Effects of Cadmium on the Activity of Matrix Metalloproteinases and Metallothionein Level in the Rat Brain

We studied the effects of long-lasting treating with cadmium in two different doses (0.1 and 1.0 μg/kg) on the activity of matrix metalloproteinases (MMP2 and MMP9) and metallothionein level in the rat brain. Cadmium in a higher dose (1 μg/kg) caused a decrease in MMP2 activity but increased that of proMMP9 in the brain. The level of MT in the hippocampus and cerebellum dropped with both Cd doses. Thus, even small Cd doses exert specific effects on the MMP activity and MT level in the brain

The investigation of technological parameters of the process control the direction split stone block when using unexplosive destructive compounds

Виконано теоретичні дослідження технології керування напрямом розколу блочного каменю за використання пластин-вставок у шпурах з невибуховими руйнуючими сумішами. Керування передбачає поворот пластини-вставки навколо осі шпуру. Наведені дослідження дають можливість розколювати блочні каміння у заданому напрямку. Вирішення такого завдання дає змогу збільшити відстань між шпурами і за рахунок цього зменшити обсяги бурових робіт.It has performed theoretical studies of technology management direction of the split block of stone, using plates, inserts in boreholes with unexplosive destroying mixtures. Management provides for rotation about an axis plate holes. Hover studies allow split stone block in a given direction. Solving this problem will increase the distance between boreholes and thus reduce the amount of drilling operations.Выполнены теоретические исследования технологии управления направлением раскола блочного камня, при использовании пластин-вставок в шпурах с невзрывчатыми разрушающими составами. Управление предусматривает поворот пластины-вставки вокруг оси шпура. Проведенные исследования позволяют обеспечить раскол блочного камня в заданном направлении. Решение поставленной задачи позволит увеличить расстояние между шпурами и за счет этого уменьшить объем буровых работ

The changes of matrix metalloproteinase 2, 9 activity and hyaluronic acid level in rat’s heartand serum under cadmium influence

The changes in the molecular mechanisms of the extracellular matrix degradation under toxic factors are not well known. The main goal of work was the investigation of the MMP2 and MMP9 activity and hyaluronic acid level in the heart and blood serum under cadmium influence at different doses

Synthesis and Characterization of Electro-Explosive Magnetic Nanoparticles for Biomedical Applications

Nowadays there are new magnetic nanostructures based on bioactive metals with low toxicity and high efficiency for a wide range of biomedical applications including drugs delivery, antimicrobial drugs design, cells' separation and contrasting. For such applications it is necessary to develop highly magnetic particles with less than100 nm in size. In the present study magnetic nanoparticles Fe, Fe[3]O[4] and bimetallic Cu/Fe with the average size of 60- 90 nm have been synthesized by electrical explosion of wire in an oxygen or argon atmosphere. The produced nanoparticles have been characterized with transmission electron microscopy, X-ray phase analysis, and nitrogen thermal desorption. The synthesized particles have shown antibacterial activity to gram-positive (S. aureus, MRSA) and gramnegative (E. coli, P. aeruginosa) bacteria. According to the cytological data Fe, Fe[3]O[4]and Cu/Fe nanoparticles have effectively inhibited viability of cancer cell lines Neuro-2a and J774. The obtained nanoparticles are promising for new antimicrobial drugs and antitumor agents' developmen

Biofeedback treatment of proctogenic constipation in adults

Aim of investigation. To study efficacy of biological feedback treatment (BFT) at proctogenic constipation in adult patients.Material and methods. Overall 30 patients with proctogenic constipation and dyssynergia of pelvic floor muscles i.e. spasm of puborectalis muscle were included in original study and treated by BFT method. Mean age of patients was 31,2±9,8 year, men to women ratio was 1:5.Results. During treatment decrease in difficulty to defecate according to Rome-III criteria was observed in 22 (73,3%) patients. The other 8 (26,7%) patients demonstrated no improvement. According to subjective assessment of rectal evacuatory function by questioning before and after BFT statistically significant reduction of proctogenic constipation symptoms was revealed. By the data of objective investigation (profilometry and electromyography) signs of dyssynergia of pelvic floor muscles were revealed in no patient.Conclusions. The biological feedback is effective treatment method for proctogenic constipation, allowing to reduce symptoms in 73,3% of patients and to correct dyssynergia of pelvic floor muscles in all cases

Synthesis and Characterization of Electro-Explosive Magnetic Nanoparticles for Biomedical Applications

Nowadays there are new magnetic nanostructures based on bioactive metals with low toxicity and high efficiency for a wide range of biomedical applications including drugs delivery, antimicrobial drugs design, cells' separation and contrasting. For such applications it is necessary to develop highly magnetic particles with less than100 nm in size. In the present study magnetic nanoparticles Fe, Fe[3]O[4] and bimetallic Cu/Fe with the average size of 60- 90 nm have been synthesized by electrical explosion of wire in an oxygen or argon atmosphere. The produced nanoparticles have been characterized with transmission electron microscopy, X-ray phase analysis, and nitrogen thermal desorption. The synthesized particles have shown antibacterial activity to gram-positive (S. aureus, MRSA) and gramnegative (E. coli, P. aeruginosa) bacteria. According to the cytological data Fe, Fe[3]O[4]and Cu/Fe nanoparticles have effectively inhibited viability of cancer cell lines Neuro-2a and J774. The obtained nanoparticles are promising for new antimicrobial drugs and antitumor agents' developmen

Анализ рисков предприятий в процессе аутсорсинга маркетинговых функций

Стаття присвячена дослідженню ризиків, що виникають при аутсорсингу маркетингових функцій, розглянуті теоретичні засади визначення маркетингових ризиків.The article is devoted the risk of marketing functions outsourcing, the theoretical base of definition of marketing risks is considered.Статья посвящена изучению рисков, которые возникают при аутсорсинге маркетинговых функций, рассмотрена теоретическая база определения маркетинговых рисков

Dielectric Conductivity of Cross-Linked Polyurethanes Modified with Heteropolynuclear Cu3Mn Complexes

The dielectric and relaxation properties of cross-linked polyurethane, modified with heteropolynuclear Cu3Mn(L4) complexes with various ligands in outer coordination sphere were analyzed by dielectric relaxation spectroscopy. It was shown, that the modifier introduction in polyurethane leads to conductivity level increasing due to: i) complex formation between functional groups of polyurethane and heteropolynuclear compounds and ii) increase in the macrochain mobility

Experience of rectosacropexy in treatment of patients with rectum prolapse

Aim of investigation. To analyze authors’ experience of rectosacropexy results at prolapse of the rectum. Material and methods. Original study included 137 patients who underwent surgery for prolapse of rectum in the State scientific center of coloproctology from January, 2007 to December, 2013. The main group have included 60 patients (43,8%) who had rectosacropexy, control group included 77 patients (56,2%) after back loop rectopexy.Results. Control examination was carried out in 24 patients (40%) of the main and in 26 patients (33,8%) of the control group. Average time of follow-up was respectively 9,8±2,0 months and 34,2±17,8 months. Relapse was diagnosed in 2 patients (7,6%) after back loop rectopexy. After surgical treatment of rectal prolapse statistically significant improvement of anal sphincter pressure was diagnosed in both groups at I and II degree of sphincter insufficiency. Application of rectosacropexy corrects pelvic floor descent syndrome and evacuatory function of the rectum. No deterioration of large intestinal transit after rectosacropexy was revealed (р>0,05). After back loop rectopexy deterioration of large intestinal emptying (р<0,05) was significant.Conclusions. Rectosacropexy is effective method of rectum prolapse treatment and improves function of anal sphincter in postoperative period, corrects pelvic floor descent syndrome and cause no constipation

Chemical behaviour of Al/Cu nanoparticles in water

Bimetallic Al/Cu nanoparticles with Al/Cu composition 10:90, 20:80, 40:60 were produced by method of simultaneous electrical explosion of metal pairs in the argon atmosphere. Nanopowders containing 20% and 40% (mass) of aluminum interacted with water at 40–70 °C and formed composite particles that were porous structures of nanopetal pseudoboehmite with nanosized copper-containing inclusions inside. Aluminum in nanopowder with Al/Cu composition 10:90 did not react with water, as far as it is in the phase of intermetallic compounds СuAl2 and Сu4Al9. Nanocomposite produced can be used as an active component of antibacterial agents