Open Science: the Very Idea

This open access book provides a broad context for the understanding of current problems of science and of the different movements aiming to improve the societal impact of science and research. The author offers insights with regard to ideas, old and new, about science, and their historical origins in philosophy and sociology of science, which is of interest to a broad readership. The book shows that scientifically grounded knowledge is required and helpful in understanding intellectual and political positions in various discussions on the grand challenges of our time and how science makes impact on society. The book reveals why interventions that look good or even obvious, are often met with resistance and are hard to realize in practice. Based on a thorough analysis, as well as personal experiences in aids research, university administration and as a science observer, the author provides - while being totally open regarding science's limitations- a realistic narrative about how research is conducted, and how reliable ‘objective’ knowledge is produced. His idea of science, which draws heavily on American pragmatism, fits in with the global Open Science movement. It is argued that Open Science is a truly and historically unique movement in that it translates the analysis of the problems of science into major institutional actions of system change in order to improve academic culture and the impact of science, engaging all actors in the field of science and academia

Ion induced segregation in gold nanostructured thin films on silicon

We report a direct observation of segregation of gold atoms to the near surface regime due to 1.5 MeV Au2+ ion impact on isolated gold nanostructures deposited on silicon. Irradiation at fluences of 6x10^13, 1x10^14 and 5x10^14 ions cm-2 at a high beam flux of 6.3x1012 ions cm-2 s-1 show a maximum transported distance of gold atoms into the silicon substrate to be 60, 45 and 23 nm, respectively. At a lower fluence (6x1013 ions cm-2) transport has been found to be associated with the formation of gold silicide (Au5Si2). At a high fluence value of 5x10^14 ions cm-2, disassociation of gold silicide and out-diffusion lead to segregation of gold to defect - rich surface and interface region.Comment: 10 pages, 2 figure

Extensive Modeling of a Coaxial Stub Resonator for Online Fingerprinting of Fluids

A straightforward method of extensive modeling of a lossy stub resonator system for online fingerprinting of fluids is presented in this paper. The proposed model solves the telegrapher's equations including the skin effect and dielectric losses and describes the amplitude versus frequency response of lossy coaxial stub resonators with a fluid under investigation as dielectric. The adequacy of the method is demonstrated by comparing simulations with experimentally obtained data. Even though we applied the model to a coaxial stub resonator for the online fingerprinting of fluids (e.g., for water quality monitoring), the potential applicability of the method reaches further. Indeed, the method introduced here may be useful for different types of sensors based on lossy transmission line theor

The HIV RNA setpoint theory revisited

This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens

Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: A longitudinal analysis of rapid progressors and long-term asymptomatics.

To gain more insight into the role of HIV-1-specific cytotoxic T lymphocytes (CTL) in the pathogenesis of AIDS, we investigated temporal relations between HIV-1 Gag-specific precursor CTL (CTLp), HIV-1 viral load, CD4+ T cell counts, and T cell function. Six HIV-1-infected subjects, who were asymptomatic for more than 8 yr with CD4+ counts > 500 cells/mm3, were compared with six subjects who progressed to AIDS within 5 yr after HIV-1 seroconversion. In the long-term asymptomatics, persistent HIV-1 Gag-specific CTL responses and very low numbers of HIV-1-infected CD4+ T cells coincided with normal and stable CD4+ counts and preserved CD3 mAb-induced T cell reactivity for more than 8 yr. In five out of six rapid progressors Gag-specific CTLp were also detected. However, early in infection the number of circulating HIV-1-infected CD4+ T cells increased despite strong and mounting Gag-specific CTL responses. During subsequent clinical progression to AIDS, loss of Gag-specific CTLp coincided with precipitating CD4+ counts and severe deterioration of T cell function. The possible relationships of HIV-1 Gag-specific CTLp to disease progression are discussed

Six principles for assessing scientists for hiring, promotion, and tenure

The negative consequences of relying too heavily on metrics to assess research quality are well known, potentially fostering practices harmful to scientific research such as p-hacking, salami science, or selective reporting. The "flourish or perish" culture defined by these metrics in turn drives the system of career advancement in academia, a system that empirical evidence has shown to be problematic and which fails to adequately take societal and broader impact into account. To address this systemic problem, Florian Naudet, John P. A. Ioannidis, Frank Miedema, Ioana A. Cristea, Steven N. Goodman and David Moher present six principles for assessing scientists for hiring, promotion, and tenure

Six principles for assessing scientists for hiring, promotion, and tenure

The negative consequences of relying too heavily on metrics to assess research quality are well known, potentially fostering practices harmful to scientific research such as p-hacking, salami science, or selective reporting. The "flourish or perish" culture defined by these metrics in turn drives the system of career advancement in academia, a system that empirical evidence has shown to be problematic and which fails to adequately take societal and broader impact into account. To address this systemic problem, Florian Naudet, John P. A. Ioannidis, Frank Miedema, Ioana A. Cristea, Steven N. Goodman and David Moher present six principles for assessing scientists for hiring, promotion, and tenure