737 research outputs found
Carrier Transport in Magnesium Diboride: Role of Nano-inclusions
Anisotropic-gap and two-band effects smear out the superconducting transition
(Tc) in literature reported thermal conductivity of MgB2, where large
electronic contributions also suppress anomaly-manifestation in their
negligible phononic-parts. Present thermal transport results on scarcely
explored specimens featuring nano-inclusions exhibit a small but clear
Tc-signature, traced to relatively appreciable phononic conduction, and its
dominant electronic-scattering. The self-formed MgO as extended defects
strongly scatter the charge carriers and minutely the phonons with their
longer-mean-free-path near Tc. Conversely, near room temperature, the
shorter-dominant-wavelength phonon's transport is hugely affected by these
nanoparticles, undergoing ballistic to diffusive crossover and eventually
entering the Ioffe-Regel mobility threshold regime.Comment: 14 pages, 4 figures, 28 reference
Modelling international monthly tourism demand at the micro destination level with climate indicators and web-traffic data
We investigate if and how climate indicators and web-traffic data may improve the estimates of demand functions\u2019 parameters, considering specific origins and destinations. Overall, augmented demand functions show better fit and more reliable price and income elasticities whether the demand is measured with arrivals or with overnights. However, heterogeneity stemming from the main type of tourism (business vs. cultural vs. sea and sun) affects both the web-based and the climate indicators better describing tourists demand as well as their optimal lags. Our findings highlight the utility of such prompt and territorial detailed information for local policymakers, showing, however, how sensitive different demand segments are to policy intervention
Structures from Powders: Polynuclear Hg(II) Complexes Containing the Flexible Bisimidazolylmethane Ligand
Microwave Response of Coaxial Cavities Made of Bulk Magnesium Diboride
We report on the microwave properties of coaxial cavities built by using bulk MgB2 superconductor prepared by reactive liquid Mg infiltration technology. We have assembled a homogeneous cavity by using an outer MgB2 cylinder and an inner MgB2 rod and a hybrid cavity by using an outer copper cylinder and the same MgB2 rod as inner conductor. By the analysis of the resonance curves, in the different resonant modes, we have determined the microwave surface resistance Rs of the MgB2 materials as a function of the temperature and the frequency, in the absence of dc magnetic fields. At T=4.2 K and f ≈ 2.5 GHz, by an mw pulsed technique, we have determined the quality factor of the homogeneous cavity as a function of the input power up to a maximum level of about 40 dBm (corresponding to a maximum peak magnetic field of about 100 Oe). Contrary to what occurs in many films, Rs of the MgB2 material used does not exhibit visible variations up to an input power level of about 10 dBm and varies less than a factor of 2 on further increasing the input power of 30 dB
THE CENTRAL CHOLINERGIC SYSTEM HAS A ROLE IN THE ANTINOCICEPTION INDUCED IN RODENTS AND GUINEA-PIGS BY THE ANTIMIGRAINE DRUG SUMATRIPTAN
Planck LFI flight model feed horns
this paper is part of the Prelaunch status LFI papers published on JINST:
http://www.iop.org/EJ/journal/-page=extra.proc5/jinst The Low Frequency
Instrument is optically interfaced with the ESA Planck telescope through 11
corrugated feed horns each connected to the Radiometer Chain Assembly (RCA).
This paper describes the design, the manufacturing and the testing of the
flight model feed horns. They have been designed to optimize the LFI optical
interfaces taking into account the tight mechanical requirements imposed by the
Planck focal plane layout. All the eleven units have been successfully tested
and integrated with the Ortho Mode transducers.Comment: This is an author-created, un-copyedited version of an article
accepted for publication in JINST. IOP Publishing Ltd is not responsible for
any errors or omissions in this version of the manuscript or any version
derived from it. The definitive publisher authenticated version is available
online at 10.1088/1748-0221/4/12/T1200
PSMA-Specific CAR-Engineered T Cells Eradicate Disseminated Prostate Cancer in Preclinical Models.
Immunology-based interventions have been proposed as a promising curative chance to effectively attack postoperative minimal residual disease and distant metastatic localizations of prostate tumors. We developed a chimeric antigen receptor (CAR) construct targeting the human prostate-specific membrane antigen (hPSMA), based on a novel and high affinity specific mAb. As a transfer method, we employed last-generation lentiviral vectors (LV) carrying a synthetic bidirectional promoter capable of robust and coordinated expression of the CAR molecule, and a bioluminescent reporter gene to allow the tracking of transgenic T cells after in vivo adoptive transfer. Overall, we demonstrated that CAR-expressing LV efficiently transduced short-term activated PBMC, which in turn were readily stimulated to produce cytokines and to exert a relevant cytotoxic activity by engagement with PSMA+ prostate tumor cells. Upon in vivo transfer in tumor-bearing mice, CAR-transduced T cells were capable to completely eradicate a disseminated neoplasia in the majority of treated animals, thus supporting the translation of such approach in the clinical setting
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