Anthropogenic factors affecting European river lamprey Lampetra fluviatilis in the Humber River Basin, north-east England

Anadromous lampreys have declined throughout the world due to damaging anthropogenic activities. This is particularly evident for the European river lamprey Lampetra fluviatilis, and studies in the Humber River Basin have shown that poor longitudinal connectivity (between their feeding and suitable spawning habitats) due to man-made barriers and their commercial exploitation for recreational angling bait, are potentially impacting upon this population. The objectives of this thesis were two-fold. Firstly, to evaluate the efficacy of technical, conventional fishways for upstream migrating river lamprey, as the effectiveness of these fishways to provide free passage for lamprey at man-made barriers in the Humber and elsewhere in Britain is unclear. Secondly, to reassess the level of exploitation in the tidal Ouse, Humber River Basin, and investigate both the scale and structure of the lamprey bait market in Britain and the knowledge and attitudes of key stakeholders within the market, which so far remain unknown. Passive Integrated Transponder telemetry revealed that two fishways of different technical designs, plain Denil and pool and weir, were extremely inefficient for river lamprey, with passage efficiencies of 0.0 and 5.0% and attraction efficiencies of 91.8 and 42.6%, respectively. Lamprey were significantly delayed, up to 150 days, at the Denil fishway and lamprey failed to pass despite re-entering fishways on up to 12 separate days. Analysis of catch data suggests that there has not been a decline in the river lamprey stock in the Ouse, although up until 2009 (inclusive) the exploitation level may have been at least twice (~20%) the level reported previously. Telephone interviews of angling wholesale supplier and tackle shop managers in Britain revealed that c.9 tonnes of river lamprey were supplied to tackle shops and anglers in Britain between 2011-2012. It also revealed that the majority of lamprey were sourced from The Netherlands and Estonia. The vast majority of tackle shop managers were unaware of which species of lamprey they sold, where they originated from and whether they were threatened, although most (77%) said there should be a ban on the capture and selling of lamprey in Britain if they were considered to be threatened. Conversely, supplier managers were generally more knowledgeable about the lamprey they sold but were more indecisive over a ban

The enhancement of science process skills in primary teacher education students

The science process skills of primary teacher education students in Western Australia are often poorly developed. Their lack of skills is part of a more general and widespread problem. Hackling and Garnett (1991) state that students at all levels show poorly developed skills of problem analysis, planning, and carrying out of controlled experiments. In a study of first year tertiary students Moneira (1980) claims that many students cannot identify the basic phenomena and even the basic question involved in experiments. He suggests that they see experiments merely as using equipment rather than as a process of generating information

Imperceptible Individuals: issues in the applications of social theory to Lower Palaeolithic material culture

This thesis aims to explore whether idiosyncrasies in Acheulean handaxe manufacture can be seen and, if so, whether these can be used to trace the actions of hominins within the Lower Palaeolithic. This analysis has important implications for the application of current social theory to Palaeolithic contexts, which advocates a 'bottom-up' approach to archaeological study. This socially orientated theoretical approach emphasises the individual as the primary unit of analysis. However, as Hopkinson and White (2005) state, there is currently no methodology for such an analysis, rendering many discussions as exercises in what has been termed 'theoretical storytelling'. Using a series of innovative experiments, the question of whether the individual is a viable unit of analysis was tested. The results show that a suite of other factors that also contribute to stone tool manufacture currently masks the actions of individuals. Chief amongst these is variability in the raw material nodules selected for reduction. However, intra-site variability may indicate differences that are linked to socially mediated knapping strategies, or 'group templates' (c.f. Ashton & McNabb 1994). While this possibility requires further exploration, the thesis suggests that the individual is currently not viable as a primary unit of analysis within Palaeolithic archaeology and stresses that the theories posited from the standpoint of the individual cannot be interpreted as fact. At the same time, it appears that further work needs to be conducted that focuses on the more traditional group as the primary analytical unit and the prospect of teasing apart the interplay between the individuals, groups and the effects of raw material variability

Energy system optimisation and smart technologies - a social sciences and humanities annotated bibliography

The challenge: * Systems perspectives on energy involve a holistic view on balancing demand and supply; system optimisation can support security of supply, affordability, sustainability and profitability. * A central, and relatively recent, element of system optimisation is the move towards smart grids, and smart technologies, which concern interconnection of system elements usually through the internet. As well as increasing the resilience of the network, it is hoped this will help “citizens take ownership of the energy transition [and] benefit from new technologies”. * ‘Smartification’ of the energy system introduces a range of new societal conditions and consequences. The aim: * European energy policy has so far mainly relied on research from Science, Technology Engineering and Mathematics (STEM) disciplines. Energy-related Social Sciences and Humanities (energy-SSH) have been significantly underrepresented. The aim of this bibliography is to give policymakers a selected yet broad impression of the SSH research community focusing on ‘energy system optimisation and smart technologies’. Wherever possible, policy deductions or research and innovation recommendations are mentioned. Coverage: * Disciplines covered in this bibliography are broadly representative of the current SSH research community in the area, with a slight bias towards Economics, Sociology and Science & Technology Studies. Nevertheless, robust accounts from Psychology, Politics, Ethnography, Development, Environmental Social Science, Geography, Planning, Law, History and other fields are also included. * Geographically, research presented is primarily from Western and Northern Europe, but with diversity across these regions, and inclusion of some Eastern European and non-European contributions. * Techno-economic accounts are very highly represented in the field of energy system optimisation and smart technologies, a fact highlighted by researchers themselves. Much of this research concentrates on financial cost/benefit of smart grid and technical design, while approaches focusing on social practices or user-centric design are increasing but still underrepresented. The latter were deliberately given higher visibility in this bibliography. Key findings: * Numerous papers presented here focus on how questions of smart technology diffusion, innovation, and adoption might be shifted away from monetary incentives or cost/benefit analyses of technologies. * A unifying message across many topics and disciplines - from energy justice or socio-technical scenarios, to Economics or Ethnography - is that co-operation between techno-economic and SSH approaches needs more attention and is crucial for successful smart grid realisation. * Another important debate for SSH researchers is the deconstruction of overly optimistic visions of smart societies. Many authors urge caution in considering the (financial and social) costs and benefits of smart technologies for all of society, including issues of privacy intrusion. There are calls for more research on both policy initiatives, preferably targeting the community level, and clear communication strategies which fully consider these aspects

Genotype-phenotype correlation at codon 1740 ofSETD2

The SET domain containing 2, histone lysine methyltransferase encoded by SETD2 is a dual-function methyltransferase for histones and microtubules and plays an important role for transcriptional regulation, genomic stability, and cytoskeletal functions. Specifically, SETD2 is associated with trimethylation of histone H3 at lysine 36 (H3K36me3) and methylation of α-tubulin at lysine 40. Heterozygous loss of function and missense variants have previously been described with Luscan-Lumish syndrome (LLS), which is characterized by overgrowth, neurodevelopmental features, and absence of overt congenital anomalies. We have identified 15 individuals with de novo variants in codon 1740 of SETD2 whose features differ from those with LLS. Group 1 consists of 12 individuals with heterozygous variant c.5218C>T p.(Arg1740Trp) and Group 2 consists of 3 individuals with heterozygous variant c.5219G>A p.(Arg1740Gln). The phenotype of Group 1 includes microcephaly, profound intellectual disability, congenital anomalies affecting several organ systems, and similar facial features. Individuals in Group 2 had moderate to severe intellectual disability, low normal head circumference, and absence of additional major congenital anomalies. While LLS is likely due to loss of function of SETD2, the clinical features seen in individuals with variants affecting codon 1740 are more severe suggesting an alternative mechanism, such as gain of function, effects on epigenetic regulation, or posttranslational modification of the cytoskeleton. Our report is a prime example of different mutations in the same gene causing diverging phenotypes and the features observed in Group 1 suggest a new clinically recognizable syndrome uniquely associated with the heterozygous variant c.5218C>T p.(Arg1740Trp) in SETD2

Mutations in the histone methyltransferase gene KMT2B cause complex early-onset dystonia.

Histone lysine methylation, mediated by mixed-lineage leukemia (MLL) proteins, is now known to be critical in the regulation of gene expression, genomic stability, cell cycle and nuclear architecture. Despite MLL proteins being postulated as essential for normal development, little is known about the specific functions of the different MLL lysine methyltransferases. Here we report heterozygous variants in the gene KMT2B (also known as MLL4) in 27 unrelated individuals with a complex progressive childhood-onset dystonia, often associated with a typical facial appearance and characteristic brain magnetic resonance imaging findings. Over time, the majority of affected individuals developed prominent cervical, cranial and laryngeal dystonia. Marked clinical benefit, including the restoration of independent ambulation in some cases, was observed following deep brain stimulation (DBS). These findings highlight a clinically recognizable and potentially treatable form of genetic dystonia, demonstrating the crucial role of KMT2B in the physiological control of voluntary movement.Funding for the project was provided by the Wellcome Trust for UK10K (WT091310) and DDD Study. The DDD study presents independent research commissioned by the Health Innovation Challenge Fund [grant number HICF-1009-003] - see www.ddduk.org/access.html for full acknowledgement. This work was supported in part by the Intramural Research Program of the National Human Genome Research Institute and the Common Fund, NIH Office of the Director. This work was supported in part by the German Ministry of Research and Education (grant nos. 01GS08160 and 01GS08167; German Mental Retardation Network) as part of the National Genome Research Network to A.R. and D.W. and by the Deutsche Forschungsgemeinschaft (AB393/2-2) to A.R. Brain expression data was provided by the UK Human Brain Expression Consortium (UKBEC), which comprises John A. Hardy, Mina Ryten, Michael Weale, Daniah Trabzuni, Adaikalavan Ramasamy, Colin Smith and Robert Walker, affiliated with UCL Institute of Neurology (J.H., M.R., D.T.), King’s College London (M.R., M.W., A.R.) and the University of Edinburgh (C.S., R.W.)

A Comparison of Tools Used for Tuberculosis Diagnosis in Resource-Limited Settings: A Case Study at Mubende Referral Hospital, Uganda

This study compared TB diagnostic tools and estimated levels of misdiagnosis in a resource-limited setting. Furthermore, we estimated the diagnostic utility of three-TB-associated predictors in an algorithm with and without Direct Ziehl-Neelsen (DZM).Data was obtained from a cross-sectional study in 2011 conducted at Mubende regional referral hospital in Uganda. An individual was included if they presented with a two weeks persistent cough and or lymphadenitis/abscess. 344 samples were analyzed on DZM in Mubende and compared to duplicates analyzed on direct fluorescent microscopy (DFM), growth on solid and liquid media at Makerere University. Clinical variables from a questionnaire and DZM were used to predict TB status in multivariable logistic and Cox proportional hazard models, while optimization and visualization was done with receiver operating characteristics curve and algorithm-charts in Stata, R and Lucid-Charts respectively.DZM had a sensitivity and specificity of 36.4% (95% CI = 24.9-49.1) and 97.1%(95% CI = 94.4-98.7) compared to DFM which had a sensitivity and specificity of 80.3%(95% CI = 68.7-89.1) and 97.1%(95% CI = 94.4-98.7) respectively. DZM false negative results were associated with patient's HIV status, tobacco smoking and extra-pulmonary tuberculosis. One of the false negative cases was infected with multi drug resistant TB (MDR). The three-predictor screening algorithm with and without DZM classified 50% and 33% of the true cases respectively, while the adjusted algorithm with DZM classified 78% of the true cases.The study supports the concern that using DZM alone risks missing majority of TB cases, in this case we found nearly 60%, of who one was an MDR case. Although adopting DFM would reduce this proportion to 19%, the use of a three-predictor screening algorithm together with DZM was almost as good as DFM alone. It's utility is whoever subject to HIV screening all TB suspects

Multidifferential study of identified charged hadron distributions in ZZ-tagged jets in proton-proton collisions at s=\sqrt{s}=13 TeV

Jet fragmentation functions are measured for the first time in proton-proton collisions for charged pions, kaons, and protons within jets recoiling against a $Z$ boson. The charged-hadron distributions are studied longitudinally and transversely to the jet direction for jets with transverse momentum 20 $< p_{\textrm{T}} < 100$ GeV and in the pseudorapidity range $2.5 < \eta < 4$. The data sample was collected with the LHCb experiment at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 1.64 fb$^{-1}$. Triple differential distributions as a function of the hadron longitudinal momentum fraction, hadron transverse momentum, and jet transverse momentum are also measured for the first time. This helps constrain transverse-momentum-dependent fragmentation functions. Differences in the shapes and magnitudes of the measured distributions for the different hadron species provide insights into the hadronization process for jets predominantly initiated by light quarks.Comment: All figures and tables, along with machine-readable versions and any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-013.html (LHCb public pages

Study of the B−→Λc+Λˉc−K−B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-} decay

The decay $B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-}$ is studied in proton-proton collisions at a center-of-mass energy of $\sqrt{s}=13$ TeV using data corresponding to an integrated luminosity of 5 $\mathrm{fb}^{-1}$ collected by the LHCb experiment. In the $\Lambda_{c}^+ K^{-}$ system, the $\Xi_{c}(2930)^{0}$ state observed at the BaBar and Belle experiments is resolved into two narrower states, $\Xi_{c}(2923)^{0}$ and $\Xi_{c}(2939)^{0}$, whose masses and widths are measured to be $$m(\Xi_{c}(2923)^{0}) = 2924.5 \pm 0.4 \pm 1.1 \,\mathrm{MeV}, \\ m(\Xi_{c}(2939)^{0}) = 2938.5 \pm 0.9 \pm 2.3 \,\mathrm{MeV}, \\ \Gamma(\Xi_{c}(2923)^{0}) = \phantom{000}4.8 \pm 0.9 \pm 1.5 \,\mathrm{MeV},\\ \Gamma(\Xi_{c}(2939)^{0}) = \phantom{00}11.0 \pm 1.9 \pm 7.5 \,\mathrm{MeV},$$ where the first uncertainties are statistical and the second systematic. The results are consistent with a previous LHCb measurement using a prompt $\Lambda_{c}^{+} K^{-}$ sample. Evidence of a new $\Xi_{c}(2880)^{0}$ state is found with a local significance of $3.8\,\sigma$, whose mass and width are measured to be $2881.8 \pm 3.1 \pm 8.5\,\mathrm{MeV}$ and $12.4 \pm 5.3 \pm 5.8 \,\mathrm{MeV}$, respectively. In addition, evidence of a new decay mode $\Xi_{c}(2790)^{0} \to \Lambda_{c}^{+} K^{-}$ is found with a significance of $3.7\,\sigma$. The relative branching fraction of $B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-}$ with respect to the $B^{-} \to D^{+} D^{-} K^{-}$ decay is measured to be $2.36 \pm 0.11 \pm 0.22 \pm 0.25$, where the first uncertainty is statistical, the second systematic and the third originates from the branching fractions of charm hadron decays.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-028.html (LHCb public pages