Comparison of Knock Indexes Based on CFD Analysis

Abstract Recent trends in gasoline engines, such as downsizing, downspeeding and the increase of the compression ratio make knocking combustions a serious limiting factor for engine performance. A detailed analysis of knocking events can help improving the engine performance and diagnostic strategies. An effective way is to use advanced 3D Computational Fluid Dynamics (CFD) simulation for the analysis and prediction of the combustion process. The effects of Cycle to Cycle Variation (CCV) on knocking combustions are taken into account, maintaining a \RANS\ (Reynolds Averaged Navier-Stokes) \CFD\ approach, while representing a complex running condition, where knock intensity changes from cycle to cycle. The focus of the numerical methodology is the statistical evaluation of the local air-to-fuel and turbulence distribution at the spark plugs and their correlation with the variability of the initial stages of combustion. \CFD\ simulations have been used to reproduce knock effect on the cylinder pressure trace. For this purpose, the \CFD\ model has been validated, proving its ability to predict the combustion evolution with respect to \SA\ variations, from non-knocking up to heavy knocking conditions. The pressure traces simulated by the \CFD\ model are then used to evaluate cylinder pressure-based knock indexes. Since the model is able to output other knock intensity tracers, such as the mass of fuel burned in knocking mode, or the local heat transferred to the piston, knock indexes based on the cylinder pressure trace can be related to parameters only available in a simulation environment, that are likely to be more representative of the actual knock intensity, with respect to the local pressure trace for the sensor position. The possibility of simulating hundredths of engine cycle allows using the methodology to compare the indexes quality (correlation with actual knock intensity) on a statistical base

Finite-top-mass effects in NNLO Higgs production

We construct an accurate approximation to the exact NNLO cross section for Higgs production in gluon-gluon fusion by matching the dominant finite top mass corrections recently computed by us to the known result in the infinite mass limit. The ensuing corrections to the partonic cross section are very large when the center of mass energy of the partonic collision is much larger than the Higgs mass, but lead to a moderate correction at the percent level to the total Higgs production cross section at the LHC. Our computation thus reduces the uncertainty related to these corrections at the LHC from the percent to the per mille level.Comment: 4 pages, 4 figures; to be published in the proceedings of QCD2008. Reference adde

Transient Spark Advance Calibration Approach

Combustion control is assuming a crucial role in reducing engine tailpipe emissions while maximizing performance. The effort in the calibration of control parameters affecting the combustion development can be very demanding. One of the most effective factors influencing performance and efficiency is the combustion phasing: in Spark Ignition (SI) engines it is affected by factors such as Spark Advance (SA), Air-Fuel Ratio (AFR), Exhaust Gas Recirculation (EGR), Variable Valve Timing (VVT). SA optimal values are usually determined by means of calibration procedures carried out in steady state conditions on the test bench by changing SA values while monitoring performance indicators, such as Brake and Indicated Mean Effective Pressure (BMEP, IMEP), Brake Specific Fuel Consumption (BSFC) and pollutant emissions. The effect of SA on combustion is stochastic, due to the cycle-to-cycle variation: the analysis of mean values requires many engine cycles to be significant of the performance obtained with the given control setting. Moreover, often the effect of SA on engine performance must be investigated for different settings of other control parameters (EGR, VVT, AFR). The calibration process is time consuming involving exhaustive tests followed by off-line data analysis. This paper presents the application of a dynamic calibration methodology, with the objective of reducing the calibration duration. The proposed approach is based on transient tests, coupled with a statistical investigation, allowing reliable performance analysis even with a low number of engine cycles. The methodology has been developed and tested off-line, then it has been implemented in Real-Time. The combustion analysis system has been integrated with the ECU management software and the test bench controller, in order to perform a fully automatic calibration. © 2013 The Authors

A Markov-model simulation of IVF programs for PCOS patients indicates that coupling myo-Inositol with rFSH is cost-effective for the Italian Health System

Accumulating evidence suggests that oral supplementation with myo-Inositol (myo-Ins) is able to reduce the amount of gonadotropins and days of controlled ovarian hyperstimulation (COS) necessary to achieve adequate oocyte maturation in assisted reproduction technology (ART) protocols, particularly in women affected by polycystic ovary syndrome (PCOS). We used computational calculations based on simulation modellings. We simulated in vitro fertilization (IVF) procedures-with or without intracytoplasmic sperm injection (ICSI)-with 100,000 virtual patients, accounting for all the stages of the entire IVF procedure. A Monte Carlo technique was used to account for data uncertainty and to generate the outcome distribution at each stage. We considered virtual patients with PCOS undergoing IVF cycles to achieve pregnancy. Computational data were retrieved from clinical experience and published data. We investigated three parameters related to ART protocols: cost of single procedure; efficacy to achieve ongoing pregnancy at 12 gestational weeks; overall cost per single pregnancy. The administration of oral myo-Ins during COH protocols, compared to the standard COH with recombinant Follicle Stimulating Hormone (rFSH) only, may be considered a potential strategy to reduce costs of ART for the Italian Health System

Differential expression of sphingolipid metabolizing enzymes in spontaneously hypertensive rats: a possible substrate for susceptibility to brain and kidney damage

Alterations in the metabolism of sphingolipids, a class of biologically active molecules in cell membranes with direct effect on vascular homeostasis, are increasingly recognized as important determinant in different vascular disorders. However, it is not clear whether sphingolipids are implicated in the pathogenesis of hypertension-related cerebrovascular and renal damage. In this study, we evaluated the existence of possible abnormalities related to the sphingolipid metabolism in the brain and kidneys of two well validated spontaneously hypertensive rat strains, the stroke-prone (SHRSP) and the stroke-resistant (SHRSR) models, as compared to the normotensive Wistar Kyoto (WKY) rat strain. Our results showed a global alteration in the metabolism of sphingolipids in both cerebral and renal tissues of both hypertensive strains as compared to the normotensive rat. However, few defects, such as reduced expression of enzymes involved in the metabolism/catabolism of sphingosine-1-phosphate and in the de novo biosynthetic pathways, were exclusively detected in the SHRSP. Although further studies are necessary to fully understand the significance of these findings, they suggest that defects in specific lipid molecules and/or their related metabolic pathways may likely contribute to the pathogenesis of hypertensive target organ damage and may eventually serve as future therapeutic targets to reduce the vascular consequences of hypertension

Predictors of Early Thrombotic Events in Adult Patients with Acute Myeloid Leukemia: A Real-World Experience

Information regarding the incidence and the prognostic impact of thrombotic events (TE) in non-promyelocytic acute myeloid leukemia (AML) is sparse. Although several risk factors associated with an increased risk of TE development have been recognized, we still lack universally approved guidelines for identification and management of these complications. We retrospectively analyzed 300 consecutive patients with newly diagnosed AML. Reporting the incidence of venous TE (VTE) and arterial TE (ATE) was the primary endpoint. Secondarily, we evaluated baseline patient- and disease-related characteristics with a possible influence of VTE-occurrence probability. Finally, we evaluated the impact of TE on survival. Overall, the VTE incidence was 12.3% and ATE incidence was 2.3%. We identified three independent predictors associated with early-VTE: comorbidities (p = 0.006), platelets count >50x10e9/L (p = 0.006), and a previous history of VTE (p = 0.003). Assigning 1 point to each variable, we observed an overall cumulative incidence of VTE of 18.4% in the high-risk group (>2 points) versus 6.4% in the low-risk group (0–1 point), log-rank = 0.002. Overall, ATE, but not VTE, was associated with poor prognosis (p < 0.001). In conclusion, TE incidence in AML patients is not negligible. We proposed an early-VTE risk score that could be useful for a proper management of VTE prophylaxis

Incidentally discovered pelvic paraganglioma: A case report

Paragangliomas (PGL) are rare neuroendocrine tumors of the autonomic nervous system originating from paraganglia. Although PGL may arise at any site where physiologic paraganglionic tissue exists, the localization in the small pelvis is extremely rare. PGL may be hormonally active and release surplus catecholamines into the blood or inactive. The asymptomatic cases pose a diagnostic dilemma. We describe the case of an asymptomatic PGL arising in the small pelvis sidewall presenting as an incidentally discovered asymptomatic mass in a male subject

The contribution of the four-parton final states to gamma* gamma* -> hadrons

In the analysis of the total cross section for the gamma* gamma* -> hadrons process, we include the four parton final states, which are part of the O(alpha_s^2) corrections. The four-parton final states contain the diagrams with gluon exchange in the crossed channel, which constitute the leading order of the BFKL resummation. We show that the diagrams with gluon exchange in the crossed channel play an important role in the large Y region, however their contribution to the cross section must be evaluated exactly. In fact, the high-energy limit, which constitutes the kinematic framework of the BFKL resummation, is not sufficiently accurate at LEP2 energies. The inclusion of the diagrams with gluon exchange in the crossed channel reduces the discrepancy between the theory and the LEP2 data collected by the L3 Collaboration, but the data still lie above the theory, even allowing for a large scale uncertainty in the theory. Thus, in order to describe accurately the data for gamma* gamma* -> hadrons in the large Y region, corrections of an order higher than O(alpha_s^2) seem to be necessary.Comment: 32 pages, 10 figures, published versio

In BCR-ABL1 Positive B-Cell Acute Lymphoblastic Leukemia, Steroid Therapy Induces Hypofibrinogenemia

Hypofibrinogenemia (HF) in adult acute lymphoblastic leukemia (ALL) of B lineage is uncommon and mostly associated with asparaginase (ASP) delivery. Since we noticed a significant reduction in fibrinogen (FBG) plasma levels even before the first ASP dose, we aim to assess the levels of FBG during induction treatment and explore if the FBG fall correlated with therapies other than asparaginase and/or specific leukemia biological features. We retrospectively analyzed FBG levels in 115 patients with B-ALL. In 74 (64%) out of 115 patients FBG decline occurred during the steroid prephase. In univariate analysis, such a steroid-related HF was significantly associated with BCR-ABL1 rearrangement (p = 0.00158). None of those experiencing HF had significant modifications of liver function tests during induction treatment. Our retrospective study suggests that in B-ALL, steroid therapy can also induce HF and that such an event is preferentially observed in patients carrying BCR-ABL1 rearrangements. The pathogenesis of this phenomenon is still unclear. We attempt to explain it by applying the International Society of Thrombosis and Hemostasis-Disseminated Intravascular Coagulation score (ISTH-DIC score); nonetheless additional studies are needed to clarify further the mechanisms of HF in this subset of patients

Higgs production via gluon-gluon fusion with finite top mass beyond next-to-leading order

We present a computation of the cross section for inclusive Higgs production in gluon-gluon fusion for finite values of the top mass in perturbative QCD to all orders in the limit of high partonic center-of-mass energy. We show that at NLO the high energy contribution accounts for most of the difference between the result found with finite top mass and that obtained in the limit of infinite top mass. We use our result to improve the known NNLO order result obtained with infinite top mass. We estimate the effect of the high energy NNLO top mass dependence on the K factor to be of the order of a few per cent.Comment: 20 pages, 5 figures, latex with epsfi