A Mixed-Methods Approach to Developing and Evaluating an SME Business Support Model for Innovation in Rural England

Cumbria is a geo-political county in Northwest England within which the Lake District National Park, a UNESCO World Heritage site is located. Whilst the area has a formidable reputation for natural beauty and historic assets, the innovation ecosystem is described as ‘patchy’ for a number of reasons. The county is one of the largest in England by area and is sparsely populated. This paper describes the needs, development and delivery of an SME business-support programme funded by the European Regional Development Fund, Lancaster University and the University of Cumbria. The Cumbria Innovations Platform (CUSP) Project has been designed to respond to the nuanced needs of SMEs in this locale, whilst promoting the adoption of research and innovation. CUSP utilizes a funnel method to support rural businesses with access to university innovation intervention. CUSP has been built on a three-tier model: Communicate, Collaborate and Create. The paper describes this project in detail and presents results in terms of output indicators achieved, a beneficiary telephone survey and wider economic forecasts. From a pragmatic point-of-view, the paper provides experiences and reflections of those people who are delivering and evaluating knowledge exchange. The authors discuss some of the benefits, challenges and implications for both policy makers and practitioners. Finally, the paper aims to serve as an invitation to others who may consider adopting a similar method of university-industry collaboration in their own region

FINIS: New Methane Detector Technology for Point-Source Detection and Leak Rate Measurements

Utah State University has been developing the Filter Incidence Narrow-band Infrared Spectrometer (FINIS) as a compact instrument for observing atmospheric methane from CubeSats. This instrument will be tested on the upcoming ACMES mission for use as a methane detector. The ACMES mission was selected in 2021 as part of the NASA In-space Validation of Earth Science Technologies (InVEST) program with an expected launch in 2024. Methane is the second most important greenhouse gas and one for which a reduction in emissions could have a significant impact on the near-term rate of global warming. As part of the effort to measure tropospheric methane concentration from space, point source leaks have shown to be challenging to be detected and measured using historic satellite sensors due to their low spatial resolution. In this context, Utah State University has been developing FINIS to be suitable for CH4 leak detection using the differential absorption technique in the 1.6 um band of methane. This paper presents the FINIS design for ACMES, including the instrument review, the concept of operation along with lessons learned from previous air-based testing of the FINIS prototype

Climate change threatens polar bear populations : a stochastic demographic analysis

Author Posting. © Ecological Society of America, 2010. This article is posted here by permission of Ecological Society of America for personal use, not for redistribution. The definitive version was published in Ecology 91 (2010): 2883–2897, doi:10.1890/09-1641.1.The polar bear (Ursus maritimus) depends on sea ice for feeding, breeding, and movement. Significant reductions in Arctic sea ice are forecast to continue because of climate warming. We evaluated the impacts of climate change on polar bears in the southern Beaufort Sea by means of a demographic analysis, combining deterministic, stochastic, environment-dependent matrix population models with forecasts of future sea ice conditions from IPCC general circulation models (GCMs). The matrix population models classified individuals by age and breeding status; mothers and dependent cubs were treated as units. Parameter estimates were obtained from a capture–recapture study conducted from 2001 to 2006. Candidate statistical models allowed vital rates to vary with time and as functions of a sea ice covariate. Model averaging was used to produce the vital rate estimates, and a parametric bootstrap procedure was used to quantify model selection and parameter estimation uncertainty. Deterministic models projected population growth in years with more extensive ice coverage (2001–2003) and population decline in years with less ice coverage (2004–2005). LTRE (life table response experiment) analysis showed that the reduction in λ in years with low sea ice was due primarily to reduced adult female survival, and secondarily to reduced breeding. A stochastic model with two environmental states, good and poor sea ice conditions, projected a declining stochastic growth rate, log λs, as the frequency of poor ice years increased. The observed frequency of poor ice years since 1979 would imply log λs ≈ − 0.01, which agrees with available (albeit crude) observations of population size. The stochastic model was linked to a set of 10 GCMs compiled by the IPCC; the models were chosen for their ability to reproduce historical observations of sea ice and were forced with “business as usual” (A1B) greenhouse gas emissions. The resulting stochastic population projections showed drastic declines in the polar bear population by the end of the 21st century. These projections were instrumental in the decision to list the polar bear as a threatened species under the U.S. Endangered Species Act.We acknowledge primary funding for model development and analysis from the U.S. Geological Survey and additional funding from the National Science Foundation (DEB-0343820 and DEB-0816514), NOAA, the Ocean Life Institute and the Arctic Research Initiative at WHOI, and the Institute of Arctic Biology at the University of Alaska–Fairbanks. Funding for the capture–recapture effort in 2001–2006 was provided by the U.S. Geological Survey, the Canadian Wildlife Service, the Department of Environment and Natural Resources of the Government of the Northwest Territories, and the Polar Continental Shelf Project, Ottawa, Canada

Challenges and Opportunities for Improving Eco-Efficiency of Tropical Forage-Based Systems to Mitigate Greenhouse Gas Emissions

Forage-based livestock production plays a key role in national and regional economies, for food security and poverty alleviation. Livestock production is also considered as a major contributor to agricultural GHG emissions, however. While demand for livestock products is predicted to continue to increase, there is political and societal pressure both to reduce environmental impacts and to convert some of the pasture area to alternative uses such as crop production and environmental conservation. Thus it is essential to develop approaches for sustainable intensification of livestock systems to mitigate GHG emissions, addressing biophysical, socioeconomic and policy challenges. This paper highlights the potential of improved tropical forages in crop-livestock systems, and linked with policy incentives, to enhance livestock production while reducing its environmental footprint. We give examples for sustainable intensification to mitigate GHG emissions based on improved forages in Brazil and Colombia and suggest future perspectives

Allergic to the Twentieth Century: Intentional Communities and Therapeutic Landscapes in The Village and Safe

The concept of therapeutic landscapes has been used to explore diverse spaces and places of healing or wellness, from hospitals to gardens, libraries to smoking areas. A central strand of this work considers rural and/or natural landscapes as affording particular healing experiences. In this paper, I draw on this lineage of work alongside research into the formation of intentional communities in rural settings and the body of writing on representations of rural landscapes and country life. The two representations I analyse are films: The Village (M. Night Shyamalan, 2004) and Safe (Todd Haynes, 1995). In the former, an apparent settler village in rural Pennsylvania is revealed, in the film’s denouement, as an intentional community built as a retreat from the violence of contemporary urban life, guarded by Elders and a shared mythology about border-policing creatures. In Safe, the health hazards of modern suburban living, which lead the central character to develop multiple chemical sensitivity (MCS), can only be escaped by a similar retreat to a wilderness commune in the American desert. In both films, the spaces of rural life are constructed as therapeutic landscapes through their nostalgic, anti-modern withdrawal, and their protective boundary keeping

New Foundations: Pseudo-pacification and special liberty as potential cornerstones of a multi-level theory of homicide and serial murder

Over the past 30 years the industrialized West has witnessed a move towards space, heterogeneity and subjectivity in the criminological study of violence and homicide. Although large-scale quantitative studies of the temporal and spatial distribution of homicide continue to provide a broad empirical context, aetiological explanations tend to be based on analyses of the heterogeneous psychological interactions and experiences of individual subjects at the micro-level. However, mid-range studies of the temporal and spatial distribution of perpetrators and victims of homicide between unrelated adults have provided a useful link between the micro- and macro-levels. Focusing primarily on British homicide and serial murder, this article attempts to strengthen this link by combining contemporary micro-analyses of the subjective motives of perpetrators with mid-range analyses of space, which can therefore be seen as part of the structural tradition of theorizing about homicide and serial murder. Placing these analyses in a broad underlying context constituted by major historical shifts in political economy and the cultural forms of ‘pseudo-pacification’ and ‘special liberty’ will lay the initial cornerstones for an integrated multi-level theory. © The Author(s) 2014

AI is a viable alternative to high throughput screening: a 318-target study

: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery

Improving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facility.

On 11th March 2020, the UK government announced plans for the scaling of COVID-19 testing, and on 27th March 2020 it was announced that a new alliance of private sector and academic collaborative laboratories were being created to generate the testing capacity required. The Cambridge COVID-19 Testing Centre (CCTC) was established during April 2020 through collaboration between AstraZeneca, GlaxoSmithKline, and the University of Cambridge, with Charles River Laboratories joining the collaboration at the end of July 2020. The CCTC lab operation focussed on the optimised use of automation, introduction of novel technologies and process modelling to enable a testing capacity of 22,000 tests per day. Here we describe the optimisation of the laboratory process through the continued exploitation of internal performance metrics, while introducing new technologies including the Heat Inactivation of clinical samples upon receipt into the laboratory and a Direct to PCR protocol that removed the requirement for the RNA extraction step. We anticipate that these methods will have value in driving continued efficiency and effectiveness within all large scale viral diagnostic testing laboratories

Legislative Powers and Executive Corruption

This research project was supported by Riksbankens Jubileumsfond, Grant M13-0559:1, PI: Staffan I. Lindberg, V- Dem Institute, University of Gothenburg, Sweden; Grant KAW 2013.0166 by Knut & Alice Wallenberg Foundation to Wallenberg Academy Fellow Staffan I. Lindberg, V-Dem Institute, University of Gothenburg, Sweden; by University of Gothenburg, Grant E 2013/43