680 research outputs found
The Effectiveness of Conservation Reserves: Land Tenure Impacts upon Biodiversity across Extensive Natural Landscapes in the Tropical Savannahs of the Northern Territory, Australia
This study examines whether there is a biodiversity benefit (“dividend”) associated with the existence and management of conservation reserves in the extensive and largely natural landscape of northern Australia. Species richness and abundance of vertebrate fauna and the intensity of a range of disturbance factors were compared across a set of 967 sampled quadrats, located either in pastoral lands, Indigenous lands or conservation reserves, with all sampled quadrats within a single vegetation type (open forests and savannah woodlands dominated by Eucalyptus miniata and/or E. tetrodonta). The relationships with land tenure varied between major taxonomic groups, but generally (and particularly for threatened species) values were highest for conservation reserves. This “biodiversity dividend” associated with conservation reserves is considered to be due to the effects of management rather than because conservation reserves were established on lands supporting atypically high conservation values. The impact of weeds and (unsurprisingly) livestock was greatest on pastoral lands, and pig impact was greatest in conservation reserves. Although pastoral and Indigenous lands supported lower biodiversity tallies than reserved lands, the conservation values of reserved lands in this region are probably substantially supported by the maintenance of relatively intact ecological systems across all lands
How acceptable is adolescent self-consent for the HPV vaccination: Findings from a qualitative study in south-west England
Quantum oscillations in the parent pnictide BaFeAs : itinerant electrons in the reconstructed state
We report quantum oscillation measurements that enable the direct observation
of the Fermi surface of the low temperature ground state of \ba122. From these
measurements we characterize the low energy excitations, revealing that the
Fermi surface is reconstructed in the antiferromagnetic state, but leaving
itinerant electrons in its wake. The present measurements are consistent with a
conventional band folding picture of the antiferromagnetic ground state,
placing important limits on the topology and size of the Fermi surface.Comment: 5 pages, 3 figure
Germ plasm in Eleutherodactylus coqui, a direct developing frog with large eggs
<p>Abstract</p> <p>Background</p> <p>RNAs for embryo patterning and for germ cell specification are localized to the vegetal cortex of the oocyte of <it>Xenopus laevis</it>. In oocytes of the direct developing frog <it>Eleutherodactylus coqui</it>, orthologous RNAs for patterning are not localized, raising the question as to whether RNAs and other components of germ plasm are localized in this species.</p> <p>Methods</p> <p>To identify germ plasm, <it>E. coqui </it>embryos were stained with DiOC<sub>6</sub>(3) or examined by <it>in situ </it>hybridization for <it>dazl </it>and <it>DEADSouth </it>RNAs. The cDNAs for the <it>E. coqui </it>orthologues were cloned by RT-PCR using degenerate primers. To examine activity of the <it>E. coqui </it>orthologues, RNAs, made from constructs of their 3'UTRs with <it>mCherry</it>, were injected into <it>X. laevis </it>embryos.</p> <p>Results</p> <p>Both DiOC<sub>6</sub>(3) and <it>dazl </it>and <it>DEADSouth in situs </it>identified many small islands at the vegetal surface of cleaving <it>E. coqui </it>embryos, indicative of germ plasm. <it>Dazl </it>was also expressed in primordial germ cells in the genital ridge. The 3'UTRs of <it>E. coqui dazl </it>and <it>DEADSouth </it>directed primordial germ cell specific protein synthesis in <it>X. laevis</it>.</p> <p>Conclusions</p> <p><it>E. coqui </it>utilizes germ plasm with RNAs localized to the vegetal cortex to specify primordial germ cells. The large number of germ plasm islands suggests that an increase in the amount of germ plasm was important in the evolution of the large <it>E. coqui </it>egg.</p
Implementing new consent procedures for the schools-based HPV vaccination programme:a qualitative study
The association of dyslexia and developmental speech and language disorder candidate genes with reading and language abilities in adults
Reading and language abilities are critical for educational achievement and success in adulthood. Variation in these traits is highly heritable, but the underlying genetic architecture is largely undiscovered. Genetic studies of reading and language skills traditionally focus on children with developmental disorders; however, much larger unselected adult samples are available, increasing power to identify associations with specific genetic variants of small effect size. We introduce an Australian adult population cohort (41.7–73.2 years of age, N = 1505) in which we obtained data using validated measures of several aspects of reading and language abilities. We performed genetic association analysis for a reading and spelling composite score, nonword reading (assessing phonological processing: a core component in learning to read), phonetic spelling, self-reported reading impairment and nonword repetition (a marker of language ability). Given the limited power in a sample of this size (~80% power to find a minimum effect size of 0.005), we focused on analyzing candidate genes that have been associated with dyslexia and developmental speech and language disorders in prior studies. In gene-based tests, FOXP2, a gene implicated in speech/language disorders, was associated with nonword repetition (p < .001), phonetic spelling (p = .002) and the reading and spelling composite score (p < .001). Gene-set analyses of candidate dyslexia and speech/language disorder genes were not significant. These findings contribute to the assessment of genetic associations in reading and language disorders, crucial for understanding their etiology and informing intervention strategies, and validate the approach of using unselected adult samples for gene discovery in language and reading
Drawing the answers: Sketching to support free and probed recall by child witnesses and victims with autism spectrum disorder
The success of witness interviews in the criminal justice system depends on the accuracy of information obtained, which is a function of both amount and quality of information. Attempts to enhance witness retrieval such as mental reinstatement of context have been designed with typically developed adults in mind. In this paper, the relative benefits of mental and sketch reinstatement mnemonics are explored with both typically developing children and children with autism. Children watched a crime event video, and their retrieval of event information was examined in free and probed recall phases of a cognitive interview. As expected, typically developing children recalled more correct information of all types than children with autism during free and probed recall phases. Sketching during free recall was more beneficial for both groups in both phases in reducing the amount of incorrect items, but the relative effect of sketching on enhancing retrieval accuracy was greater for children with autism. The results indicate the benefits of choosing retrieval mnemonics that are sensitive to the specific impairments of autistic individuals, and suggest that retrieval accuracy during interviews can be enhanced, in some cases to the same level as that of typically developing individuals
Microscopic Aquatic Predators Strongly Affect Infection Dynamics of a Globally Emerged Pathogen
Research on emerging infectious wildlife diseases has placed particular emphasis on host-derived barriers to infection and disease. This focus neglects important extrinsic determinants of the host/pathogen dynamic, where all barriers to infection should be considered when ascertaining the determinants of infectivity and pathogenicity of wildlife pathogens [1–3]. Those pathogens with free-living stages, such as fungi causing catastrophic wildlife declines on a global scale [4], must confront lengthy exposure to environmental barriers before contact with an uninfected host [5–8]. Hostile environmental conditions therefore have the ability to decrease the density of infectious particles, reducing the force of infection and ameliorating the impact as well as the probability of establishing an infection [9]. Here we show that, in nature, the risk of infection and infectious burden of amphibians infected by the chytrid fungus Batrachochytrium dendrobatidis (Bd) have a significant, site-specific component, and that these correlate with the microfauna present at a site. Experimental infections show that aquatic microfauna can rapidly lower the abundance and density of infectious stages by consuming Bd zoospores, resulting in a significantly reduced probability of infection in anuran tadpoles. Our findings offer new perspectives for explaining the divergent impacts of Bd infection in amphibian assemblages and contribute to our understanding of ecosystem resilience to colonization by novel pathogens
Genome-wide screening for DNA variants associated with reading and language traits
This research was funded by: Max Planck Society, the University of St Andrews - Grant Number: 018696, US National Institutes of Health - Grant Number: P50 HD027802, Wellcome Trust - Grant Number: 090532/Z/09/Z, and Medical Research Council Hub Grant Grant Number: G0900747 91070Reading and language abilities are heritable traits that are likely to share some genetic influences with each other. To identify pleiotropic genetic variants affecting these traits, we first performed a genome‐wide association scan (GWAS) meta‐analysis using three richly characterized datasets comprising individuals with histories of reading or language problems, and their siblings. GWAS was performed in a total of 1862 participants using the first principal component computed from several quantitative measures of reading‐ and language‐related abilities, both before and after adjustment for performance IQ. We identified novel suggestive associations at the SNPs rs59197085 and rs5995177 (uncorrected P ≈ 10–7 for each SNP), located respectively at the CCDC136/FLNC and RBFOX2 genes. Each of these SNPs then showed evidence for effects across multiple reading and language traits in univariate association testing against the individual traits. FLNC encodes a structural protein involved in cytoskeleton remodelling, while RBFOX2 is an important regulator of alternative splicing in neurons. The CCDC136/FLNC locus showed association with a comparable reading/language measure in an independent sample of 6434 participants from the general population, although involving distinct alleles of the associated SNP. Our datasets will form an important part of on‐going international efforts to identify genes contributing to reading and language skills.Publisher PDFPeer reviewe
Deficiency of the zinc finger protein ZFP106 causes motor and sensory neurodegeneration
Acknowledgements We are indebted to Jim Humphries, JennyCorrigan, LizDarley, Elizabeth Joynson, Natalie Walters, Sara Wells and the whole necropsy, histology, genotyping and MLC ward 6 teams at MRC Harwell for excellent technical assistance. We thank the staff of the WTSI Illumina Bespoke Team for the RNA-seq data, the Sanger Mouse Genetics Project for the initial mouse characterization and Dr David Adams for critical reading of the manuscript. We also thank KOMP for the mouse embryonic stem cells carrying the knockout first promoter-less allele (tm1a(KOMP)Wtsi) within Zfp016. Conflict of Interest statement. None declared. Funding This work was funded by the UK Medical Research Council (MRC) to A.A.-A. and a Motor Neurone Disease Association (MNDA) project grant to A.A.-A. and EMCF. D.L.H.B. is a Wellcome Trust Senior Clinical Scientist Fellow and P.F. is a MRC/MNDA Lady Edith Wolfson Clinician Scientist Fellow. Funding to pay the Open Access publication charges for this article was provided by the MRC grant number: MC_UP_A390_1106.Peer reviewedPublisher PD
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