Anticipation is the key to understanding music and the effects of music on emotion

There is certainly a need for a framework to guide the study of the physiological mechanisms underlying the experience of music and the emotions that music evokes. However, this framework should be organised hierarchically, with musical anticipation as its fundamental mechanism

Oral contraception and eye disease: findings in two large cohort studies

AIM : To investigate the relation between oral contraceptive use and certain eye diseases. \ud \ud METHODS : Abstraction of the relevant data from the two large British cohort studies of the effects of oral contraception, the Royal College of General Practitioners' (RCGP) Oral Contraception Study and the Oxford-Family Planning Association (Oxford-FPA) Contraceptive Study. Both cohort studies commenced in 1968 and were organised on a national basis. Between them they have accumulated over 850 000 person years of observation involving 63 000 women. \ud \ud RESULTS : The conditions considered in the analysis were conjunctivitis, keratitis, iritis, lacrimal disease, strabismus, cataract, glaucoma, retinal detachment, and retinal vascular lesions. With the exception of retinal vascular lesions, there was no consistent evidence of important increases in risk of eye diseases in users of oral contraception. There was about a twofold increase in the risk of retinal vascular lesions in recent pill users in both studies (statistically significant only in the RCGP study). The increase was not limited to any specific type of lesion and may well reflect diagnostic bias. \ud \ud CONCLUSION : Oral contraceptive use does not appear to increase the risk of eye disease, with the possible exception of retinal vascular lesions. \ud \ud Keywords: oral contraception; eye disease; cohort studie

DNA-coated Functional Oil Droplets

Many industrial soft materials often include oil-in-water (O/W) emulsions at the core of their formulations. By using tuneable interface stabilizing agents, such emulsions can self-assemble into complex structures. DNA has been used for decades as a thermoresponsive highly specific binding agent between hard and, recently, soft colloids. Up until now, emulsion droplets functionalized with DNA had relatively low coating densities and were expensive to scale up. Here a general O/W DNA-coating method using functional non-ionic amphiphilic block copolymers, both diblock and triblock, is presented. The hydrophilic polyethylene glycol ends of the surfactants are functionalized with azides, allowing for efficient, dense and controlled coupling of dibenzocyclooctane functionalized DNA to the polymers through a strain-promoted alkyne-azide click reaction. The protocol is readily scalable due to the triblock's commercial availability. Different production methods (ultrasonication, microfluidics and membrane emulsification) are used with different oils (hexadecane and silicone oil) to produce functional droplets in various size ranges (sub-micron, $\sim 20\,\mathrm{\mu m}$ and $> 50\,\mathrm{\mu m}$), showcasing the generality of the protocol. Thermoreversible sub-micron emulsion gels, hierarchical "raspberry" droplets and controlled droplet release from a flat DNA-coated surface are demonstrated. The emulsion stability and polydispersity is evaluated using dynamic light scattering and optical microscopy. The generality and simplicity of the method opens up new applications in soft matter and biotechnological research and industrial advances.Comment: 7 pages, 2 figures, 1 tabl

Neural signatures of strategic types in a two-person bargaining game

The management and manipulation of our own social image in the minds of others requires difficult and poorly understood computations. One computation useful in social image management is strategic deception: our ability and willingness to manipulate other people's beliefs about ourselves for gain. We used an interpersonal bargaining game to probe the capacity of players to manage their partner's beliefs about them. This probe parsed the group of subjects into three behavioral types according to their revealed level of strategic deception; these types were also distinguished by neural data measured during the game. The most deceptive subjects emitted behavioral signals that mimicked a more benign behavioral type, and their brains showed differential activation in right dorsolateral prefrontal cortex and left Brodmann area 10 at the time of this deception. In addition, strategic types showed a significant correlation between activation in the right temporoparietal junction and expected payoff that was absent in the other groups. The neurobehavioral types identified by the game raise the possibility of identifying quantitative biomarkers for the capacity to manipulate and maintain a social image in another person's mind

The Impact of Warm Pool El Nino Events on Antarctic Ozone

Warm pool El Nino (WPEN) events are characterized by positive sea surface temperature (SST) anomalies in the central equatorial Pacific in austral spring and summer. Previous work found an enhancement in planetary wave activity in the South Pacific in austral spring, and a warming of 3-5 K in the Antarctic lower stratosphere during austral summer, in WPEN events as compared with ENSO neutral. In this presentation, we show that weakening of the Antarctic vortex during WPEN affects the structure and magnitude of high-latitude total ozone. We use total ozone data from TOMS and OMI, as well as station data from Argentina and Antarctica, to identify shifts in the longitudinal location of the springtime ozone minimum from its climatological position. In addition, we examine the sensitivity of the WPEN-related ozone response to the phase of the quasi-biennial oscillation (QBO). We then compare the observed response to WPEN events with Goddard Earth Observing System chemistry-climate model, version 2 (GEOS V2 CCM) simulations. Two, 50-year time-slice simulations are forced by annually repeating SST and sea ice climatologies, one set representing observed WPEN events and the second set representing neutral ENSO events, in a present-day climate. By comparing the two simulations, we isolate the impact of WPEN events on lower stratospheric ozone, and furthermore, examine the sensitivity of the WPEN ozone response to the phase of the QBO

Impaired Competence for Pretense in Children with Autism: Exploring Potential Cognitive Predictors.

Lack of pretense in children with autism has been explained by a number of theoretical explanations, including impaired mentalising, impaired response inhibition, and weak central coherence. This study aimed to empirically test each of these theories. Children with autism (n=60) were significantly impaired relative to controls (n=65) when interpreting pretense, thereby supporting a competence deficit hypothesis. They also showed impaired mentalising and response inhibition, but superior local processing indicating weak central coherence. Regression analyses revealed that mentalising significantly and independently predicted pretense. The results are interpreted as supporting the impaired mentalising theory and evidence against competing theories invoking impaired response inhibition or a local processing bias. The results of this study have important implications for treatment and intervention

Ground-Based Observing Campaign of Briz-M Debris

In 2015, NASA's Orbital Debris Program Office (ODPO) completed the installation of the Meter Class Autonomous Telescope (MCAT) on Ascension Island. MCAT is a 1.3m optical telescope designed with a fast tracking capability for observing orbital debris at all orbital regimes (Low-Erath orbits to Geosyncronous (GEO) orbits) from a low latitude site. This new asset is dedicated year-round for debris observations, and its location fills a geographical gap in the Ground-based Electro Optical Space Surveillance (GEODSS) network. A commercial off the shelf (COTS) research grade 0.4m telescope (named the Benbrook telescope) will also be installed on Ascension at the end of 2016. This smaller version is controlled by the same master software, designed by Euclid Research, and can be tasked to work independently or in concert with MCAT. Like MCAT, it has a the same suite of filters, a similar field of view, and a fast-tracking Astelco mount, and is also capable of tracking debris at all orbital regimes. These assets are well suited for targeted campagins or surveys of debris. Since 2013, NASA's ODPO has also had extensive access to the 3.8m infrared UKIRT telescope, located on Mauna Kea. At nearly 14,000-ft, this site affords excellent conditions for collecting both photometery and spectroscopy at near-IR (0.9 - 2.5 micrometers SWIR) and thermal-IR (8 - 25 micrometers; LWIR) regimes, ideal for investigating material properties as well as thermal characteristics and sizes of debris. For the purposes of understanding orbital debris, taking data in both survey mode as well as targeting individual objects for more in-depth characterizations are desired. With the recent break-ups of Briz-M rocket bodies, we have collected a suite of data in the optical, near-infrared, and mid-infrared of in-tact objects as well as those classified as debris. A break-up at GEO of a Briz-M rocket occurred in January, 2016, well timed for the first remote observing survey-campaign with MCAT. Access to the 3.8m UKIRT telescope has also allowed for investigating this break-up in the near-infrared at wavelengths where debris is often much more reflective, allowing for the potential detection of a smaller population of these debris. In addition, a suite of near-IR reflectance spectroscopy (0.8-2.5 micrometers) and thermal-IR (8-15 micrometers) of individual in-tact and debris Briz-M objects has been collected. Analysis of the survey data will be discussed