An Exploratory Survey of Self-Reported Joint Pain Among College Students

Topics in Exercise Science and Kinesiology Volume 4: Issue 1, Article 13, 2023. Prior research has shown that college students are a unique subset of our global population that commonly experience stresses and strains to their musculoskeletal system as they complete their traditional coursework. Most of this population is viewed as healthy since their joints and skeletal systems have yet to be subjected to the levels of wear and tear of their elder constituents. However, there are still individuals within this population that often report experiencing some level of joint pain or discomfort that would not fall underneath the classic diagnoses of arthritis or other severe joint-related pathologies. The purpose of this descriptive study was to examine joint pain in non-clinical college students and some of the potential contributions to that pain. An email was sent to the entire current student population at a southeastern university in the United States inviting them to complete an online questionnaire about joint pain. Prior to its distribution, a pilot version of the questionnaire was distributed and tested to ensure readability and to establish content validity. The final version of the questionnaire was distributed twice during the fall 2021 semester. From the total number of students who may have received the email invitation (n = 18,985), 211 students completed the survey for a response rate of 1.11%. Of the 116 respondents who had never seen a healthcare professional for a joint injury or joint surgery, 72 reported current joint pain (62%). Thirty participants (47.6%) reported that the duration of their pain has lasted longer than three months. Participants reported cervical pain (76%), lumbar spine pain (84.8%), knee pain (65.1%), and hip or pelvis pain (76.2%) as the most frequent joints being affected. While typically considered healthy, college students are experiencing joint health-related pain and discomfort. Due to lack of past and current research on joint health in college students, the results of this exploratory study may begin to shed light on the need to implement and fund more proactive methods to best address this emerging issue

Determinants of risk: Exposure and vulnerability

Many climate change adaptation efforts aim to address the implications of potential changes in the frequency, intensity, and duration of weather and climate events that affect the risk of extreme impacts on human society. That risk is determined not only by the climate and weather events (the hazards) but also by the exposure and vulnerability to these hazards. Therefore, effective adaptation and disaster risk management strategies and practices also depend on a rigorous understanding of the dimensions of exposure and vulnerability, as well as a proper assessment of changes in those dimensions. This chapter aims to provide that understanding and assessment, by further detailing the determinants of risk as presented in Chapter 1. The first sections of this chapter elucidate the concepts that are needed to define and understand risk, and show that risk originates from a combination of social processes and their interaction with the environment (Sections 2.2 and 2.3), and highlight the role of coping and adaptive capacities (Section 2.4). The following section (2.5) describes the different dimensions of vulnerability and exposure as well as trends therein. Given that exposure and vulnerability are highly context-specific, this section is by definition limited to a general overview (a more quantitative perspective on trends is provided in Chapter 4). A methodological discussion (Section 2.6) of approaches to identify and assess risk provides indications of how the dimensions of exposure and vulnerability can be explored in specific contexts, such as adaptation planning, and the central role of risk perception and risk communication. The chapter concludes with a cross-cutting discussion of risk accumulation and the nature of disasters

Minactivin expression in human monocyte and macrophage populations

Adherent monolayer cultures of human blood monocytes, peritoneal macrophages, bone marrow macrophages, and colonic mucosa macrophages were examined for their ability to produce and secrete minactivin, a specific inactivator of urokinase-type plasminogen activator. All except colonic mucosa macrophages produced and secreted appreciable amounts of minactivin, but only blood monocytes were stimulated by muramyl dipeptide (adjuvant peptide) to increase production. The minactivin from each of these populations could be shown to preferentially inhibit urokinase-type plasminogen activator and not trypsin, plasmin, or 'tissue'-type plasminogen activator (HPA66). A plasminogen-activating enzyme present in monocyte cultures appeared unaffected by the presence of minactivin and could be shown to be regulated independently by dexamethasone

Models of spatiotemporal variation in rabbit abundance reveal management hot spots for an invasive species

First published: 25 January 2020The European rabbit (Oryctolagus cuniculus) is a notorious economic and environmental pest species in its invasive range. To better understand the population and range dynamics of this species, 41 years of abundance data have been collected from 116 unique sites across a broad range of climatic and environmental conditions in Australia. We analyzed this time series of abundance data to determine whether inter‐annual variation in climatic conditions can be used to map historic, contemporary, and potential future fluctuations in rabbit abundance from regional to continental scales. We constructed a hierarchical Bayesian regression model of relative abundance that corrected for observation error and seasonal biases. The corrected abundances were regressed against environmental and disease variables in order to project high spatiotemporal resolution, continent‐wide rabbit abundances. We show that rabbit abundance in Australia is highly variable in space and time, being driven primarily by inter‐annual variation in temperature and precipitation in concert with the prevalence of a non‐pathogenic virus. Moreover, we show that inter‐annual variation in local spatial abundances can be mapped effectively at a continental scale using highly resolved spatiotemporal predictors, allowing “hotspots” of persistently high rabbit abundance to be identified. Importantly, cross‐validated model performance was fair to excellent within and across distinct climate zones. Long‐term monitoring data for invasive species can be used to map fine‐scale spatiotemporal fluctuations in abundance patterns when accurately accounting for inherent sampling biases. Our analysis provides ecologists and pest managers with a clearer understanding of the determinants of rabbit abundance in Australia, offering an important new approach for predicting spatial abundance patterns of invasive species at the near‐term temporal scales that are directly relevant to resource management.Stuart C Brown, Konstans Wells, Emilie Roy-Dufresne, Susan Campbell, Brian Cooke, Tarnya Cox, Damien A. Fordha

The XMM-Newton serendipitous ultraviolet source survey catalogue

The XMM-Newton Serendipitous Ultraviolet Source Survey (XMM-SUSS) is a catalogue of ultraviolet (UV) sources detected serendipitously by the Optical Monitor (XMM-OM) on-board the XMM-Newton observatory. The catalogue contains ultraviolet-detected sources collected from 2,417 XMM-OM observations in 1-6 broad band UV and optical filters, made between 24 February 2000 and 29 March 2007. The primary contents of the catalogue are source positions, magnitudes and fluxes in 1 to 6 passbands, and these are accompanied by profile diagnostics and variability statistics. The XMM-SUSS is populated by 753,578 UV source detections above a 3 sigma signal-to-noise threshold limit which relate to 624,049 unique objects. Taking account of substantial overlaps between observations, the net sky area covered is 29-54 square degrees, depending on UV filter. The magnitude distributions peak at 20.2, 20.9 and 21.2 in UVW2, UVM2 and UVW1 respectively. More than 10 per cent of sources have been visited more than once using the same filter during XMM-Newton operation, and > 20 per cent of sources are observed more than once per filter during an individual visit. Consequently, the scope for science based on temporal source variability on timescales of hours to years is broad. By comparison with other astrophysical catalogues we test the accuracy of the source measurements and define the nature of the serendipitous UV XMM-OM source sample. The distributions of source colours in the UV and optical filters are shown together with the expected loci of stars and galaxies, and indicate that sources which are detected in multiple UV bands are predominantly star-forming galaxies and stars of type G or earlier.Comment: Accepted for publication in MNRA

Common cancer-associated imbalances in the DNA damage response confer sensitivity to single agent ATR inhibition

ATR is an attractive target in cancer therapy because it signals replication stress and DNA lesions for repair and to S/G2 checkpoints. Cancer-specific defects in the DNA damage response (DDR) may render cancer cells vulnerable to ATR inhibition alone. We determined the cytotoxicity of the ATR inhibitor VE-821 in isogenically matched cells with DDR imbalance. Cell cycle arrest, DNA damage accumulation and repair were determined following VE-821 exposure. Defects in homologous recombination repair (HRR: ATM, BRCA2 and XRCC3) and base excision repair (BER: XRCC1) conferred sensitivity to VE-821. Surprisingly, the loss of different components of the trimeric non-homologous end-joining (NHEJ) protein DNA-PK had opposing effects. Loss of the DNA-binding component, Ku80, caused hypersensitivity to VE-821, but loss of its partner catalytic subunit, DNA-PKcs, did not. Unexpectedly, VE-821 was particularly cytotoxic to human and hamster cells expressing high levels of DNA-PKcs. High DNA-PKcs was associated with replicative stress and activation of the DDR. VE-821 suppressed HRR, determined by RAD51 focus formation, to a greater extent in cells with high DNA-PKcs. Defects in HRR and BER and high DNA-PKcs expression, that are common in cancer, confer sensitivity to ATR inhibitor monotherapy and may be developed as predictive biomarkers for personalised medicine

The XMM-Newton Optical/UV Monitor Telescope

The XMM-OM instrument extends the spectral coverage of the XMM-Newton observatory into the ultraviolet and optical range. It provides imaging and time-resolved data on targets simultaneously with observations in the EPIC and RGS. It also has the ability to track stars in its field of view, thus providing an improved post-facto aspect solution for the spacecraft. An overview of the XMM-OM and its operation is given, together with current information on the performance of the instrument

The XMM-Newton Optical/UV Monitor Telescope

The XMM-OM instrument extends the spectral coverage of the XMM-Newton observatory into the ultraviolet and optical range. It provides imaging and time-resolved data on targets simultaneously with observations in the EPIC and RGS. It also has the ability to track stars in its field of view, thus providing an improved post-facto aspect solution for the spacecraft. An overview of the XMM-OM and its operation is given, together with current information on the performance of the instrument.Comment: Accepted by A&A for publication in the Special Issue on 1st science with XMM Newton, 9 page