Deciphering the Role of Regulatory CD4 T Cells in Oral and Oropharyngeal Cancer : A Systematic Review

CO was supported by an Innes Will Scholarship, University of Aberdeen HotStart Summer Scholarship Scheme.Peer reviewedPublisher PD

The density of seawater solutions at one atmosphere as a function of temperature and salinity

The relative density (d – d0) of diluted and evaporated standard seawater solutions have been determined at one atmosphere with a magnetic float densimeter and a suspension balance from 0.5 to 40‰ salinity and 0 to 40°C…

On the Road to Immunotherapy : Prospects for Treating Head and Neck Cancers With Checkpoint Inhibitor Antibodies

Peer reviewedPublisher PD

Enhancing Water Use Efficiency on Irrigated Dairy Pastures with Nitrogen Fertiliser

Low summer rainfall in southwest Victoria, Australia, restricts pasture growth and limits milk production. One fifth of dairy farmers in the region have some capacity to irrigate during summer. Irrigated dairy pastures are relatively poor utilisers of water with water use efficiencies (WUE) of about 1 t DM/ML water (Ward et al. 1998). Using nitrogen (N) fertiliser may increase dry matter (DM) yields for a given amount of water. Data on N response efficiencies from irrigated pasture in southwest Victoria are lacking. Two experiments determined the potential of N fertiliser to maximise the conversion of irrigated water to pasture DM

Responses of Irrigated Pasture Nutritive Characteristics to Summer Nitrogen Fertiliser

Low summer rainfall in southwest Victoria, Australia, restricts pasture growth and reduces pasture nutritive value thereby limiting potential milk production. One fifth of dairy farmers in the region have some capacity to irrigate during summer and nitrogen (N) fertiliser is used to enhance pasture dry matter (DM) yield. Data on the effects of N fertiliser on irrigated pasture nutritive characteristics during summer in southwest Victoria are lacking. Two experiments determined the potential of N fertiliser to improve pasture nutritive (crude protein, CP and metabolisable energy, ME) value during summer

Immunoregulatory soluble CTLA-4 modifies effector T cell responses in systemic lupus erythematosus

Acknowledgments This work was supported by Arthritis Research UK (Grant no. 19282). We are grateful to Dr. Nick Fluck for his invaluable support in recruiting patients for the study, and Mrs. Vivien Vaughan for her invaluable expertise in recruiting study participants and maintaining ethical documentation.Peer reviewedPublisher PD

Morphological differences between habitats are associated with physiological and behavioural trade-offs in stickleback (Gasterosteus aculeatus)

F.S. and A.J.W.W. were supported by the Australian Research Council, M.M.W. was supported by The University of St Andrews and R.S.J. and J.T. were supported by Coventry UniversityLocal specialization can be advantageous for individuals and may increase the resilience of the species to environmental change. However, there may be trade-offs between morphological responses and physiological performance and behaviour. Our aim was to test whether habitat-specific morphology of stickleback (Gasterosteus aculeatus) interacts with physiological performance and behaviour at different salinities. We rejected the hypothesis that deeper body shape of fish from habitats with high predation pressure led to decreases in locomotor performance. However, there was a trade-off between deeper body shape and muscle quality. Muscle of deeper-bodied fish produced less force than that of shallow-bodied saltmarsh fish. Nonetheless, saltmarsh fish had lower swimming performance, presumably because of lower muscle mass overall coupled with smaller caudal peduncles and larger heads. Saltmarsh fish performed better in saline water (20 ppt) relative to freshwater and relative to fish from freshwater habitats. However, exposure to salinity affected shoaling behaviour of fish from all habitats and shoals moved faster and closer together compared with freshwater. We show that habitat modification can alter phenotypes of native species, but local morphological specialization is associated with trade-offs that may reduce its benefits.Publisher PDFPeer reviewe

Toenail Manganese: A Sensitive and Specific Biomarker of Exposure to Manganese in Career Welders

Manganese (Mn) is an essential trace metal. It is also a component of welding fume. Chronic inhalation of manganese from welding fume has been associated with decreased neurological function. Currently, there is not a universally recognized biomarker for Mn exposure; however, hair and toenails have shown promise. In a cohort of 45 male welders and 35 age-matched factory control subjects, we assessed the sensitivity and specificity of toenail Mn to distinguish occupationally exposed subjects from unexposed controls. Further we examined the exposure time window that best correlates with the proposed biomarker, and investigated if non-occupational exposure factors impacted toenail Mn concentrations. Toenail clippings were analyzed for Mn using Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Exposure to respirable Mn-containing particles (<4 µm) was estimated using an exposure model that combines personal air monitoring, work history information, and dietary intake to estimate an individual's exposure to Mn from inhalation of welding fume. We assessed the group differences in toenail concentrations using a Student's t-test between welders and control subjects and performed a receiver operating characteristic (ROC) curve analysis to identify a threshold in toenail concentration that has the highest sensitivity and specificity in distinguishing welders from control subjects. Additionally, we performed mixed-model regressions to investigate the association between different exposure windows and toenail Mn concentrations. We observed that toenail Mn concentrations were significantly elevated among welders compared to control subjects (6.87 ± 2.56 versus 2.70 ± 1.70 µg g-1; P < 0.001). Our results show that using a toenail Mn concentration of 4.14 µg g-1 as cutoff allows for discriminating between controls and welders with 91% specificity and 94% sensitivity [area under curve (AUC) = 0.98]. Additionally, we found that a threshold of 4.66 µg g-1 toenail Mn concentration enables a 90% sensitive and 90% specific discrimination (AUC = 0.96) between subjects with average exposure above or below the American Conference of Governmental Industrial Hygienist (ACGIH) Threshold Limit Value (TLV) of 0.02 mg m-3 during the exposure window of 7-12 months prior to the nail being clipped. Investigating which exposure window was best reflected by toenail Mn reproduced the result from another study of toenail Mn being significantly (P < 0.001) associated with exposure 7-12 months prior to the nail being clipped. Lastly, we found that dietary intake, body mass index, age, smoking status, and ethnicity had no significant effect on toenail Mn concentrations. Our results suggest that toenail Mn is a sensitive, specific, and easy-to-acquire biomarker of Mn exposure, which is feasible to be used in an industrial welder population

721-6 Pulmonary Balloon Valvuloplasty: Effective Palliation for Infants with Tetralogy of Fallot and Small Pulmonary Arteries

Infants with tetralogy of Fallot (TOF) and small pulmonary arteries (PAs) may need palliation to improve pulmonary blood flow and allow growth of the PAs prior to complete repair. Shunts may become occluded, distort the PAs or cause pulmonary overcirculation. As an alternative palliation, we performed pulmonary balloon valvuloplasty (PBV) on infants with TOF and small PAs.20 infants, ages 1.8±1.5 mo and weights 4.1±1.6kg, undervvent PBV as initial palliation for persistent cyanosis or “spells”. 4/20 pts were intubated prior to or for PBV All pts had pre and post-PBV angiograms. In all pts, single balloon valvuloplasty was performed. The ratio of balloon: pulmonary valve annulus (PVA) diameter was 1.51±0.32. Post-PBV, there was no change in the PYA diameter (5.2±1.1mm vs 5.6 + 1.1mm; p=0.1) or PA branch diameter(4.1±1.6mm vs 4.5±1.7mm, p&gt;0.05). The systemic 02 saturation increased from 81±8% to 93±6%. (p&lt;0.001)7/20 pts undervvent follow-up (F/U) cath 8.2±2.4 mo post-PBV Compared to pre-PBV measurements, the PYA diameter increased from 5.2 ± 1.1mm to 7.1±1.4mm (p&lt;0.03) and the McGoon ratio increased from 1.4±0.4 to 2.1±0.3 (p&lt;0.02).Of the 20 pts, 11 pts undervvent corrective surgery 8.0±3.1 mo post-PBV with no surgical deaths; 5 pts remain in stable condition awaiting surgery; 3 pts required shunt placement 9-66 days post-PBV; 1 pt died due to other congenital anomalies.ConclusionsPulmonary balloon valvuloplasty promotes growth of the PAs and PYA in infants with TOF and small PAs, offering a safe and effective alternative palliation for infants who are not yet candidates for complete repair

CASIMIR: a high resolution far-IR/submm spectrometer for airborne astronomy

CASIMIR, the Caltech Airborne Submillimeter Interstellar Medium Investigations Receiver, is a far-infrared and submillimeter heterodyne spectrometer, being developed for the Stratospheric Observatory For Infrared Astronomy, SOFIA. CASIMIR will use newly developed superconducting-insulating-superconducting (SIS) mixers. Combined with the 2.5 m mirror of SOFIA, these detectors will allow observations with high sensitivity to be made in the frequency range from 500 GHz up to 1.4 THz. Initially, at least 5 frequency bands in this range are planned, each with a 4-8 GHz IF passband. Up to 4 frequency bands will be available on each flight and bands may be swapped readily between flights. The local oscillators for all bands are synthesized and tuner-less, using solid state multipliers. CASIMIR also uses a novel, commercial, field-programmable gate array (FPGA) based, fast Fourier transform spectrometer, with extremely high resolution, 22000 (268 kHz at 6 GHz), yielding a system resolution > 10^6. CASIMIR is extremely well suited to observe the warm, ≈ 100K, interstellar medium, particularly hydrides and water lines, in both galactic and extragalactic sources. We present an overview of the instrument, its capabilities and systems. We also describe recent progress in development of the local oscillators and present our first astronomical observations obtained with the new type of spectrometer