372 research outputs found
High efficiency SiO2-TiO2 hybrid sol-gel antireflective coating for infrared applications
Sol-gel derived antireflective thin films were created for chalcogenide glass substrates in the 1.5-5 mu m wavelength range of infrared region. Presented herein is a preparation and characterization of the hybrid sol-gel created including particle size, refractive index, pH, and Fourier transform infrared FTIR transmission spectra. It is shown that an increase of not less than 8% and up to 25.1% transmission is achieved using sol-gel derived antireflective coatings
Room temperature ballistic transport in InSb quantum well nanodevices
We report the room temperature observation of significant ballistic electron
transport in shallow etched four-terminal mesoscopic devices fabricated on an
InSb/AlInSb quantum well (QW) heterostructure with a crucial partitioned
growth-buffer scheme. Ballistic electron transport is evidenced by a negative
bend resistance signature which is quite clearly observed at 295 K and at
current densities in excess of 10 A/cm. This demonstrates
unequivocally that by using effective growth and processing strategies, room
temperature ballistic effects can be exploited in InSb/AlInSb QWs at practical
device dimensions
Brownian Motions on Metric Graphs
Brownian motions on a metric graph are defined. Their generators are
characterized as Laplace operators subject to Wentzell boundary at every
vertex. Conversely, given a set of Wentzell boundary conditions at the vertices
of a metric graph, a Brownian motion is constructed pathwise on this graph so
that its generator satisfies the given boundary conditions.Comment: 43 pages, 7 figures. 2nd revision of our article 1102.4937: The
introduction has been modified, several references were added. This article
will appear in the special issue of Journal of Mathematical Physics
celebrating Elliott Lieb's 80th birthda
Normalization factors for magnetic relaxation of small particle systems in non-zero magnetic field
We critically discuss relaxation experiments in magnetic systems that can be
characterized in terms of an energy barrier distribution, showing that proper
normalization of the relaxation data is needed whenever curves corresponding to
different temperatures are to be compared. We show how these normalization
factors can be obtained from experimental data by using the
scaling method without making any assumptions about the nature of the energy
barrier distribution. The validity of the procedure is tested using a
ferrofluid of Fe_3O_4 particles.Comment: 5 pages, 6 eps figures added in April 22, to be published in Phys.
Rev. B 55 (1 April 1997
Discovery of a small molecule agonist of phosphatidylinositol 3-kinase p110α that reactivates latent HIV-1
Combination antiretroviral therapy (cART) can effectively suppress HIV-1 replication, but the latent viral reservoir in resting memory CD4+ T cells is impervious to cART and represents a major barrier to curing HIV-1 infection. Reactivation of latent HIV-1 represents a possible strategy for elimination of this reservoir. In this study we describe the discovery of 1,2,9,10-tetramethoxy-7H-dibenzo[de,g]quinolin-7-one (57704) which reactivates latent HIV-1 in several cell-line models of latency (J89GFP, U1 and ACH-2). 57704 also increased HIV-1 expression in 3 of 4 CD8+-depleted blood mononuclear cell preparations isolated from HIV-1-infected individuals on suppressive cART. In contrast, vorinostat increased HIV-1 expression in only 1 of the 4 donors tested. Importantly, 57704 does not induce global T cell activation. Mechanistic studies revealed that 57704 reactivates latent HIV-1 via the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway. 57704 was found to be an agonist of PI3K with specificity to the p110a isoform, but not the p110β, δ or γ isoforms. Taken together, our work suggests that 57704 could serve as a scaffold for the development of more potent activators of latent HIV-1. Furthermore, it highlights the involvement of the PI3K/Akt pathway in the maintenance of HIV-1 latency. © 2014 Doyon et al
Central African Hunters Exposed to Simian Immunodeficiency Virus
HIV-seronegative Cameroonians with exposure to nonhuman primates were tested for simian immunodeficiency virus (SIV) infection. Seroreactivity was correlated with exposure risk (p<0.001). One person had strong humoral and weak cellular immune reactivity to SIVcol peptides. Humans are exposed to and possibly infected with SIV, which has major public health implications
Novel solid-state-detector dedicated cardiac camera for fast myocardial perfusion imaging: multicenter comparison with standard dual detector cameras
In vitroreactivation of latent HIV-1 by cytostatic bis(thiosemicarbazonate) gold(III) complexes
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