Low Acceptability of A/H1N1 Pandemic Vaccination in French Adult Population: Did Public Health Policy Fuel Public Dissonance?

International audienceBACKGROUND: In July 2009, French public health authorities embarked in a mass vaccination campaign against A/H1N1 2009 pandemic-influenza. We explored the attitudes and behaviors of the general population toward pandemic vaccination. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a cross-sectional online survey among 2,253 French representative adults aged 18 to 64 from November 17 to 25, 2009 (completion rate: 93.8%). The main outcome was the acceptability of A/H1N1 vaccination as defined by previous receipt or intention to get vaccinated ("Yes, certainly", "Yes, probably"). Overall 17.0% (CI 95%, 15.5% to 18.7%) of respondents accepted A/H1N1 vaccination. Independent factors associated with acceptability included: male sex (p = .0001); older age (p = .002); highest or lowest level of education (p = .016); non-clerical occupation (p = .011); having only one child (p = .008); and having received seasonal flu vaccination in prior 3 years (p<.0001). Acceptability was also significantly higher among pregnant women (37.9%) and other at risk groups with chronic diseases (34.8%) (p = .002). Only 35.5% of respondents perceived A/H1N1 influenza illness as a severe disease and 12.7% had experienced A/H1N1 cases in their close relationships with higher acceptability (p<.0001 and p = .006, respectively). In comparison to 26.0% respondents who did not consult their primary care physician, acceptability was significantly higher among 8.0% respondents who were formally advised to get vaccinated, and lower among 63.7% respondents who were not advised to get vaccinated (respectively: 15.8%, 59.5% and 11.7%- p<.0001). Among respondents who refused vaccination, 71.2% expressed concerns about vaccine safety. CONCLUSIONS/SIGNIFICANCE: Our survey occurred one week before the peak of the pandemic in France. We found that alarming public health messages aiming at increasing the perception of risk severity were counteracted by daily personal experience which did not confirm the threat, while vaccine safety was a major issue. This dissonance may have been amplified by having not involved primary care physicians in the mass vaccination campaign

Adherence to influenza preventive and curative treatments : from seasonal epidemics to pandemics

L’étude du comportement des patients en regard des prescriptions et recommandations qui leur sont faites dans le domaine de la santé est un domaine d’étude qui connaît un essor important. Aujourd’hui, ces comportements se déclinent au sein d’une relation forte entre patients et médecins, ce qu’illustrent par exemple de nombreuses données sur la vaccination. Par ailleurs, l’adhérence joue un rôle majeur à la phase d’évaluation des médicaments, et malgré des investissements importants, elle reste un élément limitant qui peut conduire à rendre difficile l’évaluation de l’efficacité des traitements dans le cadre des essais randomisés. Dans le cas de la grippe, les enjeux de l’étude de ces comportements sont multiples, ils concernent à la fois la vaccination et les traitements antiviraux, à la fois les épidémies de grippe saisonnière et les pandémies dues à des virus émergents. A travers deux études sur l’acceptabilité de la vaccination pandémique et sur l’adhérence au traitement antiviral contre la grippe saisonnière, nous dressons un état des lieux des principaux enjeux liés au suivi des comportements des patients et des médecins. Le travail tente de mettre en évidence l’articulation entre grippe saisonnière et pandémique et nous avons étudié comment les politiques de préparation et de lutte contre la pandémie avaient pu avoir d’importantes conséquences au sein de la communauté scientifique et dans la population. Les résultats publiés apportent un éclairage sur les pratiques des médecins généralistes dans le cadre de la pandémie et sur l’adhérence des patients aux traitements anti-viraux dans le cadre d’un essai clinique randomisé.In recent years there have been an increased interest in the scientific community for studying how patients conform, or not, to their corresponding prescribed or recommended therapies. Recent data from evaluation of vaccination policy made very clear that those behaviors have to be seen as a component of the strong relation that patients engage with their physician. They are also playing a strong role in the evaluation of treatment efficacy. Indeed the lack of measure and control of adherence to the evaluated intervention,especially in ambulatory medicine, can lead to major bias in the analysis that would give a measure of efficacy. In the context of influenza, those behaviors can have a strong impact on the epidemiology of the disease in a seasonal epidemic context and during pandemics.They concern both the acceptability of vaccination and the adherence to anti-viral therapy. We studied those dimensions through two studies, one survey of general practitioners upon the pandemic vaccinatio, and an analysis of patient adherence to antivirals. Due to its epidemic characteristics, influenza is concerned by global policies, and through those studies we discuss the relationship between those policies and patient’s adherence, and how they make a link between seasonal epidemic and pandemic

Adhérence des patients et des médecins aux traitements anti grippaux préventifs et curatifs : de la grippe saisonnière à l’épisode grippe pandémique 2009(H1N1)pdm09

In recent years there have been an increased interest in the scientific community for studying how patients conform, or not, to their corresponding prescribed or recommended therapies. Recent data from evaluation of vaccination policy made very clear that those behaviors have to be seen as a component of the strong relation that patients engage with their physician. They are also playing a strong role in the evaluation of treatment efficacy. Indeed the lack of measure and control of adherence to the evaluated intervention,especially in ambulatory medicine, can lead to major bias in the analysis that would give a measure of efficacy. In the context of influenza, those behaviors can have a strong impact on the epidemiology of the disease in a seasonal epidemic context and during pandemics.They concern both the acceptability of vaccination and the adherence to anti-viral therapy. We studied those dimensions through two studies, one survey of general practitioners upon the pandemic vaccinatio, and an analysis of patient adherence to antivirals. Due to its epidemic characteristics, influenza is concerned by global policies, and through those studies we discuss the relationship between those policies and patient’s adherence, and how they make a link between seasonal epidemic and pandemic.L’étude du comportement des patients en regard des prescriptions et recommandations qui leur sont faites dans le domaine de la santé est un domaine d’étude qui connaît un essor important. Aujourd’hui, ces comportements se déclinent au sein d’une relation forte entre patients et médecins, ce qu’illustrent par exemple de nombreuses données sur la vaccination. Par ailleurs, l’adhérence joue un rôle majeur à la phase d’évaluation des médicaments, et malgré des investissements importants, elle reste un élément limitant qui peut conduire à rendre difficile l’évaluation de l’efficacité des traitements dans le cadre des essais randomisés. Dans le cas de la grippe, les enjeux de l’étude de ces comportements sont multiples, ils concernent à la fois la vaccination et les traitements antiviraux, à la fois les épidémies de grippe saisonnière et les pandémies dues à des virus émergents. A travers deux études sur l’acceptabilité de la vaccination pandémique et sur l’adhérence au traitement antiviral contre la grippe saisonnière, nous dressons un état des lieux des principaux enjeux liés au suivi des comportements des patients et des médecins. Le travail tente de mettre en évidence l’articulation entre grippe saisonnière et pandémique et nous avons étudié comment les politiques de préparation et de lutte contre la pandémie avaient pu avoir d’importantes conséquences au sein de la communauté scientifique et dans la population. Les résultats publiés apportent un éclairage sur les pratiques des médecins généralistes dans le cadre de la pandémie et sur l’adhérence des patients aux traitements anti-viraux dans le cadre d’un essai clinique randomisé

influence de l'antibiothérapie sur la xséquence colonisation-infection à Staphylococcus aureus résistant à la méticilline en réanimation

RENNES1-BU Santé (352382103) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Antibody response to immunization with IB010.

<p>Serum samples were collected from ATCC 19606 vaccinated, IB010 vaccinated and control mice before vaccination (Day 0) and at day 7 and 21 after the first immunization, and levels of antigen specific total IgG (A) and IgM (B) were measured by ELISA (n = 8 mice/group). IgG1 (C) and IgG2c (D) levels in serum collected 7 days after the second immunization were determined in serum were measured by ELISA in ATCC 19606 vaccinated, IB010 vaccinated and control mice In all panels box and whisker plots represent the interquartile ranges and ranges, respectively, and horizontal lines represent median values. * p<0.05 compared to levels in control mice at the same time point, # p<0.05 compared to 7-day samples from the same experimental group, † p<0.05 compared to 21-day samples in ATCC 19606 vaccinated mice.</p

ECSTRA-INSERM @ CLEF eHealth2016-task 2: ICD10 Code Extraction from Death Certificates

International audienceThis paper describes the participation of ECSTRA-INSERM team at CLEF eHealth 2016, task 2.C. The task involves extracting ICD10 codes from death certificates, mainly described with short plain texts. We cast the task as a machine learning problem involving the prediction of the ICD10 codes (categorical variable) from the raw text transformed into a bag-of-words matrix. We rely on probabilistic topic models that we evaluate against classical classifiers such as SVM and Naive Bayes. We demonstrate the effectiveness of topic models for this task in terms of prediction accuracy and result interpretation

Opinions et pratiques d'un panel de médecins généralistes français vis-a-vis de la vaccination

International audienceEn France, la couverture vaccinale est insuffisante. Les médecins généralistes étant des acteurs essentiels de la politique vaccinale, il est utile de connaître leurs opinions et pratiques à ce sujet. Nous avons interrogé 1431 médecins généralistes français et 98% se déclaraient favorables à la vaccination dans leur pratique quotidienne. Leurs couvertures vaccinales étaient de 73% pour l’hépatite B, 64% pour la coqueluche et 77% pour la grippe saisonnière. Les médecins se trouvaient très efficaces pour obtenir l’adhésion pour le vaccin ROR (Rougeole-Oreillons-Rubéole) chez les enfants de moins de deux ans et la grippe saisonnière chez les adultes de moins de 65 ans à risque, mais beaucoup moins pour l’hépatite B chez les adolescents. La mise en place d’un registre national informatisé des vaccinations et de messages de promotion vaccinale différenciés par vaccin semblent les deux voies prioritaires pour améliorer la couverture vaccinale

Acceptability of A/H1N1 pandemic vaccination in French adult population (18-64 years) and its determinants (online survey, November 17 to 25, 2009, N = 2,167).

<p>*<i>60 with asthma (43%); 19 with chronic bronchitis (14.7%); 46 with diabetes (33.3%); 13 with cardiac condition (9.4%).</i></p><p>†<i>chi² test p-values (Cochran-Armitage test for age).</i></p><p>‡<i>p-values for type III tests. Hosmer-Lemeshow test (p = 0.46) and deviance (p = 1.00) suggest that the goodness of fit was adequate for the final multivariate logistic model.</i></p><p>#<i>covariates forced into multivariate model.</i></p><p><i>NS: Non significant after backward selection process, OR not provided.</i></p

Pandemic influenza (A/H1N1) vaccine uptake among French private general practitioners: a cross sectional study in 2010.

BACKGROUND: In July, 2009, French health authorities, like those in many other countries, decided to embark on a mass vaccination campaign against the pandemic A(H1N1) influenza. Private general practitioners (GPs) were not involved in this campaign. We studied GPs' pandemic vaccine (pvaccine) uptake, quantified the relative contribution of its potential explanatory factors and studied whether their own vaccination choice was correlated with their recommendations to patients about pvaccination. METHODOLOGY/PRINCIPAL FINDINGS: In this cross-sectional telephone survey, professional investigators interviewed an existing panel of randomly selected private GPs (N = 1431; response rate at inclusion in the panel: 36.8%; participation rate in the survey: 100%). The main outcome variable was GPs' own pvaccine uptake. We used an averaging multi-model approach to quantify the relative contribution of factors associated with their vaccination. The pvaccine uptake rate was 61% (95%CI = 58.3-63.3). Four independent factors contributed the most to this rate (partial Nagelkerke's R(2)): history of previous vaccination against seasonal influenza (14.5%), perception of risks and efficacy of the pvaccine (10.8%), opinions regarding the organization of the vaccination campaign (7.1%), and perception of the pandemic's severity (5.2%). Overall, 71.3% (95%CI = 69.0-73.6) of the participants recommended pvaccination to young adults at risk and 40.1% (95%CI = 37.6-42.7) to other young adults. GPs' own pvaccination was strongly predictive of their recommendation to both young adults at risk (OR = 9.6; 95%CI = 7.2-12.6) and those not at risk (OR = 8.5; 95%CI = 6.4-11.4). CONCLUSIONS/SIGNIFICANCE: These results suggest that around 60% of French private GPs followed French authorities' recommendations about vaccination of health care professionals against the A(H1N1) influenza. They pinpoint priority levers for improving preparedness for future influenza pandemics. Besides encouraging GPs' own uptake of regular vaccination against seasonal influenza, providing GPs with clear information about the risks and efficacy of any new pvaccine and involving them in the organization of any future vaccine campaign may improve their pvaccine uptake