Monte-Carlo sampling of energy-constrained quantum superpositions in high-dimensional Hilbert spaces

Recent studies into the properties of quantum statistical ensembles in high-dimensional Hilbert spaces have encountered difficulties associated with the Monte-Carlo sampling of quantum superpositions constrained by the energy expectation value. A straightforward Monte-Carlo routine would enclose the energy constrained manifold within a larger manifold, which is easy to sample, for example, a hypercube. The efficiency of such a sampling routine decreases exponentially with the increase of the dimension of the Hilbert space, because the volume of the enclosing manifold becomes exponentially larger than the volume of the manifold of interest. The present paper explores the ways to optimise the above routine by varying the shapes of the manifolds enclosing the energy-constrained manifold. The resulting improvement in the sampling efficiency is about a factor of five for a 14-dimensional Hilbert space. The advantage of the above algorithm is that it does not compromise on the rigorous statistical nature of the sampling outcome and hence can be used to test other more sophisticated Monte-Carlo routines. The present attempts to optimise the enclosing manifolds also bring insights into the geometrical properties of the energy constrained manifold itself.Comment: 9 pages, 7 figures, accepted for publication in European Physical Journal

Health Care Charges Associated With Physical Inactivity, Overweight, and Obesity

INTRODUCTION: Physical inactivity, overweight, and obesity are associated with increased morbidity and mortality. The objective of this study was to estimate the proportion of total health care charges associated with physical inactivity, overweight, and obesity among U.S. populations aged 40 years and older. METHODS: A predictive model of health care charges was developed using data from a cohort of 8000 health plan members aged 40 and older. Model cells were defined by physical activity status, body mass index, age, sex, smoking status, and selected chronic diseases. Total health care charges were estimated by multiplying the percentage of the population in each cell by the predicted charges per cell. Counterfactual estimates were computed by reclassifying all individuals as physically active and of normal weight while leaving other characteristics unchanged. Charges associated with physical inactivity, overweight, and obesity were computed as the difference between current risk profile total charges and counterfactual total charges. National population percentage estimates were derived from the National Health Interview Survey; those estimates were multiplied by the predicted charges per cell from the health plan analysis. RESULTS: Physical inactivity, overweight, and obesity were associated with 23% (95% confidence interval [CI], 10%–34%) of health plan health care charges and 27% (95% CI, 10%–37%) of national health care charges. Although charges associated with these risk factors were highest for the oldest group (aged 65 years and older) and for individuals with chronic conditions, nearly half of aggregate charges were generated from the group aged 40 to 64 years without chronic disease. CONCLUSION: Charges associated with physical inactivity, overweight, and obesity constitute a significant portion of total medical expenditures. The results underscore the importance of addressing these risk factors in all segments of the population

Accessibility-based reranking in multimedia search engines

Traditional multimedia search engines retrieve results based mostly on the query submitted by the user, or using a log of previous searches to provide personalized results, while not considering the accessibility of the results for users with vision or other types of impairments. In this paper, a novel approach is presented which incorporates the accessibility of images for users with various vision impairments, such as color blindness, cataract and glaucoma, in order to rerank the results of an image search engine. The accessibility of individual images is measured through the use of vision simulation filters. Multi-objective optimization techniques utilizing the image accessibility scores are used to handle users with multiple vision impairments, while the impairment profile of a specific user is used to select one from the Pareto-optimal solutions. The proposed approach has been tested with two image datasets, using both simulated and real impaired users, and the results verify its applicability. Although the proposed method has been used for vision accessibility-based reranking, it can also be extended for other types of personalization context

‘For Your Ears Only!’ Donald Sterling and Backstage Racism in Sport

The purpose of this paper is to elucidate how racism manifests ‘behind closed doors’ in the backstage private domain. We do this with reference to recent high-profile controversies in the US and UK. In particular, we use the concepts of frontstage (public) and backstage (private) racism to unpack the extraordinary case in point of the ex-National Basketball Association (NBA) franchise owner Donald Sterling. The paper concludes that though it is important for frontstage racism to be disrupted, activist scholars must be mindful of the lesser-known, and lesser-researched, clandestine backstage racism that, we argue, galvanises more public manifestations. The Donald Sterling case is an example of how backstage racism functions and, potentially, how it can be resisted

Eddington-limited accretion and the black hole mass function at redshift 6

We present discovery observations of a quasar in the Canada-France High-z Quasar Survey (CFHQS) at redshift z=6.44. We also use near-IR spectroscopy of nine CFHQS quasars at z~6 to determine black hole masses. These are compared with similar estimates for more luminous Sloan Digital Sky Survey (SDSS) quasars to investigate the relationship between black hole mass and quasar luminosity. We find a strong correlation between MgII FWHM and UV luminosity and that most quasars at this early epoch are accreting close to the Eddington limit. Thus these quasars appear to be in an early stage of their life cycle where they are building up their black hole mass exponentially. Combining these results with the quasar luminosity function, we derive the black hole mass function at z=6. Our black hole mass function is ~10^4 times lower than at z=0 and substantially below estimates from previous studies. The main uncertainties which could increase the black hole mass function are a larger population of obscured quasars at high-redshift than is observed at low-redshift and/or a low quasar duty cycle at z=6. In comparison, the global stellar mass function is only ~10^2 times lower at z=6 than at z=0. The difference between the black hole and stellar mass function evolution is due to either rapid early star formation which is not limited by radiation pressure as is the case for black hole growth or inefficient black hole seeding. Our work predicts that the black hole mass - stellar mass relation for a volume-limited sample of galaxies declines rapidly at very high redshift. This is in contrast to the observed increase at 4<z<6 from the local relation if one just studies the most massive black holes.Comment: 16 pages, 10 figures, AJ in pres

Early toxicity predicts long-term survival in high-grade glioma

BACKGROUND: Patients with high-grade gliomas are treated with surgery followed by chemoradiation. The risk factors and implications of neurological side effects are not known. METHODS: Acute and late ≥ grade 3 neurological toxicities (NTs) were analysed among 2761 patients from 14 RTOG trials accrued from 1983 to 2003. The association between acute and late toxicity was analysed using a stepwise logistic regression model. The association between the occurrence of acute NT and survival was analysed as an independent variable. RESULTS: There were 2610 analysable patients (86% glioblastoma, 10% anaplastic astrocytoma). All received a systemic agent during radiation (83% chemotherapy, 17% biological agents). Median radiation dose was 60 Gy. There were 182 acute and 83 late NT events. On univariate analysis, older age, poor performance status, aggressive surgery, pre-existing neurological dysfunction, poor mental status and twice-daily radiation were associated with increased acute NT. In a stepwise logistic regression model the occurrence of acute NT was significantly associated with late NT (OR=2.40; 95% CI=1.2-4.8; P=0.014). The occurrence of acute NT predicted poorer overall survival, independent of recursive partitioning analysis class (median 7.8 vs 11.8 months). INTERPRETATION: Acute NT is significantly associated with both late NT and overall survival

Maximal care considerations when treating patients with end-stage heart failure: ethical and procedural quandaries in management of the very sick

Deciding who should receive maximal technological treatment options and who should not represents an ethical, moral, psychological and medico-legal challenge for health care providers. Especially in patients with chronic heart failure, the ethical and medico-legal issues associated with providing maximal possible care or withholding the same are coming to the forefront. Procedures, such as cardiac transplantation, have strict criteria for adequate candidacy. These criteria for subsequent listing are based on clinical outcome data but also reflect the reality of organ shortage. Lack of compliance and non-adherence to lifestyle changes represent relative contraindications to heart transplant candidacy. Mechanical circulatory support therapy using ventricular assist devices is becoming a more prominent therapeutic option for patients with end-stage heart failure who are not candidates for transplantation, which also requires strict criteria to enable beneficial outcome for the patient. Physicians need to critically reflect that in many cases, the patient’s best interest might not always mean pursuing maximal technological options available. This article reflects on the multitude of critical issues that health care providers have to face while caring for patients with end-stage heart failure

Identification of the Pangenome and Its Components in 14 Distinct Aggregatibacter actinomycetemcomitans Strains by Comparative Genomic Analysis

Aggregatibacter actinomycetemcomitans is genetically heterogeneous and comprises distinct clonal lineages that may have different virulence potentials. However, limited information of the strain-to-strain genomic variations is available.The genome sequences of 11 A. actinomycetemcomitans strains (serotypes a-f) were generated de novo, annotated and combined with three previously sequenced genomes (serotypes a-c) for comparative genomic analysis. Two major groups were identified; serotypes a, d, e, and f, and serotypes b and c. A serotype e strain was found to be distinct from both groups. The size of the pangenome was 3,301 genes, which included 2,034 core genes and 1,267 flexible genes. The number of core genes is estimated to stabilize at 2,060, while the size of the pangenome is estimated to increase by 16 genes with every additional strain sequenced in the future. Within each strain 16.7-29.4% of the genome belonged to the flexible gene pool. Between any two strains 0.4-19.5% of the genomes were different. The genomic differences were occasionally greater for strains of the same serotypes than strains of different serotypes. Furthermore, 171 genomic islands were identified. Cumulatively, 777 strain-specific genes were found on these islands and represented 61% of the flexible gene pool.Substantial genomic differences were detected among A. actinomycetemcomitans strains. Genomic islands account for more than half of the flexible genes. The phenotype and virulence of A. actinomycetemcomitans may not be defined by any single strain. Moreover, the genomic variation within each clonal lineage of A. actinomycetemcomitans (as defined by serotype grouping) may be greater than between clonal lineages. The large genomic data set in this study will be useful to further examine the molecular basis of variable virulence among A. actinomycetemcomitans strains