The management of secondary lower limb lymphoedema in cancer patients: A systematic review.

BACKGROUND: Lower limb lymphoedema is a recognised complication of cancer commonly encountered in palliative care, associated with reduced mobility and poor quality of life. AIM: To evaluate the available evidence for the treatment of secondary lower limb lymphoedema in patients with malignancies. DESIGN: A systematic review of the literature. DATA SOURCES: The MEDLINE, Embase, LILACS, Science Citation Index, Cochrane Databases and conference proceedings for published data from date of inception to July 2014 were searched. Relevant unpublished studies via relevant databases, Internet searches and hand-searches of the bibliographies of relevant papers were performed. RESULTS: From 1617 citations, 32 papers were selected for full-text assessment. Two randomised trials and five observational studies were identified. The two randomised controlled trials evaluated graded compression stockings and Coumarin capsules, respectively. The five observational studies evaluated lymphovenous microsurgical shunts, pneumatic compression devices, compression bandages alone, manual lymphatic drainage with compression and a herbal remedy combining Coumarin, Ginkgo and Melitoto (with or without manual lymphatic drainage), respectively. The extracted studies showed substantial heterogeneity. Hence, a meta-analysis was inappropriate and not performed. CONCLUSION: Few studies have evaluated the clinical effectiveness and potential side effects of treatments for lower limb lymphoedema. Moreover, symptoms and quality-of-life assessments were inconsistently reported. All included studies report lower limb volume reduction after treatment, which includes complex decongestion therapy, graded compression stockings and lymphovenous microsurgical shunts. Adequately powered randomised controlled trials of these interventions are recommended. Effort should be made to establish standardised outcomes, to minimise bias and to improve reporting quality in future trials of treatment for lower limb lymphoedema

First experience in operating the population of the condition databases for the CMS experiment

Reliable population of the condition databases is critical for the correct operation of the online selection as well as of the offline reconstruction and analysis of data. We will describe here the system put in place in the CMS experiment to populate the database and make condition data promptly available both online for the high-level trigger and offline for reconstruction. The system, designed for high flexibility to cope with very different data sources, uses POOL-ORA technology in order to store data in an object format that best matches the object oriented paradigm for \texttt{C++} programming language used in the CMS offline software. In order to ensure consistency among the various subdetectors, a dedicated package, PopCon (Populator of Condition Objects), is used to store data online. The data are then automatically streamed to the offline database hence immediately accessible offline worldwide. This mechanism was intensively used during 2008 in the test-runs with cosmic rays. The experience of this first months of operation will be discussed in detail.Comment: 15 pages, submitter to JOP, CHEP0

Chronic oedema: a prevalent health care problem for UK health services

Chronic oedema is a major clinical problem worldwide, which has many important secondary consequences for health, activity and participation. Effective treatment planning and organisation of services is dependent on an understanding of the condition and its epidemiology. This cross sectional study was designed to estimate the point prevalence of chronic oedema within the health services of one UK urban population and to determine the proportions that have concurrent leg ulceration. Patients with chronic oedema were ascertained by health care professionals in one acute and one community hospital, all relevant out-patient and community nursing services, general practices and all nursing/residential homes in one urban catchment area (Derby City). The presence and distribution of oedema was confirmed through a brief clinical examination. A battery of demographic and clinical details was recorded for each case. Within the study population of Derby City residents, 971 patients were identified with chronic oedema (estimated crude prevalence 3.93 per 1,000, 95% CI 3.69-4.19). The prevalence was highest amongst those aged 85 or above (28.75 per 1,000) and was higher amongst women (5.37 per 1,000) than men (2.48 per 1,000). The prevalence amongst hospital in-patients was 28.5%. Only 5 (3%) patients in the community population had oedema related to cancer or cancer treatment. Of the 304 patients identified with oedema from the Derby hospitals or community health services 121 (40%) had a concurrent leg ulcer. Prevalence statistics and current demographic trends indicate that chronic oedema is a major and growing health care problem

Interesting magnetic properties of Fe1−x_{1-x}Cox_xSi alloys

Solid solution between nonmagnetic narrow gap semiconductor FeSi and diamagnetic semi-metal CoSi gives rise to interesting metallic alloys with long-range helical magnetic ordering, for a wide range of intermediate concentration. We report various interesting magnetic properties of these alloys, including low temperature re-entrant spin-glass like behaviour and a novel inverted magnetic hysteresis loop. Role of Dzyaloshinski-Moriya interaction in the magnetic response of these non-centrosymmetric alloys is discussed.Comment: 11 pages and 3 figure

Nanoparticles for early diagnostics of inflammatory diseases: new approaches in the field of soft and hard nanoparticles: NANOFOL NanoDiaRa Conference 7th Framework Programme

Two European Research Projects NanoDiaRA and NANOFOL, exploring novel techniques and scientific relationships in a very transdisciplinary way in the field of diagnosis and therapeutics of inflammatory diseases, have jointly organized a conference. The conference will present the results of more than 20 research groups and more than 70 scientist, engineers, technicians and trainees having had the opportunity to work together, to exchange, to learn and to profit from this interchange for their career. Starting more than 20 years ago with Cost Actions, BriteEuram and the various Framework projects, the EU funding has allowed European researchers to work in close collaboration beyond national borders, and to exchange in science and culture. The EU Commission also encouraged academia and industry to work closer together already in research and development and this conference will highlight some of this collaborative work. We expect that presentations and discussions might help to create new concept ideas to exploit results of NanoDiaRA and NANOFOL and help to build new projects under the frame of Horizon 2020. In this sense we would like to thank all participants from both projects as well outside participants who are coming to listen, to learn, and to exchange, and the EU Commission for funding these projects and by this allowing more sustainable European partnerships.info:eu-repo/semantics/publishedVersio

Proposed changes to nurse education: get ready to have your say.

Elizabeth Rosser, Deputy Dean (Education and Professional Practice) and Professor of Nursing at Bournemouth University, examines the radical changes to undergraduate nurse education currently proposed