Inventario, análisis y propuesta de rehabilitación y puesta en valor de arquitectura subterránea excavada en el Levante español : Casas de Juan Nuñez

The cave-houses are a type of subtractive architecture that is obtained by excavation. These are distributed throughout the Spanish territory. They form numerous sets of great importance. The cave-houses studied here belong to the neighborhoods of San Pedro and Azaña of the town of Casas de Juan Núñez, whose origin was around 1600. This type of architecture has special interior comfort conditions that make them different. The temperature is constant throughout the whole year because the ground has a lot of thermal inertia. On the other hand, they have some problems like natural ventilation and lighting in the interior room. Ultimately, the conservation of this architecture is necessary given that normally they are forgotten and neglected; nevertheless the cave houses are a type with great historical and architectural interest.Las casas-cueva son un tipo de arquitectura sustractiva obtenida por excavación. Estas se distribuyen por todo el territorio español constituyendo numerosos conjuntos de gran importancia. Las estudiadas en este trabajo, pertenecen a los barrios de San Pedro y Azaña de la localidad albacetense de Casas de Juan Núñez datadas del 1600. Este tipo de arquitectura cuenta con unas condiciones de confort en el interior que las hacen especiales, debido a la gran inercia térmica que tiene el terreno la temperatura se mantiene constante a lo largo de todo el año. Por otro lado, tienen una serie de problemas como la ventilación e iluminación en las estancias interiores. Por último, la conservación de este tipo de arquitectura es necesaria debido a que normalmente se encuentran menospreciadas y olvidadas siendo una tipología de gran interés tanto arquitectónico como histórico.Rey Gómez, CD. (2016). Inventario, análisis y propuesta de rehabilitación y puesta en valor de arquitectura subterránea excavada en el Levante español : Casas de Juan Nuñez. http://hdl.handle.net/10251/92122TFG

Evaluation of the end-of-life of electric vehicle batteries according to the state-of-health

As a result of monitoring thousands of electric vehicle charges around Europe, this study builds statistical distributions that model the amount of energy necessary for trips between charges, showing that most of trips are within the range of electric vehicle even when the battery degradation reaches the end-of-life, commonly accepted to be 80% State of Health. According to these results, this study analyses how far this End-of-Life can be pushed forward using statistical methods and indicating the provability of failing to fulfill the electric vehicle (EV) owners’ daily trip needsPeer ReviewedPostprint (published version

Self-Triggered Formation Control of Nonholonomic Robots

In this paper, we report the design of an aperiodic remote formation controller applied to nonholonomic robots tracking nonlinear, trajectories using an external positioning sensor network. Our main objective is to reduce wireless communication with external sensors and robots while guaranteeing formation stability. Unlike most previous work in the field of aperiodic control, we design a self-triggered controller that only updates the control signal according to the variation of a Lyapunov function, without taking the measurement error into account. The controller is responsible for scheduling measurement requests to the sensor network and for computing and sending control signals to the robots. We design two triggering mechanisms: centralized, taking into account the formation state and decentralized, considering the individual state of each unit. We present a statistical analysis of simulation results, showing that our control solution significantly reduces the need for communication in comparison with periodic implementations, while preserving the desired tracking performance. To validate the proposal, we also perform experimental tests with robots remotely controlled by a mini PC through an IEEE 802.11g wireless network, in which robots pose is detected by a set of camera sensors connected to the same wireless network

Early efficacy evaluation of mesenchymal stromal cells (MSC) combined to biomaterials to treat long bone non-unions

Artículo con numerosos autores, sólo se recogen el primero y los pertenecientes a la UAMBackground and study aim: Advanced therapy medicinal products (ATMP) frequently lack of clinical data on efficacy to substantiate a future clinical use. This study aims to evaluate the efficacy to heal long bone delayed unions and non-unions, as secondary objective of the EudraCT 2011-005441-13 clinical trial, through clinical and radiological bone consolidation at 3, 6 and 12 months of follow-up, with subgroup analysis of affected bone, gender, tobacco use, and time since the original fracture. Patients and methods: Twenty-eight patients were recruited and surgically treated with autologous bone marrow derived mesenchymal stromal cells expanded under Good Manufacturing Practices, combined to bioceramics in the surgical room before implantation. Mean age was 39 ±13 years, 57% were males, and mean Body Mass Index 27 ±7. Thirteen (46%) were active smokers. There were 11 femoral, 4 humeral, and 13 tibial non-unions. Initial fracture occurred at a mean ±SD of 27.9 ±31.2 months before recruit- ment. Efficacy results were expressed by clinical consolidation (no or mild pain if values under 30 in VAS scale), and by radiological consolidation with a REBORNE score over 11/16 points (value of or above 0.6875). Means were statistically compared and mixed models for repeated measurements estimated the mean and confidence intervals (95%) of the REBORNE Bone Healing scale. Clinical and radiological con- solidation were analyzed in the subgroups with Spearman correlation tests (adjusted by Bonferroni). Results: Clinical consolidation was earlier confirmed, while radiological consolidation at 3 months was 25.0% (7/28 cases), at 6 months 67.8% (19/28 cases), and at 12 months, 92.8% (26/28 cases including the drop-out extrapolation of two failures). Bone biopsies confirmed bone formation surrounding the bioce- ramic granules. All locations showed similar consolidation, although this was delayed in tibial non-unions. No significant gender difference was found in 12-month consolidation (95% confidence). Higher consoli- dation scale values were seen in non-smoking patients at 6 ( p = 0.012, t -test) and 12 months ( p = 0.011, t -test). Longer time elapsed after the initial fracture did not preclude the occurrence of consolidation. Conclusion: Bone consolidation was efficaciously obtained with the studied expanded hBM-MSCs com- bined to biomaterials, by clinical and radiological evaluation, and confirmed by bone biopsies, with lower consolidation scores in smokersThis research received funding from the European Union’s Sev- enth Framework Programme ( FP7/FP7-HEALTH-2009 ) with the RE- BORNE Project (under G.A. 241876), and the European Union’s Horizon 2020 Programme ( H2020-SC1 2016-2017 ), with the OR- THOUNION Project (under G.A. 7333288

Evaluation experiment of ontology tools’ interoperability with the WebODE ontology engineering workbench

This paper presents the results of the interoperability experiment proposed in EON2003, using the following ontology tools: Protégé-2000 and WebODE. We will show which knowledge is preserved and which knowledge is lost in the import/export processes between tools when using RDF(S) as an intermediate language

La formación del capital social en los ejidos mexicanos. Decisiones sobre las tierras tras el artículo 27 de la reforma constitucional

The Mexican ejidos are complex land-based structures developed by the post-revolutionary state formation (1915-1992). The success of some ejidos was based on trust ties. With the economic liberalization of the country and the changes to the national legal system in the early 1990s (specifically Article 27 reform in 1992), the state structures that ran the ejidos were reorganized, and individual land tenure strategies reappeared. In La Antigua (Veracruz), a majority of the ejidatarios (71%) reacted to this situation by adopting the dominio pleno (full domain) land tenure regime. In analyzing these features and their connections with diachronic social capital, this paper discusses the role of the national structures and institutions across generations and the destruction of trust in the ejidos. Specific ejido histories help to compare pre-ejido land strategies with the post-Article 27 reform strategies in effect today. It will be concluded that inefficient coordination of the micro, meso and macro levels of the state creates distrust and encourages individual action.Los ejidos mexicanos son complejas estructuras de propiedad colectiva de la tierra, desarrolladas por el Estado post-revolucionario (1915-1992). El éxito de algunos de estos ejidos ha estado basado en los lazos de confianza entre los campesinos. A principios de los noventa, la liberalización económica y la reforma del Artículo 27 Constitucional en 1992, favorecieron una reorganización de las estructuras del Estado que dirigían el ejido y la reaparición de estrategias individuales de tenencia de la tierra. El ejido de La Antigua (Veracruz) presenta la particularidad de que un 71% de los ejidatarios reaccionaron antes este escenario adoptando el régimen de dominio pleno de tenencia de la tierra. Este trabajo tiene como objetivo analizar la conexión entre esta situación y i) el capital social diacrónico existente en este ejido y ii) el papel de las estructuras e instituciones nacionales en la generación o destrucción de la confianza en los ejidos. El análisis de historias particulares de este ejido ayuda a comparar las estrategias anteriores a la formación ejidal con las devenidas tras la reforma del Artículo 27. Se llega a la conclusión de que la ineficiente coordinación de los niveles micro, meso y macro del Estado, ha generado desconfianza y hecho que los ejidatarios actúen de manera individualista

Management of Open Fracture

Open fractures are common and their prevalence is increasing in elderly people. The burden of open fractures is high because of economic and social costs. Most open fractures occur in lower limbs. The use of validated protocols, will optimize our outcomes when treating open fractures. The first step began with the proper identification of the fracture characteristics and the hidden soft tissue injury. The use of an adequate and early antibiotic prophylaxis is mandatory and then, we have to perform adequate irrigation and debridement. Finally, we have to decide to temporally fix the fracture or proceed with the definitive fixation method. Recently, the creation of dedicated “orthoplastic” units has increased the outcomes in high-energy tibial fractures. These fractures should be managed in adequate trauma centers that should be used to face all the complications that will appear during the reconstruction procedure because complications can be as high as 50% in high-energy open fractures

Impact of genotype, body weight and sex on the prenatal muscle transcriptome of Iberian pigs

Growth is dependent on genotype and diet, even at early developmental stages. In this study, we investigated the effects of genotype, sex, and body weight on the fetal muscle transcriptome of purebred Iberian and crossbred Iberian x Large White pigs sharing the same uterine environment. RNA sequencing was performed on 16 purebred and crossbred fetuses with high body weight (340±14g and 415±14g, respectively) and 16 with low body weight (246±14g and 311±14g, respectively), on gestational day 77. Genotype had the greatest effect on gene expression, with 645 genes identified as differentially expressed (DE) between purebred and crossbred animals. Functional analysis showed differential regulation of pathways involved in energy and lipid metabolism, muscle development, and tissue disorders. In purebred animals, fetal body weight was associated with 35 DE genes involved in development, lipid metabolism and adipogenesis. In crossbred animals, fetal body weight was associated with 60 DE genes involved in muscle development, viability, and immunity. Interestingly, the results suggested an interaction genotype∗weight for some DE genes. Fetal sex had only a modest effect on gene expression. This study allowed the identification of genes, metabolic pathways, biological functions and regulators related to fetal genotype, weight and sex, in animals sharing the same uterine environment. Our findings contribute to a better understanding of the molecular events that influence prenatal muscle development and highlight the complex interactions affecting transcriptional regulation during development.</p