4 research outputs found
Drug-related problems in patients admitted for SARS-CoV-2 infection during the COVID-19 pandemic
- Author
- Publication venue
- 'Frontiers Media SA'
- Publication date
- 01/01/2022
- Field of study
Introduction: Drug-related problems (DRP) are events or circumstances in which drug therapy does or could interfere with desired health outcomes. In December 2019, a new coronavirus, SARS-CoV-2, appeared. Little knowledge about this type of infection resulted in the administration of various drugs with limited use in other pathologies. Evidence about DRP in patients with COVID-19 is lacking. Objective: The aim of the present study is to describe identified cases of DRP and those drugs involved in the first wave of patients with COVID-19, and evaluate associated risk factors. Material and methods: Observational, retrospective study performed in a tertiary university hospital between 14th March 2020 and 31 May 2020 (corresponding to the first COVID-19 wave). We recruited patients admitted during the study period. Exclusion criteria included age < 18 years; admission to critically ill units; and care received either in the emergency room, at-home hospitalization or a healthcare center. Results: A total of 817 patients were included. The mean age was 62.5 years (SD 16.4) (range 18-97), and 453 (55.4%) were male. A total of 516 DRP were detected. Among the patients, 271 (33.2%) presented at least one DRP. The mean DRP per patient with an identified case was 1.9. The prevailing DRPs among those observed were: incorrect dosage (over or underdosage) in 145 patients (28.2%); wrong drug combination in 131 (25.5%); prescriptions not in adherence to the then COVID-19 treatment protocol in 73 (14.1%); prescription errors due to the wrong use of the computerized physician order entry in 47 (9.2%); and incorrect dosage due to renal function in 36 (7%). The logistic regression analysis showed that patients who received only prescriptions of antibacterials for systemic use (J01 ATC group) faced a higher likelihood of experiencing a DRP (OR 2.408 (1.071-5.411), p = 0.033). Conclusion: We identified several factors associated with an increased risk of DRPs, similar to those reported in other pre-pandemic studies, including a prolonged length of stay, higher number of prescribed drugs and antimicrobial administration. The relevance of pharmacists and tools like pharmacy warning systems can help prevent, identify and resolve DRP efficiently
Spirometry for detection of undiagnosed chronic obstructive pulmonary disease in primary care
- Author
- Akhar R
- Anthonisen NR
- Barberà JA
- Blanca Martínez-Andión
- Dales RE
- De Miguel Díez J
- Eaton T
- Enright PL
- Enright PL
- Ferguson GT
- Flechter CM
- Frank TL
- Gema Canals-Borrajo
- Grupo DAFNE
- Hueto J
- Magdalena Esteva
- Manresa Presaca JM
- María Angeles Llorente San Martín
- María Luisa Cigüenza-Fuster
- Miguel Góngora
- Miguel Roman
- Murray RP
- Nihlén U
- Pauwels RA
- Ruiz Aguirre J
- Schermer TR
- Siafakas NM
- Sobradillo V
- Stratelis G
- Takahashi T
- Task group on surveillance for respiratory hazards in the occupational setting
- Tinkelman DG
- Torrecilla García M
- Van Schayck CP
- Vandevoorde J
- Voelkel NF
- Zielinski J
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Mortality after surgery in Europe: a 7 day cohort study
- Author
- Aakeroey K
- Acan I
- Adams D
- Adams T
- Adanic M
- Adolfsson A
- Afonso O
- Afshari A
- Agarwal B
- Agnic I
- Aguado DN
- Ahern R
- Ahonen T
- Aignatoaie M
- Akotia N
- Akouds E
- Al Abdaly A
- Al Subaie N
- Alagarsamy F
- Alameda LE
- Alaspää A
- Albalad DD
- Albaladejo P
- Albante A
- Alberdi F
- Albu C
- Alcaide CM
- Alcantud JF
- Aldecoa C
- Aldecoa C
- Alderson L
- Aleixandre IS
- Aleksic D
- Aleman M
- Alexander D
- Alexander P
- Algarra RR
- Ali ZS
- Aliste P
- Allué RM
- Almeida E
- Almeida IM
- Almeras L
- Alonso AE
- Alonso E
- Alvarez AA
- Alvarez LR
- Amaniti E
- Amatya S
- Ampuero MS
- Anchuelo AH
- Andabaka T
- Andersen JD
- Anderson H
- Andresen B
- Angulo GO
- Anna US
- Anthopoulos G
- Antolinos MA
- Apsokardos A
- Aracil N
- Aranzubia M
- Arawwawala D
- Arcas JJ
- Arevalo J
- Argente GR
- Arif F
- Armaganidis A
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- Arnaoutoglou E
- Arnold G
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- Arpino I
- Arroyo MM
- Arteta DA
- Artigas A
- Artigas X
- Arvaniti K
- Arviza LP
- Asensio MA
- Assunção JP
- Aubrun F
- Auer P
- Austine P
- Aversano M
- Awlakpui E
- Axelsson P
- Ayman M
- Baban O
- Bacak Kocman I
- Bacci A
- Baciu M
- Baddeley S
- Bailey K
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- Bakosova E
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- Barižon M
- Baroselli A
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- Barrachima BB
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- Bataillard A
- Batchelor N
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- Battistella M
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- Bauer W
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2012
- Field of study
Background: Clinical outcomes after major surgery are poorly described at the national level. Evidence of heterogeneity between hospitals and health-care systems suggests potential to improve care for patients but this potential remains unconfirmed. The European Surgical Outcomes Study was an international study designed to assess outcomes after non-cardiac surgery in Europe.Methods: We did this 7 day cohort study between April 4 and April 11, 2011. We collected data describing consecutive patients aged 16 years and older undergoing inpatient non-cardiac surgery in 498 hospitals across 28 European nations. Patients were followed up for a maximum of 60 days. The primary endpoint was in-hospital mortality. Secondary outcome measures were duration of hospital stay and admission to critical care. We used χ² and Fisher’s exact tests to compare categorical variables and the t test or the Mann-Whitney U test to compare continuous variables. Significance was set at p<0·05. We constructed multilevel logistic regression models to adjust for the differences in mortality rates between countries.Findings: We included 46 539 patients, of whom 1855 (4%) died before hospital discharge. 3599 (8%) patients were admitted to critical care after surgery with a median length of stay of 1·2 days (IQR 0·9–3·6). 1358 (73%) patients who died were not admitted to critical care at any stage after surgery. Crude mortality rates varied widely between countries (from 1·2% [95% CI 0·0–3·0] for Iceland to 21·5% [16·9–26·2] for Latvia). After adjustment for confounding variables, important differences remained between countries when compared with the UK, the country with the largest dataset (OR range from 0·44 [95% CI 0·19 1·05; p=0·06] for Finland to 6·92 [2·37–20·27; p=0·0004] for Poland).Interpretation: The mortality rate for patients undergoing inpatient non-cardiac surgery was higher than anticipated. Variations in mortality between countries suggest the need for national and international strategies to improve care for this group of patients.Funding: European Society of Intensive Care Medicine, European Society of Anaesthesiology
Mortality after surgery in Europe: a 7 day cohort study.
- Author
- \u160akic K
- \u160aric JP
- \u160eric J
- \u160imic-Korac N
- \u160imurina T
- \u160ribar A
- \u17dilic A
- \u17dilinc\ue1rov\ue1 V
- \u17duni J
- \u17dupcic M
- \uc1lvaro JL
- \uc5lvarez JT
- \ucd\uf1igo JA
- Aakeroey K
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- Afonso O
- Afshari A
- Agarwal B
- Agnic I
- Aguado DN
- Ahern R
- Ahonen T
- Aignatoaie M
- Akotia N
- Akouds E
- Al-Abdaly A
- Al-Subaie N
- Alagarsamy F
- Alameda LE
- Alasp\ue4\ue4 A
- Albalad DD
- Albaladejo P
- Albante A
- Alberdi F
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- Alcaide CM
- Alcantud JF
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- Alderson L
- Aleixandre IS
- Aleksic D
- Aleman M
- Alexander D
- Alexander P
- Algarra RR
- Ali ZS
- Aliste P
- Allu\ue9 RM
- Almeida E
- Almeida IM
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- Alonso AE
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- Alvarez LR
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- Amatya S
- Ampuero MS
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- Gl\uf6ckner C
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- Goranovic T
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- Primieri P
- Prince L
- Pritchard F
- Psevdi A
- Puente MS
- Puentes RB
- Pugliese F
- Pujol R
- Pulkkinen A
- Pulletz M
- Pynn\uf6nen J
- Quraishi T
- R\ue4\ue4bis I
- Rabes CM
- Rafael BM
- Rafi MA
- Ragaisis V
- Rague P
- Rajamanickam S
- Rakipovic AS
- Ralph J
- Ram\uedrez A
- Ram\uedrez CN
- Ramamoorthy K
- Ramasamy R
- Ramasco F
- Ramirez ET
- Ramkumar K
- Ramminger A
- Ramneantu M
- Ramos A
- Ramos B
- Ramos C
- Ramos JG
- Ramos R
- Ramos V
- Ramov E
- Ranieri VM
- Rapido F
- Raufhake C
- Razouk K
- Read R
- Real KP
- Real V
- Recchia E
- Reed D
- Reichle F
- Reidinga A
- Reindl M
- Reinhart K
- Rello J
- Rely M
- Resende M
- Reyntiens D
- Rezek K
- Rhodes A
- Rhodes A
- Rhodes A
- Ribeiro R
- Riccioni G
- Richardson N
- Rico J
- Rico PU
- Riddington D
- Riestra EM
- Rijckaert D
- Rikmane M
- Rilo MT
- Ristescu I
- Roa JR
- Roasio A
- Roberts L
- Robin E
- Rodero AQ
- Rodr\uedguez AB
- Rodr\uedguez ER
- Rodriguez RB
- Roeselare HH
- Rogerson D
- Roiss C
- Roman C
- Romero AS
- Romero CA
- Rope T
- Roquerio BS
- Ros JJ
- Rosa R
- Rosbergen M
- Rose E
- Rose O
- Rose S
- Rossaint R
- Rosseel F
- Rossi A
- Rossi-Blancher M
- Rous DP
- Roy A
- Royle A
- Royo C
- Rozkalne D
- Rua F
- Ruberto F
- Rubio AV
- Rudlof K
- Ruiz EM
- Ruiz JA
- Ruiz NM
- Ruperez I
- Rushton A
- Rutsaert R
- Ryan D
- Ryd\ue9n J
- Rylander C
- S\ue1ez IG
- S\ue1ez VP
- S\ue1nchez CL
- S\ue1nchez JL
- S\ue1nchez ML
- S\ue4lki\uf6 S
- S\uf6ndergaard S
- S\ufctt J
- Sa\uf1a FJ
- Saarelainen M
- Saarinen A
- Saarinen K
- Sablotzki A
- Sachdeva R
- Sacramento MK
- Saeed S
- Safatle F
- Sainz JJ
- Saiz AR
- Salas E
- Salda\uf1a FJ
- Salib Y
- Salinas U
- Salo L
- Salvan JH
- Samaniego LA
- Samma C
- Sampedro MG
- Sances D
- Sanchez-Morcillo S
- Sander M
- Sandesc D
- Sandhar T
- Sandici Z
- Sandu M
- Sange M
- Saniova B
- Sanmiguel G
- Sanseverino M
- Saraiva JP
- Saran T
- Sarandan M
- Saravanmuthu R
- Sardo E
- Sari F
- Sarkar S
- Sartzi M
- Saunders D
- Savelsberg S
- Sbai H
- Scarth E
- Sch\ufcttler J
- Scheidemann M
- Schiere S
- Schmutzler M
- Schneider G
- Scholler A
- Scholz L
- Schoorl M
- Schr\uf6der S
- Schreiner F
- Schrey S
- Schultz C
- Schwarzkopf K
- Seale T
- Secher EL
- Secker C
- Seeman-Lodding H
- Seeman-Lodding H
- Seisdedos \uc1A
- Sekulic A
- Sellden E
- Sep\ufalveda I
- Sepp\ue4nen H
- Serena G
- Sergejewa O
- Seron-Arbeloa C
- Serra AM
- Serra S
- Serrano LG
- Serrano MG
- Serrano PD
- Sevilla FC
- Sfyras D
- Shahzad A
- Sheshgiri B
- Shinner G
- Siegmueller C
- Sieiro JM
- Sigurbj\uf6rnsson FT
- Sigurdardottir EE
- Sigurdsson G
- Sigurdsson GH
- Silva L
- Silvasti P
- Silvestre FP
- Silvius N
- Sime\uf3n RG
- Simkova A
- Simon M
- Simon V
- Simonsen M
- Singh N
- Singh R
- Sintes D
- Sipylaite J
- Sj\uf6vall S
- Smith A
- Smith A
- Smith N
- Smith R
- Smitz C
- Smoje M
- Snaier C
- Snaith C
- Snell J
- Snelson C
- Soar J
- Sobona V
- Sockalingam S
- Soldatou O
- Sole MJ
- Somaini M
- Soro M
- Soto CL
- Soto RA
- Soto TT
- Soultati I
- Soumpasis I
- Spagnesi L
- Spagnolo L
- Spanjersberg R
- Spano G
- Spapen H
- Spena C
- Spielvogel C
- Spies C
- Spring A
- Sprunck A
- Spyropoulou E
- Spyropoulou-Pagdatoglou K
- Srecko M
- Stafylaraki M
- Stanzani MR
- Stathopoulos A
- Stecher A
- Stegmann N
- Steib A
- Steiner L
- Stelian DS
- Stendell L
- Stepanovs J
- Stephens R
- Stewart H
- Stier M
- Stilwell S
- Stivan F
- Stocker M
- Stone A
- Stourac P
- Strandvik G
- Streanga L
- Strietzel HF
- Struthers R
- Stuart-Smith K
- Su\uf1\ue9 AB
- Suba O
- Suita L
- Sulaj M
- Surbatovic M
- Susarla J
- Sweet K
- Sysimetsa A
- Szabo E
- Szakmany T
- Szarowar B
- Szederjesi I
- Szekeres G
- Szigeti J
- Szucs A
- Szyca R
- Szymkiewicz O
- Tachon G
- Talving J
- Tamm T
- Tamowicz B
- Tanfani A
- Tappata G
- Tasopoulos K
- Tassinati T
- Taylor A
- Templeton M
- Tena B
- Terol Ade L
- Theodorou V
- Thibaud A
- Thomas J
- Thomas J
- Thomas M
- Thomas R
- Thompson C
- Thorup L
- Thuet V
- Thwaites A
- Tiainen P
- Tibblin AO
- Tikkerberi A
- Timms G
- Timoneda FL
- Tincu E
- Tindall L
- Tinti C
- Toft P
- Toft P
- Toha AC
- Toivonen J
- Toma\u161evic A
- Tomasevic B
- Tomescu D
- Tomkute G
- Tommasino C
- Tompsett L
- Tomulic K
- Topic J
- Toplice K
- Toretti I
- Tormena M
- Toro JP
- Torrente FM
- Torres BF
- Tosi M
- Tot OK
- Tounou-Akue F
- Tredici S
- Trenkler S
- Triltsch A
- Trodd D
- Tsakas P
- Tsirogianni A
- Tucker K
- Tufano R
- Turcanu R
- Turi S
- Turina M
- Turner A
- Tzani V
- Ubre M
- Ungureanu L
- Unterberg M
- Untergehrer G
- Unz\ufae CL
- Ursic T
- Ursu I
- Utrera FA
- V\ue4\ue4r\ue4niemi H
- Vaccarisi E
- Vainio K
- Vajter J
- Vakkala M
- Valc\ue1rcel IE
- Vallejo A
- Vallet B
- van Acker G
- van Bommel J
- van den Berg R
- van der A M
- van der Hoven B
- van Duijn D
- van Klei W
- Van Mossevelde V
- van Obbergh L
- Vanlinthout L
- Vaquer S
- Varela IP
- Vargas MJ
- Vasan R
- Vasanth S
- Vasian H
- Vega JL
- Velasco AR
- Veld B
- Velzeboer F
- Venema A
- Venkatesh S
- Venzera- Azenic D
- Verbeke A
- Vercauteren M
- Verdenelli P
- Verhamme B
- Vezzoli D
- Viarengo V
- Vicari L
- Vicente R
- Vidal FG
- Vidal SG
- Viitanen M
- Vijar K
- Vilardi A
- Villach IR
- Villagran J
- Villen LM
- Vincent JL
- Vincent JL
- Vingsnes SO
- Vinnal M
- Visentin R
- Visk E
- Viskovic N
- Vitor P
- Vizca\uedno M
- Vizcaychipi M
- Vojinovic R
- von Heymann C
- Voulas A
- Vrankovic S
- Vrbanovic V
- Vrettou E
- Vymazal T
- Wadams B
- Wagner B
- Wagner J
- Waife N
- Walder B
- Walker E
- Walker R
- Wallet F
- Walsh H
- Ward G
- Ward S
- Warde B
- Wasmund C
- Waton K
- Watters M
- Webb S
- Weber M
- Weda T
- Wepler U
- Wernerman J
- Wessels K
- Westbrook A
- Westbrook A
- Weyland A
- White N
- White S
- Wickboldt N
- Wiegand-L\uf6hnert C
- Wiese O
- Wigmore T
- Wilde J
- Willars C
- Williams C
- Williams M
- Wilson J
- Wilson R
- Wilson S
- Windsor D
- Winsser L
- Wintzheimer S
- Wittmann M
- Wollaston J
- Wong K
- Wong P
- Woolhead A
- Worton R
- Wright C
- Wright M
- Wyldbore M
- Yemnga B
- Yepes MJ
- Yeung J
- Ytrebo LM
- Zaballos J
- Zabarte M
- Zacharouli D
- Zacharovska A
- Zadrazilova K
- Zafiridis T
- Zahorec R
- Zahorec R
- Zaldibar E
- Zamora JF
- Zandvliet R
- Zantua K
- Zearo E
- Zeba S
- Ziekenhuis A
- Zittling R
- Zocca E
- Zoltowski MK
- Zompanti V
- Zsisku L
- Zunic F
- Zuzan O
- Publication venue
- Publication date
- 01/01/2012
- Field of study