Buscke-löwenstein tümörü (dev kondiloma akuminata): Cerrahi eksizyon ile tedavi

Giant condyloma acuminatum is a rare sexually transmitted disease which primarily affects genital and perianal areas. Human papilloma virus (HPV) is the most common sexually transmitted disorder in young, sexually active populations in the USA and Europe. Giant condyloma acuminatum is a uniqe variant of condyloma acuminata, characterized by local aggressive behaviour despite benign histology. It carries a substantial risk of squamous cell carcinoma. Various treatments have been used, but response is often poor and recurrence rates high. We present a case of giant condyloma acuminata succesfully treated with surgical excision.Dev kondiloma akuminata özellikle genital ve perianal alanı tutan, nadir görülen ve cinsel ilişki ile bulaşan bir hastalıktır. Human papilloma virüs enfeksiyonu A.B.D. ve Avrupa'da cinsel aktif populasyonda en sık görülen cinsel yolla bulaşan hastalıktır. Dev kondiloma akuminata benign histolojik tipte olmasına rağmen lokal olarak agresif seyreden bir kondilom çeşitidir. Düşük de olsa skuamoz hücreli kanser gelişme riski taşır. Çok çeşitli tedavi yöntemleri geliştirilmesine rağmen yanıt genellikle düşük ve nüks sık izlenmektedir. Bu olgu sunumunda dev kondiloma akuminatalı bir hastanın cerrahi eksizyon sonrası başarılı tedavisi sunuldu

Molecular Demultiplexer As A Terminator Automaton

Molecular logic gates are expected to play an important role on the way to information processing therapeutic agents, especially considering the wide variety of physical and chemical responses that they can elicit in response to the inputs applied. Here, we show that a 1:2 demultiplexer based on a Zn2+-terpyridine-Bodipy conjugate with a quenched fluorescent emission, is efficient in photosensitized singlet oxygen generation as inferred from trap compound experiments and cell culture data. However, once the singlet oxygen generated by photosensitization triggers apoptotic response, the Zn2+ complex then interacts with the exposed phosphatidylserine lipids in the external leaflet of the membrane bilayer, autonomously switching off singlet oxygen generation, and simultaneously switching on a bright emission response. This is the confirmatory signal of the cancer cell death by the action of molecular automaton and the confinement of unintended damage by excessive singlet oxygen production., Nanorobots will likely play a major role in future therapeutic approaches. Here, the authors develop a molecular automaton based on Zinc-BODIPY complexes that can autonomously switch between singlet oxygen generation and fluorescence emission, i.e., therapeutic and diagnostic modes.WoSScopusPubMe

Histo-blood group antigen-binding specificities of human rotaviruses are associated with gastroenteritis but not with in vitro infection

Human strains of rotavirus A (RVAs) recognize fucosylated glycans belonging to histo-blood group antigens (HBGAs) through their spike protein VP8*. Lack of these ligands due to genetic polymorphisms is associated with resistance to gastroenteritis caused by P[8] genotype RVAs. With the aim to delineate the contribution of HBGAs in the process, we analyzed the glycan specificity of VP8* proteins from various P genotypes. Binding to saliva of VP8* from P[8] and P[4] genotypes required expression of both FUT2 and FUT3 enzymes, whilst binding of VP8* from the P[14] genotype required FUT2 and A enzymes. We further defined a glycan motif, GlcNAc beta 3Gal beta 4GlcNAc, recognized by P[6] clinical strains. Conversion into Lewis antigens by the FUT3 enzyme impaired recognition, explaining their lower binding to saliva of Lewis positive phenotype. In addition, the presence of neutralizing antibodies was associated with the presence of the FUT2 wild type allele in sera from young healthy adults. Nonetheless, in vitro infection of transformed cell lines was independent of HBGAs expression, indicating that HBGAs are not human RV receptors. The match between results from saliva-based binding assays and the epidemiological data indicates that the polymorphism of human HBGAs controls susceptibility to RVAs, although the exact mechanism remains unclear.Funding Agencies|Agence Nationale de la Recherche (France): GASTROVIM; Region des Pays de la Loire (France): ARMINA; Merieux Research Grant GOMMs; Russian Science Foundation [14-5-00131]; Swedish Research Council [320301]</p

Charged kaon mass measurement using the Cherenkov effect

Graf N, Lebedev A, Abrams RJ, et al. Charged kaon mass measurement using the Cherenkov effect. Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment. 2010;615(1):27-32.The two most recent and precise measurements of the charged kaon mass use X-rays from kaonic atoms and report uncertainties of 14 and 22 ppm yet differ from each other by 122 ppm. We describe the possibility of an independent mass measurement using the measurement of Cherenkov light from a narrow-band beam of kaons, pions, and protons. This technique was demonstrated using data taken opportunistically by the Main Injector Particle Production experiment at Fermi National Accelerator Laboratory which recorded beams of protons, kaons, and pions ranging in momentum from +37 to +63 GeV/c. The measured value is 491.3 +/- 1.7 MeV/c(2), which is within 1.4 sigma of the world average. An improvement of two orders of magnitude in precision would make this technique useful for resolving the ambiguity in the X-ray data and may be achievable in a dedicated experiment. (C) 2010 Elsevier B.V. All rights reserved