Gaps, Rings, and Non-Axisymmetric Structures in Protoplanetary Disks - From Simulations to ALMA Observations

Recent observations by the Atacama Large Millimeter/submillimeter Array (ALMA) of disks around young stars revealed distinct asymmetries in the dust continuum emission. In this work we want to study axisymmetric and non-axisymmetric structures, evocated by the magneto-rotational instability in the outer regions of protoplanetary disks. We combine the results of state-of-the-art numerical simulations with post-processing radiative transfer (RT) to generate synthetic maps and predictions for ALMA. We performed non-ideal global 3D MHD stratified simulations of the dead-zone outer edge using the FARGO MHD code PLUTO. The stellar and disk parameters are taken from a parameterized disk model applied for fitting high-angular resolution multi-wavelength observations of circumstellar disks. The 2D temperature and density profiles are calculated consistently from a given surface density profile and Monte-Carlo radiative transfer. The 2D Ohmic resistivity profile is calculated using a dust chemistry model. The magnetic field is a vertical net flux field. The resulting dust reemission provides the basis for the simulation of observations with ALMA. The fiducial model develops a large gap followed by a jump in surface density located at the dead-zone outer edge. The jump in density and pressure is strong enough to stop the radial drift of particles. In addition, we observe the generation of vortices by the Rossby wave instability (RWI) at the jumps location close to 60 AU. The vortices are steadily generated and destroyed at a cycle of 40 local orbits. The RT results and simulated ALMA observations predict the feasibility to observe such large scale structures appearing in magnetized disks without having a planet.Comment: Language update, added comments, added citations, in press. (A&A

Polarization dependence of coherent phonon generation and detection in the 3D topological insulator Bi2Te3

We have studied the polarization dependence of coherent phonons in the topological insulator Bi2Te3. Using polarization-dependent femtosecond pump-probe spectroscopy, we measured coherent phonons as a function of angle when the pump and probe polarizations were fixed, and the crystal orientation was rotated. For isotropic detection, depending on the spot position, oscillations either from only low- and high-frequency phonons of A1g symmetry, or in addition from the mode at 3.6 THz were observed. All the modes were found to be independent of the orientation of electric field vector with respect to the crystal axes testifying to their full symmetry while no modes of lower symmetry appeared in any polarization geometry. For anisotropic detection both modes of Eg symmetry could be detected, but their amplitudes were considerably smaller than those of A1g symmetry. To clarify the coherent phonon assignment and the process of coherent phonon generation in Bi2Te3, the time-domain measurements were complemented by spontaneous Raman scattering. The comparison of frequency- and time-domain results and the polarization dependence suggest that the 3.6 THz mode belongs to crystalline Te arising due to tellurium segregation. A discrepancy between the time- and frequency domain data is discussed.Comment: Accepted to Pysical Review RB, 27 pages, 11 figure

Extracellular adherence protein (Eap) from Staphylococcus aureus does not function as a superantigen

AbstractExtracellular adherence protein (Eap) from Staphylococcus aureus has been reported to have strong anti-inflammatory properties, which make Eap a potential anti-inflammatory agent. However, Eap has also been demonstrated to trigger T-cell activation and to share structural homology with superantigens. In this study, we focused on whether Eap fulfilled the definition criteria for a superantigen. We demonstrate that T-cell activation by Eap is dependent on both major histocompatibility complex class II and intercellular adhesion molecule type 1, that cellular processing is required for Eap to elicit T-cell proliferation, and that the kinetics of proliferation resemble the profile of a conventional antigen and not that of a superantigen

A New Look at T Tauri Star Forbidden Lines: MHD Driven Winds from the Inner Disk

Magnetohydrodynamic (MHD) and photoevaporative winds are thought to play an important role in the evolution and dispersal of planet-forming disks. We report the first high-resolution ($\Delta v\sim$6\kms) analysis of [S II] $\lambda$4068, [O I] $\lambda$5577, and [O I] $\lambda$6300 lines from a sample of 48 T Tauri stars. Following Simon et al. (2016), we decompose them into three kinematic components: a high-velocity component (HVC) associated with jets, and a low-velocity narrow (LVC-NC) and broad (LVC-BC) components. We confirm previous findings that many LVCs are blueshifted by more than 1.5 kms$^{-1}$ thus most likely trace a slow disk wind. We further show that the profiles of individual components are similar in the three lines. We find that most LVC-BC and NC line ratios are explained by thermally excited gas with temperatures between 5,000$-$10,000 K and electron densities $\sim10^{7}-10^{8}$ cm$^{-3}$. The HVC ratios are better reproduced by shock models with a pre-shock H number density of $\sim10^{6}-10^{7}$ cm$^{-3}$. Using these physical properties, we estimate $\dot{M}_{\rm wind}/\dot{M}_{\rm acc}$ for the LVC and $\dot{M}_{\rm jet}/\dot{M}_{\rm acc}$ for the HVC. In agreement with previous work, the mass carried out in jets is modest compared to the accretion rate. With the likely assumption that the NC wind height is larger than the BC, the LVC-BC $\dot{M}_{\rm wind}/\dot{M}_{\rm acc}$ is found to be higher than the LVC-NC. These results suggest that most of the mass loss occurs close to the central star, within a few au, through an MHD driven wind. Depending on the wind height, MHD winds might play a major role in the evolution of the disk mass.Comment: 45 pages, 23 figures, and 7 tables, accepted by Ap

The properties of the inner disk around HL Tau: Multi-wavelength modeling of the dust emission

We conducted a detailed radiative transfer modeling of the dust emission from the circumstellar disk around HL Tau. The goal of our study is to derive the surface density profile of the inner disk and its structure. In addition to the Atacama Large Millimeter/submillimeter Array images at Band 3 (2.9mm), Band 6 (1.3mm), and Band 7 (0.87mm), the most recent Karl G. Jansky Very Large Array (VLA) observations at 7mm were included in the analysis. A simulated annealing algorithm was invoked to search for the optimum model. The radiative transfer analysis demonstrates that most radial components (i.e., >6AU) of the disk become optically thin at a wavelength of 7mm, which allows us to constrain, for the first time, the dust density distribution in the inner region of the disk. We found that a homogeneous grain size distribution is not sufficient to explain the observed images at different wavelengths simultaneously, while models with a shallower grain size distribution in the inner disk work well. We found clear evidence that larger grains are trapped in the first bright ring. Our results imply that dust evolution has already taken place in the disk at a relatively young (i.e., ~1Myr) age. We compared the midplane temperature distribution, optical depth, and properties of various dust rings with those reported previously. Using the Toomre parameter, we briefly discussed the gravitational instability as a potential mechanism for the origin of the dust clump detected in the first bright ring via the VLA observations.Comment: Accepted for publication in A&A (10 pages

Emergent Mesoscale Phenomena in Magnetized Accretion Disc Turbulence

We study how the structure and variability of magnetohydrodynamic (MHD) turbulence in accretion discs converge with domain size. Our results are based on a series of vertically stratified local simulations, computed using the Athena code, that have fixed spatial resolution, but varying radial and azimuthal extent (from \Delta R = 0.5H to 16H, where H is the vertical scale height). We show that elementary local diagnostics of the turbulence, including the Shakura-Sunyaev {\alpha} parameter, the ratio of Maxwell stress to magnetic energy, and the ratio of magnetic to fluid stresses, converge to within the precision of our measurements for spatial domains of radial size Lx \geq 2H. We obtain {\alpha} = 0.02-0.03, consistent with recent results. Very small domains (Lx = 0.5H) return anomalous results, independent of spatial resolution. The convergence with domain size is only valid for a limited set of diagnostics: larger spatial domains admit the emergence of dynamically important mesoscale structures. In our largest simulations, the Maxwell stress shows a significant large scale non-local component, while the density develops long-lived axisymmetric perturbations (zonal flows) at the 20% level. Most strikingly, the variability of the disc in fixed-sized patches decreases strongly as the simulation volume increases. We find generally good agreement between our largest local simulations and global simulations with comparable spatial resolution. There is no direct evidence that the presence of curvature terms or radial gradients in global calculations materially affect the turbulence, except to perhaps introduce an outer radial scale for mesoscale structures. The demonstrated importance of mean magnetic fields, seen in both large local and global simulations implies that the growth and saturation of these fields is likely of critical importance for the evolution of accretion discs. (abridged)Comment: 18 pages, 20 figures, accepted to MNRA

Perioperative morbidity of different operative approaches in early cervical carcinoma: a systematic review and meta-analysis comparing minimally invasive versus open radical hysterectomy

Purpose: Radical hysterectomy and pelvic lymphadenectomy is the standard treatment for early cervical cancer. Studies have shown superior oncological outcome for open versus minimal invasive surgery, but peri- and postoperative complication rates were shown vice versa. This meta-analysis evaluates the peri- and postoperative morbidities and complications of robotic and laparoscopic radical hysterectomy compared to open surgery. Methods: Embase and Ovid-Medline databases were systematically searched in June 2020 for studies comparing robotic, laparoscopic and open radical hysterectomy. There was no limitation in publication year. Inclusion criteria were set analogue to the LACC trial. Subgroup analyses were performed regarding the operative technique, the study design and the date of publication for the endpoints intra- and postoperative morbidity, estimated blood loss, hospital stay and operation time. Results: 27 studies fulfilled the inclusion criteria. Five prospective, randomized-control trials were included. Meta-analysis showed no significant difference between robotic radical hysterectomy (RH) and laparoscopic hysterectomy (LH) concerning intra- and perioperative complications. Operation time was longer in both RH (mean difference 44.79 min [95% CI 38.16; 51.42]), and LH (mean difference 20.96 min; [95% CI − 1.30; 43.22]) than in open hysterectomy (AH) but did not lead to a rise of intra- and postoperative complications. Intraoperative morbidity was lower in LH than in AH (RR 0.90 [0.80; 1.02]) as well as in RH compared to AH (0.54 [0.33; 0.88]). Intraoperative morbidity showed no difference between LH and RH (RR 1.29 [0.23; 7.29]). Postoperative morbidity was not different in any approach. Estimated blood loss was lower in both LH (mean difference − 114.34 [− 122.97; − 105.71]) and RH (mean difference − 287.14 [− 392.99; − 181.28]) compared to AH, respectively. Duration of hospital stay was shorter for LH (mean difference − 3.06 [− 3.28; − 2.83]) and RH (mean difference − 3.77 [− 5.10; − 2.44]) compared to AH. Conclusion: Minimally invasive radical hysterectomy appears to be associated with reduced intraoperative morbidity and blood loss and improved reconvalescence after surgery. Besides oncological and surgical factors these results should be considered when counseling patients for radical hysterectomy and underscore the need for new randomized trials. © 2021, The Author(s)

On Shocks Driven by High-mass Planets in Radiatively Inefficient Disks. II. Three-dimensional Global Disk Simulations

Recent high-resolution, near-infrared images of protoplanetary disks have shown that these disks often present spiral features. Spiral arms are among the structures predicted by models of disk–planet interaction and thus it is tempting to suspect that planetary perturbers are responsible for these signatures. However, such interpretation is not free of problems. The observed spirals have large pitch angles, and in at least one case (HD 100546) it appears effectively unpolarized, implying thermal emission of the order of 1000 K (465 ± 40 K at closer inspection). We have recently shown in two-dimensional models that shock dissipation in the supersonic wake of high-mass planets can lead to significant heating if the disk is sufficiently adiabatic. Here we extend this analysis to three dimensions in thermodynamically evolving disks. We use the Pencil Code in spherical coordinates for our models, with a prescription for thermal cooling based on the optical depth of the local vertical gas column. We use a 5M_J planet, and show that shocks in the region around the planet where the Lindblad resonances occur heat the gas to substantially higher temperatures than the ambient gas. The gas is accelerated vertically away from the midplane to form shock bores, and the gas falling back toward the midplane breaks up into a turbulent surf. This turbulence, although localized, has high α values, reaching 0.05 in the inner Lindblad resonance, and 0.1 in the outer one. We find evidence that the disk regions heated up by the shocks become superadiabatic, generating convection far from the planet's orbit

Molecular Principles of Gene Fusion Mediated Rewiring of Protein Interaction Networks in Cancer

Gene fusions are common cancer-causing mutations, but the molecular principles by which fusion protein products affect interaction networks and cause disease are not well understood. Here, we perform an integrative analysis of the structural, interactomic, and regulatory properties of thousands of putative fusion proteins. We demonstrate that genes that form fusions (i.e., parent genes) tend to be highly connected hub genes, whose protein products are enriched in structured and disordered interaction-mediating features. Fusion often results in the loss of these parental features and the depletion of regulatory sites such as post-translational modifications. Fusion products disproportionately connect proteins that did not previously interact in the protein interaction network. In this manner, fusion products can escape cellular regulation and constitutively rewire protein interaction networks. We suggest that the deregulation of central, interaction-prone proteins may represent a widespread mechanism by which fusion proteins alter the topology of cellular signaling pathways and promote cancer