Diritto, libertà, sicurezza. Fra inizio e compimento della Modernità

Il tema è la relazione del diritto con libertà e sicurezza. Definiti i tre lemmi, e indicata, in radice, una possibile connessione tra sicurezza e libertà, si passa a una storia della relazione nella Modernità, che inizia sotto il segno della sicurezza (spc. Hobbes) e si conclude sotto quello della libertà (spc. Tocqueville). In apertura e chiusura cenni sul bisogno post-moderno di sicurezz

Energy Retrofit of a Historic Building Using Simplified Dynamic Energy Modeling

Energy retro-commissioning of historical buildings is an important challenge that implies both historic-artistic and technological aspects concerning the improvement in energy efficiency and comfort. A critical analysis of each possibility is essential in order to preserve the balance between efficiency and architecture. The research focuses on a historical building owned by ANCE (Associazione Nazionale Costruttori Edili), situated in Rome in the Nomentano district. Retrofitting hypothesis were made in order to improve HVAC systems, building's envelope and building's management, always respecting its architectural features. An energy audit has been done in order to evaluate the possibilities. The first step of the study consisted of a measure campaign conducted by Avvenia to know more about the actual use of the building. Next, a dynamic simplified energy modeling of the building has been built using the software Archi Energy. This allowed to preview the effect of modifications on the HVAC and envelope systems. Although starting from an original medium energy performance, simulations showed that it would be possible to reach a further reduction of energy needs by making simple changes in the management/controls domain and, with higher costs, by upgrading envelope components. This study shows that a correct approach can lead to both relevant energetic results and the conservation of architectural characteristics of historical buildings

Classification and mapping of the woody vegetation of Gonarezhou National Park, Zimbabwe

Within the framework of the Great Limpopo Transfrontier Conservation Area (GLTFCA), the purpose of this study was to produce a classification of the woody vegetation of the Gonarezhou National Park, Zimbabwe, and a map of its potential distribution. Cover-abundance data of woody species were collected in 330 georeferenced relevés across the Park. These data were used to produce two matrices: the first one using the cover-abundance values as collected in five height layers and the second one based on merging the layers into a single cover value for each species. Automatic classifications were produced for both matrices to determine the optimal number of vegetation types. The two classification approaches both produced 14 types belonging to three macro-groups: mopane, miombo and alluvial woodlands. The results of the two classifications were compared looking at the constant, dominant and diagnostic species of each type. The classification based on separate layers was considered more effective and retained. A high-resolution map of the potential distribution of vegetation types for the whole study area was produced using Random Forest. In the model, the relationship between bioclimatic and topographic variables, known to be correlated to vegetation types, and the classified relevés was used. Identified vegetation types were compared with those of other national parks within the GLTFCA, and an evaluation of the main threats and pressures was conducted. Conservation implications: Vegetation classification and mapping are useful tools for multiple purposes including: surveying and monitoring plant and animal populations, communities and their habitats, and development of management and conservation strategies. Filling the knowledge gap for the Gonarezhou National Park provides a basis for standardised and homogeneous vegetation classification and mapping for the entire Great Limpopo Transfrontier Conservation Area

Anti-telomerase T cells adoptive transfer

Commentary on the application of TERT-specific T cell adoptive cell therapy for cancer treatmen

L’étranger, la Cité.

La présente contribution se concentre sur le passage d’un moment utopique à un autre dystopique dans le roman de Michel Henry L’Amour les yeux fermés à partir du modèle d’intégration de son protagoniste, un étranger, à l’intérieur de cette communauté idéale vouée à la destruction. À travers les vertus et les faiblesses du roman (à la fois philosophiques et stylistiques), le propos aboutira à considérer un imaginaire clandestin comme potentialité non dichotomique de l’expérience de la communauté.This paper examines the transition from a moment of utopia to a moment of dystopia in Michel Henry’s L’Amour les yeux fermés, questioning the model of integration of its protagonist, a foreigner, inside this ideal community doomed to destruction. Through the virtues and weaknesses of the novel (both philosophical and stylistic), the author looks at an imaginary underground and non-dichotomous potentiality of the experience of community.Dieser Beitrag untersucht den Übergang in Michel Henrys Roman L’Amour les yeux fermés zwischen einem Moment der U-topie und einem Moment der Dis-topie. Dies vom lntegrationsmodell seines Protagonisten, eines Ausländers, ausgehend, und im Rahmen dieser idealen, aber-der Zerstörung-bestimmten Gemeinschaft

L’étranger, la Cité.

La présente contribution se concentre sur le passage d’un moment utopique à un autre dystopique dans le roman de Michel Henry L’Amour les yeux fermés à partir du modèle d’intégration de son protagoniste, un étranger, à l’intérieur de cette communauté idéale vouée à la destruction. À travers les vertus et les faiblesses du roman (à la fois philosophiques et stylistiques), le propos aboutira à considérer un imaginaire clandestin comme potentialité non dichotomique de l’expérience de la communauté.This paper examines the transition from a moment of utopia to a moment of dystopia in Michel Henry’s L’Amour les yeux fermés, questioning the model of integration of its protagonist, a foreigner, inside this ideal community doomed to destruction. Through the virtues and weaknesses of the novel (both philosophical and stylistic), the author looks at an imaginary underground and non-dichotomous potentiality of the experience of community.Dieser Beitrag untersucht den Übergang in Michel Henrys Roman L’Amour les yeux fermés zwischen einem Moment der U-topie und einem Moment der Dis-topie. Dies vom lntegrationsmodell seines Protagonisten, eines Ausländers, ausgehend, und im Rahmen dieser idealen, aber-der Zerstörung-bestimmten Gemeinschaft

Monocytes in the Tumor Microenvironment

Immunotherapy has revolutionized cancer treatment over the past decade. Nonetheless, prolonged survival is limited to relatively few patients. Cancers enforce a multifaceted immune-suppressive network whose nature is progressively shaped by systemic and local cues during tumor development. Monocytes bridge innate and adaptive immune responses and can affect the tumor microenvironment through various mechanisms that induce immune tolerance, angiogenesis, and increased dissemination of tumor cells. Yet monocytes can also give rise to antitumor effectors and activate antigen-presenting cells. This yin-yang activity relies on the plasticity of monocytes in response to environmental stimuli. In this review, we summarize current knowledge of the ontogeny, heterogeneity, and functions of monocytes and monocyte-derived cells in cancer, pinpointing the main pathways that are important for modeling the immunosuppressive tumor microenvironment

Breaking the Immune Complexity of the Tumor Microenvironment Using Single-Cell Technologies

: Tumors are not a simple aggregate of transformed cells but rather a complicated ecosystem containing various components, including infiltrating immune cells, tumor-related stromal cells, endothelial cells, soluble factors, and extracellular matrix proteins. Profiling the immune contexture of this intricate framework is now mandatory to develop more effective cancer therapies and precise immunotherapeutic approaches by identifying exact targets or predictive biomarkers, respectively. Conventional technologies are limited in reaching this goal because they lack high resolution. Recent developments in single-cell technologies, such as single-cell RNA transcriptomics, mass cytometry, and multiparameter immunofluorescence, have revolutionized the cancer immunology field, capturing the heterogeneity of tumor-infiltrating immune cells and the dynamic complexity of tenets that regulate cell networks in the tumor microenvironment. In this review, we describe some of the current single-cell technologies and computational techniques applied for immune-profiling the cancer landscape and discuss future directions of how integrating multi-omics data can guide a new "precision oncology" advancement

The dark side of tumor-associated endothelial cells

Angiogenesis is a hallmark of cancer and a requisite that tumors must achieve to fulfill their metabolic needs of nutrients and oxygen. As a critical step in cancer progression, the 'angiogenic switch' allows tumor cells to survive and grow, and provides them access to vasculature resulting in metastatic progression and dissemination. Tumor-dependent triggering of the angiogenic switch has critical consequences on tumor progression which extends from an increased nutrient supply and relies instead on the ability of the tumor to hijack the host immune response for the generation of a local immunoprivileged microenvironment. Tumor angiogenic-mediated establishment of endothelial anergy is responsible for this process. However, tumor endothelium can also promote immune tolerance by unbalanced expression of co-stimulatory and co-inhibitory molecules and by releasing soluble factors that restrain T cell function and induce apoptosis. In this review, we discuss the molecular properties of the tumor endothelial barrier and endothelial anergy and discuss the main immunosuppressive mechanisms triggered by the tumor endothelium. Lastly, we describe the current anti-angiogenic therapeutic landscape and how targeting tumor angiogenesis can contribute to improve clinical benefits for patients

Targeting tumour-reprogrammed myeloid cells: the new battleground in cancer immunotherapy

Tumour microenvironment is a complex ecosystem in which myeloid cells are the most abundant immune elements. This cell compartment is composed by different cell types, including neutrophils, macrophages, dendritic cells, and monocytes but also unexpected cell populations with immunosuppressive and pro-tumour roles. Indeed, the release of tumour-derived factors influences physiological haematopoiesis producing unconventional cells with immunosuppressive and tolerogenic functions such as myeloid-derived suppressor cells. These pro-tumour myeloid cell populations not only support immune escape directly but also assist tumour invasion trough non-immunological activities. It is therefore not surprising that these cell subsets considerably impact in tumour progression and cancer therapy resistance, including immunotherapy, and are being investigated as potential targets for developing a new era of cancer therapy. In this review, we discuss emerging strategies able to modulate the functional activity of these tumour-supporting myeloid cells subverting their accumulation, recruitment, survival, and functions. These innovative approaches will help develop innovative, or improve existing, cancer treatments