess the technical success, clinical success and complications after 1 month of percutaneous biliary drainage with the placement of several metallic endoprostheses in complex hilar liver tumours.Materials and methodsThis is a retrospective study, on a homogenous target population of 68 consecutive patients, who underwent multiple percutaneous biliary drainage for complex hilar tumour (Bismuth type II, III and IV) between August 1998 and August 2010. Patients benefiting from previous endoscopic drainage were excluded from the study. The clinical data, biological data, imaging and interventional radiology procedures were studied.ResultsThe rate of success of the technique was 98.5% and the clinical rate of success was 84% after 1 week and 93% after 1 month. The rate of minor and major complications was 25 and 13% respectively.ConclusionMultiple percutaneous biliary drainage in complex hilar tumour is a safe and effective first intention procedure

Doxorubicin versus doxorubicin and cisplatin in endometrial carcinoma: definitive results of a randomised study (55872) by the EORTC Gynaecological Cancer Group

BACKGROUND: Combination chemotherapy yields better response rates which do not always lead to a survival advantage. The aim of this study was to investigate whether the reported differences in the efficacy and toxicity of monotherapy with doxorubicin (DOX) versus combination therapy with cisplatin (CDDP) in endometrial adenocarcinoma lead to significant advantage in favour of the combination. PATIENTS AND METHODS: Eligible patients had histologically-proven advanced and/or recurrent endometrial adenocarcinoma and were chemo-naïve. Treatment consisted of either DOX 60 mg/m(2) alone or CDDP 50 mg/m2 added to DOX 60 mg/m2, every 4 weeks. RESULTS: A total of 177 patients were entered and median follow-up is 7.1 years. The combination DOX-CDDP was more toxic than DOX alone. Haematological toxicity consisted mainly of white blood cell toxicity grade 3 and 4 (55% versus 30%). Non-haematological toxicity consisted mainly of grade 3 and 4 alopecia (72% versus 65%) and nausea/vomiting (36 % versus 12%). The combination DOX-CDDP provided a significantly higher response rate than single agent DOX (P <0.001). Thirty-nine patients (43%) responded on DOX-CDDP [13 complete responses (CRs) and 26 partial responses (PRs)], versus 15 patients (17%) on DOX alone (8 CR and 7 PR). The median overall survival (OS) was 9 months in the DOX-CDDP arm versus 7 months in the DOX alone arm (Wilcoxon P = 0.0654). Regression analysis showed that WHO performance status was statistically significant as a prognostic factor for survival, and stratifying for this factor, treatment effect reaches significance (hazard ratio = 1.46, 95% confidence interval 1.05-2.03, P = 0.024). CONCLUSIONS: In comparison to single agent DOX, the combination of DOX-CDDP results in higher but acceptable toxicity. The response rate produced is significantly higher, and a modest survival benefit is achieved with this combination regimen, especially in patients with a good performance status

Observational constraints on thawing quintessence models

We use a dynamical systems approach to study thawing quintessence models, using a multi-parameter extension of the exponential potential which can approximate the form of typical thawing potentials. We impose observational constraints using a compilation of current data, and forecast the tightening of constraints expected from future dark energy surveys, as well as discussing the relation of our results to analytical constraints already in the literature.Comment: 6 pages MNRAS style with 8 figures included. Minor updates to match MNRAS accepted versio

Choledocholithiasis: repetitive thick-slab single-shot projection magnetic resonance cholangiopancreaticography versus endoscopic ultrasonography

This prospective study compares repetitive thick-slab single-shot projection magnetic resonance cholangiopancreatography (MRCP) with endoscopic ultrasonography (EUS) for the detection of choledocholithiasis. Fifty-seven consecutive patients (36 women, mean age 61) referred for suspected choledocholithiasis underwent MRCP, followed by EUS. Each procedure was performed by different operators blinded to the results of the other investigation. MR technique included a turbo spin-echo T2-weighted axial sequence with selective fat saturation (SPIR/TSE, TE=70ms, TR=1,600ms), followed by coronal dynamic MRCP. The same thick-slab slice was sequentially acquired 12 times as breath-hold single-shot projection imaging (SSh, TE=900ms, TE=8,000ms) centred on the common bile duct (CBD). Two experienced radiologists independently and blindly evaluated MR images for the detection of CBD stones. Their inter-observer agreement kappa was determined. Secondly, the two observers read MR images in consensus again. CBD stones were demonstrated in 18 out of 57 patients (31.6 %) and confirmed by endoscopic retrograde cholangiography (ERCP, n=17) or intraoperative cholangiography (n=1). Clinical follow-up served as the "gold standard” in patients with negative results without following invasive procedure (n=28). Sensitivity, specificity, accuracy, positive and negative predictive value for MRCP resulting from consensus reading were 94.9%, 94.4%, 94.7%, 97.4% and 89.5%, respectively. Corresponding values of EUS were 97.4%, 94.4%, 96.5%, 97.4% and 94.4%. Inter-observer agreement kappa was 0.81. Repetitive thick-slab single-shot projection MRCP is an accurate non-invasive imaging modality for suspected choledocholithiasis and should be increasingly used to select those patients who require a subsequent therapeutic procedure, namely ERC

Extending the Hubble diagram by gamma ray bursts

A new method to constrain the cosmological equation of state is proposed by using combined samples of gamma-ray bursts (GRBs) and supernovae (SNeIa). The Chevallier-Polarski-Linder parameterization is adopted for the equation of state in order to find out a realistic approach to achieve the deceleration/acceleration transition phase of dark energy models. We find that GRBs, calibrated by SNeIa, could be good distance indicators capable of discriminating between cosmological models and $\Lambda$CDM model at high redshift.Comment: 5 pages, 5 figures, to appear in Astron. & Astrop

A positron source using an axially oriented crystal associated to a granular amorphous converter

Submitted to Chinese Physics CA non conventional positron source using the intense γ radiation from an axially oriented monocrystal which materialize into e+e- pairs in a granular amorphous converter is described. The enhancement of photon radiation by multi-GeV electrons crossing a tungsten crystal along its axis is reported. The resulting enhancement of pair production in an amorphous converter placed 2 meters downstream, is also reported. Sweeping off the charged particles from the crystal by a bending magnet upstream of the converter allows a significant reduction of the deposited energy density. Substituting a granular target made of small spheres to the usual compact one, makes easier the energy dissipation. The deposited energy and corresponding heating are analyzed and solutions for cooling are proposed. The configurations studied here for this kind of positron source allow its consideration for unpolarized positrons for the ILC

On the growth of perturbations in interacting dark energy and dark matter fluids

The covariant generalizations of the background dark sector coupling suggested in G. Mangano, G. Miele and V. Pettorino, Mod. Phys. Lett. A 18, 831 (2003) are considered. The evolution of perturbations is studied with detailed attention to interaction rate that is proportional to the product of dark matter and dark energy densities. It is shown that some classes of models with coupling of this type do not suffer from early time instabilities in strong coupling regime.Comment: 11 pages, 2 figures. v3: minor changes, typos fixe