Estimación de horas de frío para la zonificación agroclimática de frutales en la provincia de San Luis mediante información de sensores remotos

Este trabajo evalúa la factibilidad de cuantificar mediante sensores remotos la acumulación de horas de frío durante el período de reposo (HF), una variable crítica para la zonificación de cultivos frutales. Se encontró que un modelo simplificado, basado en la temperatura ambiente de los 5 meses más fríos, fue un buen estimador de HF (r2=0.93). Las estimaciones basadas en datos de temperatura de superficie del satélite MODIS tuvieron una precisión aceptable, especialmente cuando incluyeron variables complementarias como la amplitud térmica y la altitud (r2=0.80). Estos modelos permiten realizar cartas de HF de alta resolución y cobertura completa para la provincia de San Luis.Sociedad Argentina de Informática e Investigación Operativ

Estimación de horas de frío para la zonificación agroclimática de frutales en la provincia de San Luis mediante información de sensores remotos

Este trabajo evalúa la factibilidad de cuantificar mediante sensores remotos la acumulación de horas de frío durante el período de reposo (HF), una variable crítica para la zonificación de cultivos frutales. Se encontró que un modelo simplificado, basado en la temperatura ambiente de los 5 meses más fríos, fue un buen estimador de HF (r2=0.93). Las estimaciones basadas en datos de temperatura de superficie del satélite MODIS tuvieron una precisión aceptable, especialmente cuando incluyeron variables complementarias como la amplitud térmica y la altitud (r2=0.80). Estos modelos permiten realizar cartas de HF de alta resolución y cobertura completa para la provincia de San Luis.Sociedad Argentina de Informática e Investigación Operativ

Estimación de horas de frío para la zonificación agroclimática de frutales en la provincia de San Luis mediante información de sensores remotos

Este trabajo evalúa la factibilidad de cuantificar mediante sensores remotos la acumulación de horas de frío durante el período de reposo (HF), una variable crítica para la zonificación de cultivos frutales. Se encontró que un modelo simplificado, basado en la temperatura ambiente de los 5 meses más fríos, fue un buen estimador de HF (r2=0.93). Las estimaciones basadas en datos de temperatura de superficie del satélite MODIS tuvieron una precisión aceptable, especialmente cuando incluyeron variables complementarias como la amplitud térmica y la altitud (r2=0.80). Estos modelos permiten realizar cartas de HF de alta resolución y cobertura completa para la provincia de San Luis.Sociedad Argentina de Informática e Investigación Operativ

Homochiral Metal-Organic Frameworks for Enantioselective Separations in Liquid Chromatography

Selective separation of enantiomers is a substantial challenge for the pharmaceutical industry. Chromatography on chiral stationary phases is the standard method, but at a very high cost for industrial-scale purification owing to the high cost of the chiral stationary phases. Typically, these materials are poorly robust, expensive to manufacture and often too specific for a single desired substrate, lacking desirable versatility across different chiral analytes. Here we disclose a porous, robust homochiral metal-organic framework (MOF), TAMOF-1, built from copper(II) and an affordable linker prepared from natural L-histidine. TAMOF-1 has shown to be able to separate a variety of model racemic mixtures, including drugs, in a wide range of solvents of different polarity, outperforming several commercial chiral columns for HPLC separations. Although not exploited in the present article, it is worthy to mention that the preparation of this new material is scalable to the multikilogram scale, opening unprecedented possibilities for low-energy chiral separation at the industrial scale

Safety and immunogenicity of the protein-based PHH-1V compared to BNT162b2 as a heterologous SARS-CoV-2 booster vaccine in adults vaccinated against COVID-19 : a multicentre, randomised, double-blind, non-inferiority phase IIb trial

A SARS-CoV-2 protein-based heterodimer vaccine, PHH-1V, has been shown to be safe and well-tolerated in healthy young adults in a first-in-human, Phase I/IIa study dose-escalation trial. Here, we report the interim results of the Phase IIb HH-2, where the immunogenicity and safety of a heterologous booster with PHH-1V is assessed versus a homologous booster with BNT162b2 at 14, 28 and 98 days after vaccine administration. The HH-2 study is an ongoing multicentre, randomised, active-controlled, double-blind, non-inferiority Phase IIb trial, where participants 18 years or older who had received two doses of BNT162b2 were randomly assigned in a 2:1 ratio to receive a booster dose of vaccine-either heterologous (PHH-1V group) or homologous (BNT162b2 group)-in 10 centres in Spain. Eligible subjects were allocated to treatment stratified by age group (18-64 versus ≥65 years) with approximately 10% of the sample enrolled in the older age group. The primary endpoints were humoral immunogenicity measured by changes in levels of neutralizing antibodies (PBNA) against the ancestral Wuhan-Hu-1 strain after the PHH-1V or the BNT162b2 boost, and the safety and tolerability of PHH-1V as a boost. The secondary endpoints were to compare changes in levels of neutralizing antibodies against different variants of SARS-CoV-2 and the T-cell responses towards the SARS-CoV-2 spike glycoprotein peptides. The exploratory endpoint was to assess the number of subjects with SARS-CoV-2 infections ≥14 days after PHH-1V booster. This study is ongoing and is registered with , . From 15 November 2021, 782 adults were randomly assigned to PHH-1V (n = 522) or BNT162b2 (n = 260) boost vaccine groups. The geometric mean titre (GMT) ratio of neutralizing antibodies on days 14, 28 and 98, shown as BNT162b2 active control versus PHH-1V, was, respectively, 1.68 (p < 0.0001), 1.31 (p = 0.0007) and 0.86 (p = 0.40) for the ancestral Wuhan-Hu-1 strain; 0.62 (p < 0.0001), 0.65 (p < 0.0001) and 0.56 (p = 0.003) for the Beta variant; 1.01 (p = 0.92), 0.88 (p = 0.11) and 0.52 (p = 0.0003) for the Delta variant; and 0.59 (p ≤ 0.0001), 0.66 (p < 0.0001) and 0.57 (p = 0.0028) for the Omicron BA.1 variant. Additionally, PHH-1V as a booster dose induced a significant increase of CD4 + and CD8 + T-cells expressing IFN-γ on day 14. There were 458 participants who experienced at least one adverse event (89.3%) in the PHH-1V and 238 (94.4%) in the BNT162b2 group. The most frequent adverse events were injection site pain (79.7% and 89.3%), fatigue (27.5% and 42.1%) and headache (31.2 and 40.1%) for the PHH-1V and the BNT162b2 groups, respectively. A total of 52 COVID-19 cases occurred from day 14 post-vaccination (10.14%) for the PHH-1V group and 30 (11.90%) for the BNT162b2 group (p = 0.45), and none of the subjects developed severe COVID-19. Our interim results from the Phase IIb HH-2 trial show that PHH-1V as a heterologous booster vaccine, when compared to BNT162b2, although it does not reach a non-inferior neutralizing antibody response against the Wuhan-Hu-1 strain at days 14 and 28 after vaccination, it does so at day 98. PHH-1V as a heterologous booster elicits a superior neutralizing antibody response against the previous circulating Beta and the currently circulating Omicron BA.1 SARS-CoV-2 variants in all time points assessed, and for the Delta variant on day 98 as well. Moreover, the PHH-1V boost also induces a strong and balanced T-cell response. Concerning the safety profile, subjects in the PHH-1V group report significantly fewer adverse events than those in the BNT162b2 group, most of mild intensity, and both vaccine groups present comparable COVID-19 breakthrough cases, none of them severe. HIPRA SCIENTIFIC, S.L.U

Memoria del Centro Infantil Laboratorio (1984-2014). Sede Rodrigo Facio, Universidad de Costa Rica

Describe y analiza los hitos históricos del Centro Infantil Laboratorio, su consolidación, como un centro con una filosofía holística, integradora, innovadora y humanista, cuyos alcances aportaron al desarrollo de la educación preescolar costarricenseUCR::Vicerrectoría de Acción Social::Trabajo Comunal Universitario (TCU)UCR::Vicerrectoría de Acción Social::Centros Infantiles Universitario