Chapter 21- Mentoring Graduate Underrepresented Minorities in STEM

In this chapter, we discuss high-impact mentoring practices for graduate students in science, technology, engineering, and mathematics (STEM). We make a case for inclusive and assets/strengths-based mentoring approaches as a strategy for increasing the number of doctoral degrees awarded to historically underrepresented minorities (i.e., Hispanics, African Americans, Native Americans, Alaska Natives, and Pacific Islanders); improving their levels of satisfaction with doctoral programs and reducing the notoriously extended time to the PhD that they endure. We offer two examples of national programs committed to promoting graduate student success through professional development and mentoring strategies in which instrumental support, sponsorship, psychological support, and access to funding play key roles. We also summarize relevant aspects of assessing a mentorship project and highlight the culture of an institution with sustainable mentoring practices. We conclude with recommendations and provide additional perspective on the need for scaling up the replication of evidence-based practices through effective activities such as mentorship workshops for faculty

Do Outcomes of Arthroscopic Subscapularis Tendon Repairs Depend on Rotator Cuff Fatty Infiltration?

Background:Rotator cuff fatty infiltration has been correlated with poorer radiographic and clinical outcomes in supraspinatus and infraspinatus tendon repairs, but this has not been well-studied in subscapularis tendon repairs. Purpose:To evaluate the influence of preoperative rotator cuff fatty infiltration on postoperative outcomes for patients undergoing arthroscopic subscapularis tendon repair. Study Design:Cohort study; Level of evidence, 3. Methods:Patients who underwent arthroscopic subscapularis repair between 2010 and 2016 were retrospectively identified, and demographic data and surgical findings were recorded. The extent of fatty infiltration was determined on preoperative magnetic resonance imaging by the Fuchs modification of the Goutallier classification. At the most recent follow-up, patients completed the Patient-Reported Outcomes Measurement Information System for Upper Extremity (PROMIS-UE) computer adaptive test and a postoperative visual analog scale for pain. The distribution of fatty infiltration was compared between patients undergoing subscapularis tendon repair versus subscapularis tendon repair combined with a posterior cuff repair. Outcomes were compared for patients using Goutallier grade 0-1 versus grade ≥2 changes in each rotator cuff muscle. Multivariate linear regression analysis was performed to evaluate the influence of muscle quality, as well as demographic factors, on PROMIS-UE scores. Significance was defined as P < .05. Results:There were 140 shoulders included (mean age, 61.8 years; 42.1% female; mean follow-up, 51.7 months). The prevalence of Goutallier grade 2 changes or higher was significantly greater in patients with multitendon repair relative to isolated subscapularis tendon repair. For the overall group of all patients undergoing subscapularis tendon repair, whether in isolation or as part of a multitendon repair, PROMIS-UE scores were significantly lower for patients with infraspinatus muscle grade 2 or higher Goutallier changes relative to grade 0 or 1. After adjustment for age, body mass index, patient sex, and fatty infiltration in other rotator cuff muscles, poor infraspinatus muscle quality remained the only significant predictor for lower PROMIS-UE scores. Conclusion:Patients undergoing arthroscopic subscapularis tendon repair with poor infraspinatus muscle quality had worse patient-reported outcomes. This was true whether subscapularis tendon repair was isolated or was performed in conjunction with supraspinatus and infraspinatus tendon repairs

The relationship between truncation and phosphorylation at the C-terminus of tau protein in the paired helical filaments of Alzheimer's disease

Acknowledgements: Authors want to express their gratitude to Dr. P. Davies (Albert Einstein College of Medicine, Bronx, NY, USA) and Lester I. Binder (NorthWestern, Chicago, IL, USA) for the generous gift of mAbs (TG-3, Alz-50, and MC1), and (TauC-3), respectively, and to M. en C. Ivan J. Galván-Mendoza for his support in confocal microscopy, and Ms. Maricarmen De Lorenz for her secretarial assistance. We also want to express our gratitude to the Mexican Families who donate the brain of their loved ones affected with Alzheimer's disease, and made possible our research. This work was financially supported by CONACyT grant, No. 142293 (For R.M).Peer reviewedPublisher PD

An earthquake-triggered submarine mass failure mechanism for the 1994 Mindoro tsunami in the Philippines : Constraints from numerical modeling and submarine geomorphology

Tsunamis have been known to result from a wide range of phenomena, such as earthquakes, volcanic eruptions, submarine mass failures, and meteorite impacts. Of earthquake-generated tsunamis, those arising from strike-slip mechanisms are less common, with the 1994 Mindoro tsunami in the Philippines among the few known examples. The 1994 Mindoro tsunami followed a Mw 7.1 earthquake along the right-lateral Aglubang River Fault. The tsunami affected the coasts surrounding the Verde Island Passage, one of the Philippines’ insular seas located between the islands of Luzon and Mindoro, and east of the West Philippine Sea margin. A total of 78 lives were lost due to the earthquake and tsunami, with 41 being directly attributed to the tsunami alone. Despite the close spatial and temporal association between the 1994 Mindoro earthquake and tsunami, previous numerical modeling suggests the need for other contributing mechanisms for the 1994 tsunami. In this study, we conducted submarine geomorphological mapping of the South Pass within the Verde Island Passage, with particular focus on identifying possible submarine mass failures. Identification of submarine features were based on Red Relief Image Map (RIMM), Topographic Position Index (topographic position index)-based landform classification, and profile and plan curvatures derived from high-resolution bathymetry data. Among the important submarine features mapped include the San Andres submarine mass failure (SASMF). The San Andres submarine mass failure has an estimated volume of 0.0483 km3 and is located within the Malaylay Submarine Canyon System in the Verde Island Passage, ∼1 km offshore of San Andres in Baco, Oriental Mindoro. We also explored two tsunami models (EQ-only and EQ+SMF) for the 1994 Mindoro tsunami using JAGURS. The source mechanisms for both models included an earthquake component based on the Mw 7.1 earthquake, while the EQ+SMF also included an additional submarine mass failure component based on the mapped San Andres submarine mass failure. Modeled wave heights from the EQ-only model drastically underestimates the observed wave heights for the 1994 Mindoro tsunami. In contrast, the EQ+SMF model tsunami wave height estimates were closer to the observed data. As such, we propose an earthquake-triggered, submarine mass failure source mechanism for the 1994 Mindoro tsunami

PREVALENCY OF FASCIOLIASIS IN LLAMAS AND ALPACAS IN TWO RURALCOMMUNITIES OF JAUJA, PERU

El objetivo del presente estudio fue determinar la prevalencia y carga parasitaria de Fasciola hepatica en llamas y alpacas de 12 a 48 meses de edad en los distritos de Masma Chiche y Llocllapampa, Jauja, Perú, así como determinar la asociación entre la prevalencia de F. hepatica con las variables sexo y edad. Se recolectaron 200 muestras fecales de llamas (n=97) y alpacas (n=103) en octubre de 2011, y se analizaron mediante la técnica parasitológica de sedimentación espontánea, en tanto que la estimación de la carga parasitaria se hizo con el método de McMaster modificado. La prevalencia de F.hepatica fue de 49.5% en llamas y 73.8% en alpacas, sin diferencias estadísticas por efecto de sexo o grupo etario. La carga promedio fue de 12.6 y 19.9 huevos por gramo de heces (hpg) en llamas y alpacas, respectivamente.The aim of this study was to determine the prevalence and parasite load of Fasciolahepatica in llamas and alpacas of 12-48 months of age in the districts of Masma Chiccheand Llocllapampa, Jauja, Peru, and to determine the association between the prevalenceof F. hepatica with sex and age. Two hundred fecal samples were collected from llamas (n= 97) and alpacas (n= 103) in October 2011. The samples were analyzed by thespontaneous sedimentation technique and the parasite load by the modified McMastermethod. The prevalence of F. hepatica in llamas was 49.5% and in alpacas was 73.8%without statistical differences due to sex and age. The parasite load was 12.6 and 19.9eggs per gram of faeces (epg) in llamas and alpacas respectively

Oxford SWIFT IFS and multi-wavelength observations of the Eagle galaxy at z=0.77

The `Eagle' galaxy at a redshift of 0.77 is studied with the Oxford Short Wavelength Integral Field Spectrograph (SWIFT) and multi-wavelength data from the All-wavelength Extended Groth strip International Survey (AEGIS). It was chosen from AEGIS because of the bright and extended emission in its slit spectrum. Three dimensional kinematic maps of the Eagle reveal a gradient in velocity dispersion which spans 35-75 +/- 10 km/s and a rotation velocity of 25 +/- 5 km/s uncorrected for inclination. Hubble Space Telescope images suggest it is close to face-on. In comparison with galaxies from AEGIS at similar redshifts, the Eagle is extremely bright and blue in the rest-frame optical, highly star-forming, dominated by unobscured star-formation, and has a low metallicity for its size. This is consistent with its selection. The Eagle is likely undergoing a major merger and is caught in the early stage of a star-burst when it has not yet experienced metal enrichment or formed the mass of dust typically found in star-forming galaxies.Comment: accepted for publication in MNRA

The Antioxidant Potential of the Mediterranean Diet in Patients at High Cardiovascular Risk: An In-Depth Review of the PREDIMED

Cardiovascular disease (CVD) is the leading global cause of death. Diet is known to be important in the prevention of CVD. The PREDIMED trial tested a relatively low-fat diet versus a high-fat Mediterranean diet (MedDiet) for the primary prevention of CVD. The resulting reduction of the CV composite outcome resulted in a paradigm shift in CV nutrition. Though many dietary factors likely contributed to this effect, this review focuses on the influence of the MedDiet on endogenous antioxidant systems and the effect of dietary polyphenols. Subgroup analysis of the PREDIMED trial revealed increased endogenous antioxidant and decreased pro-oxidant activity in the MedDiet groups. Moreover, higher polyphenol intake was associated with lower incidence of the primary outcome, overall mortality, blood pressure, inflammatory biomarkers, onset of new-onset type 2 diabetes mellitus (T2DM), and obesity. This suggests that polyphenols likely contributed to the lower incidence of the primary event in the MedDiet groups. In this article, we summarize the potential benefits of polyphenols found in the MedDiet, specifically the PREDIMED cohort. We also discuss the need for further research to confirm and expand the findings of the PREDIMED in a non-Mediterranean population and to determine the exact mechanisms of action of polyphenols

Strong lensing in the MareNostrum Universe: biases in the cluster lens population

Strong lensing is one of the most direct probes of the mass distribution in the inner regions of galaxy clusters. It can be used to constrain the density profiles and to measure the mass of the lenses. Moreover, the abundance of strong lensing events can be used to constrain the structure formation and the cosmological parameters through the so-called "arc-statistics" approach. However, several issues related to the usage of strong lensing clusters in cosmological applications are still controversial, leading to the suspect that several biases may affect this very peculiar class of objects. With this study we aim at better understanding the properties of galaxy clusters which can potentially act as strong lenses. We do so by investigating the properties of a large sample of galaxy clusters extracted from the N-body/hydrodynamical simulation MareNostrum Universe. We explore the correlation between the cross section for lensing and many properties of clusters, like the mass, the three-dimensional and projected shapes, their concentrations, the X-ray luminosity and the dynamical activity. We find that the probability of strong alignments between the major axes of the lenses and the line of sight is a growing function of the lensing cross section. In projection, the strong lenses appear rounder within R200, but we find that their cores tend to be more elliptical as the lensing cross section increases. We also find that the cluster concentrations estimated from the projected density profiles tend to be biased high. The X-ray luminosity of strong lensing clusters is higher than that of normal lenses of similar mass and redshift. This is particular significant for the least massive lenses. Finally, we find that the strongest lenses generally exhibit an excess of kinetic energy within the virial radius, indicating that they are more dynamically active than usual clusters.Comment: 22 pages, 18 figures, accepted for publication on A&