Mecanismo de acción antiplaquetario de guanosina

49 p.Guanosina es un nucleósido de origen natural, que se puede encontrar en frutas y verduras. Sin embargo, su efecto sobre la agregación de plaquetas, que es un factor crítico en la trombosis arterial. Por lo tanto, el objetivo de este estudio fue examinar sistemáticamente los mecanismos detallados de guanosina en la prevención de la activación plaquetaria. Se evaluó el efecto de guanosina en agregación plaquetaria utilizando ADP 4 uM, colágeno 1ug/mL y ácido araquidónico 1 mM. Los niveles intraplaquetarios de AMPc y la expresión de PKA fueron determinados mediante Elisa kit y Western blot, respectivamente. Guanosina inhibió la agregación plaquetaria inducida por ADP, colágeno y ácido araquidónico. A distintas concentraciones guanosina aumento los niveles de AMPc intraplaquetario y se observó la fosforilación de PKA. Por lo tanto guanosina es un agente antiplaquetario eficaz

Plataforma de difusión y divulgación de las actividades del CIC-IBMCC

Memoria ID-0284. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2014-2015

Plataforma de difusión y divulgación de las actividades del CIC-IBMCC

Memoria ID-0146. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2015-2016

An efficient method for particle-resolved simulations of neutrally buoyant spheres

We present a simple modification of the direct-forcing immersed boundary method (IBM) proposed by Uhlmann (2005) in order to enable it to be applied to particulate flows with solid-to-fluid density ratios around unity. The main difference with respect to the original formulation lies in the particle velocity update which is performed directly after the preliminary velocity field has been computed in the absence of any IBM volume forcing term. In addition, we apply the forcing term to the entire space occupied by the immersed solid object (instead of to the vicinity of its interface only). The present approach requires the evaluation of integrals of the velocity field over the volume occupied by the solid particle, which are evaluated efficiently as sums over the respective quantities available at particle-attached force points. The resulting method can be used seamlessly for density ratios down to _∕_ > 0.5. The new formulation has been validated using three configurations: (i) lateral migration of a neutrally buoyant circular particle in two-dimensional Couette flow; (ii) the release from rest of a neutrally buoyant sphere in a free stream; (iii) the release of a particle in a free stream after an initial phase in which it is translationally fixed with an imposed angular velocity. In all three test cases the present IBM formulation yields a very good agreement with the available reference data. Thus, the proposed approach is a cost-efficient and accurate modification of the original method which allows for the simulation of fluid systems involving density-matched solid particles

Dual Vocational Education and Training Policy in Andalusia: The Nexus between the Education System and the Business Sector in the Higher-Level Training Cycle of Early Childhood Education

Dual vocational education and training (dual VET) is a recent policy aimed at establishing strong connections between the education system and the business sector. It serves to ensure the continuity of training, reduce early school leaving, and actively involve the business sector in the training and qualification of students, known as apprentices. Consequently, this approach has a favourable impact on their successful integration into the labour market upon completion of the dual training program. In this study, we investigate the implementation of dual VET in the autonomous community of Andalusia, Spain, focusing on the higher-level training cycle of early childhood education, which falls under the professional family of sociocultural and community services. Through a thorough analysis of interview accounts involving various stakeholders, we shed light on the outcomes of this policy’s implementation. The findings suggest that this emerging policy may have a positive impact on the employability of young individuals by enabling in-company training, which provides them an opportunity to showcase their vocational skills and to combine practical experience with theoretical knowledge. Work mentors are identified as essential contributors to the success of in-company training, as they help foster the necessary capabilities to ensure that dual VET is perceived as a comprehensive training experience rather than as just work experienceMinistry of Science and Innovation of the Government of Spain; grant number RTI2018-101660-B-100

Community identity, life satisfaction, empowerment and health: suggesting a model for the immigrant population

The academic literature shows that studies in the fields of Community Psychology and Group Psychology have reached the same conclusion: belonging to and identifying with a group has an impact on health. However, when the studies are reviewed, there seems to be little communication between those engaged in these two lines of work, as contributions made from the perspective of Community are not compared with those made from that of Social Identity. Therefore, this study opts for an integrative perspective that makes possible progress towards a political/social viewpoint. Specifically, it is sought to understand the relationship between identification with the neighbourhood in which one lives (what has been called "community identity") and the mental health of Malaga's immigrant population, a model being proposed in which the relationship between health and identity is mediated by empowerment.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. Government of Spain's Ministry of Economy and Competitiveness, reference: PSI2013-40508-

Expanding borders of communication and collaboration through the network: digital competence as a means to promote academic interculturality

Las Tecnologías de la Información y la Comunicación han permitido el establecimiento de espacios virtuales que modifican el modo de interacción social. En este trabajo se analiza la percepción de los futuros docentes del grado de Educación Infantil sobre el uso de redes digitales para fomentar la interculturalidad académica. Se ha utilizado una metodología cuantitativa, basada en la aplicación de un cuestionario construido ad hoc. Entre los resultados se resalta principalmente el uso social que los estudiantes hacen de las redes digitales por encima del académico para la comunicación y colaboración entre iguales. Finalmente se constata que el uso de las redes digitales en la actividad docente favorece la interculturalidadInformation and Communication Technologies allow the establishment of virtual spaces that modify the way people interacts between themselves. This paper analyzes the perception of future teachers who are studying Preschool Education on the use of digital networks to promote academic interculturality. For this, we carry out a quantitative methodology by applying an ad hoc questionnaire. Among the results, it is highlighted the social use that students make of digital networks over academic use for communication and collaboration among equals. Finally, we found that the use of digital networks in teaching bring on interculturalit