Ergodicity breaking in strong and network-forming glassy system

The temperature dependence of the non-ergodicity factor of vitreous GeO$_2$, $f_{q}(T)$, as deduced from elastic and quasi-elastic neutron scattering experiments, is analyzed. The data are collected in a wide range of temperatures from the glassy phase, up to the glass transition temperature, and well above into the undercooled liquid state. Notwithstanding the investigated system is classified as prototype of strong glass, it is found that the temperature- and the $q$-behavior of $f_{q}(T)$ follow some of the predictions of Mode Coupling Theory. The experimental data support the hypothesis of the existence of an ergodic to non-ergodic transition occurring also in network forming glassy systems

Long-term placement of continuous popliteal nerve block catheter for management of a wounded patient in a combat field environment: A case report

Continuous peripheral nerve block is a relevant part of multimodal treatment of postoperative pain. In this context the continuous popliteal nerve block is described as an option for postoperative pain management for surgical procedures on the leg, and particularly on the ankle and foot. We applied continuous popliteal nerve block for different types of anesthesia and postoperative pain management via the same catheter. No clear evidence of this specific use has been described in the literature. A 38 year-old patient wounded in combat with a displaced fracture of left tibia and extensive loss of substance needed orthopedic surgeries as well as several reconstructive procedures. A continuous popliteal nerve block was applied via ultrasound-guided catheter for anesthesia at different times, and postoperative pain control for all surgical procedures. The continuous popliteal nerve block and its long-term positioning, of non-common evidence in literature, was utilized to treat a poly-traumatized patient, thereby avoiding repeated general anesthesia and opioid use and their adverse effects. This technique, within a complicated combat field environment, was demonstrated to be clinically effective with high patient satisfaction

Comparison of the Diagnostic Accuracy of Brain Natriuretic Peptide (BNP) and the N-Terminal Part of the Propeptide of BNP Immunoassays in Chronic and Acute Heart Failure: A Systematic Review

Abstract Study aim The current study compares the diagnostic accuracy of BNP and NT-proBNP assays for the diagnosis of heart failure, according to evidence based laboratory medicine (EBLM) principles. Methods In May 2006, studies specifically designed to compare the diagnostic accuracy of BNP and NT-proBNP assays were selected by means of a computerized literature search performed on National Library of Medicine. The comparison took into account the area under the curve (AUC) and diagnostic odds ratio (DOR) derived from ROC analysis of original studies. Results Both BNP and NT-proBNP assays were found to be clinically useful for the diagnosis of heart failure. A meta-analysis of these data was made difficult by the heterogeneity of data, regarding patient population, diagnostic criteria, end-points and immunoassay methods for both BNP and NT-proBNP. Separate meta-analyses were performed for acute and chronic heart failure. In chronic heart failure, the diagnostic odds ratio (DOR) for BNP assay (DOR 8.44, 95% CI 4.66 – 15.30) was not significantly different from NT-proBNP one (23.36, 95% CI 9.38 – 58.19). In patients with acute heart failure, the mean DOR for BNP assay was 16.46 (95% CI 10.65 – 25.43) and for NT-proBNP assay 18.61 (95% CI 12.99 – 26.65), without a significant difference. Conclusion Our results indicate that both BNP and NT-proBNP assays have a high degree of diagnostic accuracy and clinical relevance in both acute and chronic heart failure

Association between Resistin Levels and All-Cause and Cardiovascular Mortality: A New Study and a Systematic Review and Meta-Analysis.

CONTEXT: Studies concerning the association between circulating resistin and mortality risk have reported, so far, conflicting results. OBJECTIVE: To investigate the association between resistin and both all-cause and cardiovascular (CV) mortality risk by 1) analyzing data from the Gargano Heart Study (GHS) prospective design (n=359 patients; 81 and 58 all-cause and CV deaths, respectively); 2) performing meta-analyses of all published studies addressing the above mentioned associations. DATA SOURCE AND STUDY SELECTION: MEDLINE and Web of Science search of studies reporting hazard ratios (HR) of circulating resistin for all-cause or CV mortality. DATA EXTRACTION: Performed independently by two investigators, using a standardized data extraction sheet. DATA SYNTHESIS: In GHS, adjusted HRs per one standard deviation (SD) increment in resistin concentration were 1.28 (95% CI: 1.07-1.54) and 1.32 (95% CI: 1.06-1.64) for all-cause and CV mortality, respectively. The meta-analyses included 7 studies (n=4016; 961 events) for all-cause mortality and 6 studies (n=4,187: 412 events) for CV mortality. Pooled HRs per one SD increment in resistin levels were 1.21 (95% CI: 1.03-1.42, Q-test p for heterogeneity<0.001) and 1.05 (95% CI: 1.01-1.10, Q-test p for heterogeneity=0.199) for all-cause and CV mortality, respectively. At meta-regression analyses, study mean age explained 9.9% of all-cause mortality studies heterogeneity. After adjusting for age, HR for all-cause mortality was 1.24 (95% CI: 1.06-1.45). CONCLUSIONS: Our results provide evidence for an association between circulating resistin and mortality risk among high-risk patients as are those with diabetes and coronary artery disease

Carbapenem-resistant Pseudomonas aeruginosa with acquired bla(vim) metallo-beta-lactamase determinants, Italy.

6nonenoneROSSOLINI G.M.; RICCIO M.L.; CORNAGLIA G.; PAGANI L.; LAGATOLLA C.; SELAN L. AND FONTANA R.Rossolini, G. M.; Riccio, M. L.; Cornaglia, G.; Pagani, L.; Lagatolla, Cristina; Selan, L. AND FONTANA R

Peering through the holes: the far UV color of star-forming galaxies at z~3-4 and the escaping fraction of ionizing radiation

We aim to investigate the effect of the escaping ionizing radiation on the color selection of high redshift galaxies and identify candidate Lyman continuum (LyC) emitters. The intergalactic medium prescription of Inoue et al.(2014) and galaxy synthesis models of Bruzual&Charlot (2003) have been used to properly treat the ultraviolet stellar emission, the stochasticity of the intergalactic transmission and mean free path in the ionizing regime. Color tracks are computed by turning on/off the escape fraction of ionizing radiation. At variance with recent studies, a careful treatment of IGM transmission leads to no significant effects on the high-redshift broad-band color selection. The decreasing mean free path of ionizing photons with increasing redshift further diminishes the contribution of the LyC to broad-band colors. We also demonstrate that prominent LyC sources can be selected under suitable conditions by calculating the probability of a null escaping ionizing radiation. The method is applied to a sample of galaxies extracted from the GOODS-S field. A known LyC source at z=3.795 is successfully recovered as a LyC emitter candidate and another convincing candidate at z=3.212 is reported. A detailed analysis of the two sources (including their variability and morphology) suggests a possible mixture of stellar and non-stellar (AGN) contribution in the ultraviolet. Conclusions: Classical broad-band color selection of 2.5<z<4.5 galaxies does not prevent the inclusion of LyC emitters in the selected samples. Large fesc in relatively bright galaxies (L>0.1L*) could be favored by the presence of a faint AGN not easily detected at any wavelength. A hybrid stellar and non-stellar (AGN) ionizing emission could coexist in these systems and explain the tensions found among the UV excess and the stellar population synthesis models reported in literature.Comment: Accepted for publication in Astronomy & Astrophysics. 13 pages, 7 figure

Carbono orgânico e as frações húmicas em diferentes horizontes diagnósticos de solos brasileiros.

Avaliar o carbono orgânico e as frações húmicas quanto à participação, as relações e a capacidade de distinção de diferentes horizontes diagnósticos de solos brasileiros.bitstream/item/104971/1/Doc-156-Carbono-organico.pd

Classificação de horizontes diagnósticos em níveis hierárquicos inferiores com base nas frações húmicas.

Com desenvolvimento da classificação dos solos até o quarto nível categórico do Sistema Brasileiro de Classificação de Solos - SiBCS, busca-se a elaboração e padronização de propostas para a classificação dos solos no quinto e sexto níveis categóricos (família e série). Nesse sentido, o presente trabalho teve como objetivo verificar a viabilidade das frações húmicas para a classificação de horizontes diagnósticos no quinto ou sexto níveis categóricos (família e série) do SiBCS. Para o desenvolvimento da proposta, foram utilizados 169 horizontes diagnósticos distribuídos entre O hístico, H hístico, A chernozêmico, A húmico e B espódico. Esses horizontes foram analisados quanto à composição química e física. Também foram quantificados os teores de C orgânico nas frações: ácidos fúlvicos (C-FAF), ácidos húmicos (C-FAH) e humina (C-HUM), extrato alcalino (C-EA). Foram calculadas as relações C-FAH/C-FAF, C-EA/C-HUM (C-EA = C-FAF + C-FAH) e a %FAF, %FAH e %HUM. As propostas de classes estabelecidas para cada horizonte diagnóstico no quinto ou sexto níveis categóricos estão relacionadas ao C-FAH e CHUM e às relações C-FAH/C-FAF e C-EA/C-HUM, identificadas a partir de correlações significativas com os atributos químicos e físicos. Quanto aos horizontes O e H hístico, apresentam-se classes com base na relação C-FAH/C-FAF. Nos horizontes A chernozêmico e A húmico há duas classes para cada um deles, tendo como base C-HUM e a relação C-FAH/C-FAF, para o primeiro, e C-FAH e C-HUM, para o segundo. Para os horizontes B espódico, apresentam-se três classes, a partir do C-FAH e das relações C-FAH/C-FAF e C-EA/C-HUM

Critical role for prokineticin 2 in CNS autoimmunity

Objective: To investigate the potential role of prokineticin 2 (PK2), a bioactive peptide involved in multiple biological functions including immune modulation, in CNS autoimmune demyelinating disease. Methods: We investigated the expression of PK2 in mice with experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS), and in patients with relapsing-remitting MS. We evaluated the biological effects of PK2 on expression of EAE and on development of T-cell response against myelin by blocking PK2 in vivo with PK2 receptor antagonists. We treated with PK2 immune cells activated against myelin antigen to explore the immune-modulating effects of this peptide in vitro. Results: Pk2 messenger RNA was upregulated in spinal cord and lymph node cells (LNCs) of mice with EAE. PK2 protein was expressed in EAE inflammatory infiltrates and was increased in sera during EAE. In patients with relapsing-remitting MS, transcripts for PK2 were significantly increased in peripheral blood mononuclear cells compared with healthy controls, and PK2 serum concentrations were significantly higher. A PK2 receptor antagonist prevented or attenuated established EAE in chronic and relapsing-remitting models, reduced CNS inflammation and demyelination, and decreased the production of interferon (IFN)-γ and interleukin (IL)-17A cytokines in LNCs while increasing IL-10. PK2 in vitro increased IFN-γ and IL-17A and reduced IL-10 in splenocytes activated against myelin antigen. Conclusion: These data suggest that PK2 is a critical immune regulator in CNS autoimmune demyelination and may represent a new target for therapy