447 research outputs found
A note on log-convexity of q-Catalan numbers
The q-Catalan numbers studied by Carlitz and Riordan are polynomials in q
with nonnegative coefficients. They evaluate, at q=1, to the Catalan numbers:
1, 1, 2, 5, 14,..., a log-convex sequence. We use a combinatorial
interpretation of these polynomials to prove a q-log-convexity result. The
sequence of q-Catalan numbers is not q-log-convex in the narrow sense used by
other authors, so our work suggests a more flexible definition of q-log convex
be adopted
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Macrophage migration inhibitory factor downregulation: a novel mechanism of resistance to anti-angiogenic therapy.
Anti-angiogenic therapies for cancer such as VEGF neutralizing antibody bevacizumab have limited durability. While mechanisms of resistance remain undefined, it is likely that acquired resistance to anti-angiogenic therapy will involve alterations of the tumor microenvironment. We confirmed increased tumor-associated macrophages in bevacizumab-resistant glioblastoma patient specimens and two novel glioblastoma xenograft models of bevacizumab resistance. Microarray analysis suggested downregulated macrophage migration inhibitory factor (MIF) to be the most pertinent mediator of increased macrophages. Bevacizumab-resistant patient glioblastomas and both novel xenograft models of resistance had less MIF than bevacizumab-naive tumors, and harbored more M2/protumoral macrophages that specifically localized to the tumor edge. Xenografts expressing MIF-shRNA grew more rapidly with greater angiogenesis and had macrophages localizing to the tumor edge which were more prevalent and proliferative, and displayed M2 polarization, whereas bevacizumab-resistant xenografts transduced to upregulate MIF exhibited the opposite changes. Bone marrow-derived macrophage were polarized to an M2 phenotype in the presence of condition-media derived from bevacizumab-resistant xenograft-derived cells, while recombinant MIF drove M1 polarization. Media from macrophages exposed to bevacizumab-resistant tumor cell conditioned media increased glioma cell proliferation compared with media from macrophages exposed to bevacizumab-responsive tumor cell media, suggesting that macrophage polarization in bevacizumab-resistant xenografts is the source of their aggressive biology and results from a secreted factor. Two mechanisms of bevacizumab-induced MIF reduction were identified: (1) bevacizumab bound MIF and blocked MIF-induced M1 polarization of macrophages; and (2) VEGF increased glioma MIF production in a VEGFR2-dependent manner, suggesting that bevacizumab-induced VEGF depletion would downregulate MIF. Site-directed biopsies revealed enriched MIF and VEGF at the enhancing edge in bevacizumab-naive patients. This MIF enrichment was lost in bevacizumab-resistant glioblastomas, driving a tumor edge M1-to-M2 transition. Thus, bevacizumab resistance is driven by reduced MIF at the tumor edge causing proliferative expansion of M2 macrophages, which in turn promotes tumor growth
Ultra High Energy Cosmology with POLARBEAR
Observations of the temperature anisotropy of the Cosmic Microwave Background
(CMB) lend support to an inflationary origin of the universe, yet no direct
evidence verifying inflation exists. Many current experiments are focussing on
the CMB's polarization anisotropy, specifically its curl component (called
"B-mode" polarization), which remains undetected. The inflationary paradigm
predicts the existence of a primordial gravitational wave background that
imprints a unique B-mode signature on the CMB's polarization at large angular
scales. The CMB B-mode signal also encodes gravitational lensing information at
smaller angular scales, bearing the imprint of cosmological large scale
structures (LSS) which in turn may elucidate the properties of cosmological
neutrinos. The quest for detection of these signals; each of which is orders of
magnitude smaller than the CMB temperature anisotropy signal, has motivated the
development of background-limited detectors with precise control of systematic
effects. The POLARBEAR experiment is designed to perform a deep search for the
signature of gravitational waves from inflation and to characterize lensing of
the CMB by LSS. POLARBEAR is a 3.5 meter ground-based telescope with 3.8
arcminute angular resolution at 150 GHz. At the heart of the POLARBEAR receiver
is an array featuring 1274 antenna-coupled superconducting transition edge
sensor (TES) bolometers cooled to 0.25 Kelvin. POLARBEAR is designed to reach a
tensor-to-scalar ratio of 0.025 after two years of observation -- more than an
order of magnitude improvement over the current best results, which would test
physics at energies near the GUT scale. POLARBEAR had an engineering run in the
Inyo Mountains of Eastern California in 2010 and will begin observations in the
Atacama Desert in Chile in 2011.Comment: 8 pages, 6 figures, DPF 2011 conference proceeding
The new generation CMB B-mode polarization experiment: POLARBEAR
We describe the Cosmic Microwave Background (CMB) polarization experiment
called Polarbear. This experiment will use the dedicated Huan Tran Telescope
equipped with a powerful 1,200-bolometer array receiver to map the CMB
polarization with unprecedented accuracy. We summarize the experiment, its
goals, and current status
The bolometric focal plane array of the Polarbear CMB experiment
The Polarbear Cosmic Microwave Background (CMB) polarization experiment is
currently observing from the Atacama Desert in Northern Chile. It will
characterize the expected B-mode polarization due to gravitational lensing of
the CMB, and search for the possible B-mode signature of inflationary
gravitational waves. Its 250 mK focal plane detector array consists of 1,274
polarization-sensitive antenna-coupled bolometers, each with an associated
lithographed band-defining filter. Each detector's planar antenna structure is
coupled to the telescope's optical system through a contacting dielectric
lenslet, an architecture unique in current CMB experiments. We present the
initial characterization of this focal plane
The Green Bank Northern Celestial Cap Pulsar Survey - I: Survey Description, Data Analysis, and Initial Results
We describe an ongoing search for pulsars and dispersed pulses of radio
emission, such as those from rotating radio transients (RRATs) and fast radio
bursts (FRBs), at 350 MHz using the Green Bank Telescope. With the Green Bank
Ultimate Pulsar Processing Instrument, we record 100 MHz of bandwidth divided
into 4,096 channels every 81.92 . This survey will cover the entire sky
visible to the Green Bank Telescope (, or 82% of the sky)
and outside of the Galactic Plane will be sensitive enough to detect slow
pulsars and low dispersion measure (30 ) millisecond
pulsars (MSPs) with a 0.08 duty cycle down to 1.1 mJy. For pulsars with a
spectral index of 1.6, we will be 2.5 times more sensitive than previous and
ongoing surveys over much of our survey region. Here we describe the survey,
the data analysis pipeline, initial discovery parameters for 62 pulsars, and
timing solutions for 5 new pulsars. PSR J02145222 is an MSP in a long-period
(512 days) orbit and has an optical counterpart identified in archival data.
PSR J06365129 is an MSP in a very short-period (96 minutes) orbit with a
very low mass companion (8 ). PSR J06455158 is an isolated MSP
with a timing residual RMS of 500 ns and has been added to pulsar timing array
experiments. PSR J14347257 is an isolated, intermediate-period pulsar that
has been partially recycled. PSR J18164510 is an eclipsing MSP in a
short-period orbit (8.7 hours) and may have recently completed its spin-up
phase.Comment: 18 pages, 10 figures, 5 tables, accepted by Ap
The Green Bank North Celestial Cap Pulsar Survey. IV: Four New Timing Solutions
We present timing solutions for four pulsars discovered in the Green Bank
Northern Celestial Cap (GBNCC) survey. All four pulsars are isolated with spin
periods between 0.26s and 1.84s. PSR J00382501 has a 0.26s
period and a period derivative of ,
which is unusually low for isolated pulsars with similar periods. This low
period derivative may be simply an extreme value for an isolated pulsar or it
could indicate an unusual evolution path for PSR J00382501, such as a
disrupted recycled pulsar (DRP) from a binary system or an orphaned central
compact object (CCO). Correcting the observed spin-down rate for the Shklovskii
effect suggests that this pulsar may have an unusually low space velocity,
which is consistent with expectations for DRPs. There is no X-ray emission
detected from PSR J00382501 in an archival swift observation, which suggests
that it is not a young orphaned CCO. The high dispersion measure of PSR
J1949+3426 suggests a distance of 12.3kpc. This distance indicates that PSR
J1949+3426 is among the most distant 7% of Galactic field pulsars, and is one
of the most luminous pulsars.Comment: 7 pages, 5 figure
Searching for pulsars using image pattern recognition
In the modern era of big data, many fields of astronomy are generating huge volumes of data, the analysis of which can sometimes be the limiting factor in research. Fortunately, computer scientists have developed powerful data-mining techniques that can be applied to various fields. In this paper, we present a novel artificial intelligence (AI) program that identifies pulsars from recent surveys by using image pattern recognition with deep neural nets - the PICS (Pulsar Image-based Classification System) AI. The AI mimics human experts and distinguishes pulsars from noise and interference by looking for patterns from candidate plots. Different from other pulsar selection programs that search for expected patterns, the PICS AI is taught the salient features of different pulsars from a set of human-labeled candidates through machine learning. The training candidates are collected from the Pulsar Arecibo L-band Feed Array (PALFA) survey. The information from each pulsar candidate is synthesized in four diagnostic plots, which consist of image data with up to thousands of pixels. The AI takes these data from each candidate as its input and uses thousands of such candidates to train its ;9000 neurons. The deep neural networks in this AI system grant it superior ability to recognize various types of pulsars as well as their harmonic signals. The trained AI\u27s performance has been validated with a large set of candidates from a different pulsar survey, the Green Bank North Celestial Cap survey. In this completely independent test, the PICS ranked 264 out of 277 pulsar-related candidates, including all 56 previously known pulsars and 208 of their harmonics, in the top 961 (1%) of 90,008 test candidates, missing only 13 harmonics. The first non-pulsar candidate appears at rank 187, following 45 pulsars and 141 harmonics. In other words, 100% of the pulsars were ranked in the top 1% of all candidates, while 80% were ranked higher than any noise or interference. The performance of this system can be improved over time as more training data are accumulated. This AI system has been integrated into the PALFA survey pipeline and has discovered six new pulsars to date. © 2014. The American Astronomical Society. All rights reserved
The Green Bank Northern Celestial Cap Pulsar Survey II: The Discovery and Timing of Ten Pulsars
We present timing solutions for ten pulsars discovered in 350 MHz searches
with the Green Bank Telescope. Nine of these were discovered in the Green Bank
Northern Celestial Cap survey and one was discovered by students in the Pulsar
Search Collaboratory program in analysis of drift-scan data. Following
discovery and confirmation with the Green Bank Telescope, timing has yielded
phase-connected solutions with high precision measurements of rotational and
astrometric parameters. Eight of the pulsars are slow and isolated, including
PSR J09302301, a pulsar with nulling fraction lower limit of 30\% and
nulling timescale of seconds to minutes. This pulsar also shows evidence of
mode changing. The remaining two pulsars have undergone recycling, accreting
material from binary companions, resulting in higher spin frequencies. PSR
J05572948 is an isolated, 44 \rm{ms} pulsar that has been partially recycled
and is likely a former member of a binary system which was disrupted by a
second supernova. The paucity of such so-called `disrupted binary pulsars'
(DRPs) compared to double neutron star (DNS) binaries can be used to test
current evolutionary scenarios, especially the kicks imparted on the neutron
stars in the second supernova. There is some evidence that DRPs have larger
space velocities, which could explain their small numbers. PSR J1806+2819 is a
15 \rm{ms} pulsar in a 44 day orbit with a low mass white dwarf companion. We
did not detect the companion in archival optical data, indicating that it must
be older than 1200 Myr.Comment: 9 pages, 5 figure
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