Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway.

The liver is responsible for key metabolic functions, including control of normal homoeostasis in response to diet and xenobiotic metabolism/detoxification. We have shown previously that inactivation of the hepatic cytochrome P450 system through conditional deletion of POR (P450 oxidoreductase) induces hepatic steatosis, liver growth and P450 expression. We have exploited a new conditional model of POR deletion to investigate the mechanism underlying these changes. We demonstrate that P450 induction, liver growth and hepatic triacylglycerol (triglyceride) homoeostasis are intimately linked and provide evidence that the observed phenotypes result from hepatic accumulation of unsaturated fatty acids, which mediate these phenotypes by activation of the nuclear receptor CAR (constitutive androstane receptor) and, to a lesser degree, PXR (pregnane X receptor). To our knowledge this is the first direct evidence that P450s play a major role in controlling unsaturated fatty acid homoeostasis via CAR. The regulation of P450s involved in xenobiotic metabolism by this mechanism has potentially significant implications for individual responses to drugs and environmental chemicals

Back to Balance: A Shadow Federal Budget for 2010

Spending restraint is key to achieving a balanced federal budget over the next five years and should form part of Ottawa’s March Budget. This Backgrounder demonstrates how to limit the rise in the federal debt by prudently reining in spending growth rather than raising taxes, so that past and pending improvements to the nation’s tax competitiveness are not erased.Fiscal and Tax Competitiveness, shadow budget, federal budget, federal deficit

Steering Through Turbulence: The Shadow Federal Budget for 2008

Near-term turbulence should not distract Ottawa budget-makers from critical long-term tasks. This 2008 shadow federal budget will move Canada a key step forward by providing improved incentives and rewards for Canadians' work and saving, and a more congenial environment for investment and innovation.fiscal policy, Canadian government budget

Obligations in the Shade: The Application of Fiduciary Directors’ Duties to Shadow Directors

This paper argues that shadow directors, as defined in English law, ought to owe the full range of directors’ duties, both fiduciary and non-fiduciary, enacted in the Companies Act 2006 (CA 2006), ss 171-177, to the relevant company under their influence. Following the enactment of the recent Small Business, Enterprise and Employment Act (SBEEA) 2015, these general duties are likely to apply to shadow directors, although there is still a case to be made as to why shadow directors should owe fiduciary duties to the relevant company. It is argued here that such a relationship is fiduciary in nature, but the current approach deployed in the English courts, based upon the application of Finn’s originally formulated ‘undertaking’ test alone, is inadequate. Given these inadequacies, it is proposed that the Canadian ‘power and discretion’ test be deployed alongside the ‘undertaking’ test, in order to provide a far more comprehensive justification for the application of fiduciary obligations to shadow directors. This position is supported by establishing a theoretical basis for the ‘power and discretion’ test, via Paul Miller’s ‘fiduciary powers theory’, as well as considering the application of such a test to shadow directors

Multiple resilience dividends at the community level: a comparative study on disaster risk reduction interventions in different countries

The costs of disasters have been increasing in many parts of the world as a result of an increase in exposed and vulnerable assets as well as the effects of climate change. However, investments in disaster risk reduction (DRR)remain insufficient to manage these growing risks. To make investments in DRR more attractive and to shift investments from post-event response and recovery to pre-event resilience, there has been a push to account for the full range of benefits of those investments including economic, ecological and social ‘resilience dividends’. While the concept of ‘multiple resilience dividends’ is now frequently used to strengthen the DRR narrative, it has not yet been widely applied in practice when appraising DRR interventions. The paper analyses the knowledge gaps and challenges that arise from applying the ‘multiple resilience dividends’ in planning, implementation and evaluation of disaster risk reduction interventions on the community level. A newly developed framework is used to analyse empirical survey data on community level DRR interventions as well as five in-depth community case studies in Vietnam, Nepal, Indonesia, Afghanistan and the UK. The analysis reveals a disconnect between the available planning tools and the evidence on materialized multiple resilience dividends, which pose a key obstacle in successfully applying the concept on the community level. The paper concludes that a structured consideration of multiple dividends of resilience from the planning to the monitoring stage is important to secure local buy-in and to ensure that the full range of benefits can materialize

Case Report: Concomitant Diagnosis of Plasma Cell Leukemia in Patient With JAK2 Positive Myeloproliferative Neoplasm.

Plasma cell dyscrasias and myeloproliferative neoplasms (MPN) are hematologic malignancies arising from two distinct hematopoietic cell lineages. They rarely occur concomitantly. Here, we report a case of a patient with a recent diagnosis of a JAK2 V617F positive MPN who presented with a new diagnosis of plasma cell leukemia. The patient had presented to the hospital with a leukocytosis predominantly comprised of plasma cells, followed by work-up involving peripheral blood flow cytometry, FISH analysis, and bone-marrow biopsy. FISH analysis was suggestive of a common progenitor cell for these distinct hematologic malignancies. To our knowledge, this case represents the second reported instance of a concomitant JAK2 positive MPN with primary plasma cell leukemia

Buses with High Level Of Service (BHLS) – Operational, Regulatory And Contractual Dimensions

Buses with High Level of Service (BHLS) is an emerging term in Europe for higher quality bus services in urban areas, based on a combination of better operating environment, high quality vehicles, upgraded infrastructure, improved customer services, marketing, image and a systemic approach. BHLS is not the same product as Bus Rapid Transit (BRT), although there are many features in common. The primary objective of BHLS is to uplift the quality of the bus mode rather than to provide the mass transit function. Many European cities have extreme limitations in available road width, BHLS aims to get the maximum capacity and quality within the available space. This paper reports the findings of an EU COST Action on BHLS, which includes practitioners and researchers from 14 EU countries. It presents BHLS practice, a set of 5 Case Studies (France, Netherlands, Ireland, Spain and Sweden, and operational characteristics of BHLS systems in Europe. A review of procurement and contractual aspects indicates that BHLS has been implemented within existing regulations, procedures, contract structures and performance parameters. Information on the COST TU603 action on BHLS can be obtained at www.bhls.euInstitute of Transport and Logistics Studies. Faculty of Economics and Business. The University of Sydne

The Anatomical Society core embryology syllabus for undergraduate medicine

A modified Delphi methodology was used to develop a consensus regarding a series of learning outcome statements to act as the foundation of an undergraduate medical core embryology syllabus. A Delphi panel was formed by recruiting stakeholders with experience in leading undergraduate teaching of medical students. The panel (n = 18), including anatomists, embryologists and practising clinicians, were nominated by members of Council and/or the Education Committee of the Anatomical Society. Following development of an a priori set of learning outcome statements (n = 62) by the authors, panel members were asked in the first of a two‐stage process to ‘accept’, ‘reject’ or ‘modify’ each learning outcome, to propose additional outcomes if desired. In the second stage, the panel was asked to either accept or reject 16 statements which had either been modified, or had failed to reach consensus, during the first Delphi round. Overall, 61 of 62 learning outcome statements, each linked to examples of clinical conditions to provide context, achieved an 80% level of agreement following the modified Delphi process and were therefore deemed accepted for inclusion within the syllabus. The proposed syllabus allows for flexibility within individual curricula, while still prioritising and focusing on the core level of knowledge of embryological processes by presenting the essential elements to all newly qualified doctors, regardless of their subsequent chosen specialty

Troubled Worlds: A Course Syllabus about Information Work and the Anthropocene

The goal of this syllabus is to interrogate the material, and socioeconomic processes which underpin our everyday information work. In particular, we examine the relationships developing between contemporary information practices and what problematically gets configured as “nature”—that messy world of non-human entanglements that often exists beyond the purview of innovation work, whether digital software development or industrial engineering. Much recent work on the environmental conditions of computing has sought to break down technology-nature dualisms in order to expose the implication of information technology in broader social and material ecologies. Library and information professionals and researchers are well poised to deepen this inquiry by presenting alternative nature-technology epistemologies grounded in longstanding analyses of information resources and their consumption. The “Troubled Worlds” syllabus starts with a discussion of concerns most obviously germane to the work of most library and information science professionals: practices at the intersection of structuring information and computing. Building on this attention, we turn to humanistic approaches to thinking through the era of dominant human activities widely known as the “Anthropocene” by introducing poetic, artistic, and activist lenses. We explore how artistic objects representing an increasingly troubled natural world raise awareness of the challenges facing it, as well as how they may incorporate and reshape information for aesthetic ends. We then look to questions of disability justice and how it works in blended built and natural spaces as well as the many different ways in which bodies respond to the toxic environments produced by information technologies. We next consider the newer design approaches to library and information research, specifically asking how design perspectives on digital information objects get inscribed in the Anthropocene. Lastly, we consider paradigms of repair and making and analyze the different valences through which information researchers and professionals categorize and contextualize what is possible with them. This compilation does not provide a comprehensive review of the literature on the environment within the information fields. Instead, it extends this literature to promote experimental research and practice. The modules construct an interdisciplinary and provisional path through the related literature in a form that we hope may be continually adjusted, rearranged, and augmented. Pre-print first published online 03/15/202