Patch Tests Under Systemic Immunossupression - An Absolute Contra-Indication?

Introdução: As provas epicutâneas (PE) são o exame complementar de diagnóstico indicado para avaliação de suspeita de dermite de contacto alérgica. Idealmente, devem ser realizadas sem que o doente se encontre sob imunossupressores. Existem contudo situações clínicas em que tal não é possível, não havendo informação disponível acerca de como realizar e valorizar os resultados das PE nestes doentes. O objectivo do presente trabalho é rever a literatura no que concerne à realização de PE sob imunossupressão iatrogénica. Material e Métodos: Revisão da literatura relevante para o tema publicada até Janeiro de 2015 e indexada à Medline. Resultados: De acordo com o reportado na literatura, foram realizadas PE em 77 doentes sob corticóide sistémico, 78 doentes sob ciclosporina (CyA), 6 sob azatioprina, 10 sob metotrexato (MTX), 4 sob micofenolato de mofetil (MMF), 11 sob fármacos anti-factor de necrose tumoral e 7 sob fármaco anti-IL-12/23. Foram ainda descritos 15 casos de realização de PE sob associação de imunossupressores. Verificaram-se reacções positivas em todos os grupos. Conclusão: O tratamento concomitante com imunossupressores não deve ser uma contra-indicação para realização de PE, estando descritas reacções positivas em doentes sob prednisolona, azatioprina, CyA, MTX, MMF, infliximab, etanercept, adalimumab e ustecinumab. Os resultados negativos ou duvidosos devem, contudo, ser interpretados de forma cautelosa

Hábitos alimentares de utentes adultos do centro de saúde de Castelo Branco

Em Portugal têm vindo a revelar-se alguns erros alimentares praticados por grande parte da população. Esses erros cometem-se por excesso de ingestão de certo tipo de alimentos que, consequentemente, levam a problemas no organismo, como é o caso da obesidade, diabetes, hipertensão arterial, entre outras doenças

MAGIC sensitivity to millisecond-duration optical pulses

The MAGIC telescopes are a system of two Imaging Atmospheric Cherenkov Telescopes (IACTs) designed to observe very high energy (VHE) gamma rays above ~50 GeV. However, as IACTs are sensitive to Cherenkov light in the UV/blue and use photo-detectors with a time response well below the ms scale, MAGIC is also able to perform simultaneous optical observations. Through an alternative system installed in the central PMT of MAGIC II camera, the so-called central pixel, MAGIC is sensitive to short (1ms - 1s) optical pulses. Periodic signals from the Crab pulsar are regularly monitored. Here we report for the first time the experimental determination of the sensitivity of the central pixel to isolated 1-10 ms long optical pulses. The result of this study is relevant for searches of fast transients such as Fast Radio Bursts (FRBs).Comment: Proceedings of the 35th International Cosmic Ray Conference (ICRC 2017), Bexco, Busan, Korea (arXiv:1708.05153

Influence of filtration and glucose amendment on bacterial growth rate at different tidal conditions in the Minho Estuary River (NW Portugal)

Bacterioplankton abundance, biomass and growth rates were studied in theMinho Estuary River (NW Portugal). The influence of tidal conditions, glucose amendment, and the filtration process on total bacterial abundance, total and faecal coliforms, as well as faecal streptococci, were evaluated in laboratory incubation experiments. Physical and chemical conditions, as well as bacterial abundance in this estuary were found to be typical for oligo-mesotrophic coastal ecosystems. Bacterial abundance was higher at high tide, probably due to hydrodynamics and resuspension of bacteria from sediments. In contrast, a significant decrease of bacterial indicators of faecal pollution at high tide was probably the result of various causes, such as the decrease of continental and agricultural land run-off effect by dilution, and/or increase in the abundance of potential specific predators. Thus, drastic changes were induced at high tide that led to a lack of bacterial growth and the net disappearance of most of the bacterial populations. Glucose amendment, at used concentration, was not found to stimulate bacterial growth, which instead could be limited by inorganic nutrients.La abundancia, la biomasa y las tasas de crecimiento de bacterioplancton fueron estudiadas en el estuario del río Miño (NW Portugal). La influencia de condiciones de marea, de la adición de glucosa y del proceso de filtración en la abundancia total de bacterias, coliformes totales y coliformes fecales, así como de estreptococos fecales, fue evaluada en experimentos de incubación en laboratorio. Las condiciones físicas y quíımicas, así como la abundancia bacteriana encontradas en este estuario son típicas para los ecosistemas costeros oligo-mesotroficos. La abundancia bacteriana fue más alta en la alta marea, probablemente debido a la hidrodinámica y a la resuspensión de bacterias de los sedimentos. En contraste, la disminución significativa de los indicadores bacterianos de la contaminación fecal en la alta marea resultó probablemente de varias causas, tales como la disminución del efecto de vertido de la región continental y agrícola por la dilución, y/o aumento en la abundancia de depredadores específicos potenciales. En resultado, cambios drásticos fueron inducidos en la alta marea originando la ausencia de crecimiento bacteriano y la desaparición neta de la mayoría de las poblaciones bacterianas. La adición de la glucosa, en la concentración usada, no estimuló el crecimiento bacteriano, que se podría limitar por los alimentos inorgánicos

Caracterização climática do Município de São José de Ubá, Estado do Rio de Janeiro.

bitstream/CNPS-2010/14921/1/bpd95-2006-clima-sao-jose-uba.pd

Diagnóstico do espaço turístico e das propostas de gestão no município de Cachoeiras de Macacu.

bitstream/CNPS-2010/14742/1/bpd135-2009-planejamento-espaco-turistico.pd

A population-based cohort study

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Exploring the feasibility and acceptability of a sleep wearable headband among a community sample of chronic pain individuals: An at-home observational study

Background Chronic pain conditions affect up to one third of the adult population in the United Kingdom. Sleep problems are prevalent and negatively impact quality of life. Lack of standardised tools for routine screening and assessment of sleep changes have been a barrier for sleep management. Novel sleep wearables offer an exciting and accessible way to measure sleep but have not been tested outside of the consumer-led landscape and are not commonly used in research and clinical settings. Aims The study aimed to explore the feasibility and acceptability of a sleep monitoring headband (Dreem 2) utilising EEG technology and accompanying smartphone application among a cohort of adults with chronic pain. Results Twenty-one adults (81% women) completed a one-week home sleep study using a sleep headband and accompanying app. Ninety per cent of participants met the pre-defined requirement of two-night's sleep recording. All participants recorded one night of sleep data via the sleep headband. The majority (76%) of participants were satisfied with the sleep study, and 86% of participants were willing to wear the headband longer than the 2-night minimum requirement. Finally, 76% reported the headband as ‘somewhat’ or ‘extremely’ comfortable whist awake; 57% rated the headband as comfortable during sleep. Conclusion The Dreem 2 headband appears to be a feasible and acceptable means of collecting sleep measurements among individuals with chronic pain, despite common sleep disturbances. These devices may have utility for screening, assessment and monitoring in research and practice. Further research is needed to provide guidelines and training for integration

Performance of the freshwater shrimp <i>Atyaephyra desmarestii</i> as indicator of stress imposed by textile effluents

Textile plants consume large volumes of water and produce a great amount of wastewaters, which can be important sources of toxic discharges in receiving environments. The objective of this study was to evaluate the acute toxicity of textile effluents on the freshwater shrimp A. desmarestii. A whole effluent toxicity test procedure was used to determine the aggregate toxicity of three samples taken before and after wastewater treatment in a textile mill. The following LC50 &minus; 48 h values (%, v/v) were calculated: Untreated effluent &minus;29% effluent (sample 1), 22% effluent (sample 2), and 47% (sample 3); Treated effluent &minus;73% effluent (sample 1), 74% effluent (sample 2), and &gt; 100% (sample 3). Based upon acute toxicity units (TUa = 100/LC50), untreated effluent varied from toxic in samples 1 and 3 (2.00 &le; TUa &le; 4.00) to very toxic in sample 2 (TUa &gt; 4.0), whereas treated effluent varied from no toxic in sample 3 to moderately toxic in samples 1 and 2 (1.33 &le; TUa &le; 1.99). Despite some limitations and constraints related to innate variability of industrial effluents, our results suggested that A. desmarestii can be a promising and potential test organism for assessing toxicity of complex chemical mixtures