UV Dust Attenuation in Star-forming Galaxies: II Calibrating the A(UV) vs. L_TIR/L_UV relation

We investigate the dependence of the total-infrared (TIR) to UV luminosity ratio method for calculating the UV dust attenuation A(UV) from the age of the underlying stellar populations by using a library of spectral energy distributions for galaxies with different star formation histories. Our analysis confirms that the TIR/UV vs. A(UV) relation varies significantly with the age of the underlying stellar population: i.e. for the same TIR/UV ratio, systems with low specific star formation rate (SSFR) suffer a lower UV attenuation than starbursts. Using a sample of nearby field and cluster spiral galaxies we show that the use of a standard (i.e. age independent) TIR/UV vs. A(UV) relation leads to a systematic overestimate up to 2 magnitudes of the amount of UV dust attenuation suffered by objects with low SSFR and in particular HI-deficient star forming cluster galaxies. This result points out that the age independent $TIR/UV$ vs. $A(UV)$ relation cannot be used to study the UV properties of large samples of galaxies including low star-forming systems and passive spirals. Therefore we give some simple empirical relations from which the UV attenuation can be estimated taking into account its dependence on the age of the stellar populations, providing a less biased view of UV properties of galaxies.Comment: 16 pages, 10 figures, 6 tables. Accepted for publication on MNRAS main journal. High resolution version and tables also available at http://www.astro.cf.ac.uk/pub/Luca.Cortese/UVattenuation.htm

Genotoxicity testing for radon exposure: Dolichopoda (Orthoptera, Rhaphidophoridae) as potential bio-indicator of confined environments

Abstract Radon represents the major source of natural radioactivity in confined environments. Despite the clear evidence of a direct association between residential exposure and human lung cancer provided by case-control studies, results relating indoor exposure and genotoxic/mutagenic effect induction are still contradictory. The present study attempts to estimate the genotoxic effects induced by exposure to radioactive radon in wild cricket populations sampled from caves where varying concentrations of radon are present. Cave crickets are also tested as possible bio-indicator organisms of genotoxic potential of contaminated residential and confined environments. Six caves in Central Italy are considered covering a broad spectrum of radon radioactivity concentration (221–26, 000 Bq/m3). Dolichopoda specimens were sampled from each cave; both haemocytes and brain cells taken from individuals were tested for responsiveness to DNA damage induced by radon through the Comet assay. Specimens from the least radioactive cave, housed in controlled conditions for 60 days before analysis, were used as control group. Statistically significant increase of DNA damage was found in all groups of individuals from each cave, for both cell types. Very low values of all Comet parameters were found in control group individuals, which gave indications of a good responsiveness of the organism to the variable environmental levels of radioactive contamination. Results indicate that cave crickets represent a reliable tool for the detection of genotoxic potential induced by radioactive contamination of confined environments and can be proposed as a possible bio-indicator system for air (-radioactive) pollution related to indoor exposure

A Computational Framework for Pre-Interventional Planning of Peripheral Arteriovenous Malformations

PURPOSE: Peripheral arteriovenous malformations (pAVMs) are congenital lesions characterised by abnormal high-flow, low-resistance vascular connections-the so-called nidus-between arteries and veins. The mainstay treatment typically involves the embolisation of the nidus, however the complexity of pAVMs often leads to uncertain outcomes. This study aims at developing a simple, yet effective computational framework to aid the clinical decision making around the treatment of pAVMs using routinely acquired clinical data. METHODS: A computational model was developed to simulate the pre-, intra-, and post-intervention haemodynamics of a patient-specific pAVM. A porous medium of varying permeability was employed to simulate the sclerosant effect on the nidus haemodynamics. Results were compared against clinical data (digital subtraction angiography, DSA, images) and experimental flow-visualization results in a 3D-printed phantom of the same pAVM. RESULTS: The computational model allowed the simulation of the pAVM haemodynamics and the sclerotherapy-induced changes at different interventional stages. The predicted inlet flow rates closely matched the DSA-derived data, although the post-intervention one was overestimated, probably due to vascular system adaptations not accounted for numerically. The nidus embolization was successfully captured by varying the nidus permeability and increasing its hydraulic resistance from 0.330 to 3970 mmHg s ml-1. The nidus flow rate decreased from 71% of the inlet flow rate pre-intervention to 1%: the flow completely bypassed the nidus post-intervention confirming the success of the procedure. CONCLUSION: The study demonstrates that the haemodynamic effects of the embolisation procedure can be simulated from routinely acquired clinical data via a porous medium with varying permeability as evidenced by the good qualitative agreement between numerical predictions and both in vivo and in vitro data. It provides a fundamental building block towards a computational treatment-planning framework for AVM embolisation

Trasporto di pesce dal punto vendita al domicilio del consumatore : prove preliminari di monitoraggio e valutazioni qualitative

La catena del freddo applicata alla filiera del pesce (filetti di branzino) \ue8 scelta obbligata data l\u2019elevata deperibilit\ue0 che lo caratterizza, e interessante oggetto di analisi in virt\uf9 della rilevanza che questo prodotto ha assunto in termini di consumo in Italia. L\u2019attenzione \ue8 stata focalizzata sulla fase di trasporto dal punto di vendita al domicilio del consumatore, un aspetto poco studiato della catena del freddo. Sono state indagate le condizioni microclimatiche (temperatura e umidit\ue0 relativa) del sistema di trasporto del prodotto (busta termica e sacchetto di stoffa), le cinetiche di riscaldamento del prodotto nel corso del trasporto, quindi gli effetti, in termini di sicurezza e qualit\ue0, sui filetti di branzino. Il trasporto del prodotto \ue8 stato simulato all\u2019interno di una stufa impostata a 40\ub0C per tempi stabiliti (30 minuti il tempo minimo e 120 minuti come tempo massimo), in seguito ai quali il pesce \ue8 stato conservato in condizioni refrigerate per tutta la durata della shelf-life (3 giorni). Nel corso della simulazione di trasporto le temperature registrate all\u2019interno dei sacchetti di stoffa non sono risultate significativamente differenti dalle temperature rilevate nelle buste termiche (fatta eccezione per i primi 25 minuti). Al fine di valutare gli effetti del trasporto sul pesce sono stati determinati: la carica batterica totale (CBT), come indicatore di sicurezza del prodotto, e parametri qualitativi oggettivi quali, il colore, e il profilo aromatico. Sulla base dei risultati microbiologici ottenuti, \ue8 possibile affermare che l\u2019andamento della CBT sia influenzato dal tempo di trasporto ma non dal tipo di sacchetto impiegato. In relazione ai parametri qualitativi di colore e odore, non sono state evidenziate differenze in grado di discriminare i campioni in funzione delle diverse modalit\ue0 di trasporto

Virtual TEVAR: Overcoming the Roadblocks of In-Silico Tools for Aortic Dissection Treatment

The use of in silico tools for the interventional planning of complex vascular conditions, such as Aortic Dissections has been often limited by high computational cost, involving long timescales for accurate results to be produced and low numbers of patients, precluding the use of statistical analyses to inform individual-level models. In the paper [Theranostics 2018; 8(20):5758-5771. doi:10.7150/thno.28944], Chen et al. proposed a novel algorithm to compute patient-specific ‘virtual TEVAR’ that will help clinicians to approach individual treatment and decision-making based on objective and quantifiable metrics and validated on a cohort of 66 patients in real time. This research will significantly impact the field and has the potential to transform the way clinical interventions will be approached in the futur

Low Cost Fabrication of PVA Based Personalized Vascular Phantoms for in Vitro Haemodynamic Studies: Three Applications

Vascular phantoms mimicking human vessels are commonly used to perform in vitro haemodynamic studies for a number of bioengineering applications, such as medical device testing, clinical simulators and medical imaging research. Simplified geometries are useful to perform parametric studies, but accurate representations of the complexity of the in vivo system are essential in several applications as personalised features have been found to play a crucial role in the management and treatment of many vascular pathologies. Despite numerous studies employing vascular phantoms produced through different manufacturing techniques, an economically viable technique, able to generate large complex patient-specific vascular anatomies, still needs to be identified. In this work, a manufacturing framework to create personalised and complex phantoms with easily accessible and affordable materials is presented. In particular, 3D printing with polyvinyl alcohol (PVA) is employed to create the mould, and lost core casting is performed to create the physical model. The applicability and flexibility of the proposed fabrication protocol is demonstrated through three phantom case studies - an idealised aortic arch, a patient-specific aortic arch, and a patient-specific aortic dissection model. The phantoms were successfully manufactured in a rigid silicone, a compliant silicone and a rigid epoxy resin, respectively; using two different 3D printers and two casting techniques, without the need of specialist equipment

Contribution of transgender sex workers to the complexity of the HIV-1 epidemic in the metropolitan area of Milan

Objectives: Transgender people are disproportionately affected by the HIV-1 epidemic. We evaluated the origin of HIV-1 variants carried by South American transgenders living in Milan by combining accurate phylogenetic methods and epidemiological data. Methods: We collected 156 HIV-1 pol sequences obtained from transgender patients engaged in sex work (TSWs) followed between 1999 and 2015 at L. Sacco Hospital, Milan, Italy. Phylogenetic analyses were conducted by HIV-TRACE, MrBayes, MacClade and Beast programs. Reference sequences were retrieved from Los Alamos and local databases. Last negative testing or proxy data from clinical records of infected individuals were used to investigate the country of infection. Results: Among South American TSWs, the most represented HIV-1 subtypes were B (70.5%), F1 (12.8%) and C (4.4%). Gene flow migrations of B subtype indicated significant fluxes from TSWs to Italians (21.3%) belonging to all risk groups (26.4% to heterosexuals (HEs), 18.9% to men who have sex with men (MSM), 15.1% to injecting drug users). The largest proportion of bidirectional fluxes were observed between Italians and TSWs (24.6%). For F1 subtype, bidirectional viral fluxes involved TSWs and Italians (7.1% and 14.3%), and a similar proportion of fluxes linked TSWs and Italian HEs or MSM (both 15.8%). Significant fluxes were detected from Italians to TSWs for subtype C involving both MSM (30%) and HEs (40%). Country of HIV-1 acquisition was identified for 72 subjects; overall, the largest proportion of patients with B subtype (73.5%) acquired HIV-1 infection in South America. Conclusions: Our results indicated that South American transgenders largely contribute to the heterogeneity of HIV-1 variants in our country. The high number of clusters based on all subtypes indicated numerous transmission chains in which TSWs were constantly intermixed with HEs and MSM. Our results strongly advocate interventions to facilitate prevention, diagnosis and HIV-1 care continuum among transgender people

Extreme emission-line galaxies out to z∼\sim1 in zCOSMOS. I. Sample and characterization of global properties

We present a thorough characterization of a large sample of 183 extreme emission-line galaxies (EELGs) at redshift 0.11 < z < 0.93 selected from the 20k zCOSMOS Bright Survey because of their unusually large emission line equivalent widths. We use multiwavelength COSMOS photometry, HST-ACS I-band imaging and optical zCOSMOS spectroscopy to derive the main global properties of EELGs, such as sizes, masses, SFRs, reliable metallicities from both "direct" and "strong-line" methods. The EELGs are compact (R_50 ~ 1.3 kpc), low-mass (log(M*/Msol)~7-10) galaxies forming stars at unusually high specific SFR (log(sSFR/yr) up to ~ -7) compared to main sequence SFGs of the same stellar mass and redshift. At UV wavelengths, the EELGs are luminous and show high surface brightness and include strong Ly$\alpha$ emitters, as revealed by GALEX spectroscopy. We show that zCOSMOS EELGs are high-ionization, low-metallicity systems, with median 12+log(O/H)=8.16, including a handful of extremely metal-deficient galaxies (<10% solar). While ~80% of the EELGs show non-axisymmetric morphologies, including clumpy and tadpole galaxies, we find that ~29% of them show additional low surface-brightness features, which strongly suggest recent or ongoing interactions. As star-forming dwarfs in the local Universe, EELGs are most often found in relative isolation. While only very few EELGs belong to compact groups, almost one third of them are found in spectroscopically confirmed loose pairs or triplets. We conclude that EELGs are galaxies caught in a transient and probably early period of their evolution, where they are efficiently building-up a significant fraction of their present-day stellar mass in an ongoing galaxy-wide starburst. Therefore, the EELGs constitute an ideal benchmark for comparison studies between low- and high-redshift low-mass star-forming galaxies.Comment: Accepted in A&A. Final replacement to match the version in press. It includes a minor change in the title and a new figur

The VLA-VIRMOS Deep Field I. Radio observations probing the microJy source population

We have conducted a deep survey (r.m.s noise 17 microJy) with the Very Large Array (VLA) at 1.4 GHz, with a resolution of 6 arcsec, of a 1 square degree region included in the VIRMOS VLT Deep Survey. In the same field we already have multiband photometry down to I(AB)=25, and spectroscopic observations will be obtained during the VIRMOS VLT survey. The homogeneous sensitivity over the whole field has allowed to derive a complete sample of 1054 radio sources (5 sigma limit). We give a detailed description of the data reduction and of the analysis of the radio observations, with particular care to the effects of clean bias and bandwidth smearing, and of the methods used to obtain the catalogue of radio sources. To estimate the effect of the resolution bias on our observations we have modelled the effective angular-size distribution of the sources in our sample and we have used this distribution to simulate a sample of radio sources. Finally we present the radio count distribution down to 0.08 mJy derived from the catalogue. Our counts are in good agreement with the best fit derived from earlier surveys, and are about 50 % higher than the counts in the HDF. The radio count distribution clearly shows, with extremely good statistics, the change in the slope for the sub-mJy radio sources.Comment: 13 pages, Accepted for publication in Astronomy & Astrophysic