The Parton Structure of the Nucleon and Precision Determination of the Weinberg Angle in Neutrino Scattering

A recently completed next-to-leading-order program to calculate neutrino cross sections, including power-suppressed mass correction terms, has been applied to evaluate the Paschos-Wolfenstein relation, in order to quantitatively assess the validity and significance of the NuTeV anomaly. In particular, we study the shift of $\sin^2 \theta_{\mathrm{W}}$ obtained in calculations with a new generation of PDF sets that allow $s(x)\neq \bar{s}(x)$, enabled by recent neutrino dimuon data from CCFR and NuTeV, as compared to the previous $s = \bar{s}$ parton distribution functions like CTEQ6M. The extracted value of $\sin^2 \theta_{\mathrm{W}}$ is closely correlated with the strangeness asymmetry momentum integral $\int_{0}^{1}x[s(x)-\bar{s}(x)] dx$. We also consider isospin violating effects that have recently been explored by the MRST group. The results of our study suggest that the new dimuon data, the Weinberg angle measurement, and other data sets used in global QCD parton structure analysis can all be consistent within the Standard Model.Comment: 4 page

Heavy Quarks: Lessons Learned from HERA and Tevatron

We review some of the recent developments which have enabled the heavy quark mass to be incorporated into both the calculation of the hard-scattering cross section and the PDFs. We compare and contrast some of the schemes that have been used in recent global PDF analyses, and look at issues that arise when these calculations are extended to NNLO.Comment: 11 pages, 9 figures, to appear in the proceedings of the Ringberg Workshop "New Trends in HERA Physics 2008

A Review of Target Mass Corrections

With recent advances in the precision of inclusive lepton--nuclear scattering experiments, it has become apparent that comparable improvements are needed in the accuracy of the theoretical analysis tools. In particular, when extracting parton distribution functions in the large-x region, it is crucial to correct the data for effects associated with the nonzero mass of the target. We present here a comprehensive review of these target mass corrections (TMC) to structure functions data, summarizing the relevant formulas for TMCs in electromagnetic and weak processes. We include a full analysis of both hadronic and partonic masses, and trace how these effects appear in the operator product expansion and the factorized parton model formalism, as well as their limitations when applied to data in the x->1 limit. We evaluate the numerical effects of TMCs on various structure functions, and compare fits to data with and without these corrections.Comment: 41 pages, 13 figures; minor updates to match published versio

Leptoproduction of Heavy Quarks II -- A Unified QCD Formulation of Charged and Neutral Current Processes from Fixed-target to Collider Energies

A unified QCD formulation of leptoproduction of massive quarks in charged current and neutral current processes is described. This involves adopting consistent factorization and renormalization schemes which encompass both vector-boson-gluon-fusion (flavor creation) and vector-boson-massive-quark-scattering (flavor excitation) production mechanisms. It provides a framework which is valid from the threshold for producing the massive quark (where gluon-fusion is dominant) to the very high energy regime when the typical energy scale \mu is much larger than the quark mass m_Q (where the quark-scattering should be prevalent). This approach effectively resums all large logarithms of the type (alpha_s(mu) log(mu^2/m_Q^2)^n which limit the validity of existing fixed-order calculations to the region mu ~ O(m_Q). We show that the (massive) quark-scattering contribution (after subtraction of overlaps) is important in most parts of the (x, Q) plane except near the threshold region. We demonstrate that the factorization scale dependence of the structure functions calculated in this approach is substantially less than those obtained in the fixed-order calculations, as one would expect from a more consistent formulation.Comment: LaTeX format, 29 pages, 11 figures. Revised to make auto-TeX-abl

Leptoproduction of Heavy Quarks in the Fixed and Variable Flavor Schemes

We compare the results of the fixed-flavor scheme calculation of Laenen, Riemersma, Smith and van Neerven with the variable-flavor scheme calculation of Aivazis, Collins, Olness and Tung for the case of neutral-current (photon-mediated) heavy-flavor (charm and bottom) production. Specifically, we examine the features of both calculations throughout phase space and compare the structure function $F_2(x,Q^2)$. We also analyze the dependence of $F_2$ on the mass factorization scale $\mu$. We find that the former is most applicable near threshold, while the latter works well for asymptotic $Q^2$. The validity of each calculation in the intermediate region is dependent upon the $x$ and $Q^2$ values chosen.Comment: LaTeX format, 19 pages, 20 figures in uuencoded format. Postscript file available at ftp://smuphy.physics.smu.edu/usr/ftpdir/pub/paper

2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy.

Large population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human immunology and inflammation as candidates for prognostic markers of breast cancer survival involving 1,804 oestrogen receptor (ER)-negative patients treated with chemotherapy (279 events) from 14 European studies in a prior large-scale genotyping experiment, which is part of the Collaborative Oncological Gene-environment Study (COGS) initiative. We carry out replication using Asian COGS samples (n=522, 53 events) and the Prospective Study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) study (n=315, 108 events). Rs4458204_A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49-2.19); P for trend=1.90 × 10(-9)). Such survival-associated variants can represent ideal targets for tailored therapeutics, and may also enhance our current prognostic prediction capabilities

2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy

Large population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human immunology and inflammation as candidates for prognostic markers of breast cancer survival involving 1,804 oestrogen receptor (ER)-negative patients treated with chemotherapy (279 events) from 14 European studies in a prior large-scale genotyping experiment, which is part of the Collaborative Oncological Gene-environment Study (COGS) initiative. We carry out replication using Asian COGS samples (n=522, 53 events) and the Prospective Study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) study (n=315, 108 events). Rs4458204-A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49-2.19); P for trend=1.90 × 10 â ̂'9). Such survival-associated variants can represent ideal targets for tailored therapeutics, and may also enhance our current prognostic prediction capabilities

Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.

GWAS have identified a breast cancer susceptibility locus on 2q35. Here we report the fine mapping of this locus using data from 101,943 subjects from 50 case-control studies. We genotype 276 SNPs using the 'iCOGS' genotyping array and impute genotypes for a further 1,284 using 1000 Genomes Project data. All but two, strongly correlated SNPs (rs4442975 G/T and rs6721996 G/A) are excluded as candidate causal variants at odds against >100:1. The best functional candidate, rs4442975, is associated with oestrogen receptor positive (ER+) disease with an odds ratio (OR) in Europeans of 0.85 (95% confidence interval=0.84-0.87; P=1.7 × 10(-43)) per t-allele. This SNP flanks a transcriptional enhancer that physically interacts with the promoter of IGFBP5 (encoding insulin-like growth factor-binding protein 5) and displays allele-specific gene expression, FOXA1 binding and chromatin looping. Evidence suggests that the g-allele confers increased breast cancer susceptibility through relative downregulation of IGFBP5, a gene with known roles in breast cell biology