Environmental and structural factors influencing algal communities in small streams and ditches in central Germany

The suspended algal fraction in small lotic waterbodies has rarely been investigated as the ecological importance was questioned due to low abundances. Recent findings suggest, that substantial riverine plankton communities can establish in small lotic waterbodies. The gap of knowledge concerning the composition of suspended algal assemblages and influential factors determining their composition is addressed in this study by monitoring suspended and attached algal communities over a two year period in agriculturally influenced small lotic waterbodies using delayed fluorescence spectroscopy. A quantitative comparison of suspended and attached algae indicated, that suspended algae exceeded attached algal biomass in late summer and early autumn. Redundancy analyses and corresponding generalized linear models indicated that the suspended algal groups were most influenced by nutrients, temperature and velocity, whereas light regime was of minor importance. The attached algal groups were affected by the same factors, however with differing intensity. Regional factors, such as season, were identified as the major gradients along which both algal fractions varied, inducing temporal synchronous algal assemblages. This work represents a contribution towards a better understanding of algal ecology specifically suspended algae in small lotic waterbodies

Evidence for age-invariance in associative false recognition

Older people are more prone to memory distortions and errors than young people, but do not always show greater false recognition in the Deese-Roediger-McDermott (DRM) task. We report two preregistered experiments investigating whether recent findings of age-invariant false recognition extend to designs in which studied items are blocked. According to Tun, Wingfield, Rosen, & Blanchard (1998), age effects on false recognition in the DRM task are due to a greater reliance on gist processing which is enhanced under blocked study conditions. Experiment 1 assessed false recognition in an online variant of the DRM task where words were presented visually, with incidental encoding. The results showed Bayesian evidence against greater false recognition by older adults, whether lures were semantically associated with studied lists, or perceptually related (presented in the same distinctive font as studied lists) or both. Experiment 2 used a typical DRM procedure with auditory lists and intentional encoding, closely reproducing Tun et al.’s (1998) Experiment 2 but omitting an initial test of recall. The results showed evidence against an age-related increase in critical lure false recognition under these conditions. Together, the data suggest that older people do not make more associative memory errors in recognition tests than young people

Sozialpädagogische Krisenintervention bei Kindeswohlgefährdung

Das Verhältnis von staatlicher Kontrolle und familialer Autonomie spiegelt sich in den Diskursen um Kindheit und Zugriffen auf Kindheit wider. Familien stehen in diesem Spannungsfeld von Öffentlichkeit und Privatheit unter Beobachtung. Im vorliegenden Beitrag geht es nicht um ein schlichtes Nachzeichnen von (staatlichen) Eingriffen in Familien, sondern um kritische wissenschaftliche Reflexion aktueller Interventionspolitiken und um die Rekonstruktion des Erlebens von Betroffenen. Dabei wird auf die Schweizer Gesetze und Studien zu Kindesschutz Bezug genommen. Zudem wird das Interaktionsgefüge zwischen Professionellen und AdressatInnen analysiert, welches reflexives Handeln seitens der Professionellen erfordert. Der Interaktionsraum, in dem Erleben und Erfahrung sowohl der Professionellen als auch der Eltern und nahen Bezugspersonen einfließen, enthält und erhält jeweils spezifische Strukturen und wird durch Handlungen und Interaktionen wiederum weiter strukturiert. Die Betrachtung des Interaktionsraumes als Verschränkung von Struktur und Handlung eröffnet einen Analyseraum, in dem sich Handlungsmuster herauskristallisieren lassen und gesellschaftliche, familiale oder biographische Bedingungen dennoch nicht in Vergessenheit geraten. Diese Handlungsmuster dienen den SozialpädagogInnen als Reflexionsfolie im Interventionsprozess; Handlungen der AdressatInnen können besser nachvollzogen und verstanden werde

Homozygous loss-of-function mutations in MNS1 cause laterality defects and likely male infertility.

The clinical spectrum of ciliopathies affecting motile cilia spans impaired mucociliary clearance in the respiratory system, laterality defects including heart malformations, infertility and hydrocephalus. Using linkage analysis and whole exome sequencing, we identified two recessive loss-of-function MNS1 mutations in five individuals from four consanguineous families: 1) a homozygous nonsense mutation p.Arg242* in four males with laterality defects and infertility and 2) a homozygous nonsense mutation p.Gln203* in one female with laterality defects and recurrent respiratory infections additionally carrying homozygous mutations in DNAH5. Consistent with the laterality defects observed in these individuals, we found Mns1 to be expressed in mouse embryonic ventral node. Immunofluorescence analysis further revealed that MNS1 localizes to the axonemes of respiratory cilia as well as sperm flagella in human. In-depth ultrastructural analyses confirmed a subtle outer dynein arm (ODA) defect in the axonemes of respiratory epithelial cells resembling findings reported in Mns1-deficient mice. Ultrastructural analyses in the female carrying combined mutations in MNS1 and DNAH5 indicated a role for MNS1 in the process of ODA docking (ODA-DC) in the distal respiratory axonemes. Furthermore, co-immunoprecipitation and yeast two hybrid analyses demonstrated that MNS1 dimerizes and interacts with the ODA docking complex component CCDC114. Overall, we demonstrate that MNS1 deficiency in humans causes laterality defects (situs inversus) and likely male infertility and that MNS1 plays a role in the ODA-DC assembly

Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells

Aberrant immune responses represent the underlying cause of central nervous system (CNS) autoimmunity, including multiple sclerosis (MS). Recent evidence implicated the crosstalk between coagulation and immunity in CNS autoimmunity. Here we identify coagulation factor XII (FXII), the initiator of the intrinsic coagulation cascade and the kallikrein–kinin system, as a specific immune cell modulator. High levels of FXII activity are present in the plasma of MS patients during relapse. Deficiency or pharmacologic blockade of FXII renders mice less susceptible to experimental autoimmune encephalomyelitis (a model of MS) and is accompanied by reduced numbers of interleukin-17A-producing T cells. Immune activation by FXII is mediated by dendritic cells in a CD87-dependent manner and involves alterations in intracellular cyclic AMP formation. Our study demonstrates that a member of the plasmatic coagulation cascade is a key mediator of autoimmunity. FXII inhibition may provide a strategy to combat MS and other immune-related disorders