6,813 research outputs found

    Invited Editorial: The Gifts of a Talk with TED

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    In this invited editorial, Dr. Jim Field reflects on the recent meeting of the 12th annual Canadian Hermeneutic Institute, which hosted Professor Ted George as our visiting scholar. Three days of lecture and scholarly conversation left all of us in thoughtful and interpretive spaces

    Is it Really “Yesterday’s War”? What Gadamer Has to Say About What Gets Counted

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    In this paper, the authors address the perceived recent trend of funding and publishing bodies that seem to have taken a regard of qualitative research as a subordinate to, or even a subset of, quantitative research. In this reflection, they pull on insights that Hans-Georg Gadamer offered around the history of the natural and human science bifurcation, ending with a plea that qualitative research needs to be received, appraised, judged, and promoted by different lenses and criteria of value

    Architecture of a host–parasite interface: complex targeting mechanisms revealed through proteomics

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    Surface membrane organization and composition is key to cellular function, and membrane proteins serve many essential roles in endocytosis, secretion, and cell recognition. The surface of parasitic organisms, however, is a double-edged sword; this is the primary interface between parasites and their hosts, and those crucial cellular processes must be carried out while avoiding elimination by the host immune defenses. For extracellular African trypanosomes, the surface is partitioned such that all endo- and exocytosis is directed through a specific membrane region, the flagellar pocket, in which it is thought the majority of invariant surface proteins reside. However, very few of these proteins have been identified, severely limiting functional studies, and hampering the development of potential treatments. Here we used an integrated biochemical, proteomic and bioinformatic strategy to identify surface components of the human parasite Trypanosoma brucei. This surface proteome contains previously known flagellar pocket proteins as well as multiple novel components, and is significantly enriched in proteins that are essential for parasite survival. Molecules with receptor-like properties are almost exclusively parasite-specific, whereas transporter-like proteins are conserved in model organisms. Validation shows that the majority of surface proteome constituents are bona fide surface-associated proteins and, as expected, most present at the flagellar pocket. Moreover, the largest systematic analysis of trypanosome surface molecules to date provides evidence that the cell surface is compartmentalized into three distinct domains with free diffusion of molecules in each, but selective, asymmetric traffic between. This work provides a paradigm for the compartmentalization of a cell surface and a resource for its analysis

    Book Review: Thomas C. Field, Jr. From Development to Dictatorship: Bolivia and the Alliance for Progress in the Kennedy Era.

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    This document offers reviews and discussion of Thomas C. Field, Jr.’s book From Development to Dictatorship: Bolivia and the Alliance for Progress in the Kennedy Era. Ithaca: Cornell University Press, 2014. ISBN: 978-0-8014-5260-4 (hardcover, $45.00)

    Social physique anxiety and physical activity in early adolescent girls : the influence of maturation and physical activity motives

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    This study considered the influence of maturation on social physique anxiety (SPA), the relationship between SPA and current and future physical activity (PA) levels and the influence of motives for physical activity on this relationship in early adolescent girls (n=162; mean age=11.80±0.33 years). Participants completed the Pubertal Development Scale, the modified Social Physique Anxiety Scale and the Motives for Physical Activity Scale at baseline and the Physical Activity Questionnaire for Older Children at baseline and 6 months later. The girls became less active across the 6 months and girls in the early stages of maturation had significantly lower SPA than the girls in the middle and late stages of maturation. SPA was not related to current or future physical activity in the sample as a whole. Cluster analysis identified four groups with different motive profiles and the High Appearance and Fitness group demonstrated a moderate negative relationship between SPA and PA at phase 1, whereas the other groups did not. These findings indicate that SPA may increase with maturation and the relationship between SPA and PA is dependent on reasons for being active. For girls who are motivated to be active primarily by body-related reasons SPA is likely to lead to lower levels of PA

    Flux front penetration in disordered superconductors

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    We investigate flux front penetration in a disordered type II superconductor by molecular dynamics (MD) simulations of interacting vortices and find scaling laws for the front position and the density profile. The scaling can be understood performing a coarse graining of the system and writing a disordered non-linear diffusion equation. Integrating numerically the equation, we observe a crossover from flat to fractal front penetration as the system parameters are varied. The value of the fractal dimension indicates that the invasion process is described by gradient percolation.Comment: 5 pages, 4 figures, to appear in Phys. Rev. Let
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