406 research outputs found
Book Reviews
With the observation of high-energy astrophysical neutrinos by the IceCube Neutrino Observatory, interest has risen in models of PeV-mass decaying dark matter particles to explain the observed flux. We present two dedicated experimental analyses to test this hypothesis. One analysis uses 6 years of IceCube data focusing on muon neutrino ‘track’ events from the Northern Hemisphere, while the second analysis uses 2 years of ‘cascade’ events from the full sky. Known background components and the hypothetical flux from unstable dark matter are fitted to the experimental data. Since no significant excess is observed in either analysis, lower limits on the lifetime of dark matter particles are derived: we obtain the strongest constraint to date, excluding lifetimes shorter than s at 90% CL for dark matter masses above 10 TeV
Neutrinos below 100 TeV from the southern sky employing refined veto techniques to IceCube data
Many Galactic sources of gamma rays, such as supernova remnants, are expected
to produce neutrinos with a typical energy cutoff well below 100 TeV. For the
IceCube Neutrino Observatory located at the South Pole, the southern sky,
containing the inner part of the Galactic plane and the Galactic Center, is a
particularly challenging region at these energies, because of the large
background of atmospheric muons. In this paper, we present recent advancements
in data selection strategies for track-like muon neutrino events with energies
below 100 TeV from the southern sky. The strategies utilize the outer detector
regions as veto and features of the signal pattern to reduce the background of
atmospheric muons to a level which, for the first time, allows IceCube
searching for point-like sources of neutrinos in the southern sky at energies
between 100 GeV and several TeV in the muon neutrino charged current channel.
No significant clustering of neutrinos above background expectation was
observed in four years of data recorded with the completed IceCube detector.
Upper limits on the neutrino flux for a number of spectral hypotheses are
reported for a list of astrophysical objects in the southern hemisphere.Comment: 19 pages, 17 figures, 2 table
Differential limit on the extremely-high-energy cosmic neutrino flux in the presence of astrophysical background from nine years of IceCube data
We report a quasi-differential upper limit on the extremely-high-energy (EHE)
neutrino flux above GeV based on an analysis of nine years of
IceCube data. The astrophysical neutrino flux measured by IceCube extends to
PeV energies, and it is a background flux when searching for an independent
signal flux at higher energies, such as the cosmogenic neutrino signal. We have
developed a new method to place robust limits on the EHE neutrino flux in the
presence of an astrophysical background, whose spectrum has yet to be
understood with high precision at PeV energies. A distinct event with a
deposited energy above GeV was found in the new two-year sample, in
addition to the one event previously found in the seven-year EHE neutrino
search. These two events represent a neutrino flux that is incompatible with
predictions for a cosmogenic neutrino flux and are considered to be an
astrophysical background in the current study. The obtained limit is the most
stringent to date in the energy range between and GeV. This result constrains neutrino models predicting a three-flavor
neutrino flux of $E_\nu^2\phi_{\nu_e+\nu_\mu+\nu_\tau}\simeq2\times 10^{-8}\
{\rm GeV}/{\rm cm}^2\ \sec\ {\rm sr}10^9\ {\rm GeV}$. A significant part
of the parameter-space for EHE neutrino production scenarios assuming a
proton-dominated composition of ultra-high-energy cosmic rays is excluded.Comment: The version accepted for publication in Physical Review
Search for transient optical counterparts to high-energy IceCube neutrinos with Pan-STARRS1
In order to identify the sources of the observed diffuse high-energy neutrino
flux, it is crucial to discover their electromagnetic counterparts. IceCube
began releasing alerts for single high-energy ( TeV) neutrino
detections with sky localisation regions of order 1 deg radius in 2016. We used
Pan-STARRS1 to follow-up five of these alerts during 2016-2017 to search for
any optical transients that may be related to the neutrinos. Typically 10-20
faint ( mag) extragalactic transients are found within the
Pan-STARRS1 footprints and are generally consistent with being unrelated field
supernovae (SNe) and AGN. We looked for unusual properties of the detected
transients, such as temporal coincidence of explosion epoch with the IceCube
timestamp. We found only one transient that had properties worthy of a specific
follow-up. In the Pan-STARRS1 imaging for IceCube-160427A (probability to be of
astrophysical origin of 50 %), we found a SN PS16cgx, located at 10.0'
from the nominal IceCube direction. Spectroscopic observations of PS16cgx
showed that it was an H-poor SN at z = 0.2895. The spectra and light curve
resemble some high-energy Type Ic SNe, raising the possibility of a jet driven
SN with an explosion epoch temporally coincident with the neutrino detection.
However, distinguishing Type Ia and Type Ic SNe at this redshift is notoriously
difficult. Based on all available data we conclude that the transient is more
likely to be a Type Ia with relatively weak SiII absorption and a fairly normal
rest-frame r-band light curve. If, as predicted, there is no high-energy
neutrino emission from Type Ia SNe, then PS16cgx must be a random coincidence,
and unrelated to the IceCube-160427A. We find no other plausible optical
transient for any of the five IceCube events observed down to a 5
limiting magnitude of mag, between 1 day and 25 days after
detection.Comment: 20 pages, 6 figures, accepted to A&
A Search for Neutrino Emission from Fast Radio Bursts with Six Years of IceCube Data
We present a search for coincidence between IceCube TeV neutrinos and fast
radio bursts (FRBs). During the search period from 2010 May 31 to 2016 May 12,
a total of 29 FRBs with 13 unique locations have been detected in the whole
sky. An unbinned maximum likelihood method was used to search for spatial and
temporal coincidence between neutrinos and FRBs in expanding time windows, in
both the northern and southern hemispheres. No significant correlation was
found in six years of IceCube data. Therefore, we set upper limits on neutrino
fluence emitted by FRBs as a function of time window duration. We set the most
stringent limit obtained to date on neutrino fluence from FRBs with an
energy spectrum assumed, which is 0.0021 GeV cm per burst for emission
timescales up to \textasciitilde10 seconds from the northern hemisphere
stacking search.Comment: 15 pages, 9 figure
Molecular Signatures of Prostate Stem Cells Reveal Novel Signaling Pathways and Provide Insights into Prostate Cancer
BACKGROUND:The global gene expression profiles of adult and fetal murine prostate stem cells were determined to define common and unique regulators whose misexpression might play a role in the development of prostate cancer. METHODOLOGY/PRINCIPAL FINDINGS:A distinctive core of transcriptional regulators common to both fetal and adult primitive prostate cells was identified as well as molecules that are exclusive to each population. Elements common to fetal and adult prostate stem cells include expression profiles of Wnt, Shh and other pathways identified in stem cells of other organs, signatures of the aryl-hydrocarbon receptor, and up-regulation of components of the aldehyde dehydrogenase/retinoic acid receptor axis. There is also a significant lipid metabolism signature, marked by overexpression of lipid metabolizing enzymes and the presence of the binding motif for Srebp1. The fetal stem cell population, characterized by more rapid proliferation and self-renewal, expresses regulators of the cell cycle, such as E2f, Nfy, Tead2 and Ap2, at elevated levels, while adult stem cells show a signature in which TGF-beta has a prominent role. Finally, comparison of the signatures of primitive prostate cells with previously described profiles of human prostate tumors identified stem cell molecules and pathways with deregulated expression in prostate tumors including chromatin modifiers and the oncogene, Erg. CONCLUSIONS/SIGNIFICANCE:Our data indicate that adult prostate stem or progenitor cells may acquire characteristics of self-renewing primitive fetal prostate cells during oncogenesis and suggest that aberrant activation of components of prostate stem cell pathways may contribute to the development of prostate tumors
O6-Methylguanine-DNA methyltransferase protein expression by immunohistochemistry in brain and non-brain systemic tumours: systematic review and meta-analysis of correlation with methylation-specific polymerase chain reaction
Background: The DNA repair protein O6-Methylguanine-DNA methyltransferase (MGMT) confers resistance to alkylating agents. Several methods have been applied to its analysis, with methylation-specific polymerase chain reaction (MSP) the most commonly used for promoter methylation study, while immunohistochemistry (IHC) has become the most frequently used for the detection of MGMT protein expression. Agreement on the best and most reliable technique for evaluating MGMT status remains unsettled. The aim of this study was to perform a systematic review and meta-analysis of the correlation between IHC and MSP. Methods A computer-aided search of MEDLINE (1950-October 2009), EBSCO (1966-October 2009) and EMBASE (1974-October 2009) was performed for relevant publications. Studies meeting inclusion criteria were those comparing MGMT protein expression by IHC with MGMT promoter methylation by MSP in the same cohort of patients. Methodological quality was assessed by using the QUADAS and STARD instruments. Previously published guidelines were followed for meta-analysis performance. Results Of 254 studies identified as eligible for full-text review, 52 (20.5%) met the inclusion criteria. The review showed that results of MGMT protein expression by IHC are not in close agreement with those obtained with MSP. Moreover, type of tumour (primary brain tumour vs others) was an independent covariate of accuracy estimates in the meta-regression analysis beyond the cut-off value. Conclusions Protein expression assessed by IHC alone fails to reflect the promoter methylation status of MGMT. Thus, in attempts at clinical diagnosis the two methods seem to select different groups of patients and should not be used interchangeably
IceCube Search for High-Energy Neutrino Emission from TeV Pulsar Wind Nebulae
Pulsar wind nebulae (PWNe) are the main gamma-ray emitters in the Galactic
plane. They are diffuse nebulae that emit nonthermal radiation. Pulsar winds,
relativistic magnetized outflows from the central star, shocked in the ambient
medium produce a multiwavelength emission from the radio through gamma rays.
Although the leptonic scenario is able to explain most PWNe emission, a
hadronic contribution cannot be excluded. A possible hadronic contribution to
the high-energy gamma-ray emission inevitably leads to the production of
neutrinos. Using 9.5 yr of all-sky IceCube data, we report results from a
stacking analysis to search for neutrino emission from 35 PWNe that are
high-energy gamma-ray emitters. In the absence of any significant correlation,
we set upper limits on the total neutrino emission from those PWNe and
constraints on hadronic spectral components.Comment: 11 pages, 2 figures; matches the published version in Ap
Investigation of two Fermi-LAT gamma-ray blazars coincident with high-energy neutrinos detected by IceCube
After the identification of the gamma-ray blazar TXS 0506+056 as the first
compelling IceCube neutrino source candidate, we perform a systematic analysis
of all high-energy neutrino events satisfying the IceCube realtime trigger
criteria. We find one additional known gamma-ray source, the blazar GB6
J1040+0617, in spatial coincidence with a neutrino in this sample. The chance
probability of this coincidence is 30% after trial correction. For the first
time, we present a systematic study of the gamma-ray flux, spectral and optical
variability, and multi-wavelength behavior of GB6 J1040+0617 and compare it to
TXS 0506+056. We find that TXS 0506+056 shows strong flux variability in the
Fermi-LAT gamma-ray band, being in an active state around the arrival of
IceCube-170922A, but in a low state during the archival IceCube neutrino flare
in 2014/15. In both cases the spectral shape is statistically compatible () with the average spectrum showing no indication of a significant
relative increase of a high-energy component. While the association of GB6
J1040+0617 with the neutrino is consistent with background expectations, the
source appears to be a plausible neutrino source candidate based on its
energetics and multi-wavelength features, namely a bright optical flare and
modestly increased gamma-ray activity. Finding one or two neutrinos originating
from gamma-ray blazars in the given sample of high-energy neutrinos is
consistent with previously derived limits of neutrino emission from gamma-ray
blazars, indicating the sources of the majority of cosmic high-energy neutrinos
remain unknown.Comment: 22 pages, 11 figures, 2 Table
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