Benigne zystische Raumforderungen des Hodens: Eine Übersicht

Zusammenfassung: Hodenzysten werden im Rahmen der skrotalen Sonographie zunehmend diagnostiziert. Grund hierfür ist u.a. die flächendeckende Verfügbarkeit moderner, hochauflösender Ultraschallgeräte. Differentialdiagnostisch und ätiologisch sind benigne und maligne Erkrankungen mit testikulärer Zystenbildung voneinander zu unterscheiden. Benigne Krankheitsbilder mit zystischen Raumforderungen des Hodens sind die tubuläre Ektasie des Rete testis, die zystische Dysplasie, Epidermoidzysten, einfache intraparenchymatöse Hodenzysten und Zysten der Tunica albuginea. Die testikuläre Dermoidzyste, die lange Zeit zu Unrecht als potentiell maligne angesehen wurde, ist ebenfalls als benigne zu klassifizieren. Bei Diagnose einer benignen zystischen Raumforderung des Hodens kann in den meisten Fällen eine organerhaltende operative Therapie oder ein abwartendes, überwachendes Procedere empfohlen werde

Renales Aspergillom: Retroperitoneoskopische Exzision als minimal-invasive organerhaltende Therapieoption

Zusammenfassung: Aspergillusinfektionen bei immunkompromittierten Patienten sind häufig mit einer hohen Mortalität verbunden. Wir berichten über den Fall eines renalen Aspergilloms nach hämatopoetischer Stammzelltransplantation. Neben einer systemischen antimykotischen Therapie wurde eine chirurgische Intervention unumgänglich. Eine minimal-invasive, retroperitoneoskopische Resektion des Aspergilloms wurde durchgeführt

Comparison of the roll-plate and sonication techniques in the diagnosis of microbial ureteral stent colonisation: results of the first prospective randomised study

Background: Microbial ureteral stent colonisation (MUSC) is one leading risk factor for complications associated with ureteral stent placement. As MUSC remains frequently undetected by standard urine cultures, its definitive diagnosis depends on microbiological investigation of the stent. However, a standard reference laboratory technique for studying MUSC is still lacking. Materials and methods: A total of 271 ureteral stents removed from 199 consecutive patients were investigated. Urine samples were obtained prior to device removal. Stents were divided into four parts. Each part was separately processed by the microbiology laboratory within 6h. Ureteral stents were randomly allocated to roll-plate or sonication, respectively, and analysed using standard microbiological techniques. Demographic and clinical data were prospectively collected using a standard case-report form. Results: Overall, roll-plate showed a higher detection rate of MUSC compared with sonication (35 vs. 28%, p<0.05) and urine culture (35 vs. 8%, p<0.05). No inferiority of Maki's technique was observed even when stents were stratified according to indwelling time below or above 30days. Compared with roll-plate, sonication commonly failed to detect Enterococcus spp., coagulase-negative staphylococci (CoNS) and Enterobacteriaceae. In addition, sonication required more hands-on time, more equipment and higher training than roll-plate in the laboratory. Conclusions: This prospective randomised study demonstrates the superiority of Maki's roll-plate technique over sonication in the diagnosis of MUSC and that urine culture is less sensitive than both methods. The higher detection rate, simplicity and cost-effectiveness render roll-plate the methodology of choice for routine clinical investigation as well as basic laboratory researc

Anwendungsbereiche der isothermalen Mikrokalorimetrie in der Urologie: Eine Übersicht

Zusammenfassung: Die isothermale Mikrokalorimetrie (IMC) ist ein nicht spezifisches Wärmemessverfahren. Die hohe Sensitivität des Verfahrens (0,2μW) erlaubt den Nachweis kleinster Wärmemengen z.B. produziert von Mikroorganismen oder eukaryoten Zellen. Ziel dieser Übersichtsarbeit ist es, technische Grundlagen mikrokalorimetrischer Messungen zu vermitteln sowie über Vergangenheit, Gegenwart und Zukunft dieser vielversprechenden Technologie im urologischen Kontext zu berichte

Increasing prevalence of ciprofloxacin resistance in extended-spectrum-β-lactamase-producing Escherichia coli urinary isolates

Purpose: To describe the incidence and drug susceptibility profiles of uropathogenic extended-spectrum-β-lactamase-producing Escherichia coli (ESBL-EC) during a 10-year period and to identify differences in resistance patterns between urological and non-urological ESBL-EC isolates. Methods: Retrospective analysis of 191,564 urine samples obtained during 2001 to 2010 at the University Hospital Basel, Switzerland. The computerized database of the Clinical Microbiology Laboratory and the Division of Infectious Diseases and Hospital Epidemiology was used to identify ESBL-EC positive urine samples. ESBL-EC isolates were stratified according their origin into two groups: Urology and non-Urology isolates. Results: The rate of ESBL-EC positive urine samples increased significantly during the study period (3 in 2001 compared to 55 in 2010, p<0.05). The most active agents were imipenem, meropenem, and fosfomycin (100%), followed by amikacin (99.1%) and nitrofurantoin (84%). The least active substances were ampicillin-clavulanate (20%), sulfamethoxazole (28%), and ciprofloxacin (29.6%). ESBL-EC isolates from urological and non-urological patients showed similar susceptibility profiles. However, ESBL-EC isolates from urological patients were significantly less susceptible to ciprofloxacin compared to non-urological isolates (14.7 vs. 32.7%, p<0.05). Conclusions: The rate of urinary ESBL-EC isolates is increasing. Their susceptibility to nitrofurantoin, fosfomycin, and carbapenems is excellent, whereas ampicillin-clavulanate, sulfamethoxazole, and ciprofloxacin demonstrate only low susceptibility. In particular, the use of ciprofloxacin should be strictly avoided in urologic patients with suspicion for an ESBL-EC urinary tract infection as well as routine antibiotic prophylaxis prior to urological interventions if not explicit indicated by current international guidelines or local resistance pattern

European Association of Urology Guidelines Office Rapid Reaction Group: An Organisation-wide Collaborative Effort to Adapt the European Association of Urology Guidelines Recommendations to the Coronavirus Disease 2019 Era

The coronavirus disease 2019 (COVID-19) pandemic is unlike anything seen before by modern science-based medicine. As a scientific society, the European Association of Urology, via the guidelines, section offices, and the European Urology family of journals, we believe that it is important that we try to support urologists in this difficult situation. We aim to do this by providing tools that can facilitate decision making with the goal to minimise the impact and risks for both patients and health professionals delivering urological care, whenever possible, although it is clear that it is not always possible to mitigate them entirely. We hope that these revised recommendations will fill an important urological practice void and assist urologist surgeons across the globe as they do their very best to deal with the crisis of our generation

Detection of Mycobateria in Urine using Isothermal Microcalorimetry: Implication for Urogenital Tuberculosis and other Mycobacterial infection

Geneeskunde en GesondheidswetenskappeUrologiePlease help us populate SUNScholar with the post print version of this article. It can be e-mailed to: [email protected]

Isothermal Microcalorimetry: a noval technique to detect and quantify the growth of Candida albicans in urine and to determine its antifungal drug sensitivity

Geneeskunde en GesondheidswetenskappeUrologiePlease help us populate SUNScholar with the post print version of this article. It can be e-mailed to: [email protected]