10 research outputs found
Fibulin-1 is required for morphogenesis of neural crest-derived structures
- Author
- Publication venue
- Elsevier Inc.
- Publication date
- 15/07/2008
- Field of study
AbstractHere we report that mouse embryos homozygous for a gene trap insertion in the fibulin-1 (Fbln1) gene are deficient in Fbln1 and exhibit cardiac ventricular wall thinning and ventricular septal defects with double outlet right ventricle or overriding aorta. Fbln1 nulls also display anomalies of aortic arch arteries, hypoplasia of the thymus and thyroid, underdeveloped skull bones, malformations of cranial nerves and hemorrhagic blood vessels in the head and neck. The spectrum of malformations is consistent with Fbln1 influencing neural crest cell (NCC)-dependent development of these tissues. This is supported by evidence that Fbln1 expression is associated with streams of cranial NCCs migrating adjacent to rhombomeres 2–7 and that Fbln1-deficient embryos display patterning anomalies of NCCs forming cranial nerves IX and X, which derive from rhombomeres 6 and 7. Additionally, Fbln1-deficient embryos show increased apoptosis in areas populated by NCCs derived from rhombomeres 4, 6 and 7. Based on these findings, it is concluded that Fbln1 is required for the directed migration and survival of cranial NCCs contributing to the development of pharyngeal glands, craniofacial skeleton, cranial nerves, aortic arch arteries, cardiac outflow tract and cephalic blood vessels
Novel Di-Tertiary-Butyl Phenylhydrazones as Dual Cyclooxygenase-2/5- Lipoxygenase Inhibitors: Synthesis, COX/LOX Inhibition, Molecular Modeling, and Insights into Their Cytotoxicities
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2014
- Field of study
Although dual inhibition of Cyclooxygenase-2 (COX-2) and 5-Lipoxygenase (5-LOX) enzymes is highly effective than targeting COX or LOX alone, there are only a few reports of examining such compounds in case of colorectal cancers (CRC). In the present work we report that the novel di-tert-butyl phenol-based dual inhibitors DTPSAL, DTPBHZ, DTPINH, and DTPNHZ exhibit significant cytotoxicity against human CRC cell lines. Molecular docking studies revealed a good fit of these compounds in the COX-2 and 5-LOX protein cavities. The inhibitors show significant inhibition of COX-2 and 5-LOX activities and are effective against a panel of human colon cancer cell lines including HCA-7, HT-29, SW480 and intestinal Apc10.1 cells as well as the hyaluronan synthase-2 (Has2) enzyme over-expressing colon cancer cells, through inhibition of the Hyaluronan/CD44v6 cell survival pathway. Western blot analysis and qRT-PCR analyses indicated that the di-tert-butyl phenol-based dual inhibitors reduce the expression of COX-2, 5-LOX, and CD44v6 in human colon cancer HCA-7 cells, while the combination of CD44v6shRNA and DTPSAL has an additional inhibitory effect on CD44v6 mRNA expression. The synergistic inhibitory effect of Celecoxib and Licofelone on CD44v6 mRNA expression suggests that the present dual inhibitors down-regulate cyclooxygenase and lipoxygenase enzymes through CD44v6. The compounds also exhibited enhanced antiproliferative potency compared to standard dual COX/LOX inhibitor, viz. Licofelone. Importantly, the HA/CD44v6 antagonist CD44v6shRNA in combination with synthetic compounds had a sensitizing effect on the cancer cells which enhanced their antiproliferative potency, a finding which is crucial for the anti-proliferative potency of the novel synthetic di-tert-butyl phenol based dual COX-LOX inhibitors in colon cancer cells
Small bowel adenocarcinoma and crohn’s disease
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Fibulin-1 Binds to Fibroblast Growth Factor 8 with High Affinity
- Author
- Publication venue
- 'American Society for Biochemistry & Molecular Biology (ASBMB)'
- Publication date
- Field of study
Novel di-tertiary-butyl phenylhydrazones as dual cyclooxygenase-2/5-lipoxygenase inhibitors: Synthesis, COX/LOX inhibition, molecular modeling, and insights into their cytotoxicities
- Author
- Ajit Zambre
- Alok Vyas
- Amitava Choudhury
- Aruffo
- Aruffo
- Azumaya
- Bertagnolli
- Bias
- Chowdhury
- Chowdhury
- Chowdhury
- Cicero
- Duffield-Lillico
- Figueras
- Ghatak
- Ghatak
- Ihara
- Inagaki
- K. Venkateshwara Swamy
- Kaur
- Kilic
- Kovacic
- Lesley
- Lesley
- Lesley
- Lesley
- Lesley
- Liu
- Madhukar Khetmalas
- Melstrom
- Meyerhardt
- Milaeva
- Misra
- Misra
- Misra
- Mohammed
- Moreau
- Naor
- Paul O’Brien
- Roger R. Markwald
- Shibnath Ghatak
- Siegel
- Song
- Soumaoro
- Subhash Padhye
- Suniti Misra
- Tas
- Tavolari
- Victor M. Fresco
- Wasilewicz
- Weitz
- Xiao
- Yamada
- Ye
- Ye
- Zahra Afrasiabi
- Zarghi
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Fibulin-1 is required for morphogenesis of neural crest-derived structures
- Author
- Abu-Issa
- Andy Wessels
- Arai
- Argraves
- Argraves
- Balbona
- Baldini
- Bockman
- Bockman
- Bockman
- Bouchey
- Bronner-Fraser
- Brooke
- Burns
- Byrd
- Chisaka
- Christine B. Kern
- Christopher J. Drake
- Chu
- Coles
- Conway
- Corey H. Mjaatvedt
- Costell
- D'Amico-Martel
- Dutt
- Etchevers
- Frank
- Gage
- Guris
- Hayashido
- Henderson
- Hesselson
- Hogan
- Hutson
- Ishii
- Kern
- Kikkawa
- Kimmel
- Kirby
- Korenberg
- Korn
- Kostka
- Kramer
- Kubota
- Kubota
- Kuratani
- Lee
- Li
- Liao
- Liu
- Marion A. Cooley
- Miller
- Mjaatvedt
- Montero
- Moon
- Muriel
- Perbal
- Perris
- Pietri
- Qing
- Robert P. Thompson
- Sasaki
- Schymeinsky
- Skarnes
- Spence
- Stryke
- Tim C. McQuinn
- Tran
- Twal
- Verzi
- Victor M. Fresco
- W. Scott Argraves
- Waldo
- Waleed O. Twal
- Watari
- Yelbuz
- Zhang
- Zhang
- Zhou
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Cartilage link protein 1 (Crtl1), an extracellular matrix component playing an important role in heart development
- Author
- Aimee L. Phelps
- Andy Wessels
- Binette
- Brian S. Snarr
- Bryan P. Toole
- Bushdid
- Camenisch
- Campione
- Caterson
- Christine B. Kern
- Christoffels
- Corey H. Mjaatvedt
- Czipri
- Danielian
- de Lange
- Dettman
- Eisenberg
- Elaine E. Wirrig
- Evanko
- Gassmann
- Hardingham
- Hoogaars
- Jaber
- Jeremy L. Barth
- Jessica L. O'Neal
- Kang
- Kern
- Kern
- Keyes
- Kisanuki
- Kraus
- Krug
- Kruithof
- Kruzynska-Frejtag
- Lincoln
- Lincoln
- Liu
- Manner
- Markwald
- Mastan R. Chintalapudi
- Matsumoto
- Matsumoto
- Mjaatvedt
- Mommersteeg
- Moore
- Moorman
- Nakamura
- Neame
- Norris
- Ogawa
- Perez-Pomares
- Sandy
- Schroeder
- Sheng
- Shi
- Shibata
- Snarr
- Snow
- Spicer
- Stanley Hoffman
- Sugi
- Theiler
- Thomas C. Trusk
- Toole
- Victor M. Fresco
- W. Scott Argraves
- Waller
- Watanabe
- Wessels
- Wessels
- Wessels
- Wight
- Ya
- Yamamura
- Zhao
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Stress neuropeptide levels in adults with chest pain due to coronary artery disease: potential implications for clinical assessment
- Author
- A. A. Ermolaev
- A. A. Fomin
- A. A. Grace
- A. A. J. Adgey
- A. A. J. Adgey
- A. A. J. Adgey
- A. Abdelfattah
- A. Affatato
- A. Aiello
- A. Albuquerque
- A. Albuquerque
- A. Aleixo
- A. Aleixo
- A. Aleixo
- A. Aleixo
- A. Aleixo
- A. Aleixo
- A. Aleixo
- A. Aleixo
- A. Aleixo
- A. Aleixo
- A. Aleixo
- A. Aleksic
- A. Aleksova
- A. Alexandrescu
- A. Altamirano
- A. Alvarez-San Gabriel
- A. Anzoletti Boscolo
- A. Arias
- A. Ariza Sole
- A. Ariza Sole
- A. Ariza Sole
- A. Asif
- A. Aurelio
- A. Bellemain-Appaix
- A. Berezin
- A. Beyaztas
- A. Birdane
- A. Birdane
- A. Birdane
- A. Birdane
- A. Birdane
- A. Bittlinsky
- A. Botelho
- A. Botelho
- A. Botelho
- A. Boytsov
- A. Brzozowska-Czarnek
- A. C. C. Carvalho
- A. C. C. Carvalho
- A. C. C. Carvalho
- A. C. Ferreira
- A. C. Van Rossum
- A. C. Van Rossum
- A. C. Van Rossum
- A. Cabiati
- A. Calabro
- A. Campanile
- A. Campo
- A. Cattabiani
- A. Cavusoglu
- A. Cavusoglu
- A. Cequier Fillat
- A. Chaib
- A. Chernova
- A. Comella
- A. Condac
- A. Conti
- A. Contine
- A. Correia
- A. Cristea
- A. De Caterina
- A. De Miguel
- A. Dibra
- A. Diego
- A. Dominguez-Rodriguez
- A. Drumond
- A. Drumond
- A. Drumond
- A. Drumond
- A. Dushpanova
- A. Erglis
- A. Erglis
- A. F. Simoes Marques Assuncao Caetano
- A. Fareed
- A. Faustino
- A. Faustino
- A. Faustino
- A. Faustino
- A. Fernandez-Ortiz
- A. Fernandez-Ortiz
- A. Fernandez-Ortiz
- A. Fiarresga
- A. Fruntelata
- A. Fruntelata
- A. G. Aroutunov
- A. G. Fruntelata
- A. G. Nikishin
- A. G. Nikishin
- A. G. Rebuzzi
- A. Garcia Escudero
- A. Garcia Quintana
- A. Geppert
- A. Gnanaraj
- A. Gonella
- A. Goodkova
- A. Grave
- A. Grave
- A. Hirsch
- A. Hirsch
- A. Hirsch
- A. Horvath
- A. I. Hassan
- A. I. Suceveanu
- A. I. Suceveanu
- A. Ibatov
- A. Ibatov
- A. Iniguez
- A. Ionac
- A. Izzo
- A. Izzo
- A. Izzo
- A. J. Aleksandra Jovelic
- A. J. Palomino Doza
- A. J. Six
- A. Jegou
- A. Jovelic
- A. Kalinauskas
- A. Kasai
- A. Kastrati
- A. Kawamura
- A. Kokotos
- A. Konopka
- A. Kral
- A. Kruger
- A. L. Bartorelli
- A. L. Volkova
- A. Lallo
- A. Leitao
- A. Leitao
- A. Leitao Marques
- A. Leitao Marques
- A. Leitao Marques
- A. Leitao Marques
- A. Leitao-Marques
- A. Leitao-Marques
- A. Leitao-Marques
- A. Leitao-Marques
- A. Leitao-Marques
- A. Linhart
- A. Linhart
- A. Llacer
- A. Lopez-March
- A. Lousinha
- A. Lousinha
- A. M. Abdelbary
- A. M. Fareed
- A. M. Leitao Marques
- A. M. Leitao-Marques
- A. M. Leitao-Marques
- A. M. Leitao-Marques
- A. M. Leone
- A. M. Ramirez Rodriguez
- A. M. Van Der Laan
- A. M. Van Der Laan
- A. Maisel
- A. Manerba
- A. Martinez Martinez
- A. Marzari
- A. Mayr
- A. Medina Fernandez Aceytuno
- A. Melnikov
- A. Menozzi
- A. Mercadier
- A. Mosterd
- A. Mousa
- A. Mysiak
- A. N. Kitsiou
- A. Naggar
- A. Nardelli
- A. Neji
- A. Neskovic
- A. Neskovic
- A. Omura
- A. Palazzuoli
- A. Pani
- A. Parspour
- A. Pereira
- A. Pereira
- A. Perez De Prado
- A. Pernat
- A. Peterschroeder
- A. Peterschroeder
- A. Petris
- A. Proclemer
- A. Proclemer
- A. Pullara
- A. Reda
- A. Reggiani
- A. Rialan
- A. Rincon De Arellano
- A. Rodrigues
- A. Rodriguez
- A. Rodriguez-Gonzalez
- A. Rodriguez-Gonzalez
- A. Rusali
- A. S. Mullasari
- A. S. Postadzhiyan
- A. Samborska-Sablik
- A. Sanchez Gonzalez
- A. Sanchez-Grande-Flecha
- A. Sanchez-Grande-Flecha
- A. Sarantopoulos
- A. Scafa Udriste
- A. Scafa Udriste
- A. Schaefer
- A. Schmidt
- A. Schoemig
- A. Schratter
- A. Schratter
- A. Sciahbasi
- A. Shotan
- A. Shpektor
- A. Silva
- A. Silva
- A. Silva
- A. Silva
- A. Silva
- A. Silva
- A. Silva
- A. Silva
- A. Silva
- A. Silva
- A. Silva
- A. Silva
- A. Stojkovic
- A. Stojkovic
- A. Stojkovic
- A. Stojkovic
- A. Suarez-Barrientos
- A. Suceveanu
- A. Suceveanu
- A. Suzuki
- A. Swiatkowski
- A. T. Timoteo
- A. T. Timoteo
- A. T. Timoteo
- A. T. Timoteo
- A. T. Timoteo
- A. T. Timoteo
- A. T. Timoteo
- A. Tomlin
- A. Toste
- A. Toste
- A. Toste
- A. Unalir
- A. Unalir
- A. Urbanik
- A. V. Starodubova
- A. V. Timofeev
- A. Van Der Laan
- A. Viertel
- A. Vorlat
- A. Weaver
- A. Y. A. Goodkova
- A. Y. Suvorov
- A. Yukawa
- A. Zhivkov
- A.- C. Martin
- B. B. Ong
- B. B. Ong
- B. Berdaoui
- B. Berta
- B. Brockmeyer
- B. Del Taglia
- B. Doka
- B. E. Backus
- B. Finkov
- B. Fontanella
- B. Franci
- B. G. Branko Gligic
- B. Getaldic
- B. Gligic
- B. Gok
- B. Gorenek
- B. Gorenek
- B. Gorenek
- B. Gorenek
- B. Gorenek
- B. Ibanez
- B. Ibanez
- B. Ibanez Cabeza
- B. J. Bouma
- B. Jedaida
- B. Merkely
- B. Merkely
- B. Merkely
- B. Metzler
- B. Meuris
- B. Minescu
- B. Moquet
- B. Putnikovic
- B. Putnikovic
- B. Ruiz-Mateos
- B. Ruiz-Mateos
- B. Sasko
- B. Schei
- B. Silva
- B. Silva
- B. Silva
- B. Silva
- B. Silva
- B. Smith
- B. Sredniawa
- B. Steuerova
- B. Timuralp
- B. Trimarco
- B. Valente
- B. Vega
- B. Vogel
- B. Vogel
- B. Wasan
- B. Xu
- C. A. Den Uil
- C. Acebal
- C. Acebal
- C. Aguiar
- C. Aguiar
- C. Aguiar
- C. Andrioaia
- C. Andrys
- C. Arsenescu-Georgescu
- C. Autore
- C. B. Dias
- C. B. Dias
- C. Bonanad
- C. C. Fang
- C. Cabades
- C. Caiati
- C. Calisto
- C. Calisto
- C. Calisto
- C. Calisto
- C. Cardwell
- C. Carriere
- C. Cavallini
- C. Cherfils
- C. Ciccarese
- C. Ciurea
- C. Cosson
- C. Cozma
- C. Crowe
- C. Cuellas
- C. Demirustu
- C. Demirustu
- C. Demirustu
- C. Demirustu
- C. Dubois
- C. Dubois
- C. Dubois
- C. Enjuanes-Grau
- C. Enjuanes-Grau
- C. Faustino
- C. Ferrari
- C. Fonseca
- C. Fonseca
- C. Fonseca
- C. Fonseca
- C. Fonseca
- C. Fonseca
- C. Fresco
- C. Fresco
- C. G. Owens
- C. Garcia-Garcia
- C. Ginghina
- C. Grasso
- C. Hassager
- C. Hassager
- C. Hernandez
- C. Hernandez Garcia
- C. Hernandez Garcia
- C. Hernandez Luis
- C. Hernandez Luis
- C. Hernandez Luis
- C. Homorodean
- C. I. Santos De Sousa
- C. I. Stoicescu
- C. J. Mc Cann
- C. J. Terkelsen
- C. J. Vrints
- C. Jorge
- C. Jorge
- C. Jorge
- C. Jorge
- C. L. Huang
- C. L. Yu
- C. Lombardi
- C. Macarie
- C. Macarie
- C. Macaya
- C. Macaya
- C. Martinez-Sanchez
- C. Michalakeas
- C. Moretti
- C. Morley
- C. Mornos
- C. Mornos
- C. Mueller
- C. Navarro
- C. Olariu
- C. P. G. Carlos Pena Gil
- C. Papadopoulos
- C. Paulo
- C. Paulo
- C. Pena-Gil
- C. Perigaud
- C. Poggioni
- C. Pop
- C. Pop
- C. Pop
- C. Pop
- C. Ronco
- C. Rubio-Iglesias-Garcia
- C. Rubio-Iglesias-Garcia
- C. Santos
- C. Sinescu
- C. Sinescu
- C. Spaulding
- C. Tapia
- C. Tapia Ballesteros
- C. Tapia Ballesteros
- C. Tapia Ballesteros
- C. Teodorescu
- C. Tessa
- C. Thalhammer
- C. Trani
- C. Udroiu
- C. Vignali
- C. Villa
- C. Wibberley
- C.- H. Tang
- D. Ardissino
- D. Becker
- D. Becker
- D. Blondhaim
- D. Bonnefont-Rousselot
- D. Brieger
- D. Caeiro
- D. Caeiro
- D. Caeiro
- D. Caeiro Pereira
- D. Constantinescu
- D. Cozma
- D. Cruz
- D. D. Ionescu
- D. D. Ionescu
- D. D. Ionescu
- D. Datta
- D. Deleanu
- D. Djordjevic Radojkovic
- D. Djordjevic Radojkovic
- D. Djordjevic-Radojkovic
- D. Djordjevic-Radojkovic
- D. Djordjevic-Radojkovic
- D. Djordjevic-Radojkovic
- D. Dobreanu
- D. Dobreanu
- D. Dragulescu
- D. Duveau
- D. Fredman
- D. Freitas
- D. Fusco
- D. Hazarbasanov
- D. Horak
- D. Horstkotte
- D. Horstkotte
- D. Ilic
- D. Juhnevica
- D. Juhnevica
- D. Juzar
- D. Kokkinos
- D. Labudovic
- D. Lehmann
- D. Lehmann
- D. Leibowitz
- D. M. Gualandro
- D. Milic
- D. Milicevic
- D. Milicevic
- D. Milicic
- D. Milicic
- D. Muser
- D. Muser
- D. Nait
- D. Olinic
- D. Olinic
- D. Ortiz Berbel
- D. Pereira
- D. Poyares
- D. R. Almeida
- D. R. Almeida
- D. Rott
- D. Sakac
- D. Sanmiguel
- D. Silva
- D. Silva
- D. Silva
- D. Silva
- D. Sondore
- D. Sondore
- D. Stanojevic
- D. Stanojevic
- D. Staub
- D. Tobing
- D. Tomcikova
- D. Townsend
- D. Tsaregorodtsev
- D. Vindis
- D. Vinereanu
- D. Vinogradova
- D. Vivas
- D. Vivas Balcones
- D. Vondrakova
- D. Wichterle
- D. Zamfir
- D. Zanna
- E. A. A. Emad Abu Assi
- E. A. Spiridonova
- E. Abu-Assi
- E. Abu-Assi
- E. Arroyo Ucar
- E. Arroyo Ucar
- E. Assanelli
- E. Assanelli
- E. Assante Di Panzillo
- E. Bobescu
- E. Bozas
- E. Bustamante
- E. Caballero Dorta
- E. Cerone
- E. Conti
- E. Craiu
- E. Craiu
- E. Craiu
- E. Craiu
- E. Craiu
- E. Craiu
- E. Crolla
- E. D. E. Papathanassoglou
- E. Dito
- E. Dumitru
- E. Entok
- E. Esplugas Oliveras
- E. Esplugas Oliveras
- E. Esplugas Oliveras
- E. F. Christensen
- E. Fabris
- E. Filippi
- E. Fraile
- E. Franco
- E. G. Mast
- E. Gainoiu
- E. Grikstaite
- E. Guillerm
- E. Hernadez Ortega
- E. J. Williams
- E. Jorge
- E. Jorge
- E. Jorge
- E. K. Iliodromitis
- E. Kletsiou
- E. Kovacs
- E. Lioy
- E. Madronal-Cerezo
- E. Maekawa
- E. N. Semernin
- E. N. Vorobyova
- E. Nechita
- E. Noiman
- E. Okisheva
- E. Paredes
- E. Pasotti
- E. Pavli
- E. Pereira
- E. Pereira
- E. Salengro
- E. Solinas
- E. T. Iliodromitis
- E. Tamayo
- E. Tavlueva
- E. Trendafilova
- E. V. Privalova
- E. Vandecasteele
- E. Vasilieva
- E. Voltirakis
- E. Zatarain Nicolas
- E. Zima
- F. Addad
- F. Afamefule
- F. Agostini
- F. Angeli
- F. Aros
- F. Betbout
- F. Beygui
- F. Bianchetti
- F. Blanco
- F. Borgognoni
- F. Bosa-Ojeda
- F. Bosa-Ojeda
- F. Bulletti
- F. Burzotta
- F. Caetano
- F. Caetano
- F. Caetano
- F. Caetano
- F. Calvo
- F. Canario-Almeida
- F. Castro-Ferreira
- F. Cintra
- F. Cionini
- F. Colivicchi
- F. Conrotto
- F. Corbetti
- F. Corsi
- F. Corsi
- F. Corsi
- F. Costa
- F. Crea
- F. Crea
- F. Crea
- F. D'ascenzo
- F. De Somer
- F. Feliciano
- F. Fernandez-Vazquez
- F. Franco
- F. Franco
- F. Franco
- F. G. M. Braga
- F. Guliyev
- F. Hautieva
- F. Holy
- F. Holy
- F. J. Berdejo Gago
- F. Keshavarzi
- F. L. Voinea
- F. L. Voinea
- F. M. Lauri
- F. Maatouk
- F. Maklady
- F. Maklady
- F. Mantovani
- F. Marrero Rodriguez
- F. Marrero Rodriguez
- F. Marrero-Rodriguez
- F. Marrero-Rodriguez
- F. Martens
- F. Mateen
- F. Mitu
- F. Miyake
- F. Mlejnsky
- F. Moscoso Costa
- F. Ortan
- F. Possa
- F. Quinzani
- F. Sampaio
- F. Saraiva
- F. Saraiva
- F. Saraiva
- F. Sciuto
- F. Sogorb
- F. Tromp
- F. Van De Werf
- F. Vrapi
- F. X. Hager
- F. Yuksel
- F. Yuksel
- F. Zijlstra
- F. Zijlstra
- F. Zijlstra
- G. Ambrosio
- G. Anton
- G. Antonelli
- G. Ballard
- G. Barbati
- G. Bayet
- G. Bernardi
- G. Bernardi
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- S. Barra
- S. Barra
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- S. Barra
- S. Barra
- S. Berti
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- S. I. Dragulescu
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- S. Intwala
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- S. Kafedzic
- S. Kafedzic
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- W. P. Lee
- W. P. Lee
- W. P. Lee
- W. Rottbauer
- X. Bosch
- X. Wu
- Y. Agmon
- Y. Agmon
- Y. Akashi
- Y. Beaini
- Y. Cavusoglu
- Y. Cavusoglu
- Y. Cavusoglu
- Y. Cavusoglu
- Y. Cavusoglu
- Y. Chen
- Y. D. Kim
- Y. D. Tang
- Y. D. Tang
- Y. Eki
- Y. Endo
- Y. H. Nam
- Y. Ishibashi
- Y. J. Wu
- Y. J. Wu
- Y. J. Yang
- Y. J. Yany
- Y. Levy
- Y. Li
- Y. Maazoun
- Y. N. Belenkov
- Y. Ohishi
- Y. Sato
- Y. Simova
- Y. T. F. N. Jao
- Y. Takeda
- Y. Van Belleghem
- Y. Zhang
- Y. Zhao
- Z. Babic
- Z. Babic
- Z. C. H. Cherneva
- Z. Dridi
- Z. K. Wu
- Z. Kalarus
- Z. Keca
- Z. Monhart
- Z. Motovska
- Z. Pagava
- Z. Perisic
- Z. Perisic
- Z. Perisic
- Z. Plazonic
- Z. Plazonic
- Z. Radovanovic
- Z. S. Jenei
- Z. Sablik
- Z. Vasiljevic
- Z. Y. Zhao
- Z. Y. Zhao
- Z.- S. Chen
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/10/2010
- Field of study
: Substance P (SP) and neuropeptide Y (NPY) are neuropeptides
involved in nociception. The study of biochemical markers of pain in
communicating critically ill coronary patients may provide insight for pain
assessment and management in critical care. Purpose of the study was to
to explore potential associations between plasma neuropeptide levels and
reported pain intensity in coronary critical care adults, in order to test the
reliability of SP measurements for objective pain assessment in critical
care
Dietary Polyphenols and Mitochondrial Function: Role in Health and Disease
- Author
- Adam-Vizi V.
- Agnieszka Karkucinska-Wieckowska
- Ahn J.
- Ajmo J.M.
- Alves D.S.
- Amiot M.J.
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- Chan Y.C.
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- Zhang C.
- Zhang H.
- Zhang H.
- Zhang H.S.
- Zhao B.
- Zhao C.Q.
- Zheng J.
- Zhu Y.G.
- Zingg J.M.
- Zini R.
- Publication venue
- 'Bentham Science Publishers Ltd.'
- Publication date
- Field of study
Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI) : a phase 3, placebo-controlled, randomised trial
- Author
- Abbott J
- Abe Mitsuru
- Abouglila Kamal
- Abrahamovych Orest
- Abu-Fadel Mazen
- Accini Jose
- Acikel Sadik
- Adhyapak Srilakshmi
- Agaiby John
- Aggarwala Guarav
- Aguilera Roberto M
- Ahn Taehoon
- Aksentiev Sergei
- Akyea-Djamson Ayim
- Al-Amin Jessie
- Al-Faleh Hussam
- Al-Saif Shukri
- Al-Shehri Abdullah
- Al-Zoebi Ayham
- Aladellie Layth
- Albisu Juan
- Alfata Sarab
- Alshehri Halia
- Alvarado Odilon
- Alvarez Jose
- Alvarisqueta Andres
- Amerena John
- Amerena John
- Amin Amit
- Amoroso Giovanni
- Andersson Marielle
- Andersson Marielle
- Andersson Marielle
- Andrawis Nabil
- Andries Alin
- Andrássy Péter
- Angerås Oskar
- Angiolillo Dominick
- Angoulvant Denis
- Ansari Saadat
- Antalik Lubomir
- Aoyama Takahiko
- Appel Karl-Friedrich
- Arana Camilo
- Arat Alev
- Arbanil Hugo
- Arora Satish
- Arriagada German
- Arshad Tamjeed
- Arslan Sakir
- Arvind Moogali
- Arya Ktut
- Asenjo Roberto M
- Asfour Wail
- Askar Alfredo N
- Assanelli Emilio
- Atieh Mahmoud
- Auer Johann
- Avino David
- Babapulle Mohan
- Babilonia Noe
- Babilonia Noe A
- Bae Jang-Whan
- Baglikov Andrey
- Bailey Allan
- Bailey Gordon
- Bain Stephen
- Bakai Judit
- Bakhtari Ladan
- Ballyuzek Marina
- Bander Jeffrey
- Bandh Stellan
- Banerjee Subhash
- Banerjee Supratim
- Banerjee Suvro
- Barabashkina Anna
- Baracioli Luciano
- Barbarash Olga
- Barbas Benny
- Barettella Mark
- Bashkin Amir
- Basiak Marcin
- Baszak Jacek
- Bata Iqbal
- Bauer Michael
- Bayat Junaid
- Bazari Rasha
- Bednarova Jana
- Behnke Thomas
- Bell Alan
- Belle-Isle Jasmin
- Bellotti Sandro
- Belohlavek Jan
- Benczur Bela
- Bennett James
- Berg-Johansen Jan
- Berger Rudolf
- Berrospi Percy
- Bertolet Barry
- Bertrand Olivier
- Bertsch John
- Besada Diego
- Bessoudo Ricardo
- Beth Mary
- Bhargava Anuj
- Bhatt Deepak L
- Bhatt Deepak L
- Bhavsar Janak
- Bijata-Bronisz Renata
- Bittar George
- Bitters J'Cinda
- Black Robert
- Blagden Mark
- Blanco Antonio
- Blick David
- Bochenek Anna
- Boldueva Svetlana
- Bolshoun David
- Bonansea Teresa C
- Bongo Angelo S
- Bordonava Anselmo
- Borges Joao
- Borisov Borislav
- Bortnick Anna
- Bos Robert
- Botelho Roberto
- Botero Rodrigo
- Botero Rodrigo
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- Butman Samuel
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- Cabrera Walter
- Calabrò Paolo
- Cantu Elias G
- Cantú Arnulfo G
- Carda Jiri
- Cardona Jose
- Carell Edgar
- Carnero Gabriela
- Carrasco Jose P
- Carrillo Luis V
- Cartwright Simon
- Castillo Armando G
- Cauthen Brett
- Cayla Guillaume
- Cercato Cintia
- Cermak Ondrej
- Cerqueira Maria J
- Ceyhan Ceyhun
- Cha James
- Cha Kwang S
- Chacon Carolina
- Chae In-Ho
- Chae Jei-Keon
- Chag Milan
- Chai Yingru
- Chamnarnphol Noppadol
- Chan Michael
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- Chang Kiyuk
- Chang Kuan-Cheng
- Chatrathi Sridhar
- Chavez Carlos
- Chehayeb Raja
- Cheirif Jorge
- Chen Jersey
- Chen Jersey
- Chen Zhih-Cherng
- Chernyavsky Alexander
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- Chhabra Anil
- Chiang Chern
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- Chompalova Boryana
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- Czyzycki Mariusz
- D'Agostino Ronald
- D'Urso Michael
- Dada Fredy T
- Dalby Anthony
- Dalby Anthony J
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- Danchin Nicolas
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- Das Asit
- Dawood Saleem
- de Cosmo Salvatore
- de la Torre Hernández José M
- de Labriolle Axel
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- González Juanatey José R
- González Alfonso S
- González Rosa S
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- Goodfellow Ross
- Gordon Paul
- Gosparini Diego M
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- Haro Jaime M
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- Harrington Robert A
- Hart Randy
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- Hartikainen Juha
- Hasegawa Toru
- HASH(0x55aa09b7f480)
- Hata Yoshiki
- Haught W H
- Hawa Zafir
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- He Lanjie
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- Hoffman David
- Hofseth Ola D
- Hollanders Geert
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- Huber Kurt
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- Huth Mark
- Huynh Thao T
- Hwang Jin-Yong
- Idogaki Akira
- Iliev Nikolay
- Ilieva Katya
- Ing Douglas
- Iosipescu Laura C
- Isaza Daniel
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- Javier Julian
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- Jensen Lisette O
- Jeong Myung H
- Jeong Myung H
- Jerabek Ondrej
- Jeserich Michael
- Jesionowski Pawel
- Jetty Preetham
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- Johnston Nina
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- Jurowiecki Jaroslaw
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- Kelberman Michael
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- Kerr Saraiva José F
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- Kichura George
- Kim Byung J
- Kim Doo-Il
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- Kinasz Leszek
- Kinnaman Stephanie
- Kirby William
- Kirschner Róbert
- Király Csaba
- Kiss Robert G
- Kiss Róbert G
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- Korzeniak Romuald
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- Kosiborod Mikhail
- Kosiborod Mikhail N
- Kosiborod Mikhail N
- Kosmacheva Elena D
- Kosmicki Douglas
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- Labeque Jean N
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- Lievano Triana Manuel J
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- Mediavilla García Juan D
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- Ramamurthee Kannaiyan
- Ramanathan Krishnan
- Ramos López Gabriel A
- Randeva Harpal S.
- Range Gregoire
- Ranjith Naresh
- Rao Sunder
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- Rasputina Lesya
- Rassi Nelson
- Ray Kausik K
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- Reddy M
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- Roseman Hal
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- Rozenman Yoseph
- Ruda Mikhail
- Rudenko Leonid
- Ruiz Nodar Juan M
- Ruiz Jose
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- Rusicka Teresa
- Rusinov Veselin
- Russo Michael
- Ruíz José G
- Sabbah Eric
- Saini Satinder
- Sakuragi Satoru
- Salinas Carlos A
- Samaan Rodney
- Sanchez Carlos G
- Sandoval Jorge
- Sansanayudh Nakarin
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- Saporito Wladmir
- Saraiva José
- Sasaki Kenichiro
- Sathe Prachee
- Sato Tomohiko
- Sauter Joachim
- Sawhney Jitendra S
- Saxena Manish
- Schenkenberger Isabelle
- Schernthaner Gerit-Holger
- Schiavi Beatriz
- Schmedtje John
- Schmidt Ekkehard
- Schnack Christoph
- Schock Joel
- Schön Norbert
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- Senni Michele
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- Severino Norma
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- Shah Mahesh
- Shaheen Wassim
- Shalaev Sergey
- Shammas Nicolas
- Shanes Jeffrey
- Sharma Susheel
- Sharman David
- Sharp Andrew
- Shealy Neal
- Sheu Huey-Herng
- Shibasaki Taro
- Shin Won-Yong
- Shukla Dinkar
- Shurmur Scott
- Shustov Sergey
- Shutemova Elena
- Shvarts Yuri
- Shyu Kou-Gi
- Sicer Maximiliano
- Siega Anthony D
- Silva Frederico
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- Simon Tabassome
- Simon Tabassome
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- Singal Robert
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- Sinnaeve Peter R
- Siu Shing C
- Sivak Vladimir
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- Skierkowska Joanna
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- Skura Marek
- Skwarna Bartosz
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- Steg Philippe G
- Steg Philippe Gabriel
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- Sánchez Raul V
- Sárszegi Zsolt
- Sørensen Torben
- Taggeselle Jens
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- Takagi Yuichiro
- Takase Shinichi
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- Ueng Kwo-Chang
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- Urban Miroslav
- Urbano Rafael H
- Urbinati Stefano
- Uretsky Barry
- Utsu Noriaki
- Uzunow Anna
- Vaca Carlos
- Vakaliuk Igor
- Valle Timo
- Vallejo Gregorio S
- van de Wal Ruud
- van den Heuvel Christian
- van der Zwaan Coen
- van Eck Martijn
- van Kesteren Henricus
- van Zyl Louis
- Varbella Ferdinando
- Varleta Paola
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- Vera Tomás R
- Vervoort Geert
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- Vinereanu Dragos
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- Vishnevsky Alexander
- Viswanathan Girish
- Vizel Saul
- Viñas Jaime A
- Vlastaris Anthony
- von Engelhardt Charlotte
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- Vora Kishor
- Voyce Steven
- Vrolix Mathias
- Vykoukalova Tatiana
- Wang Hao
- Wang Ji-Hung
- Wang Yi-Chih
- Weiderman Ann-Charlotte
- Weigmann Ingo
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- Wilke Andreas
- Willems Frank
- Willis John
- Wilson Vance
- Wilson William
- Wiseman Alan
- Witek Robert
- Wojcik Ronald
- Wojnowski Lukasz
- Wolzt Michael
- Wong Brian
- Wong Michelle
- Wongvipaporn Chaiyasith
- Woolf Kevin
- Worthley Matthew
- Wozakowska-Kaplon Beata
- Wu Chih-Cheng
- Wu Yen-Wen
- Wujkowski Marek
- Yagensky Andriy
- Yakushin Sergey
- Yalcin Ahmet
- Yamamoto Fumi
- Yaneva Zdravka
- Yeh Hung-I
- Ying Man
- Yokoya Koichi
- Yoon Junghan
- Young Douglas
- Younis Liwa
- Yuan Zuyi
- Zadra Remo
- Zakharov Konstantin
- Zakhary Bosh
- Zaman Azfar
- Zamorano Gómez José L
- Zangroniz Pedro
- Zaniewski Michelle
- Zanini Alejandra
- Zarich Stuart
- Zateyschikova Anna
- Zateyshchikov Dmitry A
- Zebrack James
- Zelazowska Katarzyna
- Zhang Aidong
- Zhang Jian
- Zhang Ningru
- Zhang Wenwu
- Zhao Qiang
- Zhao Qiang
- Zhao Xue-Qiao
- Zharinova Viktoria
- Zidkova Eva
- Zilahi Zsolt
- Zinka Elzbieta
- Zonova Elena
- Zubeeva Galina
- Zucconi-Mazzini Roberto
- Zurakowski Aleksander
- Zólyomi Szilárd
- Édes István
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background:
Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin. In this trial, we aimed to investigate if these patients would benefit from treatment with aspirin plus ticagrelor.
Methods:
The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS) was a phase 3 randomised, double-blinded, placebo-controlled trial, done in 1315 sites in 42 countries. Patients were eligible if 50 years or older, with type 2 diabetes, receiving anti-hyperglycaemic drugs for at least 6 months, with stable coronary artery disease, and one of three other mutually non-exclusive criteria: a history of previous PCI or of coronary artery bypass grafting, or documentation of angiographic stenosis of 50% or more in at least one coronary artery. Eligible patients were randomly assigned (1:1) to either ticagrelor or placebo, by use of an interactive voice-response or web-response system. The THEMIS-PCI trial comprised a prespecified subgroup of patients with previous PCI. The primary efficacy outcome was a composite of cardiovascular death, myocardial infarction, or stroke (measured in the intention-to-treat population).
Findings:
Between Feb 17, 2014, and May 24, 2016, 11 154 patients (58% of the overall THEMIS trial) with a history of previous PCI were enrolled in the THEMIS-PCI trial. Median follow-up was 3·3 years (IQR 2·8–3·8). In the previous PCI group, fewer patients receiving ticagrelor had a primary efficacy outcome event than in the placebo group (404 [7·3%] of 5558 vs 480 [8·6%] of 5596; HR 0·85 [95% CI 0·74–0·97], p=0·013). The same effect was not observed in patients without PCI (p=0·76, p interaction=0·16). The proportion of patients with cardiovascular death was similar in both treatment groups (174 [3·1%] with ticagrelor vs 183 (3·3%) with placebo; HR 0·96 [95% CI 0·78–1·18], p=0·68), as well as all-cause death (282 [5·1%] vs 323 [5·8%]; 0·88 [0·75–1·03], p=0·11). TIMI major bleeding occurred in 111 (2·0%) of 5536 patients receiving ticagrelor and 62 (1·1%) of 5564 patients receiving placebo (HR 2·03 [95% CI 1·48–2·76], p<0·0001), and fatal bleeding in 6 (0·1%) of 5536 patients with ticagrelor and 6 (0·1%) of 5564 with placebo (1·13 [0·36–3·50], p=0·83). Intracranial haemorrhage occurred in 33 (0·6%) and 31 (0·6%) patients (1·21 [0·74–1·97], p=0·45). Ticagrelor improved net clinical benefit: 519/5558 (9·3%) versus 617/5596 (11·0%), HR=0·85, 95% CI 0·75–0·95, p=0·005, in contrast to patients without PCI where it did not, p interaction=0·012. Benefit was present irrespective of time from most recent PCI.
Interpretation:
In patients with diabetes, stable coronary artery disease, and previous PCI, ticagrelor added to aspirin reduced cardiovascular death, myocardial infarction, and stroke, although with increased major bleeding. In that large, easily identified population, ticagrelor provided a favourable net clinical benefit (more than in patients without history of PCI). This effect shows that long-term therapy with ticagrelor in addition to aspirin should be considered in patients with diabetes and a history of PCI who have tolerated antiplatelet therapy, have high ischaemic risk, and low bleeding risk