Modeling Oxygen Transport in Three-Dimensional Capillary Networks

The purpose of this thesis was to examine how the use of real 3-dimensional (3D) capillary network geometries affect models of oxygen transport to tissue. Software was developed to reconstruct microvascular geometry in 3D from intravital video. Characterization of 3D reconstructions demonstrated that capillary density, length and capillary diameter were consistent with previous findings. Using reconstructed capillary networks a strategy was devised that utilized red blood cell (RBC) supply rate (SR) as a metric for flow modeling. Applying the RBC SR based flow model on baseline and perturbed flow conditions demonstrated that RBC SR is a major determinant of oxygen delivery that is insensitive to changes in flow distribution. The resulting flow solutions were used for comparing oxygen transport in 3D networks and synthetic parallel arrays. A variety of physiological conditions were simulated and it was determined that parallel arrays resulted in oxygen transport solutions with higher mean PO2 due to homogeneous distribution of vessels in the volume. Lastly, to investigate oxygen transport in a complex pathology a model of sepsis was used to investigate how incremental perfusion loss, consumption increase and change in RBC SR affect oxygen delivery. It was shown that perfusion loss did not markedly impair oxygen delivery provided that RBC SR was maintained. These results have improved our understanding of oxygen transport to tissue in normal and diseased conditions; the use of reconstructed networks and measurements of blood flow & oxygen saturation in computer models provides different solutions than those using statistical averages and synthetic networks

Eltrombopag for the treatment of chronic idiopathic (immune) thrombocytopenic purpura : A Single Technology Appraisal

Evidence Review Group (ERG) final report for the National Institute for Health and Clinical ExcellencePublisher PD

Community experiences of organised crime in Scotland

The research explored community experiences of serious organised crime in Scotland (SOC). The report provides information on the nature and extent of the impact of SOC on everyday life in the community, as well as offering suggestions for policy development. The study sought to answer the following questions: 1)What are the relationships that exist between SOC and communities in Scotland? 2)What are the experiences and perceptions of residents, stakeholders and organisations of the scope and nature of SOC within their local area? and 3)How does SOC impact on community wellbeing, and to what extent can the harms associated with SOC be mitigated

Systematic review of the efficacy and safety of using mesh in surgery for uterine or vaginal vault prolapse

The original publication is available at www.springerlink.comPeer reviewedPostprin

Impact of Incremental Perfusion Loss on Oxygen Transport in a Capillary Network Mathematical Model.

OBJECTIVES: To quantify how incremental capillary perfusion loss, such as that seen in experimental models of sepsis, affects tissue oxygenation using a computation model of oxygen transport. METHODS: A computational model was applied to capillary networks with dimensions 84x168x342 (NI) and 70x157x268 (NII) μm, reconstructed in vivo from rat skeletal muscle. Functional capillary density (FCD) loss was applied incrementally up to ~40% and combined with high tissue oxygen consumption to simulate severe sepsis. RESULTS: A loss of ~40% FCD loss decreased median tissue PO2 to 22.9 and 20.1 mmHg in NI and NII compared to 28.1 and 27.5 mmHg under resting conditions. Increasing red blood cell supply rate (SR) to baseline levels returned tissue PO2 to within 5% of baseline. High consumption combined with a 40% FCD loss, resulted in tissue anoxia in both network volumes and median tissue PO2 of 11.5 and 8.9 mmHg in NI and NII respectively; median tissue PO2 was recovered to baseline levels by increasing total SR 3 - 4 fold. CONCLUSIONS: These results suggest a substantial increase in total SR is required in order to compensate for impaired oxygen delivery as a result of loss of capillary perfusion and increased oxygen consumption during sepsis. This article is protected by copyright. All rights reserved

Conceptualisations of children’s wellbeing at school: the contribution of recognition theory

A large study in Australian schools aimed to elucidate understandings of ‘wellbeing’ and of factors in school life that contribute to it. Students and teachers understood wellbeing primarily, and holistically, in terms of interpersonal relationships, in contrast to policy documents which mainly focused on ‘problem areas’ such as mental health. The study also drew on recognition theory as developed by the social philosopher Axel Honneth. Results indicate that recognition theory may be useful in understanding wellbeing in schools, and that empirical research in schools may give rise to further questions regarding theory

Impact of opioid substitution therapy for Scotland's prisoners on drugs-related deaths soon after prisoner-release

AIM: To assess whether the introduction of a prison‐based opioid substitution therapy (OST) policy was associated with a reduction in drug‐related deaths (DRD) within 14 days after prison release. DESIGN: Linkage of Scotland's prisoner database with death registrations to compare periods before (1996–2002) and after (2003–07) prison‐based OST was introduced. SETTING: All Scottish prisons. PARTICIPANTS: People released from prison between 1 January 1996 and 8 October 2007 following an imprisonment of at least 14 days and at least 14 weeks after the preceding qualifying release. MEASUREMENTS: Risk of DRD in the 12 weeks following release; percentage of these DRDs which occurred during the first 14 days. FINDINGS: Before prison‐based OST (1996–2002), 305 DRDs occurred in the 12 weeks after 80 200 qualifying releases, 3.8 per 1000 releases [95% confidence interval (CI) = 3.4–4.2]; of these, 175 (57%) occurred in the first 14 days. After the introduction of prison‐based OST (2003–07), 154 DRDs occurred in the 12 weeks after 70 317 qualifying releases, a significantly reduced rate of 2.2 per 1000 releases (95% CI = 1.8–2.5). However, there was no change in the proportion which occurred in the first 14 days, either for all DRDs (87: 56%) or for opioid‐related DRDs. CONCLUSIONS: Following the introduction of a prison‐based opioid substitution therapy (OST) policy in Scotland, the rate of drug‐related deaths in the 12 weeks following release fell by two‐fifths. However, the proportion of deaths that occurred in the first 14 days did not change appreciably, suggesting that in‐prison OST does not reduce early deaths after release

Community Experiences of Serious Organised Crime in Scotland

This summary sets out key findings from a research project that aimed to explore the community experiences of serious organised crime ( SOC) in Scotland. The study sought to answer the following questions: 1) What are the relationships that exist between SOC and communities in Scotland? 2) What are the experiences and perceptions of residents, stakeholders and organisations of the scope and nature of SOC within their local area? and 3) How does SOC impact on community wellbeing, and to what extent can the harms associated with SOC be mitigated? The work involved in-depth qualitative research, to understand both direct and indirect forms of harm. Key points pertaining to the research and its results are as follows: - The study involved the selection of three community case study sites based on a typology of ' SOC-affected' communities. These sites were based in varying urban and semi-urban settings. - The impact of SOC at a more 'diffuse' national level was explored via research in a range of smaller case study sites and via interviews with national stakeholders. This included a consideration of SOC impacts in rural and remote areas, and on populations that were not concentrated in any defined geographic community. - The case study areas were selected on the basis of pre-existing academic and policy literature, an initial set of interviews with key experts, and on the basis of aggregated and anonymised intelligence summaries provided by Police Scotland. - 188 individuals participated in the study, which mostly involved semi-structured qualitative interviews, but also a small number of focus groups, unstructured interviews and observational research. Interviews were conducted with residents, local businesses, service providers, community groups, and national organisations, as well as with a small number of individuals with lived experience of SOC. - Interviews comprised of questions about: the relationship between SOC and communities; the experiences and perceptions of residents and local service providers as to the nature and extent of SOC; and the impact of SOC on community wellbeing. - Preliminary findings were presented back to a sub-sample of 33 community residents and representatives, across three of the case study areas, through a feedback method called 'co-inquiry'. This involved the organisation of events designed to assess the integrity of the findings, and elicit reflections on the implications of the findings for potential actions

Tsunami awareness and preparedness in Aotearoa New Zealand:The evolution of community understanding

After catastrophic events such as the 2004 Indian Ocean tsunami and the 2011 Great East Japan earthquake and tsunami there is a clear need for vulnerable countries like Aotearoa New Zealand to get prepared for tsunami. In the last ten years, the New Zealand government initiated major efforts to raise awareness of tsunami risk among coastal residents. This study explores tsunami awareness, preparedness, and evacuation intentions among residents of the East Coast of the North Island in a 2015 survey. The ten chosen locations also participated in a tsunami survey in 2003, with results demonstrating that tsunami awareness rose in the twelve years between the surveys. The 2015 survey also included questions on preparedness and intended action. Even though coastal residents know they live in a tsunami prone area, preparedness is relatively low and high expectations of a formal warning remain, even for a local source tsunami scenario. Furthermore, survey respondents had unrealistic ideas of evacuation procedures. When asked about their evacuation intentions, respondents intended to undertake a number of different actions before evacuating their homes, which could cause significant delays in the evacuation process. Most respondents were also reluctant to evacuate on foot and prefer using their vehicles instead, which could create dangerous traffic congestion. These surveyed intentions are consistent with a study of actual evacuation behaviours in the subsequent 2016 Kaikōura earthquake and tsunami, providing validation for the survey indicators. This paper identifies the procedures least understood by the public and offers some solutions to improve tsunami preparedness.</p

On the Fundamental Line of Galactic and Extragalactic Globular Clusters

In a previous paper we found that the Globular Clusters of our Galaxy lie around a line in the log(Re), SBe, log(sigma) parameter space, with a moderate degree of scatter and remarkable axi-symmetry. This implies the existence of a purely photometric scaling law obtained by projecting such a line onto the log(Re), SBe plane. Such photometric quantities are readily available for large samples of clusters, as opposed to stellar velocity dispersion data. We study a sample of 129 Galactic and extragalactic clusters on such photometric plane in the V-band. We look for a linear relation between SBe and log(Re) and study how the scatter around it is influenced by age and dynamical environment. We interpret our results as a test on the evolutionary versus primordial origin of the Fundamental Line. We perform a detailed analysis of surface brightness profiles, which allows us to present a catalogue of structural properties, without relying on a given dynamical model. We find a linear relation between SBe and log(Re), in the form SBe = (5.25 +- 0.44) log(Re) + (15.58 +- 0.28), where SBe is measured in mag/arcsec^2 and Re in parsec. Both young and old clusters lie on the scaling law, with a scatter of approximately 1 mag in SBe. However, young clusters display more scatter and a clear trend of such scatter with age, which old clusters do not. Such trend becomes tighter if cluster age is measured in units of the cluster half-light relaxation time. Two-body relaxation therefore plays a major role, together with passive stellar population evolution, in shaping the relation between SBe, log(Re), and cluster age. We argue that the log(Re)-SBe relation and hence the Fundamental Line scaling law is not primordially set at cluster formation, but rather is the result of combined stellar evolution and collisional dynamical evolution.Comment: Accepted for publication on Astronomy and Astrophysics, official acceptance date November 2, 200