Heat transfer and pressure drop correlations for laminar flow in an in-line and staggered array of circular cylinders

Enhanced heat transfer surfaces based on cylindrically shaped pin fins with wire diameters in the range of 100 µm were analyzed. The design is based on a high pin length to diameter ratio in the range of 20–100. Correlations for thermal and fluid dynamic characteristics of these fine wire structures are not available in literature. An in-line and staggered arrangement of pins were simulated for a variety of operational and geometrical conditions with a twodimensional computational thermal and fluid dynamics model. Correlations for Nusselt number and friction factor with respect to Reynolds number and geometry were derived thereby. Reynolds numbers based on the wire diameter are in the range of 3–60. The correlations for the Nusselt number and friction factor can predict 93% and 97% of the simulated data within ±10%

Gravitational Lensing as Signal and Noise in Lyman-alpha Forest Measurements

In Lyman-alpha forest measurements it is generally assumed that quasars are mere background light sources which are uncorrelated with the forest. Gravitational lensing of the quasars violates this assumption. This effect leads to a measurement bias, but more interestingly it provides a valuable signal. The lensing signal can be extracted by correlating quasar magnitudes with the flux power spectrum and with the flux decrement. These correlations will be challenging to measure but their detection provides a direct measure of how features in the Lyman-alpha forest trace the underlying mass density field. Observing them will test the fundamental hypothesis that fluctuations in the forest are predominantly driven by fluctuations in mass, rather than in the ionizing background, helium reionization or winds. We discuss ways to disentangle the lensing signal from other sources of such correlations, including dust, continuum and background residuals. The lensing-induced measurement bias arises from sample selection: one preferentially collects spectra of magnified quasars which are behind overdense regions. This measurement bias is ~0.1-1% for the flux power spectrum, optical depth and the flux probability distribution. Since the effect is systematic, quantities such as the amplitude of the flux power spectrum averaged across scales should be interpreted with care.Comment: 22 pages, 8 figures; v2: references added, discussion expanded, matches PRD accepted versio

Acceleration and Classical Electromagnetic Radiation

Classical radiation from an accelerated charge is reviewed along with the reciprocal topic of accelerated observers detecting radiation from a static charge. This review commemerates Bahram Mashhoon's 60th birthday.Comment: To appear in Gen. Rel. Gra

Galaxy-Quasar correlations between APM galaxies and Hamburg-ESO QSOs

We detect angular galaxy-QSO cross-correlations between the APM Galaxy Catalogue and a preliminary release (consisting of roughly half of the anticipated final catalogue) of the Hamburg-ESO Catalogue of Bright QSOs as a function of source QSO redshift using multiple cross-correlation estimators. Each of the estimators yield very similar results, implying that the APM catalogue and the Hamburg-ESO survey are both fair samples of the respective true galaxy and QSO populations. Though the signal matches the expectations of gravitational lensing qualitatively, the strength of the measured cross-correlation signal is significantly greater than the CDM models of lensing by large scale structure would suggest. This same disagreement between models and observation has been found in several earlier studies. We estimate our confidence in the correlation detections versus redshift by generating 1000 random realizations of the Hamburg-ESO QSO survey: We detect physical associations between galaxies and low-redshift QSOs at 99% confidence and detect lensing associations at roughly 95% confidence for QSOs with redshifts between 0.6 and 1. Control cross-correlations between Galactic stars and QSOs show no signal. Finally, the overdensities (underdensities) of galaxies near QSO positions relative to those lying roughly 135 - 150 arcmin away are uncorrelated with differences in Galactic extinction between the two regions, implying that Galactic dust is not significantly affecting the QSO sample.Comment: 35 pages total, including 9 figures. Accepted by the Astrophysical Journa

Cosmological Information from Quasar-Galaxy Correlations induced by Weak Lensing

The magnification bias of large-scale structures, combined with galaxy biasing, leads to a cross-correlation of distant quasars with foreground galaxies on angular scales of the order of arc minutes and larger. The amplitude and angular shape of the cross-correlation function w_QG contain information on cosmological parameters and the galaxy bias factor. While the existence of this cross-correlation has firmly been established, existing data did not allow an accurate measurement of w_QG yet, but wide area surveys like the Sloan Digital Sky Survey now provide an ideal database for measuring it. However, w_QG depends on several cosmological parameters and the galaxy bias factor. We study in detail the sensitivity of w_QG to these parameters and develop a strategy for using the data. We show that the parameter space can be reduced to the bias factor b, Omega_0 and sigma_8, and compute the accuracy with which these parameters can be deduced from SDSS data. Under reasonable assumptions, it should be possible to reach relative accuracies of the order of 5%-15% for b, Omega_0, and sigma_8. This method is complementary to other weak-lensing analyses based on cosmic shear.Comment: 11 pages, 7 figures, accepted for publication in Astronomy and Astrophysic

Functional Glycosylation of Dystroglycan Is Crucial for Thymocyte Development in the Mouse

BACKGROUND: Alpha-dystroglycan (alpha-DG) is a cell surface receptor providing a molecular link between the extracellular matrix (ECM) and the actin-based cytoskeleton. During its biosynthesis, alpha-DG undergoes specific and unusual O-glycosylation crucial for its function as a high-affinity cellular receptor for ECM proteins. METHODOLOGY/PRINCIPAL FINDINGS: We report that expression of functionally glycosylated alpha-DG during thymic development is tightly regulated in developing T cells and largely confined to CD4(-)CD8(-) double negative (DN) thymocytes. Ablation of DG in T cells had no effect on proliferation, migration or effector function but did reduce the size of the thymus due to a significant loss in absolute numbers of thymocytes. While numbers of DN thymocytes appeared normal, a marked reduction in CD4(+)CD8(+) double positive (DP) thymocytes occurred. In the periphery mature naïve T cells deficient in DG showed both normal proliferation in response to allogeneic cells and normal migration, effector and memory T cell function when tested in acute infection of mice with either lymphocytic choriomeningitis virus (LCMV) or influenza virus. CONCLUSIONS/SIGNIFICANCE: Our study demonstrates that DG function is modulated by glycosylation during T cell development in vivo and that DG is essential for normal development and differentiation of T cells

Correlation between galaxies and QSO in the SDSS:na signal from gravitational lensing magnification?

We report a detection of galaxy-QSO cross-correlation w_GQ in the Sloan Digital Sky Survey (SDSS) Early Data Release (EDR) over 0.2-30 arc-minute scales. We cross-correlate galaxy samples of different mean depths r'=19-22 (z_G =0.15-0.35) with the main QSO population (i'<19.1) at mean z_Q=1.6. We find significant positive correlation in all cases except for the faintest QSOs, as expected if the signal were due to weak lensing magnification. The amplitude of the signal on arc-minute scales is about 20%. This is a few times larger than currently expected from weak lensing in LCDM but confirms, at a higher significance, previous measurements by several groups. When compared to the galaxy-galaxy correlation w_GG, a weak lensing interpretation indicates a strong and steep non-linear amplitude for the underlaying matter fluctuations: sigma=400 on scales of 0.2 Mpc/h, in contradiction with non-linear modeling of LCDM fluctuations. We also detect a normalized skewness (galaxy-galaxy-QSO correlation) of S_3=21 +/-6 at z=0.15 (S_3= 14 +/- 4 at z=0.35), which several sigma low, as compared to LCDM expectations. These observational trends can be reconciled with lensing in a flat Lambda universe with sigma_8=1, provided the linear spectrum is steeper (n = 1) than in the LCDM model on these small (cluster) scales. Under this interpretation, the galaxy distribution traces the matter variance with an amplitude that is 100 times smaller: ie galaxies are anti-bias with b=0.1 on small scales, increasing to b=1 at 10 Mpc/h.Comment: Final version accepted in ApJ. Minor changes and ref

Large Scale QSO-galaxy correlations for radio loud and optically selected QSO samples

We have studied the distribution of $B_J<20.5$ galaxies from the ROE/NRL COSMOS/UKST catalogue around two samples of $z>0.3$ QSOs with similar redshift distributions. The first sample is formed by 144 radio-loud QSOs from the Parkes Catalogue, and the other contains 167 optically selected QSOs extracted from the Large Bright Quasar Survey. It is found that there is a $\approx 99.0$ significance level excess of COSMOS/UKST galaxies around the PKS QSOs, whereas there is a marginal defect of galaxies around the LBQS QSOs. When the distribution of galaxies around both samples is compared, we found that there is an overdensity of galaxies around the PKS sample with respect to the LBQS sample anticorrelated with the distance from the QSOs at a $99.7$ significance level. Although this result apparently agrees with the predictions of the double magnification bias, it is difficult to explain by gravitational lensing effects alone; dust in the foreground galaxies and selection effects in the detection of LBQS QSOs should be taken into account. It has been established that the lines of sight to PKS flat-spectrum QSOs go through significatively higher foreground galaxy densities than the directions to LBQS quasars, what may be partially related with the reported reddening of PKS QSOs.Comment: 18 pages, 8 figures, AASTeX, accepted for publication in Ap

Thermal Degradation of Adsorbed Bottle-Brush Macromolecules: Molecular Dynamics Simulation

The scission kinetics of bottle-brush molecules in solution and on an adhesive substrate is modeled by means of Molecular Dynamics simulation with Langevin thermostat. Our macromolecules comprise a long flexible polymer backbone with $L$ segments, consisting of breakable bonds, along with two side chains of length $N$, tethered to each segment of the backbone. In agreement with recent experiments and theoretical predictions, we find that bond cleavage is significantly enhanced on a strongly attractive substrate even though the chemical nature of the bonds remains thereby unchanged. We find that the mean bond life time decreases upon adsorption by more than an order of magnitude even for brush molecules with comparatively short side chains $N=1 \div 4$. The distribution of scission probability along the bonds of the backbone is found to be rather sensitive regarding the interplay between length and grafting density of side chains. The life time declines with growing contour length $L$ as $\propto L^{-0.17}$, and with side chain length as $\propto N^{-0.53}$. The probability distribution of fragment lengths at different times agrees well with experimental observations. The variation of the mean length $L(t)$ of the fragments with elapsed time confirms the notion of the thermal degradation process as a first order reaction.Comment: 15 pages, 7 figure

Understanding how the V(D)J recombinase catalyzes transesterification: distinctions between DNA cleavage and transposition

The Rag1 and Rag2 proteins initiate V(D)J recombination by introducing site-specific DNA double-strand breaks. Cleavage occurs by nicking one DNA strand, followed by a one-step transesterification reaction that forms a DNA hairpin structure. A similar reaction allows Rag transposition, in which the 3′-OH groups produced by Rag cleavage are joined to target DNA. The Rag1 active site DDE triad clearly plays a catalytic role in both cleavage and transposition, but no other residues in Rag1 responsible for transesterification have been identified. Furthermore, although Rag2 is essential for both cleavage and transposition, the nature of its involvement is unknown. Here, we identify basic amino acids in the catalytic core of Rag1 specifically important for transesterification. We also show that some Rag1 mutants with severe defects in hairpin formation nonetheless catalyze substantial levels of transposition. Lastly, we show that a catalytically defective Rag2 mutant is impaired in target capture and displays a novel form of coding flank sensitivity. These findings provide the first identification of components of Rag1 that are specifically required for transesterification and suggest an unexpected role for Rag2 in DNA cleavage and transposition