Embodiment, sound and visualization : a multimodal perspective in music education

Recently, many studies have emphasized the role of body movements in processing, sharing and giving meaning to music. At the same time, neuroscience studies, suggest that different parts of the brain are integrated and activated by the same stimuli: sounds, for example, can be perceived by touch and can evoke imagery, energy, fluency and periodicity. This interaction of auditory, visual and motor senses can be found in the verbal descriptions of music and among children during their spontaneous games. The question to be asked is, if a more multisensory and embodied approach could redefine some of our assumptions regarding musical education. Recent research on embodiment and multimodal perception in instrumental teaching could suggest new directions in musical education. Can we consider the integration between the activities of body movement, listening, metaphor visualization, and singing, as more effective than a disembodied and fragmented approach for the process of musical understanding

Factors affecting value industrial sector manufacturing companies registered consumption items on bei from 2018 to 2020

The purpose of this study is to investigate how business value is impacted by sound corporate governance, profitability, managerial ownership, institutional ownership, and firm size. A manufacturing firm in the consumer products industry is the focus of this study. The methodology used in this study is quantitative. The use of study variables to test hypotheses is emphasized in the quantitative technique of research. The secondary data used in this study came from the IDX-published summary of the yearly financial statements' outcomes. 43 manufacturing enterprises were chosen as the sample for this study using the purposive sampling method. Multiple linear regression analysis is the statistical technique used to assess statistical hypotheses. According to the study's findings, only one of the two hypotheses was confirmed, and the other was disproved. This study finds that management ownership, profitability, strong corporate governance, and business size have little bearing on the value of a firm, while institutional ownership affects firm value

A chiral electrokinetic chromatography method for the separation and quantitation of licarbazepine and licarbazepine acetate in pharmaceutical formulations and urine samples

S-Licarbazepine acetate is a new antiepileptic that is quickly metabolized to S-licarbazepine which is the active principle. In this study, an enantioselective methoddology enabling the simultaneous separation of licarbazepine acetate and licarbazepine by Electrokinetic Chromatography has been developed for the first time. After evaluating the potential of different chiral selectors, including bile salts and cyclodextrins, and selecting carboxymethyl-?-cyclodextrin as the most appropriate, a Box-Behnken experimental design was effectively applied for the optimization of the experimental separation conditions. Employing the best conditions, the four enantiomers were simultaneously separated (resolution values > 2.4) in less than 7 min. The evaluation of the figures of merit of the developed methodology showed to be suitable to determine both compounds. Finally, the EKC method was successfully applied in three different studies: (i) the quality control of the enantiopure pharmaceutical formulation, (ii) the monitoring of the stability and gastrointestinal digestion of the pharmaceutical formulation through a hydrolysis study, and (iii) the determination of licOH enantiomers in urine samples

Enantiomeric determination of econazole and sulconazole by electrokinetic chromatography using hydroxypropyl-b-cyclodextrin combined with ionic liquids based on L-lysine and Ly-glutamic acid

Two analytical methodologies based on the combined use of hydroxypropyl-beta-cyclodextrin and two different amino acid-based chiral ionic liquids (tetrabutylammonium-L-lysine or tetrabutylammonium-L-glutamic acid) in electrokinetic chromatography were developed in this work to perform the enantios-elective determination of econazole and sulconazole in pharmaceutical formulations. The influence of different experimental variables such as buffer concentration, applied voltage, nature and concentration of the ionic liquid, temperature and injection time, on the enantiomeric separation was investigated. The combination of hydroxypropyl-beta-cyclodextrin and tetrabutylammonium-L-lysine under the optimized conditions enabled to achieve the enantiomeric determination of both drugs with high enantiomeric resolution (3.5 for econazole and 2.4 for sulconazole). The analytical characteristics of the developed methodologies were evaluated in terms of linearity, precision, LOD, LOQ and recovery showing good performance for the determination of both drugs which were successfully quantitated in pharmaceutical formulations. This work reports the first analytical methodology enabling the enantiomeric determination of sulconazole in pharmaceutical formulations

Chiral micellar electrokinetic chromatography

The potential of Micellar Electrokinetic Chromatography to achieve enantiomeric separations is reviewed in this article. The separation principles and the most frequently employed separation strategies to achieve chiral separations by Micellar Electrokinetic Chromatography are described. The use of chiral micellar systems alone or combined with other micellar systems or chiral selectors, as well as of mixtures of achiral micellar systems with chiral selectors is discussed together with the effect of different additives present in the separation medium. Indirect methods based on the derivatization of analytes with chiral derivatizing reagents and the use of achiral micelles are also considered. Preconcentration techniques employed to improve sensitivity and the main approaches developed to facilitate the coupling with Mass Spectrometry are included. The most recent and relevant methodologies developed by chiral Micellar Electrokinetic Chromatography and their applications in different fields are presented

Determinantes da participação dos beneficiários no programa do Rendimento Mínimo Garantido no mercado de trabalho

We present micro econometric evidence on the determinants of the probability that beneficiaries of the Minimum Guaranteed Income (MGI) participate in market production or in home production. We use a micro data set which covers all the beneficiaries of the MGI, up to 2001, for the Portuguese Region with the highest incidence of this program, namely, the Azores. We find striking diferences between women’s and men’s behaviour with respect to labour market participation decisions, with women heavily specialized in home production and men in market production. The probability of participating decreases with income support. Moreover, there are several aspects of household demographics that matter to female participation decisions. Therefore, policies designed to promote female labour supply should not be of the type one size fits all and must improve the terms of trade between home production and market production for women

Use of choline chloride-D-sorbitol deep eutectic solvent as additive in cyclodextrin-electrokinetic chromatography for the enantiomeric separation of lacosamide

The potential of chiral deep eutectic solvents to enhance the chiral discrimination in Cyclodextrin-Electrokinetic Chromatography is demonstrated in this work. With this aim, a method enabling the enantiomeric separation of the antiepileptic drug lacosamide was developed. After a screening using 12 cyclodextrin derivatives, succinyl-B-CD was chosen due to its higher discrimination power to separate lacosamide enantiomers. The effect of different variables, such as cyclodextrin concentration, buffer concentration, temperature and separation voltage, on the enantiomeric separation of lacosamide, was studied. As the maximum enantiomeric resolution achieved under the optimized conditions was lower than 1.5, the effect of the addition of methanol or different deep eutectic solvents (choline chloride - ethylene glycol, choline chloride - urea, choline chloride - D-glucose, and choline chloride - D-sorbitol) as additives to the separation medium was investigated. The best results in terms of enantiomeric resolution and analysis time were obtained using choline chloride - D-sorbitol at a 0.5 % (w/v) in a 100 mM borate buffer (pH 9.0) with 18 mM succinyl-B-CD. Under these conditions, lacosamide enantiomers were separated with a resolution value of 2.8. Analytical characteristics of the developed method were evaluated and demonstrated to be adequate to apply the methodology to the enantiomeric analysis of lacosamide in a pharmaceutical formulation

Advances in the determination of non-protein amino acids in foods and biological samples by capillary electrophoresis

There are hundreds of non-protein amino acids whose importance in food and biological matrices is still unknown. Many of these compounds mainly exist in food as products formed during food processing, as metabolic intermediates or as additives to increase nutritional and functional properties of food. Moreover, they have also demonstrated to play an important role in the pharmaceutical and clinical fields since they may be used therapeutically in the treatment of some pathologies and their levels may be related with some diseases. For this reason, the analysis of non-protein amino acids may provide relevant information in the food and biological fields. This article reviews the most recent advances in the development of analytical methodologies employing capillary electrophoresis for the achiral and chiral analysis of non-protein amino acids in food and biological samples. With this aim, the most relevant information concerning the separation and detection of these compounds by capillary electrophoresis is discussed and detailed experimental conditions under which their determination was achieved in food and biological samples are given covering the period of time from 2015 to 2018

Impact of alternative carbon sources and antifungal treatment on Candida glabrata biofilms transcription profile

Candida glabrata is considered a major opportunistic fungal pathogen of humans and has emerged as a leading cause of nosocomial fungal infections. The capacity of this yeast species to cause infections is dependent on the ability to grow within the human host environment and to assimilate the carbon sources available. Previous studies have suggested that Candida can encounter glucose-poor microenvironments during infection and that the ability to use alternative non-fermentable carbon sources, such as carboxylic acids, contributes to the virulence of these fungi. Our recent study (Mota et al., 2015) supported this view by demonstrating that acetic acid influences C. glabrata behavior in biofilm formation, antifungal drug resistance and phagocytosis; and suggesting a potential role of putative carboxylate transporters on these processes. In order to extend our studies and provide a comprehensive view of the C. glabrata biofilms’ response to alternative carbon sources and antifungal treatment, we performed comparative transcriptomics analyses using RNA-sequencing. Our data support the view that adaptative responses of Candida cells to the types of carbon source present in host niches affects the virulence of these fungal cells through multifarious mechanisms (Brown et al., 2014). Finally, elucidating the effect of local nutrients and pH environment on drug resistance can potentially provide new and effective treatment strategies for C. glabrata infections such as vaginal candidiasis.info:eu-repo/semantics/publishedVersio