UB Knightlines Fall 2010

The UB Knightlines newsletter for Fall 2010. This issue contains articles discussing UB's Chiropractic School working with Bridgeport Bluefish Baseball, UB's student Francisco Eguiguren leading the United Nations 7th Annual Youth Assembly, UB's program for helping disadvantaged children prepare for college, poetry at UB with Dick Allen, Ikuko Jassey, and Amy Nawroki, UB's increase in undergraduate enrollment, UB and UConn creating a pre-pharmacy program, campus participation in the "Walk Against Hunger", UB's new website, the appointment of Joseph Vittoria and C. Gene Kirby the the UB Board of Trustees, a computer model examining the treatment of sickle-cell anemia, SASD's designing of a winery tasting room in Italy, Jeffrey Johnson's reviews column being picked up by the Boston Globe, James Sagner's new book on Capital Management, Eric Lehman and Amy Nawrocki's book on Connecticut wine, Margaret Queenan winning the Connecticut Reading Association's Distinguished Literacy Award, alumni news, UB's alum Manute Bol who played for UB's Basketball team in the 1980s, UB's alum Sydney Parsons joining a German Basketball team, Stephanie Del Preore becoming the coach of women's Basketball and Cross Country, and other campus news

Prospectus, May 2, 1969

SG RAPS PROSPECTUS; Board Approves 2 New Programs; Board Meets Tuesday Over Student Rights; Permanent Officers Elected; Dr. Smith Resigns, Gets Doctorate; Applications Open For Art Exhibit; Editors\u27 Column; Readerspeak; Queen hopefuls Make Ready, BSA Pulls Out; Draft Counselor Opens At PC; Betas To State; Parkland\u27s Para-Professionals; Culture Abounds In Mrs. Clore\u27s Home; Gayle Wright: Won\u27t Accept Second Best; Counselors\u27 Corner...; GI\u27s Survive To Get Home; Klapperich Entered At Meet; IM Softball; Parkland\u27s Liz Sharp; New Bill Limits JC Recruiting; At PCKFA Meet: Kite Flying Instructors Battle April\u27s Breezes;https://spark.parkland.edu/prospectus_1969/1007/thumbnail.jp

Consequences of Internet Use in College Students

The purposes of the research project were to explore how much time college students spend on the Internet and the consequences for college students who use the Internet

Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours

Currently available human tumour cell line panels consist of a small number of lines in each lineage that generally fail to retain the phenotype of the original patient tumour. Here we develop a cell culture medium that enables us to routinely establish cell lines from diverse subtypes of human ovarian cancers with >95% efficiency. Importantly, the 25 new ovarian tumour cell lines described here retain the genomic landscape, histopathology and molecular features of the original tumours. Furthermore, the molecular profile and drug response of these cell lines correlate with distinct groups of primary tumours with different outcomes. Thus, tumour cell lines derived using this methodology represent a significantly improved platform to study human tumour pathophysiology and response to therapy

The Apache Point Observatory Galactic Evolution Experiment (APOGEE)

The Apache Point Observatory Galactic Evolution Experiment (APOGEE), one of the programs in the Sloan Digital Sky Survey III (SDSS-III), has now completed its systematic, homogeneous spectroscopic survey sampling all major populations of the Milky Way. After a three-year observing campaign on the Sloan 2.5 m Telescope, APOGEE has collected a half million high-resolution (R ~ 22,500), high signal-to-noise ratio (>100), infrared (1.51–1.70 μm) spectra for 146,000 stars, with time series information via repeat visits to most of these stars. This paper describes the motivations for the survey and its overall design—hardware, field placement, target selection, operations—and gives an overview of these aspects as well as the data reduction, analysis, and products. An index is also given to the complement of technical papers that describe various critical survey components in detail. Finally, we discuss the achieved survey performance and illustrate the variety of potential uses of the data products by way of a number of science demonstrations, which span from time series analysis of stellar spectral variations and radial velocity variations from stellar companions, to spatial maps of kinematics, metallicity, and abundance patterns across the Galaxy and as a function of age, to new views of the interstellar medium, the chemistry of star clusters, and the discovery of rare stellar species. As part of SDSS-III Data Release 12 and later releases, all of the APOGEE data products are publicly available

Clinical Utility of Random Anti–Tumor Necrosis Factor Drug–Level Testing and Measurement of Antidrug Antibodies on the Long-Term Treatment Response in Rheumatoid Arthritis

Objective: To investigate whether antidrug antibodies and/or drug non-trough levels predict the long-term treatment response in a large cohort of patients with rheumatoid arthritis (RA) treated with adalimumab or etanercept and to identify factors influencing antidrug antibody and drug levels to optimize future treatment decisions.  Methods: A total of 331 patients from an observational prospective cohort were selected (160 patients treated with adalimumab and 171 treated with etanercept). Antidrug antibody levels were measured by radioimmunoassay, and drug levels were measured by enzyme-linked immunosorbent assay in 835 serial serum samples obtained 3, 6, and 12 months after initiation of therapy. The association between antidrug antibodies and drug non-trough levels and the treatment response (change in the Disease Activity Score in 28 joints) was evaluated.  Results: Among patients who completed 12 months of followup, antidrug antibodies were detected in 24.8% of those receiving adalimumab (31 of 125) and in none of those receiving etanercept. At 3 months, antidrug antibody formation and low adalimumab levels were significant predictors of no response according to the European League Against Rheumatism (EULAR) criteria at 12 months (area under the receiver operating characteristic curve 0.71 [95% confidence interval (95% CI) 0.57, 0.85]). Antidrug antibody–positive patients received lower median dosages of methotrexate compared with antidrug antibody–negative patients (15 mg/week versus 20 mg/week; P = 0.01) and had a longer disease duration (14.0 versus 7.7 years; P = 0.03). The adalimumab level was the best predictor of change in the DAS28 at 12 months, after adjustment for confounders (regression coefficient 0.060 [95% CI 0.015, 0.10], P = 0.009). Etanercept levels were associated with the EULAR response at 12 months (regression coefficient 0.088 [95% CI 0.019, 0.16], P = 0.012); however, this difference was not significant after adjustment. A body mass index of ≥30 kg/m2 and poor adherence were associated with lower drug levels.  Conclusion: Pharmacologic testing in anti–tumor necrosis factor–treated patients is clinically useful even in the absence of trough levels. At 3 months, antidrug antibodies and low adalimumab levels are significant predictors of no response according to the EULAR criteria at 12 months

Portrait of John Thomas Hinkins

A copy photograph of a portrait of John Thomas Hinkins (1805–1883) State Library of Victoria—Chuck, T. (1872). John Thomas Hinkins [picture] / T. F. Chuck., The explorers and early colonists of Victori

Portrait of David Edgar

A copy photograph of a portrait of David Edgar, J.P. (1812–1894), [Merri Creek Orphanage???]—State Library of Victoria: Chuck, T. (1872). David Edgar [picture] / T. F. Chuck., The explorers and early colonists of Victori

King Billy and family at Mellool Station, New South Wales, ca. 1888 [picture] /

Title devised by cataloguer from inscription.; Inscriptions: "King Billy & Family from N.S.W. Mellool Station"--In ink on verso; Condition: Top right corner missing; tear on right edge; surface marks; yellowing.; Mellool Station was located on the north side of the Murray River close to Balranald, N.S.W. and Swan Hill, Vic.; Also available online at: http://nla.gov.au/nla.pic-vn6152058; Purchased from Douglas Stewart Fine Books, 2012