Programación Didáctica de 4º de la ESO. La Segunda Guerra Mundial y el Holocausto

Elaboración de una programación didáctica para la asignatura de Ciencias Sociales en 4º de Educación Secundaria Obligatoria. Con nociones básicas de Historia Universal e Historia de España que comprenden desde el fin del Antiguo Régimen y el inicio de la Revolución Francesa hasta la actualidad. La primera parte de este trabajo consiste en la elaboración de la programación general. La segunda parte de este trabajo consiste en el desarrollo pormenorizado de una unidad didáctica. La unidad escogida es la que aborda la Segunda Guerra Mundial y el Holocausto.Departamento de Didáctica de las Ciencias Sociales y ExperimentalesMáster en Profesor de Educación Secundaria Obligatoria y Bachillerato, Formación Profesional y Enseñanzas de Idioma

Estudio formal y arqueométrico del material constructivo en tierra y las decoraciones murales de dos asentamientos calcolíticos del occidente de la meseta norte española

Domestic architecture is a subject that has generally been neglected in research on the Chalcolithic of the Northern Meseta. Construction materials are abundant in the settlements of the period, but until the last decade they have not received any attention. Most of them remain unstudied in the storage rooms of the provincial museums. This is the case of the items we consider here, which come from two rescue excavations carried out in the 1990s at the sites of Los Bajos (Vecilla de Trasmonte, Zamora) and Viña de Esteban García (Salvatierra de Tormes, Salamanca). Detailed study of this material three decades later has made it possible to prove the existence of previously unknown wall decorations. The petrological, geochemical and archaeomagnetic analysis of the building material has allowed the technological characterization of this material and explained its good preservation.El espacio doméstico es un campo considerablemente desatendido por la investigación del Calcolítico de la meseta norte española. Los fragmentos del barro empleado en las construcciones, frecuentes en los asentamientos de la época, no han recibido hasta la última década ninguna atención y muchos permanecen sin estudiar en los fondos de los museos provinciales. Es el caso de las piezas aquí expuestas. Proceden de dos intervenciones de urgencia llevadas a cabo en los años 1990 en los asentamientos de Los Bajos (Vecilla de Trasmonte, Zamora) y Viña de Esteban García (Salvatierra de Tormes, Salamanca). El estudio pormenorizado de dicho material tres décadas después ha acreditado decoraciones murales desconocidas hasta ahora. Los análisis petrológicos, geoquímicos y arqueomagnéticos del barro de construcción han permitido la caracterización tecnológica de este material y explicar su buena conservación

A deletion at Adamts9-magi1 Locus is associated with psoriatic arthritis risk

Objective: Copy number variants (CNVs) have been associated with the risk to develop multiple autoimmune diseases. Our objective was to identify CNVs associated with the risk to develop psoriatic arthritis (PsA) using a genome-wide analysis approach. Methods: A total of 835 patients with PsA and 1498 healthy controls were genotyped for CNVs using the Illumina HumanHap610 BeadChip genotyping platform. Genomic CNVs were characterised using CNstream analysis software and analysed for association using the χ2 test. The most significant genomic CNV associations with PsA risk were independently tested in a validation sample of 1133 patients with PsA and 1831 healthy controls. In order to test for the specificity of the variants with PsA aetiology, we also analysed the association to a cohort of 822 patients with purely cutaneous psoriasis (PsC). Results: A total of 165 common CNVs were identified in the genome-wide analysis. We found a highly significant association of an intergenic deletion between ADAMTS9 and MAGI1 genes on chromosome 3p14.1 (p=0.00014). Using the independent patient and control cohort, we validated the association between ADAMTS9-MAGI1 deletion and PsA risk (p=0.032). Using next-generation sequencing, we characterised the 26 kb associated deletion. Finally, analysing the PsC cohort we found a lower frequency of the deletion compared with the PsA cohort (p=0.0088) and a similar frequency to that of healthy controls (p>0.3). Conclusions: The present genome-wide scan for CNVs associated with PsA risk has identified a new deletion associated with disease risk and which is also differential from PsC risk

Calcolithic habitational structures in the Middle Douro Valley. A case study: El Casetón de la Era (Villalba de los Alcores, Valladolid)

Máster en Prehistoria y Arqueologí

A deletion at Adamts9-magi1 Locus is associated with psoriatic arthritis risk

Objective: Copy number variants (CNVs) have been associated with the risk to develop multiple autoimmune diseases. Our objective was to identify CNVs associated with the risk to develop psoriatic arthritis (PsA) using a genome-wide analysis approach. Methods: A total of 835 patients with PsA and 1498 healthy controls were genotyped for CNVs using the Illumina HumanHap610 BeadChip genotyping platform. Genomic CNVs were characterised using CNstream analysis software and analysed for association using the χ2 test. The most significant genomic CNV associations with PsA risk were independently tested in a validation sample of 1133 patients with PsA and 1831 healthy controls. In order to test for the specificity of the variants with PsA aetiology, we also analysed the association to a cohort of 822 patients with purely cutaneous psoriasis (PsC). Results: A total of 165 common CNVs were identified in the genome-wide analysis. We found a highly significant association of an intergenic deletion between ADAMTS9 and MAGI1 genes on chromosome 3p14.1 (p=0.00014). Using the independent patient and control cohort, we validated the association between ADAMTS9-MAGI1 deletion and PsA risk (p=0.032). Using next-generation sequencing, we characterised the 26 kb associated deletion. Finally, analysing the PsC cohort we found a lower frequency of the deletion compared with the PsA cohort (p=0.0088) and a similar frequency to that of healthy controls (p>0.3). Conclusions: The present genome-wide scan for CNVs associated with PsA risk has identified a new deletion associated with disease risk and which is also differential from PsC risk

A deletion at Adamts9-magi1 Locus is associated with psoriatic arthritis risk

Objective: Copy number variants (CNVs) have been associated with the risk to develop multiple autoimmune diseases. Our objective was to identify CNVs associated with the risk to develop psoriatic arthritis (PsA) using a genome-wide analysis approach. Methods: A total of 835 patients with PsA and 1498 healthy controls were genotyped for CNVs using the Illumina HumanHap610 BeadChip genotyping platform. Genomic CNVs were characterised using CNstream analysis software and analysed for association using the χ2 test. The most significant genomic CNV associations with PsA risk were independently tested in a validation sample of 1133 patients with PsA and 1831 healthy controls. In order to test for the specificity of the variants with PsA aetiology, we also analysed the association to a cohort of 822 patients with purely cutaneous psoriasis (PsC). Results: A total of 165 common CNVs were identified in the genome-wide analysis. We found a highly significant association of an intergenic deletion between ADAMTS9 and MAGI1 genes on chromosome 3p14.1 (p=0.00014). Using the independent patient and control cohort, we validated the association between ADAMTS9-MAGI1 deletion and PsA risk (p=0.032). Using next-generation sequencing, we characterised the 26 kb associated deletion. Finally, analysing the PsC cohort we found a lower frequency of the deletion compared with the PsA cohort (p=0.0088) and a similar frequency to that of healthy controls (p>0.3). Conclusions: The present genome-wide scan for CNVs associated with PsA risk has identified a new deletion associated with disease risk and which is also differential from PsC risk