Tuning a Simulated Annealing metaheuristic for cross-domain search

Simulated Annealing is a well known local search metaheuristic used for solving computationally hard optimization problems. Cross-domain search poses a higher level issue where a single solution method is used with minor, preferably no modification for solving characteristically different optimisation problems. The performance of a metaheuristic is often dependant on its initial parameter settings, hence detecting the best configuration, i.e. parameter tuning is crucial, which becomes a further challenge for cross-domain search. In this paper, we investigate the cross-domain search performance of Simulated Annealing via tuning for solving six problems, ranging from personnel scheduling to vehicle routing under a stochastic local search framework. The empirical results show that Simulated Annealing is extremely sensitive to the initial parameter settings leading to sub-standard performance when used as a single solution method for cross-domain search. Moreover, we demonstrate that cross-domain parameter tuning is inferior to domain-level tuning highlighting the requirements for adaptive parameter configurations when dealing with cross-domain search

A computed tomography-based morphometric study of the styloid process

Background: The styloid process (SP) refers to a cylindrical piece projecting from the inferior of the temporal bone, situated anterior to the stylomastoid foramen. It is an anatomic formation close to major vessels and nerves, and its excessive elongation results in pathologies leading to anatomical disorders, such as Eagle’s syndrome. Several studies have been conducted on SP in relation to its close proximity to vessels and nerves, but there is no study that reveals its distance to important anatomical formations, such as the internal auditory meatus (IAM), carotid canal (CC), cochlea, tegmen tympani (TT) and tragus. In the current study, we aimed to investigate the incidence of Eagle’s syndrome based on morphometric measurements of SP. Materials and methods: The patient files archived in the Radiology Department of Adiyaman University Training and Research Hospital were retrospectively examined. The study was carried out on the data of patients for whom specialist radiologists found no pathology findings on the computed tomography images. A total of 77 individuals (36 females and 41 males) aged 22 to 54 years were included in the study. The length of SP and its distances to IAM, cochlea, CC, TT and tragus were obtained using computed tomography radiological measurements. Results: When the individual measurements performed on computed tomography images were evaluated in men and women, no significant difference was found concerning the distance between SP and various anatomic structures in close proximity to SP (p > 0.05). However, there was a statistically significant difference between the genders in length of the right SP (p = 0.003) and left SP (p = 0.006). Conclusions: This anthropometric study revealed the standard morphometric measurements of SP. We believe that the data obtained will help clinicians to identify and diagnose pathologies more easily

Scalar Casimir effect between two concentric D-dimensional spheres

The Casimir energy for a massless scalar field between the closely spaced two concentric D-dimensional (for D>3) spheres is calculated by using the mode summation with contour integration in the complex plane of eigenfrequencies and the generalized Abel-Plana formula for evenly spaced eigenfrequency at large argument. The sign of the Casimir energy between closely spaced two concentric D-dimensional spheres for a massless scalar field satisfying the Dirichlet boundary conditions is strictly negative. The Casimir energy between D-1 dimensional surfaces close to each other is regarded as interesting both by itself and as the key to describing of stability of the attractive Casimir force. PACS number(s): 03.70.+k, 11.10.Kk, 11.10.Gh, 03.65.GeComment: 14 pages. arXiv admin note: substantial text overlap with arXiv:1207.418

A comparative study of fuzzy parameter control in a general purpose local search metaheuristic

There is a growing number of studies on general purpose metaheuristics that are directly applicable to multiple domains. Parameter setting is a particular issue considering that many of such search methods come with a set of parameters to be configured. Fuzzy logic has been used extensively in control applications and is known for its ability to handle uncertainty. In this study, we investigate the potential of using fuzzy systems to control the parameter settings of a threshold accepting (TA) metaheuristic for improving the overall effectiveness of a cross-domain approach. We have evaluated the performance of various general purpose local search metaheuristics which mix multiple heuristics at random and apply the TA metaheuristic with fixed threshold, crisp (non-fuzzy) rule-based control of the threshold and various fuzzy systems controlling the threshold. The empirical results show that the approach using the TA with crisp rule-based control performs the best across six problem domains from a benchmark

Fuzzy adaptive parameter control of a late acceptance hyper-heuristic

A traditional iterative selection hyper-heuristic which manages a set of low level heuristics relies on two core components, a method for selecting a heuristic to apply at a given point, and a method to decide whether or not to accept the result of the heuristic application. In this paper, we present an initial study of a fuzzy system to control the list-size parameter of late- acceptance move acceptance method as a selection hyper-heuristic component. The performance of the fuzzy controlled selection hyper-heuristic is compared to its fixed parameter version and the best hyper-heuristic from a competition on the MAX-SAT problem domain. The results illustrate that a fuzzy control system can potentially be effective within a hyper-heuristic improving its performance

Between a rock and a hard place: corporate elites in the context of religion and secularism in Turkey

Drawing on discourse analyses of 36 in-depth interviews with elite business people from Turkey, the study identifies the networking patterns of new and established business elites in the context of economic liberalization and socioreligious transformation of the country. Through a comparative analysis of the so-called secular and religious elite networks, we demonstrate the role of institutional actors such as the government, and identity networks, based on religion and place of birth in shaping the form and content of social networks among business elites in Turkey. In order to achieve this, we operationalize Bourdieu's notion of theory of practice and Granovetter's theory of social networks, illustrating the utility of combining these approaches in explicating the form and content of social networks in their situated contexts, in which power and divergent interests are negotiated.Galatasaray University Research Fund [grant number 12.102.005]

The middle to late Eocene evolution of nummulitid foraminifer Heterostegina in the Western Tethys

Megalospheric forms of Western Tethyan late Bartonian to late Priabonian involute Heterostegina from numerous localities, marking different ecological conditions, were morphometrically investigated. They belong to three species, H. armenica, H. reticulata, and H. gracilis based on the presence/absence of granulation, on the chamberlet characteristics and on the relative size of proloculus. Within these species a very rapid evolution could be observed in the reduction of the number of operculinid chambers, in the increase of the number of chamberlets and partially in the increase of the proloculus size. This evolution is demonstrated by stratigraphic superpositions in several localities (especially in the Mossano section), and is supported also by the change of co−occurring fossils, starting with the disappearance of large−sized Nummulites, then followed by the appearance of the genus Spiroclypeus and then by the disappearance of orthophragmines of middle Eocene acme. Based on the reduction of operculinid chambers, two chronosubspecies of Heterostegina armenica and seven of H. reticulata are defined biometrically (four of them: H. armenica tigrisensis, H. reticulata tronensis, H. r. hungarica, and H. r. mossanensis are introduced here). This allows to subdivide the Shallow Benthic Zone (SBZ) 18 into three and SBZ 19 into two subzones. The extremely rapid evolution of H. reticulata allows to calibrate larger foraminiferal events around the middle/late Eocene boundary. The extinction of large−sized Nummulites seems to be heterochronous in the late Bartonian in having migrated eastward, while the first appearance of Spiroclypeus is shown to be synchronous at the base of the Priabonian. The middle/upper Eocene (=Bartonian/Priabonian) boundary is to be placed at the base of the Priabona marls in the Mossano section corresponding to the SBZ 18/19 limit, to the first appearance of genus Spiroclypeus, to that of Nummulites fabianii and of Heterostegina reticulata mossanensis. It falls into the upper part of both the P15 and NP18 planktic zones. The Western Tethyan Eocene involute Heterostegina became extinct, apparently with no Oligocene successors

Esterase variation in Turkish white-toothed shrews (Crocidura): Record of a trimeric esterase

This study focuses on esterase variation of the genus Crocidura in Turkey. A total of 248 white-toothed shrews were analyzed by means of cellulose acetate gel electrophoresis. Liver tissue and alfa naphthyl acetate were used to investigate esterase variation in Turkish white-toothed shrews. A different esterase banding pattern was found in one Crocidura individual. This phenotype had four anodally migrated bands on cellulose acetate gel. The Crocidura individual displaying the given phenotype was identified as Crocidura suaveolens. The different esterase banding pattern observed in this study is considered to be a result of the trimeric structure of esterase in the lesser white-toothed shrew (Crocidura suaveolens)

Eltrombopag for the treatment of immune thrombocytopenia: The aegean region of Turkey experience

Objective: Immune thrombocytopenia (ITP) is an immune-mediated disease characterized by transient or persistent decrease of the platelet count to less than 100x109/L. Although it is included in a benign disease group, bleeding complications may be mortal. With a better understanding of the pathophysiology of the disease, thrombopoietin receptor agonists, which came into use in recent years, seem to be an effective option in the treatment of resistant cases. This study aimed to retrospectively assess the efficacy, long-term safety, and tolerability of eltrombopag in Turkish patients with chronic ITP in the Aegean region of Turkey. Materials and Methods: Retrospective data of 40 patients with refractory ITP who were treated with eltrombopag in the Aegean region were examined and evaluated. Results: The total rate of response was 87%, and the median duration of response defined as the number of the platelets being over 50x109/L was 19.5 (interquartile range: 5-60) days. In one patient, venous sinus thrombosis was observed with no other additional risk factors due to or related to thrombosis. Another patient with complete response and irregular follow-up for 12 months was lost due to sudden death as the result of probable acute myocardial infarction. Conclusion: Although the responses to eltrombopag were satisfactory, patients need to be monitored closely for overshooting platelet counts as well as thromboembolic events. © 2015 Turkish Society of Hematology. All rights reserved