10 research outputs found
Increased urinary markers of kidney damage in the institutionalized frail elderly due to recurrent urinary tract infections.
- Author
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Objective: To characterize the impact on kidney injury of recurrent urinary tract infections (RUTI) in the frail elderly. Methods: Prospective observational study in 200 frail elderly subjects for 1 year. Groups: GA (n = 100): subjects without RUTI, GB (n = 100): subjects with RUTI. Variables: age, concomitant diseases, glomerular filtration rate (GFR), urine neutrophil gelatinase-associated lipocalin (NGAL) at the beginning (NGAL-1) and end (NGAL-2) of the study, urine N-acetyl glucosaminidase (NAG) at the beginning (NAG-1) and the end (NAG-2) of the study, urine transforming growth factor-beta 1 (TGFbeta-1). Descriptive statistics, Mann-Whitney test, Chi-squared test, Fisher's exact test, and multivariate analysis were used. Results: Mean age was 84.33 (65-99) years old, with no difference between GA and GB. Mean NGAL-1 was 1.29 ng/ml (0.04-8). There was lower in GA than in GB. Mean NGAL-2 was 1.41 ng/ml (0.02-9.22). NGAL-2 was lower in GA than in GB. Mean NAG-1 was 0.38 UU.II/ml (0.01-2.63. NAG-1 in GA was lower than in GB. Mean NAG-2 was 0.44 UU.II/ml (0-3.41). NAG-2 was lower in GA compared with GB. Mean TGFbeta-1 was 23.43 pg/ml (0.02-103.76). TGFbeta-1 was lower in GA than GB. There were no differences in the presence of secondary diagnoses between GA and GB. NAG-2 and NGAL-1 were the most determining factors of renal function; in GA it was NGAL-2, followed by NAG-1; in GB it was NGAL-1, followed by NAG-2. Conclusion: Frail elderly with RUTI have higher urinary levels of renal injury markers, specifically NGAL, NAG, and TGFbeta-1, chronically in periods between urinary tract infection (UTI). Urinary markers of renal injury, specifically NGAL, NAG, and TGFbeta-1, identify early deterioration of renal function, compared with serum creatinine, or albuminuria, in frail elderly with recurrent urinary infections
Spatiotemporal Characteristics of the Largest HIV-1 CRF02_AG Outbreak in Spain: Evidence for Onward Transmissions
- Author
- Aitziber Lizardi
- Alberto Arranz Caso
- Alejandro Peña
- Alfonso del Arco
- Alfredo Cano
- Alicia GonzĂĄlez-Baeza
- Alvaro Mena de Cea
- Amaya Jimeno
- Ana LĂłpez Lirola
- Ana Moreno
- Ana Salas Aparicio
- Ana Silva
- Andreas Flampouris
- Andrés Navarro
- Angeles Castro Iglesias
- Angelos Hatzakis
- Angels Jaén
- Anna Rull
- Antoni A Campins
- Antonia Alcaraz GarcĂa
- Antonio Aguilera
- Antonio Antela
- Antonio Moreno
- Araceli Adsuar
- Arkaitz Imaz
- AsunciĂłn Hernando
- AsunciĂłn Iborra
- AsunciĂłn Vidal
- Aurora PĂ©rez
- Beatriz Pierola Ruiz de Galarreta
- Begoña Alcaraz
- Belen Alejos
- Belén Alejos
- Belén Padilla
- Berta Pernas Souto
- Berta Rodés
- Carlos Galera
- Carlos Guerrero-Beltran
- Carlos Iniesta
- Carmen Gadea
- Carmen MarĂa GonzĂĄlez
- Carmen RodrĂguez
- Carmen Vidal
- Carolina Gutiérrez
- Catalina Robledano
- Clara Martinez-Montes
- ConcepciĂłn Amador
- Consuelo Viladés
- Coral GĂłmez Rico
- CoRIS
- Crisitina GĂłmez Ayerbe
- Cristina Diez
- Cristina GĂłmez Ayerbe
- Cristina Hernåndez Gutiérrez
- Cristina Moreno
- Cristina SarriĂĄ Cepeda
- Daniel Podzamczer
- David Dalmau
- David Dalmau
- David Rial Crestelo
- David Vinuesa
- Dimitrios Paraskevis
- Dolores MartĂn Rodrigo
- DĂĄcil GarcĂa
- Eduardo Malmierca
- Elena Delgado
- Elena Ferrer
- Elena GarcĂa
- Elena Losada
- Elena Sendagorta
- Enrique Bernal
- Enrique MartĂn Gayo
- Esperanza Merino
- Esther RodrĂguez-Gallego
- Eulalia Valencia
- Eva Calabuig Muñoz
- Evangelia-Georgia Kostaki
- Federico Garcia
- Federico Garcia
- Federico GarcĂa
- Federico Pulido
- Felicitas DĂaz-Flores
- Fernando Dronda
- Fernando GarcĂa
- Fernando Montolio
- Francesc Vidal
- Francesc Vidal
- Francisco Arnalich
- Francisco Fanjul
- Francisco Homar
- Francisco JesĂșs Vera
- Francisco José Parras
- Francisco RodrĂguez-Arrondo
- Francisco Tejerina
- Félix Gutiérrez
- Félix Gutiérrez
- Harkaitz Azkune
- Helena Albendin
- Ignacio de los Santos
- Ignacio PĂ©rez-Valero
- Inma JarrĂn
- InĂ©s SuĂĄrez-GarcĂa
- Irene Consuegra FernĂĄndez
- Irene Portilla
- Isabel Gutiérrez
- Isabel MarĂa GarcĂa-Merino
- Isabel Viciana
- IvĂĄn Castro HernĂĄndez
- Javier de la torre
- Javier Martinez-Lacasa
- Javier Murillas
- Javier PĂ©rez Stachowski
- Jehovana HernĂĄndez
- JesĂșs RepĂĄraz
- JesĂșs Santos
- JesĂșs Sanz Sanz
- Joan Gregori Colomé
- JoaquĂn Bravo Urbieta
- JoaquĂn Peraire
- JoaquĂn Portilla
- Jorge Del Romero
- Jorge Gallego de la Fuente
- Jose Antonio Iribarren
- Jose Ignacio Bernardino de la Serna
- Jose Luis Blanco
- Jose Miguel Molina
- Josefina GarcĂa
- JosĂ© Alberto GarcĂa
- José Antonio Iribarren
- José Antonio Oteo
- José Hernåndez
- José Luis Casado
- José Luis Prada
- José López Aldeguer
- JosĂ© MarĂa GarcĂa de Lomas Guerrero
- José Ramón Arribas
- José Ramón Blanco
- José Sanz Moreno
- José Sånchez-Payå
- Juan A Pineda
- Juan Ballesteros
- Juan Berenguer
- Juan Berenguer
- Juan Carlos CarriĂł
- Juan Carlos LĂłpez Bernaldo de QuirĂłs
- Juan Carlos RodrĂguez
- Juan FernĂĄndez Navarro
- Juan GonzĂĄlez
- Juan GonzĂĄlez-garcia
- Juan Luis GĂłmez
- Juan MacĂas
- Juan Miguel Castro
- Juan Tiraboschi
- Julio Arrizabalaga
- JuliĂĄn Olalla
- Laura Bermejo
- Laura PĂ©rez-MartĂnez
- Leire PĂ©rez Latorre
- Leopoldo Muñoz
- Lidia Pascual Tomé
- Livia Giner
- Lorena MartĂnez
- Lourdes DomĂnguez
- Lucio Garcia-Fraile Fraile
- Luis Escosa
- Luis Fernando López-Cortés
- Luis Metola
- Luis Miguel Garcia Sousa
- M Ăngeles Muñoz-FernĂĄndez
- Ma Angels Ribas
- Ma JesĂșs Bustinduy
- Maialen Ibarguren
- Mar MasiĂĄ
- Mar Vera
- Marcos DĂez
- Margarita RamĂrez
- Maria Angustias Merlos
- Maria del Carmen Villalba
- Maria Isabel GonzĂĄlez
- Maria Jose Alcaraz
- Maria Jose Mellado
- Maria Luisa Navarro
- Maria Luz MartĂn-Carbonero
- Marino Blanes JuliĂĄ
- Mario Mayoral
- Mariona Xercavins
- Marta Alvarez
- Marta Alvarez
- Marta FernĂĄndez
- Marta Montero Alonso
- MarĂa del Mar Alonso
- MarĂa Gracia Ruiz de Alda
- MarĂa Inmaculada HernĂĄndez
- MarĂa JesĂșs PĂ©rez ElĂas
- MarĂa JesĂșs Vivancos
- MarĂa JosĂ© Aramburu
- MarĂa Leyes
- MarĂa Luisa Montes
- MarĂa Novella Mena
- MarĂa Pampliega
- MarĂa Peñaranda
- MarĂa Remedios AlemĂĄn
- MarĂa Saumoy
- MarĂa Tasias Pitarch
- MarĂa Teresa de LeĂłn Cano
- Melchor Riera
- Mercedes Sanz
- Miguel LĂłpez-Dupla
- Miguel Salavert LletĂ
- Miguel Thomson
- Miguel Ăngel Goenaga
- Miguel Ăngel von Wichmann
- Milagros GarcĂa LĂłpez-Hortelano
- Mireia CairĂł
- Mireia Santacreu
- Mohamed Omar Mohamed-Balghata
- Montse SanmartĂ
- Montserrat Olona
- Montserrat Vargas
- Nadia Madrid
- Natalia Chueca
- Natalia Chueca
- Natalia Stella AlcĂĄriz
- Nieves Sanz Perez
- NoemĂ Alonso
- Nuria Espinosa
- Onofre Juan MartĂnez
- Oskar Ayerdi
- Otilia Bisbal
- Pablo Velli
- Paloma GijĂłn
- Paloma MartĂ
- Pascual Balsalobre
- Patricia GonzĂĄlez-Ruano
- Paula Palau Concejo
- Paz Casas
- Paz Casas
- Pedro Herranz
- Pompeyo Viciana
- Rafael Esteban MicĂĄn
- Rafael Pascual
- Rafael Rubio
- Rafael Rubio
- Ricardo Pelazas
- Rocio Montejano
- Rosario Palacios
- Roser Font
- Sandra Cuéllar Tovar
- Santiago Moreno
- Santiago Moreno
- Santos del Campo TerrĂłn
- Sergio Padilla
- Sergio Reus
- Sergio Serrano
- Sergio Veloso
- Silvia GarcĂa-Bujalance
- Sonia Benito
- Talia Sainz
- Teresa Aldamiz-EchevarrĂa
- Teresa Puerta
- Timokratis Karamitros
- Timokratis Karamitros
- Uxua Ansa
- Valvanera Ibarra
- Vanessa Montero
- VerĂłnica Alba
- Vicente Boix
- Victor Hontañón
- Victoria Hernando
- Victoria Moreno
- Xabier Camino
- Xabier Kortajarena
- Xavier Barber
- Ăngeles Muñoz
- Publication venue
- 'Frontiers Media SA'
- Publication date
- 01/03/2019
- Field of study
Background and Aim: The circulating recombinant form 02_AG (CRF02_AG) is the predominant clade among the human immunodeficiency virus type-1 (HIV-1) non-Bs with a prevalence of 5.97% (95% Confidence Interval-CI: 5.41â6.57%) across Spain. Our aim was to estimate the levels of regional clustering for CRF02_AG and the spatiotemporal characteristics of the largest CRF02_AG subepidemic in Spain.Methods: We studied 396 CRF02_AG sequences obtained from HIV-1 diagnosed patients during 2000â2014 from 10 autonomous communities of Spain. Phylogenetic analysis was performed on the 391 CRF02_AG sequences along with all globally sampled CRF02_AG sequences (N = 3,302) as references. Phylodynamic and phylogeographic analysis was performed to the largest CRF02_AG monophyletic cluster by a Bayesian method in BEAST v1.8.0 and by reconstructing ancestral states using the criterion of parsimony in Mesquite v3.4, respectively.Results: The HIV-1 CRF02_AG prevalence differed across Spanish autonomous communities we sampled from (p < 0.001). Phylogenetic analysis revealed that 52.7% of the CRF02_AG sequences formed 56 monophyletic clusters, with a range of 2â79 sequences. The CRF02_AG regional dispersal differed across Spain (p = 0.003), as suggested by monophyletic clustering. For the largest monophyletic cluster (subepidemic) (N = 79), 49.4% of the clustered sequences originated from Madrid, while most sequences (51.9%) had been obtained from men having sex with men (MSM). Molecular clock analysis suggested that the origin (tMRCA) of the CRF02_AG subepidemic was in 2002 (median estimate; 95% Highest Posterior Density-HPD interval: 1999â2004). Additionally, we found significant clustering within the CRF02_AG subepidemic according to the ethnic origin.Conclusion: CRF02_AG has been introduced as a result of multiple introductions in Spain, following regional dispersal in several cases. We showed that CRF02_AG transmissions were mostly due to regional dispersal in Spain. The hot-spot for the largest CRF02_AG regional subepidemic in Spain was in Madrid associated with MSM transmission risk group. The existence of subepidemics suggest that several spillovers occurred from Madrid to other areas. CRF02_AG sequences from Hispanics were clustered in a separate subclade suggesting no linkage between the local and Hispanic subepidemics
How do women living with HIV experience menopause? Menopausal symptoms, anxiety and depression according to reproductive age in a multicenter cohort
- Author
- AbellĂĄn Javier Garcia
- Adsuar Araceli
- Agea IvĂĄn
- Aiello Francesco
- Alba VerĂłnica
- Albendin Helena
- Alcaraz GarcĂa Antonia
- Alcaraz Begoña
- Alcaraz Maria Jose
- Aldamiz-EchevarrĂa Teresa
- Aldeguer José López
- Alejos Belén
- AlemĂĄn MarĂa Remedios
- Algado Rabasa José Tomås
- Alonso Marta Moreno
- Amador Concha
- Amengual Guedan Maria Jose
- Antela Antonio
- Anxa Urroz Usua
- Aramburu Maria José
- Arazo Piedad
- Arnalich Francisco
- Arranz Caso Alberto
- Arribas José Ramón
- Arrizabalaga Julio
- Asensi Victor
- Ayerdi Oskar
- Azkune Harkaitz
- Ballesteros Juan
- Balsalobre Pascual
- Baraia-Etxaburu Josu Mirena
- Barber Xavier
- Benito Concha
- Berenguer Juan
- Bermejo Laura
- Bernal Enrique
- Bisbal Otilia
- Blanco José Ramón
- Boix Vicente
- Bravo Urbieta JoaquĂn
- Busca Carmen
- Bustinduy Maria JesĂșs
- Cabello Alfonso
- CairĂł Mireia
- Camacho Espejo Angela
- Camino Xabier
- Campins Antoni A
- Cano Sanchez Alfredo
- Cano Joanna
- Cardiñanos Julen
- Carmenado Maria Eugenia Rivas
- Carreres Melissa
- CarriĂł Juan Carlos
- Casado Osorio José Luis
- Castellanos Alfonso Javier
- Castro Iglesias Ăngeles
- Castro Juan Miguel
- CebriĂĄn Guadalupe RĂșa
- Cervero Jiménez Miguel
- Chueca Natalia
- Colomé Joan Gregori
- Corma Gomez Anais
- Crespo Manuel
- Crestelo David Rial
- Curran Adrian
- CĂĄmara LĂłpez Maria Mar
- Dalmau David
- de Alda MarĂa Gracia Ruiz
- de Galarreta Beatriz Pierola Ruiz
- de la Peña Mireia
- de la Serna Jose Ignacio Bernardino
- de la torre Javier
- de LeĂłn Cano MarĂa Teresa
- de los Santos Ignacio
- de Miguel Rosa
- de QuirĂłs Juan Carlos LĂłpez Bernaldo
- de Salazar Gonzalez Adolfo
- de Zarraga Miguel Alberto
- del Arco Alfonso
- del Campo TerrĂłn Santos
- del Carmen Villalba Maria del Carmen
- del Mar Alonso MarĂa
- Del Romero Jorge
- Diez Cristina
- DomĂnguez Lourdes
- DĂaz-Flores Felicitas
- DĂez Marcos
- Ena Javier
- Escosa Luis
- Espinosa Nuria
- Estrada PĂ©rez Vicente
- Fanciulli Chiara
- Fanjul Francisco
- Fenoll Vicenta
- Fernando Vilalta RamĂłn
- FernĂĄndez Fuertes Marta
- FernĂĄndez Irene Consuegra
- FernĂĄndez Marta
- Ferrer Ribera Ana
- Ferrero Beneitez Oscar Luis
- Font Roser
- Fraile Lucio Garcia-Fraile
- Frias Casas Mario
- Fuentes Lopez Ana
- Fuster Daniel
- Galera Carlos
- Galindo Puerto MarĂa JosĂ©
- Garcia Manel Cervantes
- GarcĂa de Lomas Guerrero JosĂ© MarĂa
- GarcĂa DĂĄcil
- GarcĂa Federico
- GarcĂa Gema
- GarcĂa Josefina
- GarcĂa JosĂ© Alberto
- GarcĂa-Bujalance Silvia
- Gayo Enrique Martin
- GijĂłn Paloma
- Gil Anguita ConcepciĂłn
- Gimeno Lina
- Giner Livia
- Goenaga Miguel Ăngel
- Gonzalez-Domenec Carmen Maria
- Gonzalez-Serna Alejandro
- GonzĂĄlez Maria Isabel
- GonzĂĄlez-Baeza Alicia
- GonzĂĄlez-Garcia Juan
- GonzĂĄlez-Ruano Patricia
- Guerrero BeltrĂĄn Carlos
- Gutiérrez Carolina
- Gutiérrez Félix
- Gutiérrez Isabel
- GĂłmez Ayerbe Cristina
- GĂłmez Vidal MarĂa Amparo
- GĂłmez Juan Luis
- GĂłrgolas Miguel
- Hernando AsunciĂłn
- Hernando Victoria
- Hernåndez Gutiérrez Cristina
- HernĂĄndez IvĂĄn Castro
- HernĂĄndez Jehovana
- HernĂĄndez MarĂa Inmaculada
- Herranz Pedro
- Hierro Ana Delgado
- Homar Francisco
- Hontañón Victor
- Ibarguren Maialen
- Ibarra Valvanera
- Iborra AsunciĂłn
- Igartua Maitane Umerez
- Imaz Arkaitz
- Iniesta Carlos
- Iribarren Jose Antonio
- Is Laura PĂ©rez
- Isbert Sonia Calzado
- Jarrin Inma
- JaĂ©n Ăngels
- JesĂșs TĂ©llez Molina Maria
- Jimeno Amaya
- JuliĂĄ Marino Blanes
- Kortajarena Xabier
- Latorre Leire PĂ©rez
- Lirola Ana LĂłpez
- Lizardi Aitzibir
- LletĂ Miguel Salavert
- Lopez Azkarreta Iñigo
- Lopez Miriam
- Losada Elena
- LĂłpez de Munain Josefina
- LĂłpez LĂłpez Pedro
- LĂłpez Carmen PĂ©rez
- López-Cortés Luis Fernando
- LĂłpez-Dupla Miguel
- LĂłpez-Hortelano Milagros GarcĂa
- Machuca SĂĄnchez Isabel
- Madrid Nadia
- Malmierca Eduardo
- Marcotegui Maria Riveiro
- Martin Maria Luisa
- Martinez Sanz Javier
- Martinez Marina
- Martinez-Lacasa Javier
- Martinez-Montes Clara
- MartĂn-Carbonero Maria Luz
- MartĂnez Lorena
- MartĂnez Onofre Juan
- MasiĂĄ Mar
- Mayoral Mario
- Meca Marisa
- Mellado Maria Jose
- Mena de Cea Ălvaro
- Merchante Gutierrez NicolĂĄs
- Merino Esperanza
- Merlos Maria Angustias
- Metola Luis
- MicĂĄn Rafael Esteban
- Miralles Celia
- Mohamed-Balghata Mohamed Omar
- Montejano Rocio
- Montes MarĂa Luisa
- Morano Luis
- Moreno Antonio
- Moreno Cristina
- Moreno Santiago
- Moreno Victoria
- Muga Roberto
- Murillas Javier
- Muñoz FernĂĄndez Maria Ăngeles
- Muñoz Medina Leopoldo
- Muñoz Perez Ăngeles
- Muñoz Eva Calabuig
- Muñoz Josefa
- Navarro Gemma
- Navarro Juan FernĂĄndez
- Navarro Maria Luisa
- Novella Mena Maria
- Nuñez Fernando Dronda
- Ocampo Antonio
- Olalla Sierra JuliĂĄn
- Olona Montserrat
- Oteo José Antonio
- Oyaga Maria Pilar Carmona
- Padilla Belén
- Padilla Sergio
- Palacios Rosario
- Parras Francisco José
- Pascual Mario
- Pascual Rafael
- Pasquau Francisco
- Payeras Antoni
- Pelazas Ricardo
- Peraire Joaquin
- Perez Nieves Sanz
- Pernas Souto Berta
- Peñaranda MarĂa
- Pineda Juan A
- Pitarch Maria Tasias
- Podzamczer Daniel
- Portilla Irene
- Portilla JoaquĂn
- Pousada Guillermo
- Povedo Eva
- Prada José Luis
- Prieto Laura
- Prieto Paula
- Puerta Teresa
- Pulido Federico
- PĂ©rez ElĂas MarĂa JesĂșs
- PĂ©rez Stachowski Javier
- PĂ©rez Alexandre
- PĂ©rez Aurora
- PĂ©rez Reyes Pascual
- PĂ©rez-ElĂas Maria JesĂșs
- PĂ©rez-MartĂnez Laura
- PĂ©rez-Somarriba Moreno Juncal
- PĂ©rez-Valero Ignacio
- Quero José Hernåndez
- RamĂrez Margarita
- Raposo Utrilla Montserrat
- Rava Marta
- Re Vanessa Agullo
- Real Luis Miguel
- RepĂĄraz JesĂșs
- Reus Sergio
- Ribas Maria Ăngels
- Ribera Esteban
- Riera Melchor
- RincĂłn Mayo Pilar
- Rivero JuĂĄrez Antonio
- Rivero RomĂĄn Antonio
- Robledano Catalina
- Roca Maria
- Rodrigo Dolores MartĂn
- RodrĂguez Carmen
- RodrĂguez Juan Carlos
- RodrĂguez-Arrondo Francesc
- RodrĂguez-Gallego Esther
- Rodés Berta
- Rubio Rafael
- Ruiz Seco Maria Pilar
- Rull Anna
- Sainz Talia
- Salas Aparicio Ana
- Sampériz Gloria
- Sanchez Juan MacĂas
- SanmartĂ Montse
- Santacreu Mireia
- Santos JesĂșs
- Sanvisens Arantza
- Sanz Moreno José
- Sanz Sanz JesĂșs
- Sanz Mercedes
- Sarria Cepeda Cristina
- Saumoy Maria
- Secades TomĂĄs SuĂĄrez Zarracina
- Sendagorta Elena
- Serrano Villar Sergio
- Silva Ana
- Sousa Luis Miguel GarcĂa
- SuĂĄrez-GarcĂa Ines
- Sånchez-Payå José
- Tasias MarĂa
- Tejerina Francisco
- Tiraboschi Juan
- Tomé Lidia Pascual
- Torres Perea Rafael
- TorrĂșs Diego
- Tovar Sandra Cuéllar
- Ugarte Sofia Ibarra
- Universitat AutĂČnoma de Barcelona. Departament de Medicina
- Valencia Eulalia
- Valle Eulalia
- Vargas Montserrat
- Velasco Tamara
- Velli Pablo
- Veloso Sergio
- Vera Francisco JesĂșs
- Vera Mar
- Vergas GarcĂa Jorge
- Viciana Isabel
- Viciana Pompeyo
- Vidal AsunciĂłn
- Vidal Carmen
- Vidal Francesc
- Viladés Consuelo
- Vilasaro Marta Navarro
- Vilchez Helem H
- Vinuesa GarcĂa David
- Vivancos Gallego Maria JesĂșs
- von Wichmann Miguel Ăngel
- Zamora Ana Moreno
- Zuriñe Zubero Miren
- Ălvarez Beatriz
- Ălvarez Marta
- Publication venue
- Publication date
- 01/01/2021
- Field of study
CatedresBackground: To estimate the prevalence and severity of menopausal symptoms and anxiety/depression and to assess the differences according to menopausal status among women living with HIV aged 45-60 years from the cohort of Spanish HIV/AIDS Research Network (CoRIS). Methods: Women were interviewed by phone between September 2017 and December 2018 to determine whether they had experienced menopausal symptoms and anxiety/depression. The Menopause Rating Scale was used to evaluate the prevalence and severity of symptoms related to menopause in three subscales: somatic, psychologic and urogenital; and the 4-item Patient Health Questionnaire was used for anxiety/depression. Logistic regression models were used to estimate odds ratios (ORs) of association between menopausal status, and other potential risk factors, the presence and severity of somatic, psychological and urogenital symptoms and of anxiety/depression. Results: Of 251 women included, 137 (54.6%) were post-, 70 (27.9%) peri- and 44 (17.5%) pre-menopausal, respectively. Median age of onset menopause was 48 years (IQR 45-50). The proportions of pre-, peri- and post-menopausal women who had experienced any menopausal symptoms were 45.5%, 60.0% and 66.4%, respectively. Both peri- and post-menopause were associated with a higher likelihood of having somatic symptoms (aOR 3.01; 95% CI 1.38-6.55 and 2.63; 1.44-4.81, respectively), while post-menopause increased the likelihood of having psychological (2.16; 1.13-4.14) and urogenital symptoms (2.54; 1.42-4.85). By other hand, post-menopausal women had a statistically significant five-fold increase in the likelihood of presenting severe urogenital symptoms than pre-menopausal women (4.90; 1.74-13.84). No significant differences by menopausal status were found for anxiety/depression. Joint/muscle problems, exhaustion and sleeping disorders were the most commonly reported symptoms among all women. Differences in the prevalences of vaginal dryness (p = 0.002), joint/muscle complaints (p = 0.032), and sweating/flush (p = 0.032) were found among the three groups. Conclusions: Women living with HIV experienced a wide variety of menopausal symptoms, some of them initiated before women had any menstrual irregularity. We found a higher likelihood of somatic symptoms in peri- and post-menopausal women, while a higher likelihood of psychological and urogenital symptoms was found in post-menopausal women. Most somatic symptoms were of low or moderate severity, probably due to the good clinical and immunological situation of these women
COVID-19 in hospitalized HIV-positive and HIV-negative patients : A matched study
- Author
- Adsuar Araceli
- Agea IvĂĄn
- Aiello Francesco
- Alba VerĂłnica
- Albendin Helena
- Alcaraz Begoña
- Alcaraz Maria Jose
- AlcarĂĄz Antonia
- Aldamiz-EchevarrĂa Teresa
- Alejos Belén
- AlemĂĄn MarĂa Remedios
- Algado José Tomås
- Alonso MarĂa del Mar
- Amador Concha
- Amengual MarĂa JosĂ©
- Antela Antonio
- Anxa Urroz Usua
- Aramburu MarĂa JosĂ©
- Arazo Piedad
- Arnalich Francisco
- Arranz Alberto
- Arribas José R.
- Arrizabalaga Julio
- Asensi VĂctor
- Ayerdi Oskar
- Azkune Harkaitz
- Ballesteros Juan
- Balsalobre Pascual
- Baraia-Etxaburu Josu Mirena
- Barber Xavier
- Benito Concha
- Berenguer Juan
- Bermejo Laura
- Bernal Enrique
- Bernardino de la Serna, Jose Ignacio
- Bisbal Otilia
- Blanco José Ramón
- Blanes Marino
- Boix Vicente
- Bravo Urbieta JoaquĂn
- Busca Carmen
- Bustinduy Maria JesĂșs
- Cabello Alfonso
- CairĂł Mireia
- Calabuig Eva
- Calzado Sonia
- Camacho Angela
- Camino Xabier
- Campins Antoni A.
- Cano Sanchez Alfredo
- Cano Joanna
- Cardiñanos Julen
- Carmona Oyaga Maria Pilar
- Carreres Melissa
- CarriĂł Juan Carlos
- Casado Jose Luis
- Castro HernĂĄndez IvĂĄn
- Castro Juan Miguel
- Castro Ăngeles
- Cervantes Manel
- Cervero Miguel
- Chueca Natalia
- Colomé Joan Gregori
- Consuegra FernĂĄndez Irene
- Corma Gomez Anais
- Crespo Manuel
- Curran Adrian
- Cuéllar Sandra
- CĂĄmara Maria Mar
- Dalmau David
- de la Peña Mireia
- de la Torre Javier
- de LeĂłn Cano MarĂa Teresa
- de los Santos Ignacio
- de Miguel Rosa
- de Salazar Gonzalez Adolfo
- de Zarraga Miguel Alberto
- del Arco Alfonso
- del Campo Santos
- Del Romero-Raposo Jorge
- Delgado Hierro Ana
- Diez Cristina
- Diez Cristina
- DomĂnguez Lourdes
- Dronda Fernando
- DĂaz-Flores Felicitas
- DĂez Marcos
- Ena Javier
- Escosa Luis
- Espinosa Nuria
- Estrada Vicente
- Fanciulli Chiara
- Fanjul Francisco
- Fenoll Vicenta
- FernĂĄndez Fuertes Marta
- FernĂĄndez Navarro Juan
- FernĂĄndez Marta
- Ferrer Ana
- Ferrero Oscar Luis
- Font Roser
- Frias Mario
- Fuentes Ana
- Fuster Daniel
- Galera Carlos
- Galindo MarĂa JosĂ©
- Garcia AbellĂĄn Javier
- Garcia-Fraile Lucio J.
- GarcĂa de Lomas JosĂ© MarĂa
- GarcĂa LĂłpez-Hortelano Milagros
- GarcĂa DĂĄcil
- GarcĂa Federico
- GarcĂa Federico
- GarcĂa Gema
- GarcĂa Josefina
- GarcĂa JosĂ© Alberto
- GarcĂa-Bujalance Silvia
- GijĂłn Paloma
- Gil Anguita ConcepciĂłn
- Gimeno Lina
- Giner Livia
- Goenaga Miguel Ăngel
- Gonzalez-Domenec Carmen Maria
- Gonzalez-Serna Alejandro
- GonzĂĄlez Maria Isabel
- GonzĂĄlez-Baeza Alicia
- GonzĂĄlez-Garcia Juan
- GonzĂĄlez-Ruano Patricia
- Guerrero Carlos
- Gutiérrez Carolina
- Gutiérrez Félix
- Gutiérrez Isabel
- GĂłmez Ayerbe Cristina
- GĂłmez Vidal MarĂa Amparo
- GĂłmez-Sirvent Juan L.
- GĂłrgolas Miguel
- Hernando AsunciĂłn
- Hernåndez Gutiérrez Cristina
- Hernåndez Quero José
- HernĂĄndez Jehovana
- HernĂĄndez MarĂa Inmaculada
- Herranz Pedro
- Homar Francisco
- Hontañón VĂctor
- Ibarguren Maialen
- Ibarra Sofia
- Ibarra Valvanera
- Iborra AsunciĂłn
- Imaz Arkaitz
- Iniesta Carlos
- Iribarren Jose Antonio
- Iribarren José Antonio
- Izquierdo Rebeca
- Jarrin Inmaculada
- Jaén Angels
- Jimeno Amaya
- Kortajarena Xabier
- Latorre Leire PĂ©rez
- Lizardi Aitziber
- Lopez Miriam
- Losada Elena
- López Azkarreta Iñigo
- LĂłpez de Munain Josefina
- LĂłpez Lirola Ana
- LĂłpez Juan Carlos
- LĂłpez Pedro
- López-Aldeguer José
- López-Cortés Luis Fernando
- Machuca Isabel
- MacĂas Juan
- Madrid Nadia
- Malmierca Eduardo
- Martin Maria Luisa
- Martinez Marina
- Martinez-Lacasa Javier
- Martinez-Montes Clara
- MartĂn Gayo Enrique
- MartĂn Rodrigo Dolores
- MartĂn-Carbonero Maria Luz
- MartĂnez Sanz Javier
- MartĂnez Lorena
- MartĂnez Onofre Juan
- Masip Jenifer
- MasiĂĄ Mar
- Mayoral Mario
- Meca Marisa
- Mellado Maria Jose
- Mena Ălvaro
- Merchante NicolĂĄs
- Merino Esperanza
- Merlos Maria Angustias
- Metola Luis
- MicĂĄn Rafael
- Miralles Celia
- Montejano Rocio
- Montero Marta
- Montes MarĂa Luisa
- Morano Luis
- Moreno Ana
- Moreno Antonio
- Moreno Cristina
- Moreno Santiago
- Moreno Victoria
- Muga Roberto
- Murillas Javier
- Muñoz Medina Leopoldo
- Muñoz Perez Ăngeles
- Muñoz Josefa
- Muñoz-FernĂĄndez M Ăngeles
- Navarro Vilasaro Marta
- Navarro Gemma
- Navarro Maria Luisa
- Novella MarĂa
- Ocampo Antonio
- Olalla Julian
- Olona Montserrat
- Omar Mohamed
- Oteo José Antonio
- Padilla Belén
- Padilla Sergio
- Palacios Rosario
- Parras Francisco José
- Pascual PĂ©rez Reyes
- Pascual Tomé Lidia
- Pascual Rafael
- Pasquau Francisco
- Payeras Antoni
- Pelazas Ricardo
- Peraire JoaquĂn
- Pernas Berta
- Peñaranda MarĂa
- Pierola Beatriz
- Pineda Juan A
- Podzamczer Daniel
- Portilla Irene
- Portilla JoaquĂn
- Pousada Guillermo
- Poveda Eva
- Poveda Eva
- Prada José Luis
- Prieto Laura
- Prieto Paula
- Puerta Teresa
- Pulido Federico
- PĂ©rez ElĂas Maria JesĂșs
- PĂ©rez Is Laura
- PĂ©rez LĂłpez Carmen
- PĂ©rez Stachowski Javier
- PĂ©rez Alexandre
- PĂ©rez Aurora
- PĂ©rez-MartĂnez Laura
- PĂ©rez-Somarriba Juncal
- PĂ©rez-Valero Ignacio
- RamĂrez Margarita
- Raposo Utrilla Montserrat
- Rava Marta
- Re Vanessa
- Real Luis Miguel
- RepĂĄraz JesĂșs
- Reus Sergio
- Reverté Laia
- Rial David
- Ribas MarĂa Angels
- Ribera Esteban
- Riera Melchor
- RincĂłn Pilar
- Rivas Carmenado MarĂa Eugenia
- Rivero JuĂĄrez Antonio
- Rivero Marcotegui Maria
- Rivero RomĂĄn Antonio
- Robledano Catalina
- Roca MarĂa
- RodrĂguez Carmen
- RodrĂguez Juan Carlos
- RodrĂguez-Arrondo Francisco
- Rodés Berta
- Rubio Rafael
- Rubio Rafael
- Ruiz de Alda MarĂa Gracia
- Ruiz Seco Maria Pilar
- Rull Anna
- RĂșa CebriĂĄn Guadalupe
- Sainz Talia
- Salas Ana
- Salavert LletĂ Miguel
- Sampériz Gloria
- SanmartĂ Montse
- Santacreu Mireia
- Santos JesĂșs
- Sanvisens Arantza
- Sanz Moreno José
- Sanz Sanz JesĂșs
- Sanz Mercedes
- SarriĂĄ Cristina
- Saumoy MarĂa
- Sendagorta Elena
- Serrano Sergio
- Silva Ana
- SuĂĄrez-GarcĂa InĂ©s
- SuĂĄrez-Zarracina TomĂĄs
- Sånchez-Payå José
- Tasias Pitarch MarĂa
- Tejerina Francisco
- Tiraboschi Juan
- Torres Rafael
- TorrĂșs Diego
- TĂ©llez Maria JesĂșs
- Umerez Igartua Maitane
- Valencia Eulalia
- Valle Eulalia
- Vallejo Alejandro
- Vargas Montserrat
- Velasco Tamara
- Velli Pablo
- Veloso Sergio
- Vera Francisco J
- Vera Mar
- Vergas Jorge
- Viciana Isabel
- Viciana Pompeyo
- Vidal AsunciĂłn
- Vidal Carmen
- Vidal Francesc
- Vidal Francesc
- Viladés Consuelo
- Vilalta Ramon Fernando
- Vilchez Helem H.
- Villalba Maria del Carmen
- Vinuesa David
- Vivancos Maria JesĂșs
- von Wichmann Miguel Ăngel
- Yeregui Elena
- Zubero Miren Zuriñe
- Ălvarez Beatriz
- Ălvarez Marta
- Publication venue
- Publication date
- 01/01/2021
- Field of study
CatedresObjectives: We compared the characteristics and clinical outcomes of hospitalized individuals with COVID-19 with [people with HIV (PWH)] and without (non-PWH) HIV co-infection in Spain during the first wave of the pandemic. Methods: This was a retrospective matched cohort study. People with HIV were identified by reviewing clinical records and laboratory registries of 10 922 patients in active-follow-up within the Spanish HIV Research Network (CoRIS) up to 30 June 2020. Each hospitalized PWH was matched with five non-PWH of the same age and sex randomly selected from COVID-19@Spain, a multicentre cohort of 4035 patients hospitalized with confirmed COVID-19. The main outcome was all-cause in-hospital mortality. Results: Forty-five PWH with PCR-confirmed COVID-19 were identified in CoRIS, 21 of whom were hospitalized. A total of 105 age/sex-matched controls were selected from the COVID-19@Spain cohort. The median age in both groups was 53 (Q1-Q3, 46-56) years, and 90.5% were men. In PWH, 19.1% were injecting drug users, 95.2% were on antiretroviral therapy, 94.4% had HIV-RNA < 50 copies/mL, and the median (Q1-Q3) CD4 count was 595 (349-798) cells/ÎŒL. No statistically significant differences were found between PWH and non-PWH in number of comorbidities, presenting signs and symptoms, laboratory parameters, radiology findings and severity scores on admission. Corticosteroids were administered to 33.3% and 27.4% of PWH and non-PWH, respectively (P = 0.580). Deaths during admission were documented in two (9.5%) PWH and 12 (11.4%) non-PWH (P = 0.800). Conclusions: Our findings suggest that well-controlled HIV infection does not modify the clinical presentation or worsen clinical outcomes of COVID-19 hospitalization
Effectiveness of the combination elvitegravir/cobicistat/tenofovir/emtricitabine (EVG/COB/TFV/FTC) plus darunavir among treatment-experienced patients in clinical practice : A multicentre cohort study
- Author
- Adsuar A.
- Agea I.
- Alba V.
- Albendin H.
- Alcaraz B.
- Alcaraz M.J.
- AlcĂĄriz N.S.
- Aldamiz-EchevarrĂa T.
- Aldeguer J.L.
- Alejos B.
- AlemĂĄn M.R.
- Alonso M.M.
- Alonso N.
- Amador C.
- Amador C.
- Amengual Guedan Maria Jose
- Anguita C.G.
- Antela A.
- Aparicio A.S.
- Aramburu M.J.
- Arazo P.
- Arnalich F.
- Arribas J. R.
- Arrizabalaga J.
- Asensi V.
- Ayerbe C.G.
- Ayerdi O.
- Azkarreta I.L.
- Azkune H.
- Ballesteros J.
- Balsalobre P.
- Baraia-Etxaburu J.M.
- Barber X.
- Beltran C.G.
- Beneitez O.L.F.
- Benito C.
- Berenguer Juan
- Bermejo L.
- Bernal E.
- Bisbal O.
- Blanco J.R.
- Boix V.
- Bustinduy M.J.
- Cabello A.
- CairĂł M.
- Calzado Isbert Sonia
- Camino X.
- Campins A.A.
- Carmenado M.E.R.
- Carreres M.
- CarriĂł J.C.
- Casas M.F.
- Caso A.A.
- Castellanos A.J.
- Castro J.M.
- Cepeda C.S.
- Cervantes Garcia Manel
- Chueca N.
- Colomé J.G.
- Crespo M.
- Crestelo D.R.
- Curran FĂĄbregas Adria
- Dalmau D.
- Dalmau D.
- De Alda M.G.R.
- De Cea A.M.
- De Galarreta B.P.R.
- De La Peña M.
- De La Serna J.I.B.
- De La Torre J.
- De LeĂłn Cano M.T.
- De Lomas Guerrero J.M.G.
- De Los Santos I.
- De Munain J.L.
- De QuirĂłs J.C.L.B.
- De Salazar Gonzalerz A.
- De Zarraga M.A.
- De Zarraga M.A.
- Del Arco A.
- Del Campo TerrĂłn S.
- Del Carmen Villalba M.
- Del Mar Alonso M.
- Del Romero J.
- Diez C.
- DomĂnguez L.
- DĂaz-Flores F.
- DĂez MartĂnez M.
- DĂez M.
- ElĂas M.J.P.
- Ena J.
- Escosa L.
- Espejo A.C.
- Espinosa N.
- Fanciulli C.
- Fanjul F.
- Fenoll V.
- FernĂĄndez I.C.
- FernĂĄndez M.
- Font R.
- Fraile L.G.F.
- Fuertes M.F.
- Fuster Daniel
- Galera C.
- Gallego M.J.V.
- GarcĂa A.A.
- GarcĂa D.
- GarcĂa D.V.
- GarcĂa E.
- GarcĂa F.
- GarcĂa F.
- GarcĂa G.
- GarcĂa J.
- GarcĂa J. A.
- GarcĂa J.V.
- GarcĂa-Bujalance S.
- Gayo E.M.
- GijĂłn P.
- Gimeno L.
- Giner L.
- Goenaga M.Ă.
- Gomez A.C.
- Gonzalez-Domenec C.M.
- Gonzalez-Serna A.
- GonzĂĄlez J.
- GonzĂĄlez M.I.
- GonzĂĄlez-Baeza A.
- GonzĂĄlez-Garcia J.
- GonzĂĄlez-Ruano P.
- Gutierrez N.M.
- Gutiérrez C.
- Gutiérrez C.H.
- Gutiérrez F.
- Gutiérrez F.
- Gutiérrez I.
- GĂłmez J.L.
- GĂłrgolas M.
- GĂłrgolas M.
- Hernando A.
- HernĂĄndez I.C.
- HernĂĄndez J.
- HernĂĄndez M.I.
- Herranz P.
- Homar F.
- Hontañón V.
- Ibarguren M.
- Ibarra V.
- Iborra A.
- Igartua M.U.
- Iglesias A.C.
- Imaz Arkaitz
- Iniesta C.
- Iribarren J.A.
- Iribarren J.A.
- Is L.P.
- Jarrin I.
- Jarrin I.
- Jarrin I.
- Jaén A.
- Jimeno A.
- Jiménez M.C.
- JuliĂĄ M.B.
- JuĂĄrez A.R.
- Kortajarena X.
- Latorre L.P.
- Leyes M.
- Lirola A.L.
- Lizardi A.
- LletĂ M.S.
- Lopez A.F.
- Lopez M.
- Losada E.
- LĂłpez C.P.
- LĂłpez M.M.C.
- LĂłpez P.L.
- López-Cortés L.F.
- LĂłpez-Dupla M.
- LĂłpez-Hortelano M.G.
- Madrid N.
- Malmierca E.
- Marcotegui M.R.
- Martinez-Lacasa J.
- Martinez-Montes C.
- MartĂn-Carbonero M.L.
- MartĂnez L.
- MartĂnez O.J.
- MasiĂĄ M.
- Mayo P.R.
- Mayoral M.
- Meca M.
- Medina L.M.
- Mellado M.J.
- Mena M.N.
- Merino E.
- Merlos M.A.
- Metola L.
- MicĂĄn R.E.
- Miralles C.
- Mohamed-Balghata M.O.
- Molina M.J.T.
- Montejano R.
- Montes M.L.
- Montolio F.
- Morano L.
- Moreno A.
- Moreno C.
- Moreno Cristina
- Moreno J.P.S.
- Moreno J.S.
- Moreno S.
- Moreno S.
- Moreno V.
- Muga Roberto
- Murillas J.
- Muñoz E.C.
- Muñoz J.
- Muñoz-FernĂĄndez M.Ă.
- Muñoz-FernĂĄndez M.Ă.
- Navarro Rubio Gemma
- Navarro A.
- Navarro J.F.
- Navarro M. L.
- Navarro Marta
- Nuñez F.D.
- Ocampo A.
- Olona M.
- Osorio J.L.C.
- Oteo J.A.
- Oyaga M.P.C.
- Padilla B.
- Padilla S.
- Palacios R.
- Parras F.J.
- Pascual R.
- Pasquau F.
- Pelazas R.
- Peraire J.
- Perea R.T.
- Perez A.M.
- Perez N.S.
- Peñaranda M.
- Pineda J.A.
- Pitarch M.T.
- Podzamczer Daniel
- Portilla I.
- Portilla J.
- Pousada G.
- Poveda E.
- Poveda E.
- Prada J.L.
- Prieto L.
- Prieto Paula
- Puerta T.
- Puerto M.J.G.
- Pulido F.
- PĂ©rez A.
- PĂ©rez A.
- PĂ©rez V.E.
- PĂ©rez-ElĂas M.J.
- PĂ©rez-MartĂnez L.
- PĂ©rez-MartĂnez L.
- PĂ©rez-Valero I.
- Quero J.H.
- Rabasa J.T.A.
- RamĂrez M.
- Rava M.
- Real L.M.
- RepĂĄraz J.
- Reus S.
- Ribas M.A.
- Ribera A.F.
- Ribera Esteban
- Riera M.
- Robledano C.
- Rodrigo D.M.
- RodrĂguez C.
- RodrĂguez J.C.
- RodrĂguez-Arrondo F.
- RodrĂguez-Gallego E.
- Rodés B.
- RomĂĄn A.R.
- Rubio R.
- Rubio R.
- Ruiz-AlguerĂł M.
- Rull A.
- Sainz T.
- Sampériz G.
- Sanchez A.C.
- Sanchez J.M.
- SanmartĂ M.
- Santacreu M.
- Santos J.
- Sanvisens Arantza
- Sanz J.M.
- Sanz J.S.
- Sanz M.
- Saumoy MarĂa
- Secades T.S.Z.
- Seco M.P.R.
- Sendagorta E.
- Sierra J.O.
- Silva Ana
- Sousa L.M.G.
- Souto B.P.
- Stachowski J.P.
- SuĂĄrez-GarcĂa I.
- SuĂĄrez-GarcĂa InĂ©s
- SĂĄnchez I. M.
- SĂĄnchez-PayĂĄ J.
- Tejerina F.
- Tiraboschi Juan
- Tomé L.P.
- TorrĂșs D.
- Tovar S.C.
- Ugarte S.I.
- Urbieta J.B.
- Urroz U.A.
- Utrilla M.R.
- Valencia E.
- Valle E.
- Vargas M.
- Velasco T.
- Velli P.
- Veloso S.
- Vera F.J.
- Vera M.
- Viciana I.
- Viciana P.
- Viciana P.
- Vidal A.
- Vidal C.
- Vidal F.
- Vidal F.
- Vidal M.A.G.
- Viladés C.
- Vilalta R.F.
- Villar S.S.
- Von Wichmann M.Ă.
- Xercavins M.
- Zamora A.M.
- Zubero M.Z.
- Ălvarez B.
- Ălvarez Mar
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Background: The aim of this study was to investigate the effectiveness and tolerability of the combination elvitegravir/cobicistat/tenofovir/emtricitabine plus darunavir (EVG/COB/TFV/FTC + DRV) in treatment-experienced patients from the cohort of the Spanish HIV/AIDS Research Network (CoRIS). Methods: Treatment-experienced patients starting treatment with EVG/COB/TFV/FTC + DRV during the years 2014-2018 and with more than 24 weeks of follow-up were included. TFV could be administered either as tenofovir disoproxil fumarate or tenofovir alafenamide. We evaluated virological response, defined as viral load (VL) < 50 copies/ml and < 200 copies/ml at 24 and 48 weeks after starting this regimen, stratified by baseline VL (< 50 or â„ 50 copies/ml at the start of the regimen). Results: We included 39 patients (12.8% women). At baseline, 10 (25.6%) patients had VL < 50 copies/ml and 29 (74.4%) had â„ 50 copies/ml. Among patients with baseline VL < 50 copies/ml, 85.7% and 80.0% had VL < 50 copies/ml at 24 and 48 weeks, respectively, and 100% had VL < 200 copies/ml at 24 and 48 weeks. Among patients with baseline VL â„ 50 copies/ml, 42.3% and 40.9% had VL < 50 copies/ml and 69.2% and 68.2% had VL < 200 copies/ml at 24 and 48 weeks. During the first 48 weeks, no patients changed their treatment due to toxicity, and 4 patients (all with baseline VL â„ 50 copies/ml) changed due to virological failure. Conclusions: EVG/COB/TFV/FTC + DRV was well tolerated and effective in treatment-experienced patients with undetectable viral load as a simplification strategy, allowing once-daily, two-pill regimen with three antiretroviral drug classes. Effectiveness was low in patients with detectable viral loads
Discovering HIV related information by means of association rules and machine learning
- Author
- Adsuar Araceli
- Agea IvĂĄn
- Agullo Vanessa
- Aiello Francesco
- Alba VerĂłnica
- Albendin Helena
- Alcaraz Antonia
- Alcaraz Begoña
- Aldamiz-EchevarrĂa Teresa
- AlemĂĄn M. Remedios
- Algado Jose TomĂĄs
- Alonso M. Mar
- Alonso NoemĂ
- Amador Concha
- Anguita Francisco
- Antela Antonio
- Aramburu M. José
- Araujo Lourdes
- Arazo Piedad
- Arce Octavio
- Arranz Alberto
- Arribas José Ramón
- Arribas VĂctor
- Asensi VĂctor
- Ayerdi Oskar
- Azkune Harkaitz
- Ballesteros Juan
- Balsalobre Luz
- Barber Xavier
- Barrios Ana
- Bautista Azucena
- Baza Begoña
- Berenguer Juan
- Bermejo Laura
- Bernal Enrique
- Bernardino Jose Ignacio
- Bisbal Otilia
- Bisbal Otilia
- Blanco José Ramón
- Blanes Marino
- Boix Vicente
- Botella Ăngela
- Bravo JoaquĂn
- Burgos JoaquĂn
- Busca Carmen
- Bustinduy M. JesĂșs
- Cabello Alfonso
- Cabello NoemĂ
- CairĂł Mireia
- Calabuig Eva
- Calvet-Mirabent Marta
- Calzado Sonia
- Camacho Ăngela
- Camino Xabier
- Campins Antoni A.
- Cano Joanna
- Cardiñanos Julen
- Carrillo Irene
- CarriĂł Juan Carlos
- Casado José Luis
- Castillo Antonia
- Castro Juan Miguel
- Castro Ăngeles
- Catalina Scévola Sofia
- Cervantes Garcia Manel
- Cervero Miguel
- Chueca Natalia
- Ciudad Marianela
- Corma Anais
- Corona Diana
- Corona Diana
- Corral Saray
- Curran AdriĂĄn
- Cuéllar Sandra
- CĂĄmara M. Mar
- Dalmau David
- de la Peña Mireia
- de la Torre Javier
- de Lagarde MarĂa
- de los Santos Alejandro
- de los Santos Ignacio
- de Miguel Joana
- de Miguel Rosa
- de Salazar Adolfo
- de Zarraga Miguel Alberto
- del Arco Alfonso
- del Campo Santos
- Del Romero Jorge
- Delgado-Hierro Ana
- Descalzo Jorro Vicente
- Diez Cristina
- Dronda Fernando
- Dueñas Carlos
- DĂaz-Flores Felicitas
- EgĂŒes Xjoylin
- Escosa Luis
- Espineira Sonia
- Espinosa Nuria
- Estrada Vicente
- Falces Iker
- Falcó Vicenç
- Fanciulli Chiara
- Fanjul Francisco J.
- FernĂĄndez Juan
- FernĂĄndez Marian
- FernĂĄndez Marta
- FernĂĄndez Marta
- Ferrer Ana
- Ferrero Ăscar Luis
- Font Roser
- Frias Mario
- Fuentes Ana
- Fuster Daniel
- Galera Carlos
- Galiana Antonio
- Galindo M. José
- Garcia-Gazalla Mercedes
- GarcĂa AbellĂĄn Javier
- GarcĂa DĂĄcil
- GarcĂa Federico
- GarcĂa Gema
- GarcĂa Guillermo
- GarcĂa Jorge
- GarcĂa Josefina
- GarcĂa JosĂ© Alberto
- GarcĂa Milagros
- GarcĂa-Fraile Lucio
- GarcĂa-Pardo Graciano
- GijĂłn Paloma
- Gil ConcepciĂłn
- Gil Leire
- Giner Livia
- Goenaga Miguel Ăngel
- Goikoetxea Maider
- Gonzalez Candela
- Gonzalez-Serna Alejandro
- GonzĂĄlez-Baeza Alicia
- GonzĂĄlez-GarcĂa Juan
- GonzĂĄlez-Ruano Patricia
- Gracia MarĂa
- GuillĂ©n LucĂa
- Guirao Emilio
- Gutierrez Isabel
- Gutiérrez Félix
- Gutiérrez Sara
- GutiĂ©rrez Ăngela
- GĂłmez Bertomeu Frederic
- GĂłmez Cristina
- GĂłmez Juan Luis
- GĂłmez M. Amparo
- GĂłrgolas Miguel
- Hermida José Manuel
- Hernando M. AsunciĂłn
- HernĂĄndez Cristina
- HernĂĄndez Jehovana
- Hernåndez José
- Herranz Pedro
- Herrero Carmen
- Homar Francisco
- Hontañón VĂctor
- Ibarguren Maialen
- Ibarra SofĂa
- Ibarra Valvanera
- Ibero Carlos
- Iborra AsunciĂłn
- Imaz Arkaitz
- Iribarren José Antonio
- JaĂ©n Ăngels
- Kortajarena Xabier
- Llaves Silvia
- Lombide Itxaso
- Lopez Iñigo
- Lopez Miriam
- Losada Elena
- LĂłpez Garcia Belen
- LĂłpez Lirola Ana
- LĂłpez Josefina
- LĂłpez Juan Carlos
- LĂłpez MarĂa
- LĂłpez Pedro
- LĂłpez Soledad
- López-Cortés Luis Fernando
- Machuca Isabel
- MacĂas Juan
- Malmierca Eduardo
- Martin Luisa
- Martinez Lorena
- Martinez Marina
- Martinez-Lacasa Javier
- Martinez-Romo Juan
- MartĂ Anna
- MartĂn Enrique
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- Moreno Ana
- Moreno Antonio
- Moreno Estela
- Moreno Santiago
- Moreno Victoria
- Muga Roberto
- Murillas Javier
- Muñoz Medina Leopoldo
- Muñoz Ăngeles
- Navarro Vilasaro Marta
- Navarro Gemma
- Navarro Jordi
- Navarro Roser
- Novella MarĂa
- Novoa Cristina
- NĂșñez MarĂa JosĂ©
- Ocampo Antonio
- Olalla JuliĂĄn
- Olona Montserrat
- Omar Mohamed
- Orviz Eva
- Oteo José Antonio
- Padilla Belén
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- Pascual José Francisco
- Pascual Rafael
- Pascual Reyes
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- Pineda Juan Antonio
- Pinto Adriana
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- Planas Bibiana
- Polo VĂctor
- Portilla Irene
- Portilla JoaquĂn
- Portilla Julia
- Pousada Guillermo
- Poveda Eva
- Prada José Luis
- Prieto Laura
- Puerta Teresa
- Pulido Federico
- PĂ©rez Alexandre
- Pérez Desiré
- PĂ©rez Ignacio
- PĂ©rez Ignacio
- PĂ©rez Javier
- PĂ©rez Leire
- PĂ©rez M. JesĂșs
- PĂ©rez VerĂłnica
- PĂ©rez-MartĂnez Laura
- Pérez-Molina José Antonio
- Ramos Luis
- RamĂrez Margarita
- Raposo Montserrat
- Real Luis Miguel
- RepĂĄraz JesĂșs
- Reus Sergio
- Rial David
- Ribas M. Ăngels
- Riera Melchor
- RincĂłn Pilar
- Rivas Carmenado MarĂa Eugenia
- Rivero JuĂĄrez Antonio
- Rivero RomĂĄn Antonio
- Rivero MarĂa
- Robledano Catalina
- Roca Cristina
- RodrĂguez Carmen
- RodrĂguez Juan Carlos
- RodrĂguez LucĂa
- Rodés Berta
- Rubio Rafael
- Ruiz M. Pilar
- Ruiz-Sancho Andrés
- Rull Anna
- RuĂz Inma
- Sagastagoitia Iñigo
- Sainz TalĂa.
- Salavert Miguel
- Sampériz Gloria
- Sanchez Matilde
- Sanchez-de-Madariaga Ricardo
- Sanchiz Cruz Marta
- SanmartĂ Montse
- Santacreu Mireia
- Santos JesĂșs
- Sanvisens Arantza
- Sanz JesĂșs
- Sanz José
- Sanz Mercedes
- Sanz Nieves
- Saumoy MarĂa
- Segarra Inmaculada
- Sendagorta Elena
- Serrano Sergio
- Silva Ana Karina
- Suanzes Paula
- Suarez-GarcĂa InĂ©s
- Suarez-Zarracina TomĂĄs
- SĂĄez Carmen
- SĂĄez Elena
- SĂĄnchez Guirao Antonio JesĂșs
- Sånchez M. José
- SĂĄnchez-Cerrillo Ildefonso
- Sånchez-Payå José
- Tapia Elena
- Tasias MarĂa
- Tejerina Francisco
- Telenti Guillermo
- Telleria Pablo
- Tiraboschi Juan Manuel
- TomĂĄs Cristina
- Torres Rafael
- Torrus Diego
- Universitat AutĂČnoma de Barcelona
- Valencia Eulalia
- Vallejo Alejandro
- Vargas Montserrat
- Velli Pablo
- Vera Francisco JesĂșs
- Vera Mar
- Vergas GarcĂa Jorge
- Viciana Isabel
- Vidal AsunciĂłn
- Vidal Francesc
- Viladés Consuelo
- Vilchez Helem H.
- Villa LĂłpez M.
- Villalba M. Carmen
- Vinuesa David
- Vivancos M. JesĂșs
- Viñuela Laura
- von Wichmann Miguel Ăngel
- VĂĄzquez Pilar
- Xercavins Mariona
- Yeregui Elena
- Ălvarez Beatriz
- Ălvarez Marta
- Ălvarez Patricia
- Ălvarez-Rodriguez Ignacio
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Acquired immunodeficiency syndrome (AIDS) is still one of the main health problems worldwide. It is therefore essential to keep making progress in improving the prognosis and quality of life of affected patients. One way to advance along this pathway is to uncover connections between other disorders associated with HIV/AIDS-so that they can be anticipated and possibly mitigated. We propose to achieve this by using Association Rules (ARs). They allow us to represent the dependencies between a number of diseases and other specific diseases. However, classical techniques systematically generate every AR meeting some minimal conditions on data frequency, hence generating a vast amount of uninteresting ARs, which need to be filtered out. The lack of manually annotated ARs has favored unsupervised filtering, even though they produce limited results. In this paper, we propose a semi-supervised system, able to identify relevant ARs among HIV-related diseases with a minimal amount of annotated training data. Our system has been able to extract a good number of relationships between HIV-related diseases that have been previously detected in the literature but are scattered and are often little known. Furthermore, a number of plausible new relationships have shown up which deserve further investigation by qualified medical experts
Characteristics and predictors of death among 4035 consecutively hospitalized patients with COVID-19 in Spain
- Author
- AdoraciĂłn Valiente
- Adriana HernĂĄndez Belmonte
- Adriana SĂĄnchez Serrano
- AdriĂĄn SĂĄnchez MontalvĂĄ
- AgustĂn Rojas-Vieyra
- Aida GutiĂ©rrez GarcĂa
- Aina Gabarrell Pascuet
- Aina Gomila Grange
- Ainhoa Urrutia Losada
- Alba Alastrué Violeta
- Alba Bergas
- Alba Rueda LĂłpez
- Albert Sabater Gil
- Alberto Arranz Caso
- Alberto Bahamonde Carrasco
- Alberto Delgado-Iribarren
- Alberto Oreja
- Alberto Serrano MartĂnez
- Alejandra Duarte Borges
- Alejandra PĂ©rez GarcĂa
- Alejandro Aguirre Vila-Cora
- Alejandro Callejas DĂaz
- Alejandro GarcĂa GarcĂa
- Alejandro SuĂĄrez-Benjumea
- Alex Smithson Amat
- Alex Soriano
- Alexander Rombauts
- Alexandre PĂ©rez GonzĂĄlez
- Alexia Costanza Espiño Ălvarez
- Alexy Inciarte
- Alfonso Cabello Ăbeda
- Alfredo Mican
- Alicia HernĂĄndez Torres
- Almudena Villa MartĂ
- AlĂ Martakoush
- Amparo Blasco Claramunt
- Amparo LĂłpez-Bernus
- Ana Alguacil
- Ana Barrios Blandino
- Ana CamĂłn
- Ana del Cielo Pérez Jaén
- Ana Escoresca
- Ana FernĂĄndez Cruz
- Ana Ferrer Ribera
- Ana GonzĂĄlez-CordĂłn
- Ana Isabel Cañabate
- Ana Isabel PelĂĄez Ballesta
- Ana Josefa Tebar MartĂnez
- Ana LĂ©rida Urteaga
- Ana Mariño Callejo
- Ana MartĂnez Sapiña
- Ana MarĂa Garijo Saiz
- Ana Milagro Beamonte
- Ana Such Diaz
- Ana Vegas Serrano
- Ander GonzĂĄlez Sarria
- Andrea Espigares Correa
- Andrea PĂ©rez RodrĂguez
- André Barbosa Ventura
- Andrés Canut Blasco
- Andrés Felipe Cardona Arias
- Andrés Javier Ruiz Fernåndez
- Anna Ferrer Santolaria
- Antonio GarcĂa Pardo
- Antonio Oteo Revuelta José
- Antonio Ramos MartĂnez
- Antonio Rezusta LĂłpez
- Arantzazu Mera Fidalgo
- ArĂĄnzazu Villasante de la Puente
- Asier Aranguren Arostegui
- AsunciĂłn DĂaz
- Beatriz Dietl GĂłmez-Luengo
- Beatriz Loureiro RodrĂguez
- Beatriz MarĂa Sanjuan
- Beatriz Mestre GĂłmez
- Beatriz PĂ©rez-Monte MĂnguez
- Beatriz RodrĂguez-Alonso
- Beatriz Ălvarez Zapatero
- Beatriz Ălvarez Ălvarez
- Belén Alejos
- Belén Gutiérrez-Gutiérrez
- BelĂ©n Loeches YagĂŒe
- Benito Almirante
- Berta Torres
- Blanca Alonso
- Blanca MartĂnez Cifre
- Blanca Marzo
- Camilo Sanz Zamudio
- Carlos Bea Serrano
- Carlos Iniesta
- Carlos JesĂșs Dueñas GutiĂ©rrez
- Carlos RodrĂguez Franco
- Carlos Ruiz MartĂnez
- Carlota Gudiol
- Carmen Ardanuy
- Carmen Busca Arenzana
- Carmen Herrero RodrĂguez
- Carmen Infante
- Carmen MartĂnez Cilleros
- Carmen Quereda
- Carmen SĂĄez BarberĂĄ
- Carmen Yera Bergua
- Carmen Yllera Gutiérrez
- Carmina Oltra
- Carolina HernĂĄndez Carballo
- Carolina RoldĂĄn Fontana
- Cecilia Tortajada Alamilla
- Celia Salamanca
- Chen
- Chen
- Chiara Fanciulli
- Cintia MarĂa MartĂnez Mateu
- Clara Muñoz Aguirre
- Clara Sala Jofre
- Claudia GonzĂĄlez Rico
- Claudio Bueno
- ConcepciĂłn Amador Prous
- ConcepciĂłn GarcĂa GarcĂa
- Conchita PĂ©rez-Jorge Peremarch
- Constanza Muñoz Hornero
- Covadonga Morcate FernĂĄndez
- Cristina Carbonell
- Cristina Cervera Acedo
- Cristina Chico Chumillas
- Cristina DĂez
- Cristina GĂłmez-Ayerbe
- Cristina HernĂĄn GarcĂa
- Cristina Hernåndez Gutiérrez
- Cristina LĂłpez Mestanza
- Cristina Morales GarcĂa
- Cristina Moreno
- Cristina Roca
- CristĂłbal Manuel RodrĂguez Leal
- Cummings
- Daniel Molina Morant
- Daniel Podzamczer
- Daniel Roger Zapata
- Daniel Useros Brañas
- David Alonso Menchén
- David Roa
- David Vinuesa GarcĂa
- Delia Quilez Ăgreda
- Docherty
- Domingo GarcĂa-JimĂ©nez
- Eduardo Malmierca Corral
- Efrén Sånchez Vidal
- Elena Chamarro MartĂ
- Elena Isaba Ares
- Elena LĂłpez TizĂłn
- Elena MarĂa Aranda Rife
- Elena Morcillo RodrĂguez
- Elena Morte
- Elena MĂșñez Rubio
- Elena Resino Foz
- Elena Salamanca
- Elena Trigo Esteban
- Elena Ălvaro Alonso
- Elisa Cordero-MatĂa
- Elisa GarcĂa VĂĄzquez
- Elisabet Delgado SĂĄnchez
- Elizabet Petkova Saiz
- Elsa Izquierdo GarcĂa
- EncarnaciĂłn Moral Escudero
- Enrique MĂguez Rey
- Enrique Peral
- Esperanza Bejarano Tello
- Esteban MartĂnez
- Estel Pons Viñas
- Ester SĂĄez de Adana ArrĂłniz
- Esther Aznar Muñoz
- Esther ExpĂłsito Palomo
- Esther Fraile Villarejo
- Esther GarcĂa AlmodĂłvar
- Eva Jiménez Gonzålez de Buitrago
- Eva MarĂa LeĂłn JimĂ©nez
- Eva MarĂa Romay Lema
- Eva Pilar GarcĂa Villalba
- Eva Talavera GarcĂa
- Eva Van den Eynde Otero
- Felipe Villar Ălvarez
- Fernando de la Calle Prieto
- Fernando GonzĂĄlez-Romo
- Francesc AlbertĂ
- Francesca Gioia
- Francesca Norman
- Francisco AlcĂĄntara NicolĂĄs
- Francisco Arnaiz de las Revillas
- Francisco Javier Membrillo de Novales
- Francisco Mora GĂłmez
- Francisco Muñoz Beamud
- Francisco Parras
- Francisco RodrĂguez GĂłmez
- Francisco Tejerina
- Fåtima Brañas Baztån
- Félix Gutiérrez Rodero
- Gabriel Gaspar Alonso-Vega
- Gabriela Abelenda-Alonso
- Gema Barbeito Castiñeiras
- Gema DomĂnguez de Pablos
- Gema Muñiz
- GermĂĄn RamĂrez-Olivencia
- Ginger Giorgiana Cabrera Tejada
- Goyal
- Grasselli
- Guan
- Guillermo Cuervo
- Guillermo Cuevas Tascon
- Guillermo Estrada FernĂĄndez
- Guillermo JimĂ©nez Ălvarez
- Guillermo Maestro de la Calle
- Guillermo MartĂn
- Harris
- Helem Haydee Vilchez
- Helena Mozas Moriñigo
- Henar Calvo SĂĄnchez
- Hernando Knobel
- Huang
- Huang
- HĂ©ctor Meijide MĂguez
- Ianire Virto Peña
- Ignacio De los Santos Gil
- Inmaculada JarrĂn
- Inmaculada JarrĂn
- Inmaculada MartĂn PĂ©rez
- Inmaculada Poquet Catala
- Inés Fernåndez Jiménez
- Inés Pérez Zapata
- InĂ©s SuĂĄrez-GarcĂa
- Irene Carrillo Acosta
- Irene DĂaz de la Torre
- Irene MartĂn Rubio
- Iris Pedrola Gorrea
- Isabel A. PĂ©rez HernĂĄndez
- Isabel Barrio LĂłpez
- Isabel Gutiérrez
- Isabel JimĂ©nez MartĂnez
- Isabel PĂ©rez-Tamayo
- Isabel RĂĄbago Lorite
- Ismail Zakariya-Yousef Breval
- Itziar Diego YagĂŒe
- Ivette Abascal Cambras
- IvĂĄn Castro HernĂĄndez
- IvĂĄn Navas Clemente
- IvĂĄn PelegrĂn Senent
- Ivån Piñero
- Jamil Cedeño
- Jara Llenas GarcĂa
- Javier Coy Coy
- Javier De la Torre Lima
- Javier Nieto Arana
- Javier Oliver Ortega
- Javier SĂĄnchez-Lora
- JerĂłnimo PachĂłn
- JerĂłnimo PachĂłn
- Jessica Abadia Otero
- JesĂșs Rodriguez Baño
- JesĂșs RodrĂguez-Baño
- JesĂșs Ruiz AragĂłn
- JesĂșs Santos GonzĂĄlez
- JesĂșs Sanz Sanz
- JesĂșs Sojo
- JesĂșs SĂĄnchez-GĂłmez
- JesĂșs Troya GarcĂa
- Jhon Rojas
- Joan GĂłmez-Junyent
- JoaquĂn LĂłpez-Contreras GonzĂĄlez
- Jon Ugalde Espiñeira
- Jonathan CĂĄmara FernĂĄndez
- Jordi CarratalĂ
- Jordi CarratalĂ
- Jordi Mancebo Cortés
- Jordi NiubĂł
- Jorge Alba FernĂĄndez
- Jorge Anel Pedroche
- Jorge CalderĂłn Parra
- Jorge Calvo
- Jorge MartĂnez JordĂĄn
- Jorge Parra Ruiz
- Jorge Valencia de la Rosa
- Jose David Ampuero Martinich
- Joseba Portu Zapirain
- Josefa Serralta Buades
- Josefina GarcĂa GarcĂa
- Josune Goikoetxea Agirre
- José Antonio Peregrina
- José Antonio Pérez de León
- José Bravo-Ferrer
- José Hernåndez Quero
- José Ignacio Bernardino de la Serna
- José Luis Blanco
- JosĂ© Luis DĂaz de Tuesta del Arco
- JosĂ© Luis GarcĂa Fogeda
- José Luis Velasco Garrido
- JosĂ© LuĂs Del Pozo LeĂłn
- José M. Azcona Gutiérrez
- José Manuel Våzquez Comendador
- JosĂ© MarĂa Aguado
- JosĂ© MarĂa MarimĂłn Ortiz de ZĂĄrate
- JosĂ© MarĂa Milicua Muñoz
- José Miguel Cisneros
- JosĂ© MÂȘ GarcĂa de Lomas Guerrero
- José R. Blanco Ramos
- José Ramón Arriba
- José Ramón Arribas López
- José Romån Muñoz del Rey
- José Sanz Moreno
- José Tomas Algado Rabasa
- Juan Berenguer
- Juan Berenguer
- Juan CantĂłn de Seoane
- Juan Carlos Abad Almendro
- Juan Carlos Gainzarain Arana
- Juan Carlos LĂłpez
- Juan Carlos Ramos Ramos
- Juan Cuadros GonzĂĄlez
- Juan Emilio Losa GarcĂa
- Juan Espinosa Pereiro
- Juan Pablo Avilés
- Juan Pablo Horcajada
- Juan Salillas Hernando
- Juan Torres Macho
- Judit Villar-GarcĂa
- Julen Cadiñaños Loidi
- Julia Pareja Coca
- Julia Praena
- Julio GarcĂa RodrĂguez
- Justo Menéndez
- JĂșlia SellarĂ©s
- Karim Mohamed RamĂrez
- Kass
- Klein
- Kuderer
- Kwong
- Lagunas-Rangel
- Laia Lorenzo-Esteller
- Lara Montes AndĂșjar
- Laura Castelo Corral
- Laura Iglesias Llorente
- Laura Mao MartĂn
- Laura Muñoz López
- Laura Prieto PĂ©rez
- Leire Balerdi Sarasola
- Leire PĂ©rez-Latorre
- Liang
- Lidia MartĂn
- Lighter
- Liu
- Lorea Arteche Eguizabal
- Lorena De la Mora
- Loreto Vidaur Tello
- Lourdes Herrera Pacheco
- Lucia Boix Palop
- Lucia Cajuela
- Lucia SuĂĄrez PĂ©rez
- Lucio GarcĂa-Fraile
- Lucy Abella VĂĄzquez
- LucĂa FernĂĄndez de Orueta
- LucĂa GĂłmez GarcĂa
- LucĂa MarĂn-Barrera
- LucĂa Ramos Merino
- Luis Alberto Nieto FernĂĄndez del Campo
- Luis E. López-Cortés
- Luis Falgueras LĂłpez
- Luis Force SanmartĂn
- Luis Metola SacristĂĄn
- Luis Puente
- Luisa Sorli RedĂČ
- Lydia GĂĄlvez-BenĂtez
- Lydia MartĂn GonzĂĄlez
- M. Teresa PĂ©rez-RodrĂguez
- Maialen Ibarguren Pinilla
- Manuel Cervantes GarcĂa
- Manuela Aguilar-Guisado
- Mar MasiĂĄ Canuto
- Mar Mosquera
- Marcelino Hayek Peraza
- Marco Antonio Sempere Alcocer
- Marcos DĂez MartĂnez
- Marcos LĂłpez Dosil
- Margarita RamĂrez-Schacke
- Maria Ălvarez de Castro
- Maribel Zamora Cintas
- Marina Pacheco MartĂnez-Atienza
- Mario FernĂĄndez-Ruiz
- Mario José Rodriguez Dominguez
- Mario Pérez Butragueño
- Marta Alvarado Blasco
- Marta Arsuaga Vicente
- Marta DĂaz MenĂ©ndez
- Marta Lamata Subero
- Marta Miarons
- Marta Mora Rillo
- Marta Navarro VilasarĂł
- Marta Rava
- Marta Rico RodrĂguez
- Marta Robledo del Prado
- Marta Ruiz-Alguero
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- Marta VizcaĂno CallejĂłn
- MarĂa Aroca Ferri
- MarĂa ArĂĄnzazu Galindo MartĂn
- MarĂa Carmen Fariñas Ălvarez
- MarĂa Cecilia CĂĄnepa
- MarĂa de la Luz Padilla Salazar
- MarĂa del Carmen Navarro SĂĄez
- MarĂa del Mar Alonso Socas
- MarĂa Dolores AvilĂ©s
- MarĂa E. GarcĂa-Leoni
- MarĂa Isabel Quijano Contreras
- MarĂa JesĂșs DomĂnguez Santalla
- MarĂa JosĂ© Blanco Vidal
- MarĂa JosĂ© Ruiz RodrĂguez
- MarĂa Larrosa
- MarĂa LorĂ©n Vargas
- MarĂa Luisa Machado Sicilia
- MarĂa LĂłpez-JĂłdar
- MarĂa Milagro Montero
- MarĂa Novella Mena
- MarĂa Paz GarcĂa Butenegro
- MarĂa Pilar GarcĂa GarcĂa
- MarĂa Rexach Fumaña
- MarĂa Roca Toda Savall
- MarĂa RodrĂguez MahĂa
- MarĂa SimĂłn SacristĂĄn
- MarĂa Yllescas
- MarĂa Ăngeles DomĂnguez
- MarĂa Ăngeles Garcinuño
- Melania Ăñigo Pestaña
- Melchor Riera Jaume
- Melchor Ălvarez de Mon Soto
- Melissa Carreres Candela
- Merce Cardona Rivera
- Merce Sirisi
- Mercedes Clemente Presas
- Mercedes GuillamĂłn SĂĄnchez
- Mercedes San Franco
- Mercedes Villarreal GarcĂa-Lomas
- MercĂš GurguĂ Ferrer
- Miguel Cervero
- Miguel Corral Saracho
- Miguel FernĂĄndez-Huerta
- Miguel GĂłrgolas HernĂĄndez-Mora
- Miguel Pedromingo Kus
- Miguel Salavert LletĂ
- Miguel Sampedro NĂșñez
- Miguel Torralba GonzĂĄlez de Suso
- Miguel VillamarĂn
- Miguel Ăngel Moran RodrĂguez
- Mikel del Ălamo MartĂnez de Lagos
- Ministerio de Sanidad
- Miquel Pujol
- Mireia Puig Campmany
- Miriam Estébanez Muñoz
- Miriam GarcĂa GĂłmez
- Miriam Latorre-MillĂĄn
- Moncef Belhassen-GarcĂa
- Montaña JimĂ©nez Ălvaro
- Montserrat Laguno
- Montserrat Sanmarti Vilamala
- MÂȘ Antonia SepĂșlveda Berrocal
- MÂȘ Carmen SĂĄnchez Arenas
- MÂȘ del Mar Lago NĂșñez
- MÂȘ Ăngeles Marcos
- MĂłnica GonzĂĄlez Bardanca
- MĂłnica Gozalo
- Mónica Liébana Gómez
- Natalia Carrasco Fons
- Natividad Benito HernĂĄndez
- Nerea Carrasco AntĂłn
- Nicolas Merchante Gutiérrez
- Nieves Valcarce Pardeiro
- Noelia Arenal Andrés
- Nora Izko Gartzia
- Nuria FernĂĄndez
- Nuria Parra Arribas
- Nuria Rabella GarcĂa
- NĂșria Trullen
- Olalla MartĂnez Macias
- Oriol Gasch Blasi
- Oscar del RĂo PĂ©rez
- Oscar Sanz PelĂĄez
- Pablo FernĂĄndez-GonzĂĄlez
- Pablo Marguenda Contreras
- Pablo Pascual Alonso
- Pablo Ryan
- Pablo Ryan
- Paloma Merino Amador
- Patricia Gonzålez Muñiz
- Patricia GonzĂĄlez- Ruano
- Patricia MartĂnez MartĂn
- Patricia PĂ©rez-Palacios
- Patricia SornĂ Moreno
- Paula Runza Buznego
- Paula Santibåñez Såenz
- Paula SĂĄez Escolano
- Paula Villares FernĂĄndez
- Pedro Gil Divasson
- Pere Comas Casanova
- Pere Domingo Pedrol
- Pilar CatalĂĄn
- Pilar HernĂĄndez MachĂn
- Pilar Retamar
- Pilar Toledano Sierra
- Pilar Vizcarra
- Rafael CantĂłn Moreno
- Rafael PadrĂłs Selma
- Rafael Silvariño Fernåndez
- Rafael Torres Perea
- RamĂłn PĂ©rez Tanoira
- Raquel Aranega
- Raquel BarrĂłs GonzĂĄlez
- Raquel Elisa RodrĂguez Tarazona
- Raquel MartĂnez Goñi
- Raquel Ălvarez Franco
- Rebeca Izquierdo
- Remedios AlemĂĄn Valls
- Ricardo FernĂĄndez Roblas
- Richard Rojas
- Richardson
- Robert Torres SĂĄnchez del Arco
- Roberto GĂŒerri-FernĂĄndez
- Roberto Vates GĂłmez
- RocĂo MartĂnez AvilĂ©s
- Rodrigo Alonso Navarro
- Rodrigo Sierra RodrĂguez
- Roi SuĂĄrez Gil
- Rosa de Miguel Buckley
- Rosana Rouco Esteves Marques
- Ruth Brea Aparicio
- Ruth Figueroa CerĂłn
- Sadaf Zafar Iqubal-Mirza
- Salvador Ălvarez Martin
- Sandra PĂ©rez-Recio
- Santos Del Campo
- Sara FernĂĄndez RodrĂguez
- Sara Heili Frades
- Sara Lidia Kamal
- Sara Medrano Pardo
- Sara Rodrigo GonzĂĄlez
- Sarah Caro Bragado
- Schiffrin
- Sergio España Cueto
- Sergio Gilaberte ReyzĂĄbal
- Sergio PĂ©rez Pinto
- Silvana Fiorante
- Silvia Castañeda Espinosa
- Silvia HernĂĄez Crespo
- Silvia Loscos
- Silvia Paulos Viñas
- Silvia SuĂĄrez Diaz
- Silvia Valero Rovira
- Silvia Ălvarez Kaelis
- Simonnet
- Singh
- Sonia Calzado Isbert
- Sonia GarcĂa
- Sonia GarcĂa Calvo
- Sonia Vega Molpeceres
- Susana Casas RodrĂguez
- Tamara Manso GĂłmez
- Teresa AldabĂł
- Teresa AldĂĄmiz-EchevarrĂa
- Teresa GarcĂa Delange
- Teresa Ălvarez de Espejo Montiel
- TomĂĄs Tosco NĂșñez
- Valvanera Ibarra CucalĂłn
- Vanessa Alende Castro
- VerĂłnica Cano Llorente
- Vicente Boix
- Vicente Ferrer DĂaz de Brito FernĂĄndez
- Victoria Hernando
- Violeta Ramos Sesma
- Virginia FernĂĄndez Espinilla
- Virginia Molina Peinado
- Virginia Naranjo Velasco
- Virginia Pomar Solchaga
- Virginia Pérez Doñate
- VĂctor Asensi Ălvarez
- VĂctor J. Moreno Cuerda
- Wadhera
- World Health Organization
- Xabier Kortajarena Urkola
- Xavier Bonfill Cosp
- Yang
- Yolanda MartĂnez MartĂnez
- Yolanda Meije
- Yolanda Posada Franco
- Young
- Zaira R. Palacios
- Zeltia Valcarce GonzĂĄlez
- Zhou
- Zhou
- Zineb Karroud
- Zuriñe Ortiz de Zårate Ibarra
- Ălvaro Navarro Batet
- Ălvaro Varela Plaza
- Ăngeles GarcĂa Flores
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries
- Author
- A Yacoub Mina
- A. Adam Mohammed
- A. Nassar Mahmoud
- A.Nemer Ayoob
- Aahlin Eirik Kjus
- Ab Rahim Mohd Fadliyazid
- Abad Gurumeta Alfredo
- Abad-Motos Ane
- Abang Jamari Dyg Zahratul Hamrak
- Abantanga Francis
- Abarca Sol
- Abazid Eias
- Abbas Abbas
- Abbas Khalid
- Abbas Mohammad Monir
- Abbasy Jibran
- Abbosh Ali
- Abd Karim Muhammad Fairuz Shah
- Abd Wahab Haidar Hadri
- Abd Barook
- Abdalei Abdulwahab
- Abdalla Ahmed Elkamel Ahmed
- Abdallah Aya
- AbdAllah Mostafa Salim Mohamed
- Abdel Malik Abu Baker
- Abdelhady Mousa Heba
- Abdelhady Samar
- Abdelhakim Ahmed
- Abdelkader Muhammad
- Abdelkawy Shaza
- Abdelkhalek Mohamed
- Abdellatif Esraa
- Abdelmaksoud Tawakel Noura
- Abdelmohsen Naglaa
- Abdelmotaleb Ibrahem
- Abdelrazek Aly
- Abdelsalam Israa
- Abdelshakour Mahmoud
- Abdelwahed Ahmed Mohamed
- Abdou Abdulrahman Osama
- Abdou Alrawy
- Abdou Hossam
- Abdul Aziz Mohamed Rezal
- Abdul Aziz Nora
- Abdulgawad Almogy Mariam
- Abdulla Mazin A.
- Abdullah Muhammad Tariq
- Abdullahi Lawal
- Abdullayev Seymur
- Abed Saeed
- AbellĂł David
- Abiola Olajide
- Abo mahadi Asmaa'
- Abo-khammash Areej
- Abou Chaar Mohamad K.
- Abou El.soud Moustafa Ramadan
- Abouelsoad Nervana
- Abraham Joyner
- Abreu da Silva Alberto
- Abu Ahammala Ayman B.
- Abu Al Amrain Mahmoud
- Abu Al-saleem Hasan
- Abu Alamrain Abdulwhhab
- Abu Alqumboz Amjad
- Abu Ataya Ahmed
- Abu hallalah Muad fathi khalleefah
- Abu Jamie Najlaa
- Abu Jayyab Israa
- Abu shua'ib Rana
- Abu Zainah Baraa
- Abu-Nimeh Samar
- Abu-Rous Mohammed R.
- Abu-srour Abrar
- Abuelhatal Hasan
- Abuelqomboz Ayham
- Abuhilal Baseel
- Abuhlaiga Ma'aly
- Abujamra Saleh
- Abukhalaf Sadi A.
- Abusalem Lana
- AbuSirrees Mahmoud
- Acevedo Veronica
- Acharya Rajgopal
- Achkasov Sergey
- Acosta Eric
- Adamo Karin
- Adamou Harissou
- Adams Jamie
- Adams Lawrence
- Adawi Samer
- Adebanjo Ademola
- Adel Marina
- Adel Sawsan
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji
- Adenuga Adedire
- Aderounmu Adewale
- Adesanya Opeoluwa
- Adesina Alaba
- Adesunkanmi Abdul-Rashid
- Adeyeye Ademola
- Adidharma Peter
- Adisa Adewale O
- Adnan Nour
- Afifi Amr Abdelghani
- Afifi Eman
- Afolayan Michael Olatunji
- Afzal Asma
- Agarwal Arnav
- Agarwal Raksheeth
- Agbakwuru Augustine
- Agbeko Anita Eseenam
- Aguilar Martinez Maria Del Mar
- Aguilera Maria Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahlqvist Sandra
- Ahmad Izzuddin Ahmad Imran
- Ahmad Kasim
- Ahmad Sarwat
- Ahmed Ahmedgaber
- Ahmed Hazem Abdelkarem
- Ahmed Mariam
- Ahmed Nabila
- Ahmed Zahra
- Ainoa Eppu
- Aithie Joanna M S
- Ajani Costanza
- Ajao Akinlabi
- Ajiboye Anthony
- Ajmera Ankit
- Akande Oluwatosin
- Akaydin Elif
- Akbaba Ata Cem
- Akbar Sana Amir
- Akeel Nouf
- Akeem Aderogba Adeleke
- Akin Alp
- Akinkuolie Akinbolaji
- Akisheva Aygulya
- Akitikori Mabel Temisanren
- Akrida Ioanna
- Aktas Melik Kagan
- Al basos Iyad
- Al Farsi Maryam
- Al Nassrallah Majdi
- Al Sagheir Eman
- Al Saqqa Sara
- Al Saqqa Sara
- Al-Allaf Omar
- Al-Busaidi Ibrahim S.
- Al-Dhufri Ali
- Al-Himyari Hamza S.
- Al-Masri Mahmoud
- Al-Najjar Hani
- Al-Sabbagh Yusra
- Al-Shwaikh Samar
- Al-Slaibi Ibrahim
- Al-Taher Raed
- Al-Tammam Hiba
- Alabuzidi Aya
- Alagha Othman
- Alammarin Mohammad
- Alapatt John
- Alasttal Mohammed
- Alatise Olusegun Isaac
- Albaggar Marwa
- Albahnasawi Moath A.
- Albati Naif
- Alberga Anna
- Alberts Justin
- AlBsoul Ahmad
- Albsoul Nader
- Alcorta Rodrigo
- Alejandre Villalobos Cristina
- Alemdag Gökçe nur
- Alexander Philip
- Alfarra Nada
- Alfitory Asma
- Alhabil Belal
- Alhaj Ahmad
- Alherz Mohammad
- Alhimyar Maryam
- Ali Ahmad Syed Mustafa
- Ali SANI Samuel
- Ali Amr
- Ali Asmaa
- Ali Mahmoud
- Ali Shabina
- Alimi Marjan
- Aliosin Oleg
- Aliyu Halima
- Aljaafreh Almoutuz
- Aljaber Dana
- Aljaberi Loay
- Aljanfi Asma
- Aljiffry Murad
- Aljohmani Lylas
- Alkhaledi Ahmad
- Alkhatib Ala'a Aldeen
- Alkhatib Haya
- Alkhatib Mo'min
- Allen Ingabire J.C.
- Almasri Murad
- Almeida Braga Sara
- Almeida Filipe
- Almigheerbi Alabas
- Almoqayyad Abdelrahman
- Almuzghi Fakhruddin
- Alnoury Mostafa
- Alonso Batanero Ester
- Alqadi Mohammad
- Alsaid Bayan
- Alsalameh Barah
- Alsallaq Osama
- Alser Osaid
- Alshaar Muhammad
- Alsharef Tagwa
- Alsharqawi Nourah
- Alswerki Mohammad
- Altaf Amna
- Altaf Rabiya
- AlTaweel Mohammed
- Althini Abdulmunem Ahmed Mustafa
- Altibi Ahmed M.
- Altinel Yuksel
- Altiner Saygin
- Altomare Donato Francesco
- Altumei Zohoor
- Alvarez Rivera Alvaro Eduardo
- Alvarez-Cano Alethia
- Alves do Canto Brum Homero
- Alves Daniela Macedo
- Alves Magda
- Alvi Abdul
- Alwaheidi Malak
- Alwali Abdallah
- Alwerfally AbdulMawlay
- Alwhaidi Noor
- Alyafi Amr
- Alzabti Fatima
- Alzahaf Ahmed
- AlZohour Mohammad
- Amadou Magagi Ibrahim
- Amandito Radhian
- Amarin Justin Z.
- Amaro Margarida
- Ambrazevicius Marijus
- Amendola Alfonso
- Amin Leila
- Amine Souadka
- Amjad Talal
- Amorim Edgar
- Amro Adham
- Anandan Premkumar
- Anas khalifa Rawda
- Anastasio Lorenzo
- Andersson Yvette
- Andreotti Dario
- Andrew David
- André Benoßt
- Ang Sue Ean
- Angel Miguel
- Anggita Gultom Phebe
- Annapureddy Naga
- Anokhin Evgeny
- Ansaloni Luca
- Ansarei Dhirar
- Ansari Abdul Basit
- Antaky Marco
- Anthony Natasha
- Anthoulakis Christos
- Antonopoulou Maria Ioanna
- Anwar Mohamed
- Anwer Abdul Wahid
- Anyanwu Chikamuche
- Anyanwu Lofty-John
- Anyanwu Mercy Chinemerem
- Anyomih Theophilus Teddy Kojo
- Appukuttan Akhila
- Aquilino Fabrizio
- Archibald Jess
- ArciĂ©nega Yañez MarĂa del pilar
- Argentou Maria-Ioanna
- Argudo Nuria
- Argyriou Eleftherios Orestis
- Arias Madrid Natalia
- Aribi Sarra
- Arifin Ghafur Rasyid
- Arizpe Daniel
- Arnaud Alexis P
- Arora Bharti
- Arora Deeksha
- Arowolo Olukayode
- Arrangoiz Rodrigo
- Arslan Ekin
- Artigau Eva
- Ashfaq Ahsan
- Ashour Dina
- Ashour Firas
- Ashoushan Hana
- Ashraf Ahmed
- Ashraf Alaa
- Asif Ashar
- Asnel Dorisme
- Asok Anjitha
- Assa Rawan
- Assalhi Mohamed
- Asta Martina
- Asti Emanuele Luigi Giuseppe
- Atakul Onur
- Atallah Khalid
- Atanasov Boyko
- Atawneh Mohammad
- Athamneh Sarah
- Ather Muaaz
- Athisayaraj Thomas
- Atkociunas Aivaras
- Attia Mohamed
- Au Angela
- Awad Israa
- Awadallah Haneen
- Awaji Kholoud
- Awesat Eman
- Awolowo Ajibola
- Ayandipo Omobolaji
- Ayash Mohammad
- Ayau Fernanda
- Ayesh Kholoud
- Ayman El-sawy Esraa
- Ayoub Rami
- Aytac Erman
- Ayub Bushra
- Ayub Saima
- Ayyad Rawan
- Azevedo José
- Azodo Ijeoma
- Azzubia Joma
- B L Ashika
- Ba Mouhamadou Bachir
- Babaa Basheer
- Babirye Lilian
- Bacic Ivan
- Badr Esraa Tarek
- Badr Helmy
- Badran Abdul
- Badwe Rajendra
- Bafford Andrea Chao M.D.
- Baggaley Caitlin
- Bahroun Sumayyah Ghayth
- Baiao José Miguel
- Baiocchi Daniella
- Bairos Menezes Maria
- Baiu Ioana
- Bajilan Mohammad
- Bajomo Oreoluwa
- Bake Jacques
- Baki Bahadir Emre
- Bakoleas Panagiotis
- Balaawi Reem
- Balalis Dimitrios
- Balata Mohamed
- Balkarov Artem
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- Balogun Olanrewaju
- Baloyiannis Ioannis
- Baltaci Ege
- Bamaca Ixcajoc Elvis Benjamin
- Banaz Tuba
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- Bani hani Mohammad
- Bani hani Zeina
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- Banks Alexander
- Bannister Sharon
- Baranyai Zsolt
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- Barbosa Camacho Francisco José
- Barbosa José
- Bardos David
- Barendegere Venerand
- Barghuthi Lutfi
- Barhoush Ola
- Barnes Nicole
- Baronio Gianluca
- Barreda Zelaya Lilian Elizabeth
- Barrera LĂłpez Francisco Javier
- Barsic Neven
- Barter Charlotte
- Bartosiak Katarzyna
- Basarab Maksym
- Basso Stefano Maria Massimiliano.
- Bastiaenen Vivian
- Batashki Ilia
- Bath Michael
- Beattie Miriam
- Bedada Alemayehu Ginbo
- Belais Fanny
- Belal qadomi Asef
- Belev Nikolay
- Belli Andrea
- BeltrĂĄn de Heredia Juan
- Belvedere Angela
- Ben Dallah Najah
- Ben Saoud Abdulsalam Ali
- Bengur Fuat Baris
- Benkabbou Amine
- Benke Marton
- Benyaiche Chaymae
- Bergeat Damien
- Bernstein Mitchell
- Beshtawi Doha
- Besli Sevval
- Beuran Mircea
- Bhandare Manish
- Bhangu Aneel
- Bhatti Muhammad Iqbal
- Bianchini Stefania
- Bianco Francesco
- Bibas Fatma
- Biccard Bruce M
- Bielosludtsev Oleksii
- Bienfait Mumbere
- Billy Matthew
- Bin Mohamad Sithik Muhammad Navid
- Binetti Margherita
- Bingham Janne
- Bird Jonathan
- Birindelli Arianna
- Birks Sarah
- Birutis Justas
- Björklund Ida
- Blackman Brighid
- Blackwell James
- Blanco-Colino Ruth
- Blok Robin
- Blomme Nina
- Blomqvist Malin
- Blunnie Eimear
- Bnhameida Sondos
- Boddy Alex
- Bodur Muhammed Selim
- Boereboom Catherine
- Bogusevicius Algirdas
- Bolzonaro Elisa
- Bonavina Luigi
- Bondurri Andrea
- Bonghaseh Divine Tim
- Bono Lorenzo
- Borda-Luque Giuliano
- Borg Elaine
- Borghi Felice
- Borham Hala
- Borowski David W
- Bortolasi Luca
- Bosch Marina
- Bosire Fridah
- Bossi Daniela
- Botes Azel
- Bouaziz Hanen
- Bougard Heather
- Boutall Adam
- Boutros Marylise
- Bouzaiene Hatem
- Boyce Stephen
- Boyd-Carson Hannah
- Boyle Connor
- Braccio Bartolomeo
- Bradulskis Saulius
- Brata Santi Yuanita
- Bratu Matei Razvan
- Brito Diana
- Brocklehurst Peter
- Brooker Ethan
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- Bruce Eilidh
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- Bua Emmanuel
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- Budzynski Andrzej
- Budzynski Piotr
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- Bulaya Anadi
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- Burke Daniel
- Burman Shivang
- Bury Pawel
- Busuttil Zachary
- Butt Eman
- Buxant Frederic
- Buzaite Kristina
- C S Archana
- Caballero DĂaz Yurena
- Cabrera Rivera Paulo Andrés
- Cagigas Fernandez Carmen
- Calik Adnan
- Calleja Thomas
- Camelo Saul
- Camilo Correa Juan
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- Carrington Emma Victoria
- Caruso Emanuele
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- Carvalho LĂșcia
- Carvalho MĂĄrcia
- Carvello Michele Maria
- Castaldi Antonio
- Castanedo Bezanilla Sonia
- Castilla Moreno Miguel Angel
- Castillo Arrascue José Neiser
- Castillo Barbosa Andrea Carolina
- Castro LĂłpez Elizabeth Victoria
- Castro Ernes John
- Castro Luis
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- Cañete Joannes Paul
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- ChacĂČn-Herrera Patricia
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- Chirengendure Bright
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- Christoforidis Dimitrios
- Christou Niki
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- Cirillo Bruno
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- Claro Mariana
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- Clements Joshua Michael
- Clerc Daniel
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- Cocco Annelise
- Cockbain Andrew J
- Cocorullo Gianfranco
- Coleman Maggie
- Colli Francesco
- Colombo Francesco
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- Confalonieri Gianmaria
- Connors Joseph
- Contreras Saiz Elisa
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- Corrigan Robert
- Corro DĂaz GonzĂĄlez Samantha
- Corsi Fabio
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- Costa Santos Maria Teresa
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- Curletti Gianluca
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- Dawidziuk Aleksander
- Dawoud Amr
- Dawson Amanda Caroline
- De Azevedo Bernardo
- De Castro Parga Gonzalo
- De Giovanni Jasmine
- de Jonge Joske
- de la Torre Javier
- De Luca Emilia
- De Marco Paolino
- de Muijnck Cansu
- de Oliveira Daniela
- De Rosa Michele
- De Santiago Alvarez Irene
- De Silva April
- De Silva Kasun
- De Simone Veronica
- de Sousa Xavier
- De Toma Giorgio
- Deans Chris
- DeBiasio Ashe
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- Delhen Malik
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- Delrio Paolo
- Demartines Nicolas
- Demirkaya Hasan Can
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- den Boer Frank
- Deng Idy
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- Dhital Bal
- Di Candido Francesca
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- Di Maso Sara
- Diab Samar
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- Diallo Adja Coumba
- Dickfos Marilla
- Dimech Andrew Michael
- Dimitrov Dobromir
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- Diéguez Beatriz
- Doe Matthew
- Dogruoz Alper
- Doherty Ronan J
- Dollie Qaasim
- Dominguez Genieve
- Dominguez Joaquina
- Domini Edgar
- Dossou Francis
- Dousset Bertrand
- Draganic Brian
- Drake Thomas M
- Drane Andrew
- Duarte Marina
- Dudi-Venkata Nagendra Naidu
- Duggan William
- Duke Kathryn
- Duller Alexander
- Dulskas Audrius
- Dumitra Sinziana
- Dural Ahmet Cem
- Dworak Jadwiga
- Dzhumabaev Khasan
- Dziedzic Jacek
- DĂaz Vico Tamara
- Eaazim Jose
- Eardley Nicola
- Echeverria-Davila Guillermo
- Edirisooriya Monisha
- Eerola Verner
- Eid Esraa
- Eismontas Vitalijus
- Eklöv Karolina
- Ekpete Ogbonnia
- Ekwen Gerald
- El Gharmoul Tasnim
- El Jamassi Alaa
- El Muhtaseb M.S.
- El Nakeeb Ayman
- El sheikh Enas
- El Zoghby Naira
- El-Kahlout Sahar
- El-remaily Amira
- El-Sawy Aya
- El-taweel Alaa
- Elazab Yasmin
- Elbarouni Sofian
- Elbealawy Mohamed
- Elbeshina Aya Elseed
- Elblbessy Mahmood
- Eldeep Ahmed
- Eldeep Mostafa
- Eldmaty Asmaa
- Eldoseuky mohammed Amany
- Elemile Peter
- Elewaily Mohamed Ibrahim Elsayed
- Elfaituri Taha
- Elfallal Ahmed
- Elfanty Mahmoud
- ElFayoumy Ahmed Moustafa
- Elfeki Hossam
- Elfizri Zatira
- Elgammudi Mala
- Elghareeb Nourhan
- Elhadi Ahmed
- Elhadi Muhammed
- Elhajjaji Yasmine
- Elhelow Esraa
- Elhout Somaya
- Elkabir Osama
- Elkhadragy Ahmed
- Elkhalawy Aya
- Ellaby-Hall Jordan
- Ellul Sarah
- Elmahdy Marwa
- Elmeslemany Nehal
- Elmokadem Aya
- Elqadi Muawiyah
- Elrais Safa
- Elsayed Mai
- Elsayed Mohammad
- Elshafei Houssein
- Elshafey Ahmed
- Elshaibani Mahmoud
- Elshatby Bassant
- Elshawy Mohamed Elemam
- Elsherbeny Mohammed Yasser
- Elsherif Fawzia
- Elshimy Ahmed
- Elsobky Hager
- Elteir Hana
- Eltoum Ruba
- Elzanfaly Ali Abdelazez
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- M R Rashmi
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- NA N.A.
- Naabo Nuhu
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- Nsengiyumva Carlos
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- Ogundoyin Olakayode
- Ojewola Rufus Wale
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- Wogensen Fredrik
- Wondoh Paul M.
- Wong Florence
- Wong Hsu Ven
- Wong Jane J
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- Xanthopoulou Georgia
- Yabut Kenneth
- Yacoub Aseel
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- Yaghi Yasmine
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- Yakushkina Al'ona
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- Yanikoglu Erkan
- Yanni Fady
- Yates Charlotte
- Ye Geoffrey
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- Yemez KĂŒrsat
- YenidĂŒnya NilĂŒfer
- Yenli Edwin
- Yeo Jeremy
- Yeoh Andrea
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- Yildirim Reyyan
- Yildiz Alp
- Yilmaz Duygu
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- Yong Shun Qi
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- Yorke Joseph
- Yotsov Tsanko
- You Lucia
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- Yu Kristin
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- Yusuf Baasil
- YĂŒksel Osman
- Zabiyaka Mikhail
- Zachariah Sanoop Koshy
- Zafar Syed Nabeel
- Zaffaroni Gloria
- Zahra Baryab
- Zahran Diaaaldin
- Zakaria Andee Dzulkarnaen
- Zakaria Mai
- Zakaria Omar
- Zakaria Zaidi
- Zambrana Campos Vanesa
- Zammit Matthew
- Zanini Nicola
- Zara Vlu Jean
- Zara Vlu Jean
- Zarti Heba
- Zarzycki Piotr
- Zattoni Davide
- Zavala Gabriela
- Zawahrah Hassan
- Zeiton Asaid
- Zeko Amanda
- Zeng Zhi
- Zeromskas Paulius
- Zhang Geoffrey
- Zhivkov Evgeni
- Zid Esraa
- Zidan Ahmed Mohy
- Zielasek Christian
- Zilinskas Justas
- Zimmermann Bernd
- Ziprin Paul
- Zizzo Maurizio
- Zografos George
- Zoikas Athanasios
- Zorrilla Matilla Laura Patricia
- Zoulamoglou Menelaos
- Zreeg Dafer
- Zub-Pokrowiecka Anna
- Zubiaurre Vanessa
- Zuhdy Mohammed
- Zuikyte Diana
- Zuloaga Fernandez del Valle Carlos Jose
- Zulu Stanley
- Ăngelo Miguel
- ĂlgĂ„ Andreas
- Ăolak Elif
- Ămarik Toomas
- Ć atkauskas Mindaugas
- Ć kimelyte Monika
- Ć lenfuktas Vygintas
- Ć uman Oliver
- ĆœateckĂœ Jan
- Ćœumbakys Ćœygimantas
- Ćœupan Domagoj
- Publication venue
- 'Elsevier BV'
- Publication date
- 30/01/2021
- Field of study
© 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 licenseBackground: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70â8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39â8·80) and upper-middle-income countries (2·06, 1·11â3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26â11·59) and upper-middle-income countries (3·89, 2·08â7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit
Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study
- Author
- A Yacoub Mina
- A. Adam Mohammed
- A. Nassar Mahmoud
- A.Nemer Ayoob
- Aahlin Eirik Kjus
- Ab Rahim Mohd Fadliyazid
- Abad Gurumeta Alfredo
- Abad-Motos Ane
- Abang Jamari Dyg Zahratul Hamrak
- Abantanga Francis
- Abarca Sol
- Abazid Eias
- Abbas Abbas
- Abbas Khalid
- Abbas Mohammad Monir
- Abbasy Jibran
- Abbosh Ali
- Abd Karim Muhammad Fairuz Shah
- Abd Wahab Haidar Hadri
- Abd Barook
- Abdalei Abdulwahab
- Abdalla Ahmed Elkamel Ahmed
- Abdallah Aya
- AbdAllah Mostafa Salim Mohamed
- Abdel Malik Abu Baker
- Abdelhady Mousa Heba
- Abdelhady Samar
- Abdelhakim Ahmed
- Abdelkader Muhammad
- Abdelkawy Shaza
- Abdelkhalek Mohamed
- Abdellatif Esraa
- Abdelmaksoud Tawakel Noura
- Abdelmohsen Naglaa
- Abdelmotaleb Ibrahem
- Abdelrazek Aly
- Abdelsalam Israa
- Abdelshakour Mahmoud
- Abdelwahed Ahmed Mohamed
- Abdou Abdulrahman Osama
- Abdou Alrawy
- Abdou Hossam
- Abdul Aziz Mohamed Rezal
- Abdul Aziz Nora
- Abdulgawad Almogy Mariam
- Abdulla Mazin A.
- Abdullah Muhammad Tariq
- Abdullahi Lawal
- Abdullayev Seymur
- Abed Saeed
- AbellĂł David
- Abiola Olajide
- Abo mahadi Asmaa'
- Abo-khammash Areej
- Abou Chaar Mohamad K.
- Abou El.soud Moustafa Ramadan
- Abouelsoad Nervana
- Abraham Joyner
- Abreu da Silva Alberto
- Abu Ahammala Ayman B.
- Abu Al Amrain Mahmoud
- Abu Al-saleem Hasan
- Abu Alamrain Abdulwhhab
- Abu Alqumboz Amjad
- Abu Ataya Ahmed
- Abu hallalah Muad fathi khalleefah
- Abu Jamie Najlaa
- Abu Jayyab Israa
- Abu shua'ib Rana
- Abu Zainah Baraa
- Abu-Nimeh Samar
- Abu-Rous Mohammed R.
- Abu-srour Abrar
- Abuelhatal Hasan
- Abuelqomboz Ayham
- Abuhilal Baseel
- Abuhlaiga Ma'aly
- Abujamra Saleh
- Abukhalaf Sadi A.
- Abusalem Lana
- AbuSirrees Mahmoud
- Acevedo Veronica
- Acharya Rajgopal
- Achkasov Sergey
- Acosta Eric
- Adamo Karin
- Adamou Harissou
- Adams Jamie
- Adams Lawrence
- Adawi Samer
- Adebanjo Ademola
- Adel Marina
- Adel Sawsan
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Adenuga Adedire
- Aderounmu Adewale
- Adesanya Opeoluwa
- Adesina Alaba
- Adesunkanmi Abdul-Rashid
- Adeyeye Ademola
- Adidharma Peter
- Adisa Adewale
- Adisa Adewale O
- Adnan Nour
- Afifi Amr Abdelghani
- Afifi Eman
- Afolayan Michael Olatunji
- Afzal Asma
- Agarwal Arnav
- Agarwal Raksheeth
- Agbakwuru Augustine
- Agbeko Anita Eseenam
- Aguilar Martinez Maria Del Mar
- Aguilera Maria Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahlqvist Sandra
- Ahmad Izzuddin Ahmad Imran
- Ahmad Kasim
- Ahmad Sarwat
- Ahmed Ahmedgaber
- Ahmed Hazem Abdelkarem
- Ahmed Mariam
- Ahmed Nabila
- Ahmed Zahra
- Ainoa Eppu
- Aithie Joanna M S
- Ajani Costanza
- Ajao Akinlabi
- Ajiboye Anthony
- Ajmera Ankit
- Akande Oluwatosin
- Akaydin Elif
- Akbaba Ata Cem
- Akbar Sana Amir
- Akeel Nouf
- Akeem Aderogba Adeleke
- Akin Alp
- Akinkuolie Akinbolaji
- Akisheva Aygulya
- Akitikori Mabel Temisanren
- Akrida Ioanna
- Aktas Melik Kagan
- Al basos Iyad
- Al Farsi Maryam
- Al Nassrallah Majdi
- Al Sagheir Eman
- Al Saqqa Sara
- Al Saqqa Sara
- Al-Allaf Omar
- Al-Busaidi Ibrahim S.
- Al-Dhufri Ali
- Al-Himyari Hamza S.
- Al-Masri Mahmoud
- Al-Najjar Hani
- Al-Sabbagh Yusra
- Al-Shwaikh Samar
- Al-Slaibi Ibrahim
- Al-Taher Raed
- Al-Tammam Hiba
- Alabuzidi Aya
- Alagha Othman
- Alammarin Mohammad
- Alapatt John
- Alasttal Mohammed
- Alatise Olusegun Isaac
- Albaggar Marwa
- Albahnasawi Moath A.
- Albati Naif
- Alberga Anna
- Alberts Justin
- AlBsoul Ahmad
- Albsoul Nader
- Alcorta Rodrigo
- Alejandre Villalobos Cristina
- AlemdaÄ Gökçe nur
- Alexander Philip
- Alfarra Nada
- Alfitory Asma
- Alhabil Belal
- Alhaj Ahmad
- Alherz Mohammad
- Alhimyar Maryam
- Ali Ahmad Syed Mustafa
- Ali SANI Samuel
- Ali Amr
- Ali Asmaa
- Ali Mahmoud
- Ali Shabina
- Alimi Marjan
- Aliosin Oleg
- Aliyu Halima
- Aljaafreh Almoutuz
- Aljaber Dana
- Aljaberi Loay
- Aljanfi Asma
- Aljiffry Murad
- Aljohmani Lylas
- Alkhaledi Ahmad
- Alkhatib Ala'a Aldeen
- Alkhatib Haya
- Alkhatib Mo'min
- Allen Ingabire J.C.
- Almasri Murad
- Almeida Braga Sara
- Almeida Filipe
- Almigheerbi Alabas
- Almoqayyad Abdelrahman
- Almuzghi Fakhruddin
- Alnoury Mostafa
- Alonso Batanero Ester
- Alqadi Mohammad
- Alsaid Bayan
- Alsalameh Barah
- Alsallaq Osama
- Alser Osaid
- Alshaar Muhammad
- Alsharef Tagwa
- Alsharqawi Nourah
- Alswerki Mohammad
- Altaf Amna
- Altaf Rabiya
- AlTaweel Mohammed
- Althini Abdulmunem Ahmed Mustafa
- Altibi Ahmed M.
- Altinel Yuksel
- Altiner Saygin
- Altomare Donato Francesco
- Altumei Zohoor
- Alvarez Rivera Alvaro Eduardo
- Alvarez-Cano Alethia
- Alves do Canto Brum Homero
- Alves Daniela Macedo
- Alves Magda
- Alvi Abdul
- Alwaheidi Malak
- Alwali Abdallah
- Alwerfally AbdulMawlay
- Alwhaidi Noor
- Alyafi Amr
- Alzabti Fatima
- Alzahaf Ahmed
- AlZohour Mohammad
- Amadou Magagi Ibrahim
- Amandito Radhian
- Amarin Justin Z.
- Amaro Margarida
- Ambrazevicius Marijus
- Amendola Alfonso
- Amin Leila
- Amine Souadka
- Amjad Talal
- Amorim Edgar
- Amro Adham
- Anandan Premkumar
- Anas khalifa Rawda
- Anastasio Lorenzo
- Andersson Yvette
- Andreotti Dario
- Andrew David
- André Benoßt
- Ang Sue Ean
- Angel Miguel
- Anggita Gultom Phebe
- Annapureddy Naga
- Anokhin Evgeny
- Ansaloni Luca
- Ansarei Dhirar
- Ansari Abdul Basit
- Antaky Marco
- Anthony Natasha
- Anthoulakis Christos
- Antonopoulou Maria Ioanna
- Anwar Mohamed
- Anwer Abdul Wahid
- Anyanwu Chikamuche
- Anyanwu Lofty-John
- Anyanwu Mercy Chinemerem
- Anyomih Theophilus Teddy Kojo
- Appukuttan Akhila
- Aquilino Fabrizio
- Archibald Jess
- ArciĂ©nega Yañez MarĂa del pilar
- Argentou Maria-Ioanna
- Argudo Nuria
- Argyriou Eleftherios Orestis
- Arias Madrid Natalia
- Aribi Sarra
- Arifin Ghafur Rasyid
- Arizpe Daniel
- Arnaud Alexis P
- Arora Bharti
- Arora Deeksha
- Arowolo Olukayode
- Arrangoiz Rodrigo
- Arslan Ekin
- Artigau Eva
- Ashfaq Ahsan
- Ashour Dina
- Ashour Firas
- Ashoushan Hana
- Ashraf Ahmed
- Ashraf Alaa
- Asif Ashar
- Asnel Dorisme
- Asok Anjitha
- Assa Rawan
- Assalhi Mohamed
- Asta Martina
- Asti Emanuele Luigi Giuseppe
- Atakul Onur
- Atallah Khalid
- Atanasov Boyko
- Atawneh Mohammad
- Athamneh Sarah
- Ather Muaaz
- Athisayaraj Thomas
- Atkociunas Aivaras
- Attia Mohamed
- Au Angela
- Awad Israa
- Awadallah Haneen
- Awaji Kholoud
- Awesat Eman
- Awolowo Ajibola
- Ayandipo Omobolaji
- Ayash Mohammad
- Ayau Fernanda
- Ayesh Kholoud
- Ayman El-sawy Esraa
- Ayoub Rami
- Aytac Erman
- Ayub Bushra
- Ayub Saima
- Ayyad Rawan
- Azevedo José
- Azodo Ijeoma
- Azzubia Joma
- B L Ashika
- Ba Mouhamadou Bachir
- Babaa Basheer
- Babirye Lilian
- Bacic Ivan
- Badr Esraa Tarek
- Badr Helmy
- Badran Abdul
- Badwe Rajendra
- Bafford Andrea Chao M.D.
- Baggaley Caitlin
- Bahroun Sumayyah Ghayth
- Baiao José Miguel
- Baiocchi Daniella
- Bairos Menezes Maria
- Baiu Ioana
- Bajilan Mohammad
- Bajomo Oreoluwa
- Bake Jacques
- Baki Bahadir Emre
- Bakoleas Panagiotis
- Balaawi Reem
- Balalis Dimitrios
- Balata Mohamed
- Balkarov Artem
- Ballouhey Quentin
- Balogun Olanrewaju
- Baloyiannis Ioannis
- Baltaci Ege
- Bamaca Ixcajoc Elvis Benjamin
- Banaz Tuba
- Banda Bitiel
- Banglani Muntaha
- Bani Hani Farah
- Bani hani Mohammad
- Bani hani Zeina
- Baniowda Muath
- Banks Alexander
- Bannister Sharon
- Baranyai Zsolt
- Barati Nastaran
- Barbosa Camacho Francisco José
- Barbosa José
- Bardos David
- Barendegere Venerand
- Barghuthi Lutfi
- Barhoush Ola
- Barnes Nicole
- Baronio Gianluca
- Barreda Zelaya Lilian Elizabeth
- Barrera LĂłpez Francisco Javier
- Barsic Neven
- Barter Charlotte
- Bartosiak Katarzyna
- Basarab Maksym
- Basso Stefano Maria Massimiliano.
- Bastiaenen Vivian
- Batashki Ilia
- Bath Michael
- Beattie Miriam
- Bedada Alemayehu Ginbo
- Belais Fanny
- Belal qadomi Asef
- Belev Nikolay
- Belli Andrea
- BeltrĂĄn de Heredia Juan
- Belvedere Angela
- Ben Dallah Najah
- Ben Saoud Abdulsalam Ali
- Bengur Fuat Baris
- Benkabbou Amine
- Benke Marton
- Benyaiche Chaymae
- Bergeat Damien
- Bernstein Mitchell
- Beshtawi Doha
- Besli Sevval
- Beuran Mircea
- Bhandare Manish
- Bhangu Aneel
- Bhatti Muhammad Iqbal
- Bianchini Stefania
- Bianco Francesco
- Bibas Fatma
- Biccard Bruce M
- Bielosludtsev Oleksii
- Bienfait Mumbere
- Billy Matthew
- Bin Mohamad Sithik Muhammad Navid
- Binetti Margherita
- Bingham Janne
- Bird Jonathan
- Birindelli Arianna
- Birks Sarah
- Birutis Justas
- Björklund Ida
- Blackman Brighid
- Blackwell James
- Blanco-Colino Ruth
- Blok Robin
- Blomme Nina
- Blomqvist Malin
- Blunnie Eimear
- Bnhameida Sondos
- Boddy Alex
- Bodur Muhammed Selim
- Boereboom Catherine
- Bogusevicius Algirdas
- Bolzonaro Elisa
- Bonavina Luigi
- Bondurri Andrea
- Bonghaseh Divine Tim
- Bono Lorenzo
- Borda-Luque Giuliano
- Borg Elaine
- Borghi Felice
- Borham Hala
- Borowski David W
- Bortolasi Luca
- Bosch Marina
- Bosire Fridah
- Bossi Daniela
- Botes Azel
- Bouaziz Hanen
- Bougard Heather
- Boutall Adam
- Boutros Marylise
- Bouzaiene Hatem
- Boyce Stephen
- Boyd-Carson Hannah
- Boyle Connor
- Braccio Bartolomeo
- Bradulskis Saulius
- Brata Santi Yuanita
- Bratu Matei Razvan
- Brito Diana
- Brocklehurst Peter
- Brooker Ethan
- Brooks Savannah
- Brown James
- Bruce Eilidh
- Bsisu Isam
- Bua Emmanuel
- Bucci Luigi
- Budd Gabrielle
- BudzyĆski Andrzej
- BudzyĆski Piotr
- Bujda Michele
- Bulaya Anadi
- Bullock Cameron
- Burger Sule
- Burgu Gökçen
- Burke Daniel
- Burman Shivang
- Bury Pawel
- Busuttil Zachary
- Butt Eman
- Buxant Frederic
- Buzaite Kristina
- C S Archana
- Caballero DĂaz Yurena
- Cabrera Rivera Paulo Andrés
- Cagigas Fernandez Carmen
- Calik Adnan
- Calleja Thomas
- Camelo Saul
- Camilo Correa Juan
- Caminsky Natasha
- Cammarata Francesco
- Campagnaro Tommaso
- Campanella Sofia
- Campanelli Michela
- Campo Veronica
- Campos Costa Filipa
- Campos Maite
- Candas Altinbas Bahar
- Canic Renata
- Canonica Claudia
- Canonico Silvestro
- Canotilho Rita
- Cansana Bernalynn Eris
- Capote Hugo
- Capunge Ines
- Carballo Federico
- Cardia Roberto
- Cardoso Louro Hugo
- Cardoso Diogo
- Cardoso Vasco
- Carella Marcella
- Carlini Massimo
- Carrano Francesco Maria
- Carrington Emma Victoria
- Caruso Emanuele
- Carvalho Ana Cristina
- Carvalho LĂșcia
- Carvalho MĂĄrcia
- Carvello Michele Maria
- Castaldi Antonio
- Castanedo Bezanilla Sonia
- Castilla Moreno Miguel Angel
- Castillo Arrascue José Neiser
- Castillo Barbosa Andrea Carolina
- Castro LĂłpez Elizabeth Victoria
- Castro Ernes John
- Castro Luis
- Catarino Santos Sara
- Cañete Joannes Paul
- Ceballos André
- Celebioglu Fuat
- Celentano Valerio
- Cenal Ulukan
- Cengiz Yucel
- Cervone Carmela
- Cesleviciene Ieva
- Cesna Vaidotas
- Chabok Abbas
- Chachaima Mar Jorge Emerson
- ChacĂČn-Herrera Patricia
- Chaggar Gurpreet
- Chamberlain Carla
- Chambers Alice
- Chan Claudia
- Chan Erick
- Chandler Julia
- Chandrasinghe Pramodh
- Chang Ern Ng
- Chanousi Iris
- Chantalat Elodie
- Chapman Gavin
- Charalabopoulos Alexandros
- Charalampidou Lydia
- Charman Lillian
- Chatzakis Christos
- Chau Charlene Yat Che
- Che Husin Nurfariza
- Chen José
- Cheong Yih Jeng
- Chetta Nicola
- Chibuye Chali
- Chieng Loo Ling
- Chinchihualpa Paredes Nathaly Olga
- Chinnery Galya
- Chircop Kurt Lee
- Chirengendure Bright
- Choi Seung il
- Chong Chester
- Chopra Prakshi
- Chopra Sharat
- Chouliaras Christos
- Chow Bing Lun
- Chrapko Phillip
- Christodoulides Natasha
- Christoforidis Dimitrios
- Christou Niki
- ChroĆ Maciej
- Chu Kathryn
- Chu Michael Jen Jie
- Cianchetti Ettore
- Cicuttin Enrico
- Cifrian Canales Isabel
- Ciftci Ahmet Burak
- Cihanyurdu Irem
- Cillara Nicola
- Cinza Margarida
- Cirelli Riccardo
- Cirillo Bruno
- Ciubotaru Cezar
- Cizauskaite Agne
- Clark Gemma
- Clark Laura
- Clarke Damian
- Claro Mariana
- Clements Hollie A
- Clements Joshua Michael
- Clerc Daniel
- Clonda Octavian
- Coburn Natalie
- Coccia Anna
- Cocco Annelise
- Cockbain Andrew J
- Cocorullo Gianfranco
- Coleman Maggie
- Colli Francesco
- Colombo Francesco
- Compagnoni Bruno
- Condie Natalie
- Confalonieri Gianmaria
- Connors Joseph
- Contreras Saiz Elisa
- Conway Alison
- Cordera Fernando
- Corea Ruiz Ligia Margarita
- Cornwall Hannah
- Correia Ana Margarida
- Corrigan Robert
- Corro DĂaz GonzĂĄlez Samantha
- Corsi Fabio
- Cortes-Flores Ana Olivia
- Costa Santos Daniel
- Costa Santos Maria Teresa
- Costa-Maia Jose
- Costanzo Antonio
- Costas-Chavarri Ainhoa
- Coulter-Nile Sarah Michelle Crystal Jade
- Cowan Sarah
- Crawford James
- Crocetti Daniele
- Crutcher Madison
- Cruz GonzĂĄlez EfraĂn
- Cruz Martins Marta Cristina
- Ctercteko Grahame
- Cuba Vicente
- Cubas Santiago
- Cuk Vladica
- Cunha Miguel F.
- Curletti Gianluca
- Currow Chelise
- Curry Heather
- Curtis MartĂnez Carolina
- Cutajar Ruth
- CzerwiĆska Agata
- Cömert Didem
- D'Alessandro Nicola
- D.k Vijaykumar
- Da Silva Medina Luis
- Dabin Elsa
- Dahy Ahmed
- Dailidenas Sarunas
- Dainius Edvinas
- Dal Molin Marco
- Damianov Nikolai
- DamjĂĄn Pekli
- DamuleviÄienĂš GytĂš
- Danial Aghyad
- Daniels Ian
- Daniyan Muhammad
- Danys Donatas
- Daraghmeh Laith
- Dardanov Dragomir
- Dare Anna
- Das Andre
- Davidson Sophie
- Davies Justine
- Davis Laura
- Davis Rowan
- Dawidziuk Aleksander
- Dawoud Amr
- Dawson Amanda Caroline
- Daya Leonid
- De Azevedo Bernardo
- De Castro Parga Gonzalo
- De Giovanni Jasmine
- de Jonge Joske
- de la Torre Javier
- De Luca Emilia
- De Marco Paolino
- de Muijnck Cansu
- de Oliveira Daniela
- De Rosa Michele
- De Santiago Alvarez Irene
- De Silva April
- De Silva Kasun
- De Simone Veronica
- de Sousa Xavier
- De Toma Giorgio
- Deans Chris
- DeBiasio Ashe
- Deepika Garg
- Delhen Malik
- Dell Angela
- Delrio Paolo
- Demartines Nicolas
- Demirkaya Hasan Can
- Demolin Rodrigo
- den Boer Frank
- Deng Idy
- Dennis Grace
- Deskou Eirini
- Deva Tata Mahadevan
- Devesa Helena
- Devezas VĂtor
- Dhital Bal
- Di Candido Francesca
- Di Lascio Pierpaolo
- Di Maso Sara
- Diab Samar
- Diachenko Andrii
- Diaconescu Bogdan
- Diallo Adja Coumba
- Dickfos Marilla
- Dimech Andrew Michael
- Dimitrov Dobromir
- Dinuzzi Vincenza Paola
- Diéguez Beatriz
- Doe Matthew
- Dogruoz Alper
- Doherty Ronan J
- Dollie Qaasim
- Dominguez Genieve
- Dominguez Joaquina
- Domini Edgar
- Donaldson Rachel
- Dossou Francis
- Dousset Bertrand
- Draganic Brian
- Drake Thomas M
- Drane Andrew
- Duarte Marina
- Dudi-Venkata Nagendra Naidu
- Duggan William
- Duke Kathryn
- Duller Alexander
- Dulskas Audrius
- Dumitra Sinziana
- Dural Ahmet Cem
- Dworak Jadwiga
- Dzhumabaev Khasan
- Dziedzic Jacek
- DĂaz Vico Tamara
- Eaazim Jose
- Eardley Nicola
- Echeverria-Davila Guillermo
- Ede Chikwendu
- Edirisooriya Monisha
- Eerola Verner
- Eid Esraa
- Eismontas Vitalijus
- Eklöv Karolina
- Ekpete Ogbonnia
- Ekwen Gerald
- El Aroussi Nouhaila
- El Gharmoul Tasnim
- El Jamassi Alaa
- El Muhtaseb M.S.
- El Nakeeb Ayman
- El sheikh Enas
- El Zoghby Naira
- El-Kahlout Sahar
- El-remaily Amira
- El-Sawy Aya
- El-taweel Alaa
- Elazab Yasmin
- Elbarouni Sofian
- Elbealawy Mohamed
- Elbeshina Aya Elseed
- Elblbessy Mahmood
- Eldeep Ahmed
- Eldeep Mostafa
- Eldmaty Asmaa
- Eldoseuky mohammed Amany
- Elemile Peter
- Elewaily Mohamed Ibrahim Elsayed
- Elfaituri Taha
- Elfallal Ahmed
- Elfanty Mahmoud
- ElFayoumy Ahmed Moustafa
- Elfeki Hossam
- Elfizri Zatira
- Elgammudi Mala
- Elghareeb Nourhan
- Elhadi Ahmed
- Elhadi Muhammed
- Elhajjaji Yasmine
- Elhelow Esraa
- Elhout Somaya
- Elkabir Osama
- Elkhadragy Ahmed
- Elkhalawy Aya
- Ellaby-Hall Jordan
- Ellul Sarah
- Elmahdy Marwa
- Elmeslemany Nehal
- Elmokadem Aya
- Elqadi Muawiyah
- Elrais Safa
- Elsayed Mai
- Elsayed Mohammad
- Elshafei Houssein
- Elshafey Ahmed
- Elshaibani Mahmoud
- Elshatby Bassant
- Elshawy Mohamed Elemam
- Elsherbeny Mohammed Yasser
- Elsherif Fawzia
- Elshimy Ahmed
- Elsobky Hager
- Elteir Hana
- Eltoum Ruba
- Elzanfaly Ali Abdelazez
- Emara Eman
- Emeghara Okechukwu
- Emile Sameh
- Enumah Zachary
- Eraslan Huseyin
- Eray Ismail Cem
- Erkul OÄuz
- Esbaga Fatima
- Escobar Dennis
- Escrevente Ricardo
- Eskander John
- Eslam Sara
- Esmat Nourhan Ahmed
- Esper Asil
- Espin-Basany Eloy
- Espina Perez Beatriz
- Espinosa-Bravo Martin
- Esposito Giovanni
- Essam Ibrahim El Desouki Muhammad Ahmed Muhammad
- Essam Eman
- Estalagem InĂȘs
- Estevez Tesouro José
- Eswaye Haitem
- Etchill Eric
- Etonyeaku Amarachukwu
- Eusebio Zegarra Ivan Edward
- Ezzat Helmy
- Fadel Ahmed
- Fahira Alessa
- Fahmawee Toqa
- Fairfield Cameron J
- Falato Armando
- Falco Giuseppe
- Falco NicolĂČ
- Fareleira Ana
- Fares Bucci Andrea
- Fares Jehad
- Farid Mohammad
- Farik Shebani
- Farina Pablo
- Farina Valeria
- Farnan Richard
- Farooq Muhammad
- Farsi Ali
- Fasolini Fabrizio
- Faustin Ntirenganya
- Fayed Notila
- Fazenda Ana
- Felicia Devi
- Felix Rosa
- Feng Daniel
- Fermani Claudio Gabriel
- Fernandes Cristina
- Fernandes Sara
- Fernandez Arias Sebastian
- Fernandez-Diaz Maria Jose
- Fernandez-Hevia Maria
- FernĂĄndez MartĂnez Daniel
- FernĂĄndez Veiga Maria Pilar
- Ferrari Guglielmo
- Ferreira Fernandes Martin
- Ferreira Andreia
- Ferreira Pedro
- Ferrero Esther
- Ferri Lorenzo
- Fialho Guilherme
- Figueiredo Ana Gabriela
- Finlay Ben
- Fitchat Nicolas
- Fitzgerald J Edward
- Flamey Nicolas
- Flannery Oliver
- Fleming Christina
- Fleming Hannah
- Flores Mario-Andrés
- Fonseca Telma
- Fontana Tommaso
- Fontanilla Mark Anthony
- Forero-Torres Alexander
- Fortuna Martins SĂłnia
- Foschi Diego
- Foster Deshka S
- Fox Benjamin
- Fragoso Marta
- Francisco VĂtor
- Franczak Paula
- Franklin Oskar
- Frasson Matteo
- Freigofer Maryna
- Freire Ligia
- Freitas Oliveira Nuno Miguel
- French James
- Frutuoso LuĂsa
- Fryba Vladimir
- FrÄnberg Andreas
- Fuentes Orozco Clotilde
- Fuentes Joseph Roy
- Gaafar Shireen
- Gaballa Khaled
- Gaber Gehad
- Gabre-Kidan Alodia
- Gad Ahmed
- Gadallah Ahmed
- Gadelkarim Mohamed
- Gaffuri Paolo
- Gaitanidis Apostolos
- Galal Elnagar Ahmed
- Galanos-Demiris Konstantinos
- Galea Joseph
- Galleano Raffaele
- Gallo Gaetano
- GalvĂŁo Diogo
- Gama BĂĄrbara
- Gamal Fatma Alzahraa
- Gamal Mohammed
- Gamal Norhan
- Gan Ying Yee
- Gandhi Nirav
- Gani Jonathan
- Ganugapati Anurag
- Garba Stephen
- Garces-Otero Juan Sebastian
- Garcia Gonzalez Luis Alberto
- Garcia Gutierrez Carmen
- Garcia Allan
- Garcia Mario
- Garcia-Granero Alvaro
- Garcia-Sancho Tellez Luis
- GarcĂa Bernardo Carmen
- GarcĂa Cardo Juan
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- Manatakis Dimitrios K.
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- Meani Francesco
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- Misk Rami
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- Moawad Mf
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- Mohamed Abobakr Norhan
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- Nsengiyumva Carlos
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- O'Connor Donal B
- O'Neill Maeve
- O'Shea Margaret
- Obaid Mohammed
- Obery Gareth
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- Ogundoyin Olakayode
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- van Berge Henegouwen Mark I.
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- Willemin Melissa
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- Wilson Michael
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- Winoto Hadi
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- Winter Des
- Wisal Maham
- Wisselink Daan
- Wogensen Fredrik
- Wondoh Paul M.
- Wong Florence
- Wong Hsu Ven
- Wong Jane J
- Wong Jeremy
- Wong Lai Fen
- Wong Michael Pak-Kai
- Wong Sui-Weng
- Wong Tsz Lun Ernest
- Wood Lauren
- Woon-Shoo-Tong Xiao-Ming Sarah
- Wren Sherry
- Wuraola Funmilola
- Xanthopoulou Georgia
- Yabut Kenneth
- Yacoub Aseel
- Yaghi Nadine
- Yaghi Yasmine
- Yahia Mohamed Ali Mohamed
- Yakushkina Al'ona
- Yalçinkaya Ali
- Yang P Zichu
- YanikoÄlu Erkan
- Yanni Fady
- Yates Charlotte
- Ye Geoffrey
- Yeen Chin Leow
- Yemez KĂŒrĆat
- YenidĂŒnya NilĂŒfer
- Yenli Edwin
- Yeo Jeremy
- Yeoh Andrea
- Yepez Raul
- YeĆilsancak Merve
- Yildirim Reyyan
- Yildiz Alp
- Yilmaz Duygu
- Yip Ching Wan
- Ylatoma DĂaz Edgar Alcides
- Yong Shun Qi
- Yoong Andrel
- Yorke Joseph
- Yotsov Tsanko
- You Lucia
- Younes Eman
- Younes Maha
- Yousry Basant
- Yozgatli Tahir Koray
- Yu Kristin
- Yue Sum Yu Pansy
- Yunes Asmaa
- Yusuf Baasil
- YĂŒksel Osman
- Zabiyaka Mikhail
- Zachariah Sanoop Koshy
- Zafar Syed Nabeel
- Zaffaroni Gloria
- Zahra Baryab
- Zahran Diaaaldin
- Zakaria Andee Dzulkarnaen
- Zakaria Mai
- Zakaria Omar
- Zakaria Zaidi
- Zambrana Campos Vanesa
- Zammit Matthew
- Zanini Nicola
- Zara Vlu Jean
- Zarti Heba
- Zarzycki Piotr
- Zattoni Davide
- Zavala Gabriela
- Zawahrah Hassan
- Zeiton Asaid
- Zeko Amanda
- Zeng Zhi
- Zeromskas Paulius
- Zhang Geoffrey
- Zhivkov Evgeni
- Zid Esraa
- Zidan Ahmed Mohy
- Zielasek Christian
- Zilinskas Justas
- Zimmermann Bernd
- Ziprin Paul
- Zizzo Maurizio
- Zografos George
- Zoikas Athanasios
- Zorrilla Matilla Laura Patricia
- Zoulamoglou Menelaos
- Zreeg Dafer
- Zub-Pokrowiecka Anna
- Zubiaurre Vanessa
- Zuhdy Mohammed
- Zuikyte Diana
- Zuloaga Fernandez del Valle Carlos Jose
- Zulu Stanley
- Ăngelo Miguel
- ĂlgĂ„ Andreas
- Ăolak Elif
- Ămarik Toomas
- ÄepulienĂ© Daiva
- Ćahin Can
- Ć atkauskas Mindaugas
- Ć kimelytĂš Monika
- Ć lenfuktas Vygintas
- Ć uman Oliver
- ĆœateckĂœ Jan
- Ćœumbakys Ćœygimantas
- Ćœupan Domagoj
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/2022
- Field of study
© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide. Methods: A multimethods analysis was performed as part of the GlobalSurg 3 studyâa multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital. Findings: Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3·85 [95% CI 2·58â5·75]; p<0·0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63·0% vs 82·7%; OR 0·35 [0·23â0·53]; p<0·0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer. Interpretation: Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised. Funding: National Institute for Health and Care Research
Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries
- Author
- Aarts Frits
- Ababneh Hazim
- Abad-Motos Ane
- Abaidalla Ahmed
- Abbakar Malaz
- Abd El Aal Ahmed
- Abd-Errazik Mohammad Ahmad
- Abdalradiy Abdalrahmman G
- Abdelkhalek Mohamed
- Abdelkhalek Mostafa
- Abdellatif Ahmed
- Abdellatif Mohamed
- Abdelsaid Kirolas
- Abdou Khaled
- Abdulfatah Mustapha
- Abdullah Mohammad Amer
- Abdullahi Mustapha Miko Mohammed
- AbellĂĄn Antonio Melero
- Abeysinghe Nayana
- Abiyere Henry
- Achimas-Cadariu Patriciu Andrei
- Adakaya Sıla
- Adam Nicolas
- Adams Benita
- Adams Ferdinand
- Adegboye Kazeem
- Adeyeye Ademola
- Adra Lama
- Adu-Poku Patricia
- Afuwape Oludolapo
- Afzal Ameer
- Afzal Muhammad Farooq
- Agapov Mihail
- Agara Daniel
- Aggarwal Manisha
- Agger Erika
- Aghadi Ifeanyi Kene
- Ahmed Amjed Yassir
- Ahmed Haleemasahdia
- Ahmed Khalil
- Ahmed Manar
- Ahmed Masood
- Ahmed Safia
- Ahn Hong Min
- Aibe Raquel
- Aigner Felix
- Aissat Abdenour
- Aitbaeva Arai
- Akay Omer
- Akbar Ali
- Akbas Ahmet
- Akere Abidemi
- Akesen Selcan
- Akgun Erhan
- Akhtar Naseem
- Akın Emrah
- Akova Elif
- Aktas Serhat
- Akçay Ăzlem
- Al Masri Mahmoud
- Al-Alnsi Ahmed
- Al-Hutheifi Roqia'A
- Al-Jarrah Amar
- Al-Naggar Hamza
- Al-Shehari Mohammed
- Alamin Nadeen
- Alawi Raneen
- Alawlaqi Dina
- Alawneh Fade
- Alberola Maria José
- Albers Michael
- Alcolea Natalia GonzĂĄlez
- Aleem Muhammad
- Alegre InĂȘs
- Alegre Javier Martinez
- Alexandre Flavia
- Alexandrescu Corina
- Alexnder Abelevich
- Alexopoulou Kalliopi
- Alfonso Beatriz AmorĂłs
- Ali Ahmed
- Ali Che Saniati Che
- Ali Danish
- Ali Madeeha
- Ali Mahmoud Abdelwahab
- Ali Manhal Hashim
- Ali Noura Al
- Alikhanli Jhale
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- de Andrés-Asenjo Beatriz
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- Ene-Cocis Mihaela-Valentina
- Eng Stanley Chee Ren
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- Felix Michael Shalzim
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- Ferlengez Aysegul
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- Fernandes Andre
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- FernĂĄndez Ignacio Ortega
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- Futaba Kaori
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- Garcia-FlĂłrez Luis Joaquin
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- Hamid Hytham K S
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- Hodzic Samir
- Hoetzel Alexander
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- Hooper Richard L
- Horiguchi Akihiko
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- Hoyos-Torres Alejandro
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- Trafeli Martina
- Trama Mauro
- Trani Antonella Di
- Treiber Michael
- Triantafyllou Alexandra
- Triantafyllou Tania
- Tripodi Vincenzo Francesco
- Tropeano Francesca Paola
- Tsarkov Petr
- Tse Wing Kin
- Tsiaoussis John
- Tsigara Stavroula
- Tsiotos Gregory
- Tsourouflis Gerasimos
- Tufail Sabeen
- Tulina Inna
- Turgut Mehmet Alim
- Turi Stefano
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- Tverdohlebova Tatyana
- Tweedle Elizabeth
- Tzoneva Dochka
- Tzovaras George
- Ukwubile Linus
- Ulasi Ikechukwu
- Ulgur Hanife Seyda
- UludaÄ Server Sezgin
- Um Jun Won
- Umar Garzali Ibrahim
- Umar Nura Aliyu
- Umberto Casiraghi
- Unal Neslisah
- Ungureanu Raluca
- Uranitsch Stefan
- Utkan Nihat Zafer
- Vacca Cristina
- Vailas Michail
- Vaira Giulia
- VaitkutÄ Kristina
- Vaizey Carolynne
- Valbuena Ana Lozano
- ValcĂĄrcel Cristina Rey
- Valderrama Ăscar Cano
- Valdes-Hernandez Javier
- Valentino Cristina
- Valenzuela Andres
- Valero-Navarro Graciela
- Valli Diego
- Van de Steen Katrien
- Van Charles Berlo
- Van Maarten Heinsbergen
- Vardanyan Armen
- Varela-RodrĂguez Lorena
- Varghese Chris
- Varoli Michele
- Vasale Alessandro
- Vasiukova Evgeniia-Surgeon
- Vassiliu Pantelis
- Vaughan-Shaw Peter G
- Vecchio Pablo
- Vederaki Styliani-Aikaterini
- Veetil Sreejith Kannummal
- Velchuru Vamsi
- Velez Cristina
- Vendrell Laura Lopez
- Venezia Dario Francesco
- Venn Mary
- Venn Mary L
- Venskutonis Donatas
- Ventorutti Tatiana
- Vera Marina Teresa Ramirez
- Vera-Mansilla Cristina
- Veracierto Federico
- Vergara-FernĂĄndez Omar
- Verma Devanshi
- Verre Luigi
- Vespo Damiano
- Vicente-Villena Juan Pablo
- Victor Catherine
- Vieira Pedro
- Vieyra Nicolas
- Vignali Andrea
- Vigneswaran Natalia
- Vigorita Vincenzo
- Vihervaara Hanna
- Vijayagopal Kesav Aditya
- Vijayan Varun
- Vilain Luciano Ferreira
- Villa Gianluca
- Villalobos Santiago
- Villarino-Villa Laura
- Vino Smila
- Viola Marcelo
- Viscosi Francesca
- Vishnoi Jeewan Ram
- Vlad Catalin
- Volkoviene Gerda
- Volturo Lino
- Vural Ummuhan
- VĂĄzquez-FernĂĄndez Andrea
- VĂ€yrynen Antti
- Wagdy Michael
- Waha James
- Waheed Mariam
- Waindeskar Vaishali
- Wakkaf Habib
- Walsh Adam
- WalÄdziak Maciej
- Wang Jaw Yuan
- Wani Rauf
- Wanshantha Dinamulla
- Waqar Usama
- Ward Nicholas
- Watanabe Jun
- Wells Johanna
- Westzaan Natalia
- Wickramarathne Rasika
- Wickramasinghe Dakshitha
- Widatalla Abu Bakr H
- Widyaningsih Rizky
- Wijenayake Wasantha
- Wilson Jeremy
- Wilson Kasmira
- Windels An
- Witjes Caroline
- Wong Siew Ching
- Woodward Andrew
- Wright Deborah
- Wright Jonathan
- Wu Scott
- WÄ troba Anna
- Xanthis Athanasios
- Xavier Ruben
- Xenaki Sofia
- Xynos Evangelos
- Yadav Ram Kishan
- Yadev I P
- Yague Julio
- Yakout Nadia
- Yakunina Natalia
- Yalkin Ămer
- Yanishev Alexey
- Yao Hongwei
- Yazici Pinar
- Yemez Kursat
- Yew Chor Kuan
- Yılmaz GĂŒlseren
- Yilmazlar Tuncay
- YiÄit Direnç
- Yoldas Tayfun
- Yonekura Hiroshi
- Yorkmui Liu
- Yoshino Kenji
- Younes Lina
- Young Trudi
- Yule Michael
- Yusoff Zakiah Mohd
- Zaari Fatimazahraa
- Zabiyaka Mikhail
- ZadroĆŒna Monika
- Zafar Madiha
- Zagaynov Eugeny
- Zaidi Syed-Nadeem
- Zaimis Tilemachos
- Zain Wan Zainira Wan
- Zainy Rhendra Hardy Mohamad
- Zakaria Andee Dzulkarnaen
- Zakaria Maheen
- Zakaria Zaidi
- Zamudio-Bautista Jorge Luis
- Zanc Loredana
- Zanoni Andrea
- Zanus Giacomo
- Zapparoli Alessandro
- Zappone Anna
- Zarzava Eirini
- Zatari Dirar
- Zawadzki Marek
- Zayakov Georgi
- Zaycev Andrey
- Zazo Aya
- Zazo Rama
- Zdravkovic Maja
- Zengin Abdullah KaÄan
- Zeringa Georgia
- Zimmerman David D E
- Zuhdy Mohammad
- Zvirych Vitalii
- Zywicka Ewa
- Ălvarez-Llano Laura
- Ăngelo Miguel Duarte
- ĂSullivan Sara Nuñez
- Ăzçelik Mehmet Faik
- Äoza Ivo
- Ćanlı Ahmet Necati
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background
Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks.
Methods
The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned.
Results
A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31).
Conclusion
Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)