Allergic contact dermatitis from modified colophonium in wound dressings

This study concerns a 69-year-old female patient with a longstanding history of venous ulcerations on both lower legs and multiple sensitivities, who developed eczematous lesions with the hydrocolloid dressing Combiderm (Convatec Ltd., a Bristol-Myers Squibb division, Ickenham, Middlesex, UK). Epicutaneous tests were positive to this dressing and to a modified colophonium derivative, i.e. glyceryl rosinate, however not to the unmodified colophonium from the standard series. A review of the literature showed several case reports about sensitization to similar hydrocolloids being distributed under various brand names in different countries and which contain the pentaerythritol ester of the hydrogenated rosin as the tackifying agent. Some of the patients described did, while others did not, react to colophonium but only to a modified derivative. In our patient, the reaction to glyceryl rosinate most probably represent cross-sensitivity with the modified colophonium derivative used in Combiderm, the presence (but not the exact nature) of which was showed by the company. In patients where allergic contact dermatitis from hydrocolloid dressings is strongly suspected and colophonium tests negatively, patch testing to modified colophonium derivatives should therefore be performed. As the complete composition of wound dressings is most often unknown, we urgently advocate legal requirements for labelling of those and in fact all medically used devices

« L’empreinte de Pascal » dans l’œuvre graphique de Bertrand Flour

« Toute image artistique renferme une part de vérité en adéquation avec la nature même de son auteur. » Je me suis intéressé aux Pensées de Blaise Pascal en voulant inscrire au dos de mes dessins au fusain des textes d’auteurs qui traduisaient littéralement le contenu de ma propre expression artistique. Une manière de rechercher des preuves tangibles de mon inspiration dans un livre reconnu pour son ingéniosité. On me demanda ensuite de réaliser une œuvre graphique en se référant aux citation..

PROSES PEMESINAN GEAR RUNOUT TESTER

Tujuan laporan proses pemesinan gear runout tester adalah untuk mengetahui: (1) langkah-langkah proses pembuatan gear runout tester; (2) perbandingan ukuran pada desain gambar dengan komponen yang sudah dilakukan pengerjaan; (3) tingkat kekasaran dari pembuatan gear runout tester; (4) kelebihan alat gear runout tester. Metode yang digunakan dalam pembuatan komponen gear runout tester yaitu: (1) menentukan bahan yang digunakan; (2) memilih alat mesin yang digunakan; (3) langkah-langkah proses pembuatan komponen gear runout tester; melakukan pengujian pada gear runout tester. Hasil dari proses pembuatan dari alat gear runout tester yaitu: (1) pada proses pembuatan komponen-komponen alat gear runout tester terdapat pada rencana kerja (work preparation); (2) terdapat perbedaan ukuran beberapa komponen dimensi desain dengan dimensi komponen jadi; (3) klasifikasi tingkat kekasaran komponen-komponen gear runout tester termasuk dalam kelas kekasaran N7-N8 dengan nilai kekasaran 1,6-3,

Preliminary analysis of the drive system of the CTA LST Telescope and its integration in the whole PLC architecture

This work aims to present a preliminary analysis of the drive system configuration for the CTA telescopes array and more specifically a possible architecture for the sub-array of Large Size Telescopes - LSTs. The first part of this document is focused on the control command architecture of the drive system dedicated to the LST including a view on some mechanical aspects concerning the telescopes of this class. In particular the current investigation on the interfaces between the drive system and the automatic system in charge of the camera mast control system (e.g. the arch damping) is presented. In the second part of this work the issue of the integration of the telescope drive system within a global PLC (Programmable Logic Controller) architecture for the CTA array is addressed with the corresponding links to the control software layer

From Design to Production Control Through the Integration of Engineering Data Management and Workflow Management Systems

At a time when many companies are under pressure to reduce "times-to-market" the management of product information from the early stages of design through assembly to manufacture and production has become increasingly important. Similarly in the construction of high energy physics devices the collection of (often evolving) engineering data is central to the subsequent physics analysis. Traditionally in industry design engineers have employed Engineering Data Management Systems (also called Product Data Management Systems) to coordinate and control access to documented versions of product designs. However, these systems provide control only at the collaborative design level and are seldom used beyond design. Workflow management systems, on the other hand, are employed in industry to coordinate and support the more complex and repeatable work processes of the production environment. Commercial workflow products cannot support the highly dynamic activities found both in the design stages of product development and in rapidly evolving workflow definitions. The integration of Product Data Management with Workflow Management can provide support for product development from initial CAD/CAM collaborative design through to the support and optimisation of production workflow activities. This paper investigates this integration and proposes a philosophy for the support of product data throughout the full development and production lifecycle and demonstrates its usefulness in the construction of CMS detectors.Comment: 18 pages, 13 figure

Classification of forefoot plantar pressure distribution in persons with diabetes : a novel perspective for the mechanical management of diabetic foot?

Background: The aim of this study was to identify groups of subjects with similar patterns of forefoot loading and verify if specific groups of patients with diabetes could be isolated from non-diabetics. Methodology/Principal Findings: Ninety-seven patients with diabetes and 33 control participants between 45 and 70 years were prospectively recruited in two Belgian Diabetic Foot Clinics. Barefoot plantar pressure measurements were recorded and subsequently analysed using a semi-automatic total mapping technique. Kmeans cluster analysis was applied on relative regional impulses of six forefoot segments in order to pursue a classification for the control group separately, the diabetic group separately and both groups together. Cluster analysis led to identification of three distinct groups when considering only the control group. For the diabetic group, and the computation considering both groups together, four distinct groups were isolated. Compared to the cluster analysis of the control group an additional forefoot loading pattern was identified. This group comprised diabetic feet only. The relevance of the reported clusters was supported by ANOVA statistics indicating significant differences between different regions of interest and different clusters. Conclusion/s Significance: There seems to emerge a new era in diabetic foot medicine which embraces the classification of diabetic patients according to their biomechanical profile. Classification of the plantar pressure distribution has the potential to provide a means to determine mechanical interventions for the prevention and/or treatment of the diabetic foot

Status and Plans for the Array Control and Data Acquisition System of the Cherenkov Telescope Array

The Cherenkov Telescope Array (CTA) is the next-generation atmospheric Cherenkov gamma-ray observatory. CTA will consist of two installations, one in the northern, and the other in the southern hemisphere, containing tens of telescopes of different sizes. The CTA performance requirements and the inherent complexity associated with the operation, control and monitoring of such a large distributed multi-telescope array leads to new challenges in the field of the gamma-ray astronomy. The ACTL (array control and data acquisition) system will consist of the hardware and software that is necessary to control and monitor the CTA arrays, as well as to time-stamp, read-out, filter and store -at aggregated rates of few GB/s- the scientific data. The ACTL system must be flexible enough to permit the simultaneous automatic operation of multiple sub-arrays of telescopes with a minimum personnel effort on site. One of the challenges of the system is to provide a reliable integration of the control of a large and heterogeneous set of devices. Moreover, the system is required to be ready to adapt the observation schedule, on timescales of a few tens of seconds, to account for changing environmental conditions or to prioritize incoming scientific alerts from time-critical transient phenomena such as gamma ray bursts. This contribution provides a summary of the main design choices and plans for building the ACTL system.Comment: In Proceedings of the 34th International Cosmic Ray Conference (ICRC2015), The Hague, The Netherlands. All CTA contributions at arXiv:1508.0589

Detector Construction Management and Quality Control: Establishing and Using a CRISTAL System

The CRISTAL (Cooperating Repositories and an Information System for Tracking Assembly Lifecycles) project is delivering a software system to facilitate the management of the engineering data collected at each stage of production of CMS. CRISTAL captures all the physical characteristics of CMS components as each sub-detector is tested and assembled. These data are retained for later use in areas such as detector slow control, calibration and maintenance. CRISTAL must, therefore, support different views onto its data dependent on the role of the user. These data viewpoints are investigated in this paper. In the recent past two CMS Notes have been written about CRISTAL. The first note, CMS 1996/003, detailed the requirements for CRISTAL, its relationship to other CMS software, its objectives and reviewed the technology on which it would be based. CMS 1997/104 explained some important design concepts on which CRISTAL is and showed how CRISTAL integrated the domains of product data man- agement and workflow management. This note explains, through the use of diagrams, how CRISTAL can be established for detector production and used as the information source for analyses, such as calibration and slow controls, carried out by physicists. The reader should consult the earlier CMS Notes and conference papers for technical detail on CRISTAL - this note concentrates on issues surrounding the practical use of the CRISTAL software.Comment: 16 pages, 14 figure