Propuesta Estratégica de Mejora en la Implementación de los Estándares Mínimos del Sistema de Gestión de la Seguridad y Salud en el Trabajo (SG-SST) en la compañía de Seguridad Azimut Caribabare Ltda para el primero y segundo semestre del año 2020

Sistema de gestión, accidente de trabajo, ciclo phva, consecuencia, Indicadores de matriz.Resumen En el presente trabajo analizaremos el sistema de SG-SST de la empresa COMPAÑÍA DE SEGURIDAD AZIMUT CARIBABARE LTDA, en donde analizaremos por medio de la tabla de valores los estándares mínimos del sistema de gestión de la seguridad y salud en el trabajo (SG-SST), identificando las debilidades e implementado un plan de acción de mejora que contribuyan a la planeación, organización, ejecución, y evaluación de las intervenciones sobre las condiciones de salud (Medicina Preventiva y del Trabajo), y de trabajo (Higiene y Seguridad Industrial), tendientes a mejorar la salud individual y colectiva de los trabajadores en su labor y que deben ser desarrolladas en sus sitios de trabajo en forma integral e interdisciplinaria. Asumiendo la responsabilidad de diseñar e implementar un sistema de gestión de la seguridad y salud en el trabajo (SG-SST), que tiene como propósito la acción conjunta entre la corporación y los trabajadores, en la aplicación de las medidas de Seguridad y Salud en el Trabajo (SST) a través del mejoramiento continuo de las condiciones y el medio ambiente laboral, y el control eficaz de los peligros y riesgos en el lugar de trabajo. Palabras claves: Sistema de gestión, accidente de trabajo, ciclo phva, consecuencia, Indicadores de matriz.Abstract In this paper we will analyze the SG-SST system of the company COMPAÑÍA DE SEGURIDAD AZIMUT CARIBABARE LTDA, where we will analyze through the table of values the minimum standards of the occupational health and safety management system (SG-SST ), identifying weaknesses and implementing an improvement action plan that contributes to the planning, organization, execution, and evaluation of interventions on health conditions (Preventive and Work Medicine), and work (Industrial Hygiene and Safety) , aimed at improving the individual and collective health of workers in their work and that must be developed in their work sites in an integral and interdisciplinary way. Assuming the responsibility of designing and implementing a system of occupational safety and health management (SG-SST), whose purpose is joint action between the corporation and the workers, in the application of Health and Safety measures in Work (OSH) through continuous improvement of working conditions and environment, and effective control of hazards and risks in the workplace. Keywords: Management system, work accident, phva cycle, consequence, Matrix indicators

Compromising between European and US allergen immunotherapy schools: Discussions from GUIMIT, the Mexican immunotherapy guidelines

Background: Allergen immunotherapy (AIT) has a longstanding history and still remains the only disease-changing treatment for allergic rhinitis and asthma. Over the years 2 different schools have developed their strategies: the United States (US) and the European. Allergen extracts available in these regions are adapted to local practice. In other parts of the world, extracts from both regions and local ones are commercialized, as in Mexico. Here, local experts developed a national AIT guideline (GUIMIT 2019) searching for compromises between both schools. Methods: Using ADAPTE methodology for transculturizing guidelines and AGREE-II for evaluating guideline quality, GUIMIT selected 3 high-quality Main Reference Guidelines (MRGs): the European Academy of Allergy, Asthma and Immunology (EAACI) guideines, the S2k guideline of various German-speaking medical societies (2014), and the US Practice Parameters on Allergen Immunotherapy 2011. We formulated clinical questions and based responses on the fused evidence available in the MRGs, combined with local possibilities, patient's preference, and costs. We came across several issues on which the MRGs disagreed. These are presented here along with arguments of GUIMIT members to resolve them. GUIMIT (for a complete English version, see Supplementary data) concluded the following: Results: Related to the diagnosis of IgE-mediated respiratory allergy, apart from skin prick testing complementary tests (challenges, in vitro testing and molecular such as species-specific allergens) might be useful in selected cases to inform AIT composition. AIT is indicated in allergic rhinitis and suggested in allergic asthma (once controlled) and IgE-mediated atopic dermatitis. Concerning the correct subcutaneous AIT dose for compounding vials according to the US school: dosing tables and formula are given; up to 4 non-related allergens can be mixed, refraining from mixing high with low protease extracts. When using European extracts: the manufacturer's indications should be followed; in multi-allergic patients 2 simultaneous injections can be given (100% consensus); mixing is discouraged. In Mexico only allergoid tablets are available; based on doses used in all sublingual immunotherapy (SLIT) publications referenced in MRGs, GUIMIT suggests a probable effective dose related to subcutaneous immunotherapy (SCIT) might be: 50–200% of the monthly SCIT dose given daily, maximum mixing 4 allergens. Also, a table with practical suggestions on non-evidence-existing issues, developed with a simplified Delphi method, is added. Finally, dissemination and implementation of guidelines is briefly discussed, explaining how we used online tools for this in Mexico. Conclusions: Countries where European and American AIT extracts are available should adjust AIT according to which school is followed

Espirales de reflexividad crítica y propositiva para escribir la educación media de Bogotá

399 p. Libro digita

ENGIU: Encuentro Nacional de Grupos de Investigación de UNIMINUTO.

El desarrollo del prototipo para el sistema de detección de Mina Antipersona (MAP), inicia desde el semillero ADSSOF perteneciente al programa de Administración en Seguridad y Salud en el trabajo de la UNIMINUTO, se realiza a partir de un detector de metales que emite una señal audible, que el usuario puede interpretar como aviso de presencia de un objeto metálico, en este caso una MAP. La señal audible se interpreta como un dato, como ese dato no es perceptible a 5 metros de distancia, se implementa el transmisor de Frecuencia Modulada FM por la facilidad de modulación y la escogencia de frecuencia de transmisión de acuerdo con las normas y resolución del Ministerio de Comunicaciones; de manera que esta sea la plataforma base para enviar los datos obtenidos a una frecuencia establecida. La idea es que el ser humano no explore zonas peligrosas y buscar la forma de crear un sistema que permita eliminar ese riesgo, por otro lado, buscar la facilidad de uso de elementos ya disponibles en el mercado

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele