Synthesis of oxadiazole substituted new carbazole derivatives as antioxidant and antiurease agent

Heterocyclic compounds containing nitrogen together with an oxygen atom in their structures are an important class of medicinal chemistry compounds due to their interesting diverse biological applications. Some compounds including carbazole ring, which are aromatic organic compounds in tricyclic structure, show biological activity in a wide spectrum. Oxadiazole compounds attract the attention of many chemists thanks to their antibacterial, antitumor, anticancer, anti-viral, antimicrobial, anti-HIV, antituberculosis and antioxidant properties. In this study, new oxadiazole substituted carbazole derivatives were synthesized and their antioxidant, antiurease activities were investigated. 9H-carbazole is a good starting material for the synthesis of carbazole derivatives. The antioxidant and antiurease activities of synthesized oxadiazole substituted new carbazole derivatives were investigated. Antioxidant activity methods such as DPPH (1,1’-diphenyl-2-picrylhydrazyl), ABTS (2,2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt) radical scavenging activities and iron reducing power capacities were used to determine antioxidant activity of the compounds. All synthesized carbazole compounds showed antioxidant and antiurease activity. While compound 4 shows the strongest enzyme inhibition activity, the least active compound was found 5. All tested compounds showed higher enzyme inhibition activity than thiourea. The highest and the lowest antioxidant activities were observed as compounds 3 and 6, respectively. DOI: http://dx.doi.org/10.5281/zenodo.661244

Synthesis of some 3,5-diphenyl-4<i>H</i>-1,2,4-triazole derivatives as antitumor agents

2107-2113 A series of 4-arylidenamino-4H-1,2,4-triazoles 2-14 and 4-(1-aryl)ethylidenamino-4H-1,2,4-triazoles 28-30 have been synthesized by the treatment of 4-amino-4H-1,2,4-triazole 1 with certain aldehydes and ketones. Compounds 2-14 and 28-30 have been reduced with NaBH4 to afford the corresponding 4-arylmethylamino-4H-1,2,4-triazoles 15-27 and 4-(1-aryl)ethylamino-4H-1,2,4-triazoles 31-33. The compounds 2-33 have been characterized by 1H NMR, 13C NMR, IR, Mass and UV-Vis spectral data. Compounds 12, 17, 18, 19, 20, 21, 22, 24, 29 and 32 have been screened on three human tumor cell lines, breast cancer (MCF7), non small cell lung cancer (NCI-H460), and CNS cancer (SF-268) at the National Cancer Institute (NIH), USA. The compounds are found to exhibit low antiproliferative activity in the anticancer tests. </smarttagtype

The Synthesis of New Triazole Ligands and Determination of Complex Stability Constants with Transition Metal Cations in Aqueous Media

WOS: 000260045800002Six new triazole compounds were synthesized. These compounds containing the substituted benzylidenamino group were obtained by reaction of 3-(pyridine-4-yl)-5-p-tolyl-4-amino-4H-1,2,4-triazole 1 with the corresponding aldehyde. The reduced forms were prepared with NaBH4 in methanol. The structures of the compounds were determined by IR, H-1 NMR, and C-13 NMR spectral data, and their interaction with cations such as Li+, Na+, K+, Rb+, Cs+, Ba2+ Sr2+, Ca2+, Cu2+, Cr3+, Co2+, Ni2+, Zn2+, Cd2+, Pb2+ and Ag+ were investigated by using UV-visible spectrophotometry. Of the tested metal cations, Cu2+, Cr3+, Co2+, Ni2+, Zn2+, Cd2+, Pb2+ and Ag+ complexed with the ligands. The complex stability constants (log(10) K) were measured in slightly acidic aqueous media at 25.0 +/- 0.1 degrees C. These stability constants were determined by measuring the increase in solubility of the nearly insoluble ligand molecule due to complex formation with a soluble cation, and this method is discussed. It was found that the position of chlorine atoms on the benzene ring strongly affects the complexation of Cu2+ ion with these ligands.Deutsches Textilforschungszentrum Nord-West; Scientific and Technical Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)The authors thank the Deutsches Textilforschungszentrum Nord-West and The Scientific and Technical Research Council of Turkey (TUBITAK) for the financial support of this study

Synthesis, antibacterial, antielastase, antiurease and antioxidant activities of new 1,4-butylene bridged bis-1,2,4-triazole derivatives

yanardag, refiye/0000-0003-4185-4363WOS: 000313663400011PubMed: 22145614A new bis schiffbases, 3 a-b were synthesized compound 2 with various bis aldehydes. Compounds 3 a-b have been reduced with NaBH4 to afford the corresponding bis amino triazole compounds 4 a-b. The obtained products 3 a-b and 4 a-b were identified by FTIR, H-1-NMR, C-13-NMR. A series of triazol derivatives were evaluated for their antibacterial, antioxidant, antiurease and antielastase activities. The results showed that the synthesized new bis-1,2,4-triazole derivatives had effective antioxidant, antiurease and antielastase activities

Development of a New Solid Phase Extraction Procedure for Selective Separation and Enrichment of Au(III) Ions in Environmental Samples

A highly sensitive, selective and low cost solid phase extraction (SPE) procedure was developed for separation and enrichment of Au(III) ions in environmental samples prior to its flame atomic absorption spectrometric detection. Au(III)-2-pyridin-5-(4-tolyl)-1,3,4-oxadiazole (PYTOX) complex was adsorbed quantitatively on Amberlite XAD-4 resin in 0.5 mol L-1 HNO3 condition and the elution was carried out with 7.5 mL of 1.0 mol L-1 HCl in acetone. Some analytical parameters, affect the recoveries of Au(III) ions, such as HNO3 concentration of sample solution, amount of PYTOX, type, concentration and volume of eluent, sample volume and concomitants were examined. Adopting optimized experimental conditions, the limit of detection for Au(III) ions was 1.03 mu g L-1 with preconcentration factor of 50 and a relative standard deviation (RSD) of 3.7%. The determination of Au(III) ions in anodic slime, gold ore, soil and sea and stream waters was performed after checking the accuracy of the method by addition-recovery tests

Synthesis, antibacterial, antiurease, and antioxidant activities of some new 1,2,4-triazole schiff base and amine derivatives

Sahin, Huseyin/0000-0002-6018-1494WOS: 000348103100007PubMed: 25342259The acylhydrazone compound named ethyl N'-furan-2-carbonylbenzohydrazonate was synthesized by the condensation of ethyl benzimidate hydrochloride with furan-2-carbohydrazide. The treatment of the acylhydrazone with hydrazine hydrate afforded 4-amino-3-furan-2-yl-5-phenyl-1,2,4-triazole. The usage of this compound with various aromatic aldehydes resulted in the formation of 4-arylidenamino-3-furan-2-yl-5-phenyl-1,2,4-triazoles. Sodium borohydride reduction of 4-arylidenamino derivatives afforded 4-alkylamino-3-furan-2-yl-5-phenyl-1,2,4-triazoles. The obtained products were identified by FT-IR, H-1-NMR, C-13-NMR. A series of compounds were evaluated for their antibacterial, antiurease, and antioxidant activities. The results showed that the synthesized new compounds had effective antiurease and antioxidant activities