470 research outputs found
Period-Luminosity Relations Derived from the OGLE-III Fundamental Mode Cepheids
In this Paper, we have derived Cepheid period-luminosity (P-L) relations for
the Large Magellanic Cloud (LMC) fundamental mode Cepheids, based on the data
released from OGLE-III. We have applied an extinction map to correct for the
extinction of these Cepheids. In addition to the VIW band P-L relations, we
also include JHK and four Spitzer IRAC band P-L relations, derived by matching
the OGLE-III Cepheids to the 2MASS and SAGE datasets, respectively. We also
test the non-linearity of the Cepheid P-L relations based on
extinction-corrected data. Our results (again) show that the LMC P-L relations
are non-linear in VIJH bands and linear in KW and the four IRAC bands,
respectively.Comment: 6 pages, 3 figures and 3 tables, ApJ accepte
The Extinction and Distance of Maffei 1
We have obtained low- and high-resolution spectra of the core of the
highly-reddened elliptical galaxy Maffei 1. From these data, we have obtained
the first measurement of the Mg2 index, and have measured the velocity
dispersion and radial velocity with improved accuracy. To evaluate the
extinction, a correlation between the Mg2 index and effective V-I colour has
been established for elliptical galaxies. Using a new method for correcting for
effective wavelength shifts, we find A_V = 4.67 +/- 0.19 mag, which is lower by
0.4 mag than previously thought. To establish the distance, the Fundamental
Plane for elliptical galaxies has been constructed in I. The velocity
dispersion of Maffei 1, measured to be 186.8 +/- 7.4 km/s, in combination with
modern wide-field photometry in I, leads to a distance of 2.92 +/- 0.37 Mpc.
The Dn-sigma relation, which is independently calibrated, gives 3.08 +/- 0.85
Mpc and 3.23 +/- 0.67 Mpc from photometry in B and K`, respectively. The
weighted mean of the three estimates is 3.01 +/- 0.30 Mpc. The distance and
luminosity make Maffei 1 the nearest giant elliptical galaxy. The radial
velocity of Maffei 1 is +66.4 +/- 5.0 km/s, significantly higher than the
accepted value of -10 km/s. The Hubble distance corresponding to the mean
velocity of Maffei 1, Maffei 2 and IC342 is 3.5 Mpc. Thus, it is unlikely that
Maffei 1 has had any influence on Local Group dynamics
Cost-effectiveness of alternative methods of surgical repair of inguinal hernia
Objectives: To assess the relative cost-effectiveness of laparoscopic methods of inguinal hernia repair compared with open flat mesh and open non-mesh repair. Methods: Data on the effectiveness of these alternatives came from three systematic reviews comparing: (i) laparoscopic methods with open flat mesh or non-mesh methods; (ii) open flat mesh with open non-mesh repair; and (iii) methods that used synthetic mesh to repair the hernia defect with those that did not. Data on costs were obtained from the authors of economic evaluations previously conducted alongside trials included in the reviews. A Markov model was used to model cost-effectiveness for a five-year period after the initial operation. The outcomes of the model were presented using a balance sheet approach and as cost per hernia recurrence avoided and cost per extra day at usual activities. Results: Open flat mesh was the most cost-effective method of preventing recurrences. Laparoscopic repair provided a shorter period of convalescence and less long-term pain compared with open flat mesh but was more costly. The mean incremental cost per additional day back at usual activities compared with open flat mesh was €38 and €80 for totally extraperitoneal and transabdominal preperitoneal repair, respectively. Conclusions: Laparoscopic repair is not cost-effective compared with open flat mesh repair in terms of cost per recurrence avoided. Decisions about the use of laparoscopic repair depend on whether the benefits (reduced pain and earlier return to usual activities) outweigh the extra costs and intraoperative risks. On the evidence presented here, these extra costs are unlikely to be offset by the short-term benefits of laparoscopic repair.Luke Vale, Adrian Grant, Kirsty McCormack, Neil W. Scott and the EU Hernia Trialists Collaboratio
Laparoscopic peritoneal lavage: A definitive treatment for diverticular peritonitis or a "bridge" to elective laparoscopic sigmoidectomy?
To this day, the treatment of generalized peritonitis secondary to diverticular perforation is still controversial. Recently, in patients with acute sigmoid diverticulitis, laparoscopic lavage and drainage has gained a wide interest as an alternative to resection. Based on this backdrop, we decided to perform a systematic review of the literature to evaluate the safety, feasibility, and efficacy of peritoneal lavage in perforated diverticular disease. A bibliographic search was performed in PubMed for case series and comparative studies published between January 1992 and February 2014 describing laparoscopic peritoneal lavage in patients with perforated diverticulitis. A total of 19 articles consisting of 10 cohort studies, 8 case series, and 1 controlled clinical trial met the inclusion criteria and were reviewed. In total these studies analyzed data from 871 patients. The mean follow-up time ranged from 1.5 to 96 months when reported. In 11 studies, the success rate of laparoscopic peritoneal lavage, defined as patients alive without surgical treatment for a recurrent episode of diverticulitis, was 24.3%. In patients with Hinchey stage III diverticulitis, the incidence of laparotomy conversion was 1%, whereas in patients with stage IV it was 45%. The 30-day postoperative mortality rate was 2.9%. The 30-day postoperative reintervention rate was 4.9%, whereas 2% of patients required a percutaneous drainage. Readmission rate after the first hospitalization for recurrent diverticulitis was 6%. Most patients who were readmitted (69%) required redo surgery. A 2-stage laparoscopic intervention was performed in 18.3% of patients. Laparoscopic peritoneal lavage should be considered an effective and safe option for the treatment of patients with sigmoid diverticulitis with Hinchey stage III peritonitis; it can also be consider as a “bridge” surgical step combined with a delayed and elective laparoscopic sigmoidectomy in order to avoid a Hartmann procedure. This minimally invasive staged approach should be considered for patients without systemic toxicity and in centers experienced in minimally invasive surgery techniques. Further evidence is needed, and the ongoing RCTs will better define the role of the laparoscopic peritoneal lavage/drainage in the treatment of patients with complicated diverticulitis
Benchmarks in antimicrobial peptide prediction are biased due to the selection of negative data
Antimicrobial peptides (AMPs) are a heterogeneous group of short polypeptides that target not only microorganisms but also viruses and cancer cells. Due to their lower selection for resistance compared with traditional antibiotics, AMPs have been attracting the ever-growing attention from researchers, including bioinformaticians. Machine learning represents the most cost-effective method for novel AMP discovery and consequently many computational tools for AMP prediction have been recently developed. In this article, we investigate the impact of negative data sampling on model performance and benchmarking. We generated 660 predictive models using 12 machine learning architectures, a single positive data set and 11 negative data sampling methods; the architectures and methods were defined on the basis of published AMP prediction software. Our results clearly indicate that similar training and benchmark data set, i.e. produced by the same or a similar negative data sampling method, positively affect model performance. Consequently, all the benchmark analyses that have been performed for AMP prediction models are significantly biased and, moreover, we do not know which model is the most accurate. To provide researchers with reliable information about the performance of AMP predictors, we also created a web server AMPBenchmark for fair model benchmarking. AMP Benchmark is available at http://BioGenies.info/AMPBenchmark
Dense Gas in Nearby Galaxies: XVII. The Distribution of Ammonia in NGC253, Maffei2 and IC342
The central few 100 pc of galaxies often contain large amounts of molecular
gas. The chemical and physical properties of these extragalactic star formation
regions differ from those in galactic disks, but are poorly constrained. This
study aims to develop a better knowledge of the spatial distribution and
kinetic temperature of the dense neutral gas associated with the nuclear
regions of three prototypical spiral galaxies, NGC253, IC342, and Maffei2. VLA
CnD and D configuration measurements have been made of three ammonia (NH3)
inversion transitions. The (J,K)=(1,1) and (2,2) transitions of NH3 were imaged
toward IC342 and Maffei2. The (3,3) transition was imaged toward NGC253. The
entire flux obtained from single-antenna measurements is recovered for all
three galaxies observed. Derived lower limits to the kinetic temperatures
determined for the giant molecular clouds in the centers of these galaxies are
between 25 and 50K. There is good agreement between the distributions of NH3
and other H2 tracers, such as rare CO isotopologues or HCN, suggesting that NH3
is representative of the distribution of dense gas. The "Western Peak" in IC342
is seen in the (6,6) line but not in lower transitions, suggesting maser
emission in the (6,6) transition.Comment: 13 pages, 8 figures, latex format, accepted by A&
Brain catecholamine depletion and motor impairment in a Th knock-in mouse with type B tyrosine hydroxylase deficiency
Tyrosine hydroxylase catalyses the hydroxylation of L-tyrosine to l-DOPA, the rate- limiting step in the synthesis of catecholamines. Mutations in the TH gene encoding tyrosine hydroxylase are associated with the autosomal recessive disorder tyrosine hydroxylase deficiency, which manifests phenotypes varying from infantile parkinsonism and DOPA-responsive dystonia, also termed type A, to complex encephalopathy with perinatal onset, termed type B. We generated homozygous Th knock-in mice with the mutation Th-p.R203H, equivalent to the most recurrent human mutation associated with type B tyrosine hydroxylase deficiency (TH-p.R233H), often unresponsive to l-DOPA treatment. The Th knock-in mice showed normal survival and food intake, but hypotension, hypokinesia, reduced motor coordination, wide-based gate and catalepsy. This phenotype was associated with a gradual loss of central catecholamines and the serious manifestations of motor impairment presented diurnal fluctuation but did not improve with standard l-DOPA treatment. The mutant tyrosine hydroxylase enzyme was unstable and exhibited deficient stabilization by catecholamines, leading to decline of brain tyrosine hydroxylase-immunoreactivity in the Th knock-in mice. In fact the substantia nigra presented an almost normal level of mutant tyrosine hydroxylase protein but distinct absence of the enzyme was observed in the striatum, indicating a mutation-associated mislocalization of tyrosine hydroxylase in the nigrostriatal pathway. This hypomorphic mouse model thus provides understanding on pathomechanisms in type B tyrosine hydroxylase deficiency and a platform for the evaluation of novel therapeutics for movement disorders with loss of dopaminergic input to the striatum
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