Prácticas y condiciones institucionales para el desarrollo de la docencia en universidades iberoamericanas

Esta investigación se realizó con base en un modelo analítico diseñado para evaluar las condiciones institucionales que inciden en el desarrollo de la docencia en Iberoamérica, los estudios de caso corresponden a seis universidades de: Argentina, España, México y Venezuela 1. Se identificaron tanto los retos comunes como las necesidades diferenciadas a los que se enfrenta el desarrollo, con calidad, de la docencia universitaria. Se concluyó que el contexto es una variable predominante que impacta el ejercicio de la función docente y que esta es la más importante actividad académica con incidencia en la calidad de la edu-cación superior

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality