Topological code Autotune

Many quantum systems are being investigated in the hope of building a large-scale quantum computer. All of these systems suffer from decoherence, resulting in errors during the execution of quantum gates. Quantum error correction enables reliable quantum computation given unreliable hardware. Unoptimized topological quantum error correction (TQEC), while still effective, performs very suboptimally, especially at low error rates. Hand optimizing the classical processing associated with a TQEC scheme for a specific system to achieve better error tolerance can be extremely laborious. We describe a tool Autotune capable of performing this optimization automatically, and give two highly distinct examples of its use and extreme outperformance of unoptimized TQEC. Autotune is designed to facilitate the precise study of real hardware running TQEC with every quantum gate having a realistic, physics-based error model.Comment: 13 pages, 17 figures, version accepted for publicatio

Quantum computing with nearest neighbor interactions and error rates over 1%

Large-scale quantum computation will only be achieved if experimentally implementable quantum error correction procedures are devised that can tolerate experimentally achievable error rates. We describe a quantum error correction procedure that requires only a 2-D square lattice of qubits that can interact with their nearest neighbors, yet can tolerate quantum gate error rates over 1%. The precise maximum tolerable error rate depends on the error model, and we calculate values in the range 1.1--1.4% for various physically reasonable models. Even the lowest value represents the highest threshold error rate calculated to date in a geometrically constrained setting, and a 50% improvement over the previous record.Comment: 4 pages, 8 figure

Subglacial floods beneath ice sheets.

Subglacial floods (jökulhlaups) are well documented as occurring beneath present day glaciers and ice caps. In addition, it is known that massive floods have occurred from ice-dammed lakes proximal to the Laurentide ice sheet during the last ice age, and it has been suggested that at least one such flood below the waning ice sheet was responsible for a dramatic cooling event some 8000 years ago. We propose that drainage of lakes from beneath ice sheets will generally occur in a time-periodic fashion, and that such floods can be of severe magnitude. Such hydraulic eruptions are likely to have caused severe climatic disturbances in the past, and may well do so in the future

Estimation of the geophysical properties of the ocean surface using aircraft microwave measurements

An improved model of the effects of sea state on microwave signature has been developed which incorporates the different effects of whitecaps and streaks to define the response of microwave channels to wind speed. This model has been demonstrated to agree with recent measurements. An approximation model has also been incorporated to describe the effects of precipitation on microwave radiation through a computationally rapid routine. The use of these models and a new technique to allow the selection of the most climatologically appropriate D-matrix is demonstrated in the inversion of data collected over the bering Sea. Surface wind speed agrees very well with observations while good results are obtained for integrated water vapor, and liquid water

Emotional dysfunction in schizophrenia spectrum psychosis: the role of illness perceptions

Background. Assessing illness perceptions has been useful in a range of medical disorders. This study of people with a recent relapse of their psychosis examines the relationship between illness perception, their emotional responses and their attitudes to medication.Method. One hundred patients diagnosed with a non-affective psychotic disorder were assessed within 3 months of relapse. Measures included insight, self-reported. illness perceptions, medication adherence, depression, self-esteem and anxiety.Results. Illness perceptions about psychosis explained 46, 36 and 34% of the variance in depression, anxiety and self-esteem respectively. However, self-reported medication adherence was more strongly associated with a measure of insight.Conclusions. Negative illness perceptions in psychosis are clearly related to depression, anxiety and self-esteem. These in turn have been linked to symptom maintenance and recurrence. Clinical interventions that foster appraisals of recovery rather than of chronicity and severity may therefore improve emotional well-being in people with psychosis. It might be better to address adherence to medication through direct attempts at helping them understand their need for treatment

Novel approach for deriving genome wide SNP analysis data from archived blood spots.

RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are.BACKGROUND: The ability to transport and store DNA at room temperature in low volumes has the advantage of optimising cost, time and storage space. Blood spots on adapted filter papers are popular for this, with FTA (Flinders Technology Associates) Whatman™TM technology being one of the most recent. Plant material, plasmids, viral particles, bacteria and animal blood have been stored and transported successfully using this technology, however the method of porcine DNA extraction from FTA Whatman™TM cards is a relatively new approach, allowing nucleic acids to be ready for downstream applications such as PCR, whole genome amplification, sequencing and subsequent application to single nucleotide polymorphism microarrays has hitherto been under-explored. FINDINGS: DNA was extracted from FTA Whatman™TM cards (following adaptations of the manufacturer's instructions), whole genome amplified and subsequently analysed to validate the integrity of the DNA for downstream SNP analysis. DNA was successfully extracted from 288/288 samples and amplified by WGA. Allele dropout post WGA, was observed in less than 2% of samples and there was no clear evidence of amplification bias nor contamination. Acceptable call rates on porcine SNP chips were also achieved using DNA extracted and amplified in this way. CONCLUSIONS: DNA extracted from FTA Whatman cards is of a high enough quality and quantity following whole genomic amplification to perform meaningful SNP chip studies

Studies in the use of cloud type statistics in mission simulation

A study to further improve NASA's global cloud statistics for mission simulation is reported. Regional homogeneity in cloud types was examined; most of the original region boundaries defined for cloud cover amount in previous studies were supported by the statistics on cloud types and the number of cloud layers. Conditionality in cloud statistics was also examined with special emphasis on temporal and spatial dependencies, and cloud type interdependence. Temporal conditionality was found up to 12 hours, and spatial conditionality up to 200 miles; the diurnal cycle in convective cloudiness was clearly evident. As expected, the joint occurrence of different cloud types reflected the dynamic processes which form the clouds. Other phases of the study improved the cloud type statistics for several region and proposed a mission simulation scheme combining the 4-dimensional atmospheric model, sponsored by MSFC, with the global cloud model

Multicolour detection of every chromosome as a means of detecting mosaicism and nuclear organisation in human embryonic nuclei

Fluorescence in situ Hybridisation (FISH) revolutionised cytogenetics using fluorescently labelled probes with high affinity with target (nuclear) DNA. By the early 1990s FISH was adopted as a means of PGD sexing for couples at risk of transmitting X-linked disorders and later for detection of unbalanced translocations. Following a rise in popularity of PGD by FISH for sexing and the availability of multicolour probes (5-8 colour), the use of FISH was expanded to the detection of aneuploidy and selective implantation of embryos more likely to be euploid, the rationale being to increase pregnancy rates (referral categories were typically advanced maternal age, repeated IVF failure, repeated miscarriage or severe male factor infertility). Despite initial reports of an increase in implantation rates, reduction in trisomic offspring and spontaneous abortions criticism centred around experimental design (including lack of randomisation), inadequate control groups and lack of report on live births. Eleven randomised control trials (RCTs) (2004-2010) showed that PGS with FISH did not increase delivery rates with some demonstrating adverse outcomes. These RCTs, parallel improvements in culturing and cryopreservation and a shift to blastocyst biopsy essentially outdated FISH as a tool for PGS and it has now been replaced by newer technologies (array CGH, SNP arrays, qRT-PCR and NGS). Cell-by-cell follow up analysis of individual blastomeres in non-transferred embryos is however usually prohibitively expensive by these new approaches and thus FISH remains an invaluable resource for the study of mosaicosm and nuclear organization. We thus developed the approach described herein for the FISH detection of chromosome copy number of all 24 human chromosomes. This approach involves 4 sequential layers of hybridization, each with 6 spectrally distinct fluorochromes and a bespoke capturing system. Here we report previously published studies and hitherto unreported data indicating that 24 chromosome FISH is a useful tool for studying chromosome mosaicism, one of the most hotly debated topics currently in preimplantation genetics. Our results suggest that mosaic embryo aneuploidy is not highly significantly correlated to maternal age, probably due, in part, to the large preponderance of post-zygotic (mitotic) errors. Chromosome loss (anaphase lag) appears to be the most common mechanism, followed by chromosome gain (endoreduplication), however 3:1 mitotic non- disjunction of chromosomes appears to be rare. Nuclear organisation (i.e. the spatial and temporal topology of chromosomes or sub-chromosomal compartments) studies indicate that human morula or blastocyst embryos (day 4-5) appear to adopt a "chromocentric" pattern (i.e. almost all centromeric signals reside in the innermost regions of the nuclear volume). By the blastocyst stage however, a more ordered organisation with spatial and temporal cues important for embryo development appears. We have however found no association between aneuploidy and nuclear organization using this approach despite our earlier studies. In conclusion, while FISH is mostly "dead and buried" for mainstream PGS, it still has a place for basic biology studies; the development of a 24 chromosome protocol extends the power of this analysis