Effect of air pollution on onset of acute coronary syndrome in susceptible subgroups

While long-term exposure to air pollutants is associated with an increase in heart diseases and mortality, little information is available about the short-term effects of air pollution. This case-crossover study assessed the relationship of particulate matter (PM10) and carbon monoxide (CO) levels with hospital admission for acute coronary syndrome in Tehran, Islamic Republic of Iran. We interviewed 250 patients with a first episode of acute coronary syndrome and obtained data from hospital records and Tehran Air Quality Control Company. The risk of acute coronary syndrome was significantly associated with elevated concentrations of CO the day before the event (OR 1.18; 95% CI: 1.03-1.34) but not significantly with PM10 (OR 1.00; 95% CI: 0.99-1.02). Stratification by age, sex, diabetes, hypertension and smoking status did not affect the results, but women were more susceptible than men to CO levels (OR for women/men 1.68; 95% CI: 1.25-2.26)

Shape-adaptive metastructures with variable bandgap regions by 4D printing

This article shows how four-dimensional (4D) printing technology can engineer adaptive metastructures that exploit resonating self-bending elements to filter vibrational and acoustic noises and change filtering ranges. Fused deposition modeling (FDM) is implemented to fabricate temperature-responsive shape-memory polymer (SMP) elements with self-bending features. Experiments are conducted to reveal how the speed of the 4D printer head can affect functionally graded prestrain regime, shape recovery and self-bending characteristics of the active elements. A 3D constitutive model, along with an in-house finite element (FE) method, is developed to replicate the shape recovery and self-bending of SMP beams 4D-printed at different speeds. Furthermore, a simple approach of prestrain modeling is introduced into the commercial FE software package to simulate material tailoring and self-bending mechanism. The accuracy of the straightforward FE approach is validated against experimental observations and computational results from the in-house FE MATLAB-based code. Two periodic architected temperature-sensitive metastructures with adaptive dynamical characteristics are proposed to use bandgap engineering to forbid specific frequencies from propagating through the material. The developed computational tool is finally implemented to numerically examine how bandgap size and frequency range can be controlled and broadened. It is found out that the size and frequency range of the bandgaps are linked to changes in the geometry of self-bending elements printed at different speeds. This research is likely to advance the state-of-the-art 4D printing and unlock potentials in the design of functional metastructures for a broad range of applications in acoustic and structural engineering, including sound wave filters and waveguides

In vitro antiviral effects of Peganum harmala seed extract and its total alkaloids against Influenza virus

This research was aimed to evaluate the in vitro antiviral effect and the mechanism of the effect of Peganum. harmala seeds extract against influenza A virus infection using Madin-Darby canine kidney (MDCK) cells. In this research, ethyl alcohol extract of P. harmala seeds and its total alkaloids was prepared. The potential antiviral activity of the extract and its total alkaloids against influenza A/Puerto Rico/ 8/34 (H1N1; PR8) virus was assessed. The mode of action of the extract to inhibit influenza replication was investigated using virucidal activity, hemagglutination inhibition assay, time of addition assays, RNA replication, western blot analysis and RNA polymerase blocking assay. The crud extract of P. harmala seed and its total alkaloids showed the best inhibitory effect against influenza A virus replication in MDCK cells using MTT assay, TCID50 method and hemagglutination assay. Our results indicated that the extract inhibits viral RNA replication and viral polymerase activity but did not effect on hemagglutination inhibition and virucidal activity. This study showed that, in vitro antiviral activity of P. harmala seed extract against influenza virus is most probably associated with inhibiting viral RNA transcription. Therefore, this extract and its total alkaloid should be further characterized to be developed as anti-influenza A virus agent

The High Strain Rate Tension Behaviour of Pseudo-ductile High Performance Thin Ply Carbon/Glass Hybrid Composites

No abstract available

Investigating the pre-damaged PZT sensors under impact traction

Ships are usually under vibration, impact, and other kinds of static and dynamic loads. These loads arise from water flow across the hull or surfaces, the propeller cavitation, and so on. For optimal design purposes and reliable performance, experimental measurements are necessary. These sensors are often used under or near the water, working conditions that improve the risk of sensor damage. This paper aims at investigating, by the use of finite elements, the behavior of damaged piezoelectric sensors under traction and impact loads. The numerical method was calibrated using results available in the literature regarding piezoelectric and elastic plates with a central crack. After calibration, the simulation was used on two types of Lead-Zirconium-Titanium oxide (PZT) sandwich panel structures reinforced by aluminum skins. The results proved that the damage size and impact energy are important factors affecting the response of piezoelectric sensors; therefore, special attention might be considered when using these sensors for marine applications

Detection of barely visible impact damage in polymeric laminated composites using a biomimetic tactile whisker

This is a novel investigation on the possibility of detecting barely visible impact damage (BVID) in composite materials by whisking across the surface via tactile whisker sensors that resemble rats’ whiskers. A series of drop tower low-velocity impact tests were performed on quasi-isotropic composite plates. The plates were made from unidirectional T800 carbon/MTM49-3 epoxy prepregs with the stacking sequence of [45/0/90/−45]4S. Investigating the specimens’ surface by the naked eye does not reveal any significant damage, rather than a small dent on the surface, with no tangible difference in the different impact energy levels. Ultrasonic C-scan observations showed the existence of BVID in all the impact energy levels, with an increasing trend in the damage size by increasing the impact energy level. The collected data from whisker sensors were analyzed using the support vector machine classifier, based on their vibrational properties, to identify the impacted region and classify the impact severity. It was observed that after training for 13 whisker contacts, the BVID severity can be classified with an accuracy of 100%. This is offering a new BVID detection technique, with a high potential for automation and high reliability that can be used as an alternative or combined with available inspection systems

Regularity of the free boundary for a parabolic cooperative system

In this paper we study the following parabolic system Delta u - partial derivative(t)u = vertical bar u vertical bar(q-1) u chi({vertical bar u vertical bar > 0}), = (u(1), ... , u(m)), with free boundary partial derivative{vertical bar u vertical bar > 0). For 0Peer reviewe

Validity of noncycloplegic refraction in the assessment of refractive errors: the Tehran Eye Study

Purpose: To determine the sensitivity and specificity of noncycloplegic autorefraction for determining refractive status compared to cycloplegic autorefraction. Methods: The target population was noninstitutionalized citizens of all ages, residing in Tehran in 2002, selected through stratified cluster sampling. From 6497 eligible residents, 70.3% participated in the study, from August to November 2002. Here, we report data on 3501 people over the age of 5 years who had autorefraction with and without cycloplegia (two drops of cyclopentolate 1.0% 5 min apart, with autorefraction 25 min after the second drop). Results: Overall, the sensitivity of noncycloplegic autorefraction for myopia was 99%, but the specificity was only 80.4%. In contrast, the sensitivity for hyperopia was only 47.9%, but the specificity was 99.4%. At all ages, noncycloplegic autorefraction overestimated myopia and underestimated hyperopia. Overestimation of myopia was highest in the 21-30 and 31-40 year groups. Underestimation of hyperopia was high up to the age of 50 (20-40%), but decreased with age, to about 8% after the age of 50, down to almost 0% after 70. The difference in mean spherical equivalent with and without cycloplegia fell from 0.71 dioptres (D) in the 5-10 age group to 0.14D in those over 70. Conclusion: Use of noncycloplegic autorefraction in epidemiological studies leads to considerable errors relative to cycloplegic measurements, except in those over 50-60. The difference between cycloplegic and noncycloplegic measurements varies with age and cycloplegic refractive category, and there is considerable individual variation, ruling out adjusting noncycloplegic measurements to obtain accurate cycloplegic refractions

High-performance bio-inspired composite T-joints

This paper introduces a novel bio-inspired design strategy based on the optimised topology of bird bone's joint to improve the strength-to-weight ratio and damage tolerance of composite T-joints. Better structuring the constituents' materials near the sharp bends results in re-distribution of stress over a larger area and reduces the stress concentration. This is done by an integrally formed support structure that is spaced apart from the main body of the T-joint in the vicinity of the bend using a Polyvinyl Chloride (PVC) foam. The support structure acts as a buttress across the bend and improves the performance of the T-joint. The T-joints are fabricated using wet layup process, from 2/2 twill TC35-carbon fibre fabric/SR5550 epoxy resin, and are subjected to quasi-static and fatigue bending, and quasi-static tensile pull-out tests. The quasi-static results reveal that the bio-inspired T-joint design has huge improvements compared to a conventional T-joint in the elastic stiffness (over 60%), peak load (over 40%) and absorbed mechanical energy (over 130%). There is only 3% weight increase in the bio-inspired T-joint compared to the conventional one. The fatigue results show a significant improvement for the bio-inspired design proving the efficiency of the novel bio-inspired design for both quasi-static and cyclic loadings