Comparison of Manual Tools, Ultrasonic and Erbium-Doped Yttrium Aluminum Garnet (Er:YAG) Laser on the Debridement Effect of the Surface of the Root of Teeth Suffering from Periodontitis

Introduction: Periodontal diseases are considered as some of the most common reasons of teeth loss, which occur due to the aggregation of microbial plaque and other precipitations on the dental surfaces. In this study, the scaling effect using manual tools, ultrasonic machine and Erbium-Doped Yttrium Aluminum Garnet (Er:YAG)laser on the connection of the human gums connective tissue cells on the root surface of the teeth suffering from severe periodontitis will be compared.  Methods: After removal of the big precipitations with manual tools, Er:YAG laser light emission of Photona machine is used with respect to the following characteristics: wavelength: 2940μm, each pulse: 100mJ, frequency: 10 pulse/sec, optic fiber with cross section 0.5x1.65mm, fiber tip angle with root surface: 15-20 degrees with non-contact mode, 1.5mm farther than the root surface and pulse duration 230 very short. The gingival fibroblast cellular was incubated as a sample of the human gums connective tissue cells under 37C. These cells were departed from the culture medium after the cellular reproduction in the third passage.On the 3rd day after incubation, the gingival fibroblast cells morphology was studied by Scanning Electron Microscopy (SEM). Results: The results of SEM images in the present study indicated the spread fibroblast cells with philopodia were found  in all of 5 groups; untreated healthy group (control), untreated group suffering from periodontitis, the scaling effect using manual tools (Scaled Gracey), ultrasonic machine and Er:YAG laser. There is a meaningful difference among the three treatment groups (P<0.001) in the numbers of the fibroblast cells, while all the four treated groups had a meaningful difference with the positive control group (P < 0.001).Conclusion: The present study indicated that although various dental surfaces cleaning methods may be different in other aspects, but are similar concerning the fibroblasts morphology. Also in addition to power, laser emission time may also be effective in the cells morphology results

Brinzolamide-Loaded Nanoemulsions: In vitro Release Evaluation

The aim of this investigation was to design and develop nanoemulsions (NEs) as novel ophthalmic delivery systems for brinzolamide (BZD). Phase behavior of quaternary systems composed of triacetin and CapryolTM 90 (selected oils, screened through the solubility studies), various surfactants (namely, Cremophor RH 40, Brij 35, Labrasol and tyloxapol), Transcutol P (as co-surfactant) and water at different surfactant/co-surfactant weight ratios (Rsm) was investigated by the construction of phase diagrams. Formulations were taken from the o/w NE region on the phase diagrams, depending on the extent of NE domain. The spontaneous emulsification method was used to prepare various formulations containing 0.4 wt% of the drug. The nanosized character of NEs was evaluated, the cumulative drug release from of the selected formulations was determined for a period of 6 h, using a dialysis sac technique and the release efficiency for NEs was calculated. The therapeutic efficacy of the selected BZD-loaded NEs to lower the IOP was assessed by the calculation of various pharmacodynamic parameters (ie., Emax, Tmax AUC0-6h). In all cases, the average size of the droplets was found to be less than 40 nm. In vitro release studies indicated that the release efficiency in most of the NEs was higher as compared to the BZD ophthalmic suspension. Comparison of the pharmacodynamics parameters confirmed the equivalent efficacy of most BZD formulations

Advances in the Diagnosis of GERD Using the Esophageal pH Monitoring, Gastro-Esophageal Impedance-pH Monitoring, And Pitfalls

PH monitoring is not capable of detecting all types of reflux, especially when the amount of acid is very low or not at all in the refluxate. Multichannel intraluminal impedance-pH monitoring (MII-pH) is used as a new method to assess bolus transport. The types of reflexes including acid, weak acid and weak alkaline MII-pH is capable of distinguishing more reflux episodes based upon use of physical and chemical parameters of the refluxate, leads to a diagnosis of normal acid reflux from abnormal nonacidic reflux. 24-h oesophagal pH monitoring can be effectively used to assess the potential relationship between symptoms and refluxes. MII-pH is capable of distinguishing more reflux episodes based upon use of physical and chemical parameters of the refluxate, leads to a diagnosis of normal acid reflux from abnormal nonacidic reflux. It can be used to confirm gastro-oesophagal reflux episodes, where has a sensitivity and specificity for diagnosing GERD in comparison with endoscopy or pH-metry

CLINICAL CHARACTERISTICS OF ERECTILE DYSFUNCTION IN PERSIAN MEDICINE

Introduction: erectile dysfunction (ED) is a growing problem worldwide. It is age related and the use of complementary and alternative medicine (CAM) by older patients to improve their sexual function has become common. Since Persian Medicine (PM) is one of three popular medical schools with its special view point of etiology, classification of disease, diagnostic methods and therapeutic approaches; current study is designed to clarify clinical characteristics of ED in PM. Methods: information on erectile dysfunction, sexual dysfunction and their related signs, symptoms and clinical tests was obtained from original documents and manuscripts; Moreover, we investigated the utilization of these findings in conventional medicine through searching PubMed, and Google Scholar databases. Results: there is a rich human heritage still unstudied in PM dating back to ancient times. In PM documents, 35 clinical finding of ED were identified, about half of theme is objective, and while we still use most of Subjective ones in current patient report outcomes. Conclusions: diagnosis of ED in PM is logically like conventional medicine; however, its classification of ED is different because PM believes in etiology, therefore due to lack of research on clinical assessment methods, more investigations are required to evaluate PM diagnostic procedures and treatment tactics. Keywords: Persian Medicine; Arabic Medicine; Unani Medicine; Erectile Dysfunction; Impotence; Signs and Symptom

Geometry and mechanics of the active fault system in western Slovenia

Western Slovenia is part of an actively deforming region accommodating anticlockwise rotation of Adria and its continuous collision with Eurasia. The geometry of the active faulting system in this plate boundary is not well defined. In this study, detailed analysis of earthquake activity was performed with relocation of earthquakes in the period between 2006 and 2017. With inspection of the waveform data, slight temporal clustering of activity was observed. To increase the detection rate of microearthquakes we used a matched filter detection algorithm method. Templates of earthquakes were created and a database of continuous waveform data within the period 2006\u20132017 was investigated. As a result, high temporal correlation allowed us to identify swarms and earthquake sequences that affected the active fault system in the study region. Relocated seismicity allowed us to constrain the geometry of 5 nearly parallel faults, namely: Ravne, Idrija, Predjama, Selce and Ra\u161a faults. All these faults do have an expression in the geomorphology and reach a seismogenic depth of up to 20 km. Vertical and along strike extents of these active faults can favour earthquakes of moment magnitude equal to 7 or larger. The most recent large earthquake that occurred in this region is the 1511 earthquake with a magnitude 6.8. The leading fault in the system being the Idrija right-lateral strike-slip fault, experiences earthquake activity from 5 to 20 km on its northern segment, while on its southern segment no earthquake activity is detected over the decade of observations. We show that the interseismic loading on the southern segment of Idrija fault is likely unclamping the locked adjacent faults promoting the observed bursts of seismicity. Moreover, in 2009 the Predjama fault accommodated a sudden increase of the surface deformation at the extensometer accompanied by a simultaneous swarm activity at its seismogenic depth. This behaviour might correspond to velocity strengthening and weakening processes taking place at both the surface and depth terminations of a locked vertical fault. These processes can be driven by a slow-slip event on the deeper part of Idrija fault that would generate a temporary acceleration of the interseismic loading rate along with a change within the fluid circulation

Tacrolimus phospholipid based nanomicelles as a potential local delivery system for corneal neovascularization therapy

Introduction: Tacrolimus, an immunosuppressive agent, has been shown to be an effective treatment against corneal neovascularization (CNV). However, the poor solubility of this compound restricts its clinical application. The goal of this study was to incorporate tacrolimus into phospholipid-bile salt mixed micelles. Methods and Results: Tacrolimus loaded phospholipid-bile salt mixed micelles were prepared, employing three different methods of direct dispersion, thin film hydration, and remote film loading, and the effects of various formulation parameters (type of dispersion medium, phospholipid to bile salt molar ratio, lipid-to-drug (L/D) molar ratio, time of probe sonication, and type of bile salt) on the physicochemical characteristics of the mixed micelles were assessed. Remote film loading method indicated higher efficacy for drug entrapment in comparison to the other methods. Encapsulation of tacrolimus within the micelles increased remarkably by the use of sodium taurocholate (NaTC) as bile salt, higher phospholipid percentage, and increasing the total lipid level. Atomic force microscopy (AFM) studies confirmed the size and size distribution of the mixed micelles and their spherical morphology. It was observed that release of tacrolimus from the micelles was in a controlled manner, without an initial burst. Conclusions: By adjusting process and formulation factors, phospholipid-bile salt mixed micelles with high entrapment efficiency of (99.5 %) and controlled release behavior were achieved, which possess great potential to be valuable carriers for ocular delivery of tacrolimus for the treatment of CNV.                                                                                                                                       &nbsp

Paleoseismological and morphological evidence of slip rate variations along the North Tabriz fault (NW Iran)

International audienceNorthwest Iran is characterized by a high level of historical and instrumental seismicity related to the ongoing convergence between the Arabian and Eurasian plates. In this region, the main right-lateral strike-slip fault known as the North Tabriz fault (NTF) forms the central portion of a large crustal fault system called the Tabriz fault system (TFS). The NTF is a major seismic source along which at least three strong and destructive earthquakes have occurred since 858 AD. The two most recent destructive seismic events occurred in 1721 AD and 1780 AD, rupturing the SE and NW fault segments, respectively. This paper reports paleoseismological and quantitative geomorphologic investigations on the SE segment of the NTF, between the cities of Bostanabad and Tabriz. These observations help to improve our understanding of the seismic hazard for Tabriz city and its surrounding areas. Our field investigations revealed evidence of successive faulting events since the Late Quaternary. Paleoseismic investigations indicate that since 33.5 kyr, the SE segment of the NTF has experienced at least three major (M>7.5) seismic events, including the 1721 AD earthquake (M=7.6–7.7). Along the NW segment of the fault, however, our results suggest that the amount of strong (M~7.5) seismic events during the same period is significantly greater than along the SE segment. One possible explanation of such a difference in seismic activity is that the Late Quaternary-Holocene coseismic slip rate is decreasing along the NTF from the northwest to the southeast. This explanation contradicts the former hypothesis of a constant slip rate along the whole length of the NTF. In addition, more distributed deformation along several parallel fault branches, in a wider fault zone of the SE segment of the NTF may be considered as additional evidence for the estimation of lower rate of deformation along the fault segment. Such a slip distribution pattern can explain the existence of smaller (~300 m) Pliocene-Quaternary cumulative dextral offsets along the SE fault segment than the measured cumulative offsets along the NW segment (~800 m) of the NTF

Effect of ointment with cabbage, pomegranate peel, and common plantain on wound healing in male rat

زمینه و هدف: تحقیقات بالینی و تجربی متعدد اثربخشی گیاهان دارویی بر روند ترمیم زخم را به اثبات رسانده اند و انار، بارهنگ و کلم از جمله گیاهان مفید در طب سنتی هستند که برای التیام زخم مورد استفاده قرار گرفته اند؛ لذا این مطالعه با هدف بررسی اثر بخشی کرم با اختلاط گیاهان کلم برگ، پیه سفید انار و بخش های هوایی بارهنگ بر زخم پوستی در موش صحرایی طراحی و اجرا شد. روش بررسی: در این مطالعه تجربی 24 راس موش صحرایی بصورت تصادفی به 4 گروه 6 تایی شامل کنترل (سرم فیزیولوژیک)، شاهد (تحت درمان با پتادین)، کنترل مثبت (تحت درمان با فنی توئین) و گروه تجربی تحت درمان با کرم با اختلاط پیه انار، بارهنگ و کلم برگ تقسیم شدند. پس از ایجاد زخم در شرایط غیرعفونی و یکسان، حیوانات بصورت روزانه تحت درمان قرار گرفتند و در روزهای 3، 6، 9 و 14 پس از ایجاد زخم، درصد بهبودی زخم محاسبه گردید. یافته ها: درصد بهبودی زخم در گروه دریافت کننده کرم درمانی در روز های 3، 6، 9 و 14 نسبت به گروه کنترل افزایش معنی داری نشان داد (

Adipose Derived Stem Cells Affect miR-145 and p53 Expressions of Co-Cultured Hematopoietic Stem Cells

In this article published in Cell J, Vol 19, No 4, Jan-Mar (Winter) 2018, on pages 654-659, the authors found that Figures 2 and 3 had some errors that accidentally happened during organizing figures. Because of mislabeling some images and saving them in an incorrect folder, the following figures' legends are corrected.The authors would like to apologize for any inconvenience

Evaluating fatigue behavior of asphalt binders and mixes containing Date Seed Ash

Fatigue is one of the most occurring distresses in asphalt pavements. Asphalt binder plays a critical role in fa­tigue behavior of asphalt mixes. Modelling and predicting fatigue behavior of binders will result in more fatigue resistant mixes. In this research, possibility of using Date Seed Ash alongside two commonly used additives (namely, a siliceous and a limestone) as bitumen modifier were investigated. Then, the influence of these additives on fatigue behavior of asphalt binders and mixes was investigated. Linear Amplitude Sweep (LAS) test was carried out and Viscoelastic Con­tinuum Damage (VECD) parameter was determined. In addition, Indirect Tensile Fatigue Test (ITFT) was performed on mixes containing these additives. Correlation equations were developed to link fatigue behavior of binders to those of mixes. The results showed acceptable agreement between binders and mixes fatigue testing results. In addition, with predicted models it was able to obtain the asphalt binders contribution to mixes fatigue resistance. However, in the case of ash modified samples, no good correlation was observed between fatigue behavior of binders and that of mixes